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All Journal Medicina E-Jurnal Medika Udayana The Indonesian Biomedical Journal Universa Medicina Oto Rhino Laryngologica Indonesiana ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Patologi Indonesia Neurologico Spinale Medico Chirurgico Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Ni Wayan Winarti
Department Of Anatomical Pathology, Faculty Of Medicine Udayana University, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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GAMBARAN KLINIKOPATOLOGIK PENYAKIT PROSTAT DI RSUP SANGLAH DENPASAR TAHUN 2018-2020 Astuti, Ida Ayu Jelantik; Winarti, Ni Wayan; Sriwidyani, Ni Putu; Dewi, I Gusti Ayu Sri Mahendra
E-Jurnal Medika Udayana Vol 12 No 11 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i11.P07

Abstract

Prostate disease is one of the diseases with a high incidence among elderly men. . In establishing the diagnosis of prostate disease, histopathological and laboratory examinations are vital. These histopathological results can be grouped into 3, namely benign lesions, PIN, and carcinoma. This study aims to determine the clinicopathological description of prostate diseases at Sanglah Hospital Denpasar from 2018-2020. The cross-sectional research was conducted using the descriptive and analytic method. Samples were selected based on several inclusion and exclusion criteria. Data were analyzed using SPSS version 26 to obtain a general clinicopathological picture based on age, histopathological diagnosis, the relationship between age and histopathological, diagnosis, PSA level, and the relationship between PSA level with histopathological diagnosis, and grade group carcinoma. The results showed that the prostate disease with the most patients at Sanglah Hospital Denpasar from 2018-2020 occurred between the age of 70-79 years by 39,0% with the dominant histopathological diagnosis being benign prostate 240 (74,3%), followed by PIN 27 (8,4%), and carcinoma 56 (17,3%). There was no relationship found between age, mean age and histopathological diagnosis with p=0,881 and p=0,119. The highest PSA level was > 20ng/mL. It was found that the PSA level was significantly associated with histopathological diagnoses with a value of p=0,000. The most prevalent grade group characteristic was grade group 5 with 36 (64,3%). Keywords: Prostate Disease, Clinicopathologic, PSA Level
KARAKTERISTIK KLINIKOPATOLOGI LESI NEOPLASTIK TIROID DI RSUP SANGLAH DENPASAR BALI PERIODE 2016-2020 Dewi, Ida Ayu Krisna Cantika; Sriwidyani, Ni Putu; Dewi, I Gusti Ayu Sri Mahendra; Winarti, Ni Wayan
E-Jurnal Medika Udayana Vol 11 No 11 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i11.P12

Abstract

Thyroid neoplastic lesion can be either benign or malignant/cancerous. Thyroid cancer is a type of cancer that is increasing worldwide and is the most common endocrine gland malignant in Indonesia. The purpose of this study is to determine the clinicopathological characteristics of thyroid neoplastic lesion at Sanglah General Hospital Denpasar Bali for the 2016-2020 period based on age, sex, histopathological type, and location of lesion. This research is a descriptive study with a cross sectional approach. The data used are secondary data of patients with thyroid neoplastic lesion that registered for histopathological examination at the Anatomical Pathology Laboratory of Sanglah Hospital Denpasar in 2016-2020. The data collection technique used was total sampling which result in of 407 data meeting the inclusion criteria. The results show that the most common thyroid neoplastic lesion is found in the age group of 41-50 years (25.3%), female sex (77.4%), histopathological type of papillary thyroid carcinoma (79.9%), and location of the lesion is multiple (combination of two or more locations) as much as 36.9%. The conclusions that can be drawn from this study are thyroid neoplastic lesion patients at Sanglah General Hospital Denpasar for the period 2016-2020 have the most clinicopathological characteristics aged 41-50 years, female sex, papillary thyroid carcinoma histopathology, and multiple lesion locations. The results of this study can be developed and become the basis for other research with more varied variables or other research methods such as analytical research. Keywords: Thyroid Neoplastic Lesion, Clinicopathological Characteristics, Histopathological Type
CLINICOPATHOLOGICALCHARACTERISTICS OF NASOPHARYNGEALCARCINOMA AT CENTRAL GENERAL HOSPITAL PROF. DR. I.G.N.G. NGOERAH DENPASAR IN 2021-2022 Heriani, Ni Komang; Paskarani, Putu Erika; Winarti, Ni Wayan
E-Jurnal Medika Udayana Vol 13 No 2 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i02.P08

