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All Journal Dentika Dental Journal Journal of Dentistry Indonesia Indonesian Journal of Pharmaceutical Science and Technology ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Interdental Jurnal Kedokteran Gigi (IJKG) Makara Journal of Health Research Odonto dental journal
Yuniardini Septorini Wimardhani
Department Of Oral Medicine, Faculty Of Dentistry, Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Medicine & Pharmacology Public Health

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The Effectiveness of Moringa Oleifera Lam Extract as an Oral Antimicrobial: a Systematic Literature Review Indrastiti, Ratna Kumala; Rahmayanti, Febrina; Wimardhani, Yuniardini Septorini
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.39-47

Abstract

Background: The use of mouthwash to maintain oral hygiene has been carried out for many years. However, long-term use of mouthwash can cause side effects such as tooth discoloration, burning sensation and the death of normal oral flora. The use of herbal plant, such as Moringa oleifera lam has been studied as an alternative medicine because of its pharmacological properties and it is hoped to have minimum side effect. In this systematic literature review, we included the studies that have been investigate the antimicrobial capacity of Moringa oleifera lam as a basic knowledge to develop a preparation for oral hygiene maintenance.Method: A comprehensive literature search was performed utilizing four different electronic databases: PubMed, Scopus, Cochrane library, and EBSCO. Articles included in this study were published from 2013 to September 2023, with broad search criteria comprising MeSH-terms and free-text keywords Moringa Oleifera, Oral Antimicrobial, and Mouthwash.Result: At the beginning our search resulted in 17 articles, with 14 articles remaining after removal of duplication. We exclude five studies that do not meet the PICO criteria, resulting seven articles which included to this study.Conclusion: According to the literature review that has been carried out, Moringa oleifera lam has antimicrobial capacity which allows it to be used as a material in medicinal preparations. Further research, both in vitro and clinical research, will determine the effectiveness of Moringa oleifera lam in suppressing microorganisms.
Mapping the Anticancer Mechanism of Asiatic Acid : A systematic review of preclinical evidence Sari, Rina Kartika; Dalimunthe, Rahmi Syaflida; Amir, Lisa Rinanda; Wimardhani, Yuniardini Septorini; Musfiroh, Ida; Sastradipura, Dewi Fatma Suniarti
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.62028

Abstract

Studies have demonstrated that Asiatic acid (AA) from Centella asiatica has anticancer properties in cancer cell lines, but translating these findings into clinical research remains challenging. This review aims to provide a robust scientific foundation for enhancing the translational potential of AA-based anticancer therapy. The PubMed, Scopus, and ScienceDirect databases were searched electronically using specific keywords and screened in accordance with the PRISMA 2020 guidelines.  Fourteen studies meet the criteria. All research was conducted in vitro; four studies were conducted both in vitro and in vivo, and three were conducted in silico.Asiatic acid (AA) demonstrates potent anticancer activity by modulating key signaling pathways, including PI3K/Akt and NF-κB, thereby inhibiting proliferation, promoting apoptosis, and reducing metastasis. Its cytotoxic effects are time- and dose-dependent (1–50 µM) and minimal in normal cells. While AA and its derivatives consistently outperform controls, limitations such as missing control dose data warrant further investigation. Future studies should focus on in vivo validation, clinical translation, and advanced strategies such as targeted delivery and AI-assisted drug development to fully realize AA’s therapeutic potential.
Factors Associated with Oral Discomfort at The Menopausal Stage: A Systematic Review Yuli Fatzia Ossa; Yuniardini Septorini Wimardhani; Iwany Amaliah Badraduddin; Febriana Setiawati; Steffano Aditya Handoko; Lindawati Soetanto Kusdhany
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 22 No. 2 (2026): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v22i2.14274

Abstract

Introduction: Menopause is a physiological process that all women experience and is often regarded as a sign of aging in women. The signs and symptoms of menopause are very diverse, and oral discomfort is one of the symptoms. Oral discomfort can interfere with oral cavity function, indirectly affecting nutrient intake. This study aims to evaluate factors associated with oral discomfort and oral manifestations of the menopausal stage. Review: This review is based on the PRISMA statement. A literature review incorporated observational studies from the last five years and across 5 databases.  An investigative question was formulated using the PEOS model, studies were selected, and a quality analysis was performed in accordance with the STROBE guidelines. The bibliometric analysis was performed, and the data were qualitatively analyzed. A total of 19 articles met the inclusion criteria, with the majority of oral manifestations at the menopausal stage being xerostomia, burning sensation, taste disturbances, and periodontitis. Duration of menopause, bad oral hygiene, lower salivary flow rate, higher calcium saliva concentration, and salivary estrogen level were found to be associated factors for oral discomfort at the menopausal stage. Conclusions: The menopausal stage may increase the risk of oral discomfort due to decreased estrogen levels in saliva. Since the estrogen receptor was found in the oral cavity, especially in the mucosa, salivary gland, and periodontium, it can directly affect the oral cavity.
Co-Authors Afi Savitri Sarsito Agustina, Yohana Alfa Amir, Lisa Rinanda Anandina Irmagita Dalimunthe, Rahmi Syaflida Dewi Fatma Suniarti Ening Krisnuhoni Erik Idrus Febriana Setiawati Febrina Rahmayanti Hartanti, Pratiwi Dwi Iamaroon, Anak Ida Musfiroh -, Ida Musfiroh Indriasti Indah Wardhany Iwany Amaliah Badraduddin Lindawati S. Kusdhany Patoni, Nurfianti Ahmad Prasetyo, Sri Redjeki Ratna Kumala Indrastiti Sari, Rina Kartika Sitheeque, Mohaideen AM. Steffano Aditya Handoko Subarnbhesaj, Ajiravudh Winanda Annisa Yuli Fatzia Ossa