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Journal : Jurnal Kedokteran Hewan

THE SEDATIVE STUDY OF TABAR KEDAYAN ROOT ETHANOLIC EXTRACT (Aristolochia foveolate) IN MICE (Mus musculus) Wijayanti, Agustina Dwi; Nugroho, Alvinia Rusandriani; Yanti, Desti Ika; Fitriana, Ida ida
Jurnal Kedokteran Hewan Vol 18, No 2 (2024): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v18i2.33759

Abstract

The study was conducted to know the sedation effect of Tabar kedayan (Aristolochia faveolate). Thirty male mice were grouped into six groups, and each group contained five mice which were given six treatments. Group I, II, III, and IV were treated orally with tabar kedayan root ethanolic extract (TKREE) with a single dose of 50, 100, 200, and 400 mg/kg body weight, group V was given chlorpromazine with a dose of 20 mg/kg, and group VI was given distilled water 10 mL/kg of body weight. Based on the analysis, the results of mice falling time for group I, II, III, IV, V, and VI were 238.93101.01, 208.38115.41, 240.69102.19, 276.4268.28, 31.6464.55, and 168.09126.82 seconds, respectively. The groups were significantly different from the positive control group (P0.05). Mice treated with TKREE fell longer than negative and positive controls. Based on these results, the administration of TKREE did not cause a sedation effect on mice; otherwise, may have potential as a stimulant, and studies are needed to provide scientific evidence to support this potential.
EVALUATION OF LAPAROTOMY SURGERY WOUND HEALING IN DOGS USING THERMOGRAPHIC ANALYSIS Wijayanti, Agustina Dwi; Purnomo, Agus; Wijayanto, Hery
Jurnal Kedokteran Hewan Vol 17, No 1 (2023): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v17i1.29785

Abstract

This study aimed to develop the use of thermographic analysis to evaluate wound healing for laparotomy surgery in animals. The experiment used nine adult dogs 5 males and 4 females, bodyweight 5-10 kg) that had undergone the same general anesthesia and laparotomy procedures. Evaluation of wound healing was performed at 24, 48, and 72 hours after surgery and 7 days after operations using a digital thermal camera. During each thermographic evaluation period, blood samples were taken for analysis of total leukocytes and leukocyte differential. The results of thermal imaging were compared with the values of inflammatory cells and the clinical condition of wound healing. Comparison of thermographic analysis with inflammatory status was evaluated using the regression equation and showed a strong correlation coefficient (Y= -0.4847 + 40.14, R2= 0.867), that is, the higher the temperature, the lower the inflammation. The conclusion of study is that thermographic analysis can be used to evaluate wound healing of laparotomy surgery in dogs.
EFEKTIVITAS ENROFLOKSASIN TERHADAP INFEKSI BAKTERI PADA SALURAN PENCERNAAN ULAR SANCA BATIK (Python reticulatus) Wijayanti, Agustina Dwi; Untari, Tri; Rosetyadewi, Antasiswa W.; Rahardjo, Slamet
Jurnal Kedokteran Hewan Vol 7, No 2 (2013): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v7i2.898

Abstract

Penelitian ini bertujuan mengetahui efektivitas enrofloksasin terhadap infeksi bakteri pada saluran pencernaan ular sanca batik (Python reticulatus). Ular yang digunakan berjumlah 10 ekor dan terindikasi klinis mengalami gangguan pencernaan berupa keradangan pada mulut. Sampel yang diambil adalah swab mulut dan kloaka untuk pemeriksaan mikrobiologi berupa isolasi dan identifikasi bakteri pada media brilliant green agar, Mc Conkay agar, triple sugar iron, dan pembiakan isolat murni. Setelah pengambilan sampel semua ular diinjeksi dengan enrofloksasin 5 mg/kg bobot badan, dosis tunggal secara intramuskular anterior. Pengamatan klinis dilakukan hingga semua ular dinyatakan sembuh dari keradangan mulut. Hasil pemeriksaan mikrobiologi menunjukkan adanya bakteri Salmonella sp., E. coli, dan Proteus sp. pada saluran pencernaan ular. Enrofloksasin yang diberikan secara injeksi intramuskular anterior mampu memberikan kesembuhan dalam rentang waktu 4-16 hari setelah pemberian.