Abstract

ABSTRACT Nasopharyngeal carcinoma (NPC) epidemiologically occupies the fourth position as the highest number of malignancy cases in Bali, Indonesia. The most common histological type of NPC cases are non-keratinizing squamous cell carcinoma (NKSCC) undifferentiated subtype. This research aims to know the clinicopathological aspect of nasopharyngeal carcinoma at Central General Hospital Prof. Dr. I.G.N.G Ngoerah Denpasar in 2021-2022 regarding the distribution of age range, gender, education, occupation, clinical stage, histological type, as well as the results of anamnesis. The research design is a descriptive study of 70 cases of NPC at Central General Hospital Prof. Dr. I.G.N.G Ngoerah Denpasar from 2021 to 2022. Samples were collected retrospectively from secondary data using a total sampling technique through a cross-sectional study, samples were obtained from medical record data and hospital management system of Central General Hospital Prof. Dr. I.G.N.G Ngoerah Denpasar. In this study, the most cases of NPC were found in the range of 51-60 years old (32.9%), male sex (65.7%), high school education status (48.6%), private employee employment (32.9%), anamnesis results of a lump in the neck (77.1%), stage IVA (40%), and with the histological type of NKSCC undifferentiated subtype (90%). Men have twice the risk of suffering from NPC compared to women, most cases have complained of a lump in the neck and other symptoms such as nasal congestion, tinnitus, headaches. The most common histological type found is the NKSCC undifferentiated subtype, which mostly occurs in advanced stages of an IVA. Keywords : Clinicopathology, NPC, Nasopharynx
Akurasi Pemeriksaan Potong Beku Dibandingkan dengan Histopatologi untuk Mendiagnosis Tumor Ovarium di RSUP Sanglah Denpasar Ida Ayu, Priandini; Dewi, I Gusti Ayu Sri Mahendra; Winarti, Ni Wayan; Sriwidyani, Ni Putu
E-Jurnal Medika Udayana Vol 12 No 11 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i11.P08

Abstract

Ovarian tumors are gynecological tumors that are difficult to detect because of the variety of symptoms and signs that require a precise and accurate diagnosis. Frozen section examination is a histological examination performed rapidly in intraoperative cases in the diagnosis of ovarian tumors with paraffin block examination as the gold standard. This study aims to assess the accuracy of frozen section compared to histopathological examination of paraffin blocks in diagnosing ovarian tumors in RSUP Sanglah Denpasar. This study is a diagnostic test study with a sample of 62 patients selected by consecutive sampling method. Value of sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated from the sample obtained. On paraffin blocks examination, 36 cases of benign ovarian tumors (benign and borderline neoplasms) and 26 cases of malignant ovarian tumors were found. This study obtained a sensitivity value of 88.5%, specificity 100%, positive predictive value 100%, negative predictive value 92.3%, and frozen section accuracy value 95.2%. Therefore, the frozen section examination is a good diagnostic test tool to be used in the diagnosis of ovarian tumors. Keywords : Paraffin Block, Frozen Section, Ovarian Tumor. Tumor ovarium merupakan tumor ginekologi yang sulit dideteksi karena gejala dan tanda yang beragam sehingga memerlukan cara diagnosis yang tepat dan akurat. Pemeriksaan potong beku merupakan pemeriksaan histologi yang dilakukan secara cepat dalam kasus intraoperatif pada diagnosis tumor ovarium dengan pemeriksaan histopatologi blok parafin yang menjadi standar baku emas. Penelitian bertujuan untuk menilai akurasi dari alat uji diagnostik potong beku dengan pemeriksaan histopatologi blok parafin untuk mendiagnosis tumor ovarium di RSUP Sanglah Denpasar. Penelitian ini merupakan penelitian uji diagnostik dengan jumlah sampel 62 pasien yang dipilih dengan metode consecutive sampling. Pada sampel dihitung nilai sensitivitas, spesifisitas, nilai prediksi positif, nilai prediksi negatif, dan akurasi. Pada pemeriksaan histopatologi blok parafin ditemukan 36 kasus tumor ovarium jinak (neoplasma jinak dan borderline) dan 26 kasus tumor ovarium ganas. Penelitian ini mendapatkan nilai sensitivitas 88,5%, spesifisitas 100%, nilai prediksi positif 100%, nilai prediksi negatif 92,3%, dan nilai akurasi potong beku 95,2%. Berdasarkan hal tersebut, pemeriksaan potong beku merupakan alat uji diagnostik yang baik untuk digunakan dalam penegakan diagnosis tumor ovarium. Kata kunci : Blok Parafin, Potong Beku, Tumor Ovarium.
KARAKTERISTIK KLINIKOPATOLOGI TUMOR SINONASAL DI RSUP SANGLAH PERIODE 2016-2020 Dewi, Ida Ayu Meilasari; Sriwidyani, Ni Putu; Sri Mahendra Dewi, I Gusti Ayu; Winarti, Ni Wayan
E-Jurnal Medika Udayana Vol 11 No 11 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i11.P13

Abstract

Tumor sinonasal merupakan tumor yang melibatkan kavum nasi dan sinus paranasal. Berdasarkan pertumbuhannya dibedakan menjadi tumor jinak dan tumor ganas. Menurut prevalensi, kasus tumor jinak sinonasal jarang terjadi, namun keganasan sinonasal menempati peringkat kedua keganasan kepala leher di Asia. Tujuan penelitian ini adalah untuk mengetahui karakteristik klinikopatologi tumor sinonasal di RSUP Sanglah Denpasar pada tahun 2016-2020 berdasarkan usia, jenis kelamin, lokasi tumor, dan tipe histopatologi. Penelitian dilakukan dengan rancangan cross-sectional, menggunakan data sekunder pasien tumor sinonasal yang melakukan pemeriksaan histopatologi di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar. Sampel dikumpulkan dengan teknik total sampling, kemudian diolah menggunakan SPSS versi 23. Penelitian mendapatkan 166 kasus tumor sinonasal (jinak dan ganas) yang memenuhi kriteria penelitian. Tumor sinonasal terbanyak terjadi pada rentang usia 51-60 tahun dan 61-70 tahun dengan jumlah masing-masing 41 (24,7%), lebih banyak mengenai laki-laki (65,7%), lokasi tumor tertinggi pada daerah sinonasal (57,2%), dan tipe histopatologi yang paling sering adalah squamous cell carcinoma (22,9%) untuk tumor ganas serta inverted type sinonasal papilloma (18,1%) untuk tumor jinak. Disimpulkan bahwa tumor sinonasal sering terjadi pada usia 51-60 tahun dan 61-70 tahun, jenis kelamin laki-laki, berlokasi di sinonasal, dengan tipe squamous cell carcinoma dan inverted type sinonasal papilloma. Kata kunci : tumor sinonasal, karakteristik klinikopatologi, tipe histopatologi Sinonasal tumours are tumours that occur in the nasal cavity and paranasal sinuses. Based on its growth, classified into benign tumours and malignant tumours. According to prevalence, cases of benign sinonasal tumors are rare, but sinonasal malignancies are the second most common after head and neck malignancy in Asia. The purpose of this study was to determine the clinicopathological characteristics of sinonasal tumors at RSUP Sanglah Denpasar in 2016-2020 based on age, gender, location of the tumour, and histopathological type. The study was conducted with cross-sectional design, using secondary data from sinonasal tumor patients who underwent histopathological examination at the Anatomical Pathology Laboratory, RSUP Sanglah Denpasar Samples were collected by total sampling technique, then processed using SPSS version 23. The study found 166 cases of sinonasal tumours (benign and malignant) that met the research criteria. Sinonasal tumours were most common in the age range of 51-60 years and 61-70 years (24.7%), more common in males (65.7%), the highest tumour location was in the sinonasal (57.2%), and the most common histopathological type was squamous cell carcinoma (22.9%) for malignant tumours and inverted type sinonasal papilloma (18.1%) for benign tumours. It was concluded that most sinonasal tumours occur at the age of 51-60 years and 61-70 years, male gender, located in the sinonasal, with squamous cell carcinoma type and inverted type sinonasal papilloma. Keywords : sinonasal tumour, clinicopathological characteristics, histopathological type
The relationship between IL-6 expression and ossicular destruction in CSOM with cholesteatoma Rahayu, Made Lely; Winarti, Ni Wayan; Danastri, I Gusti Ayu Mahaprani; Handayani, Ni Komang Tri Utami; Reniati, Roselina
Oto Rhino Laryngologica Indonesiana Vol. 55 No. 1 (2025): VOLUME 55, NO. 1 JANUARY - JUNE 2025
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v55i1.704

Abstract

Background: Chronic suppurative otitis media (CSOM) is a disease that affects the middle ear, leading to perforation of the tympanic membrane. This condition involves chronic inflammation in the middle ear and mastoid cavity. A CT scan often reveals destruction to the ossicles and cholesteatoma. Purpose: To determine the relationship between increased IL-6 expression and ossicular destruction in CSOM patients with cholesteatoma. Method: This observational analytic study with a cross-sectional comparative design was conducted at the Anatomy Pathology Laboratory of Prof. Ngoerah General Hospital, Denpasar. The study used cholesteatoma tissue paraffin blocks from patients with the dangerous type of CSOM who had undergone tympanomastoidectomy from January 2022 to December 2023. Sampling was carried out through consecutive sampling, which included all cholesteatoma tissue paraffin blocks from patients with the dangerous type of CSOM that met the inclusion criteria, amounting to 17 blocks. Result: This study found a p-value >0.05, indicating no association in the bivariate analysis between the percentage, intensity, and overall score of IL-6 pathology results and ossicular destruction due to cholesteatoma, in CSOM patients. Conclusion: This study concluded that there was no significant relationship between IL-6 expression and hearing bone destruction caused by cholesteatoma in CSOM patients.
Renoprotective Effects of Hydroxychloroquine and Folinic Acid via ET-1 and NLRP3 Modulation in Reducing Tubular Injury in A Rabbit Model of Methanol-induced Acute Kidney Injury Prayuda, Prayuda; Widiana, I Gde Raka; Suega, Ketut; Kandarini, Yenny; Winarti, Ni Wayan; Purwanto, Bambang
The Indonesian Biomedical Journal Vol 17, No 4 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i4.3747

Abstract

BACKGROUND: Methanol intoxication is associated with significant morbidity and mortality, particularly when acute kidney injury (AKI) developed. Emerging evidence implicates Endothelin-1 (ET-1) and Nucleotide-binding domain leucine-rich repeat-containing pyrin receptor 3 (NLRP3) inflammasome in renal injury, but their roles in methanol-induced AKI remain unclear. To date, no studies have examined whether hydroxychloroquine or folinic acid, which are known to modulate ET-1 and NLRP3 signaling, could mitigate renal injury in this setting. This study evaluated their therapeutic effects in a rabbit model of methanol-induced AKI.METHODS: The animals subjects were randomly assigned to four groups: control group receiving aquabidest, folinic acid group receiving 2 mg/kg body weight (BW) intraperitoneal folinic acid, hydroxychloroquine group receiving 30 mg/kg BW oral hydroxychloroquine phosphate, and combination group receiving both folinic acid and hydroxychloroquine at the same dosages. Histopathological evaluation of tubular injury scores and immunohistochemical analysis of ET-1 and NLRP3 expression were then conducted.RESULTS: Expressions of ET-1, NLRP3, and tubular injury scores were significantly lower in the hydroxychloroquine, folinic acid, and combination therapy groups compared to the control group (p<0.001). Expression of ET-1 was lowest in folinic acid group (59.38±0.71%), followed by combination group (62.23±1.98%) and hydroxychloroquine group (62.43±1.81%), compared to control group (72.14±1.02%). Expression of NLRP3 was lowest in combination group (58.94±1.05%), followed by folinic acid and hydroxychloroquine group, which showed equal values (60.57±1.38%), compared to control group (72.15±1.02%). Tubular injury scores were also lowest in combination group (27.07±3.16%), followed by hydroxychloroquine group (45.29±1.75%) and folinic acid group (48.38±2.49%), compared to control group (77.15±1.66%).CONCLUSION: Expression of ET-1 and NLRP3, as well as tubular injury scores, are significantly lower in all treatment groups compared to control, suggesting hydroxychloroquine and folinic acid demonstrated renoprotective effects in methanol-induced AKI, likely through modulation of ET-1 and NLRP3 pathways.KEYWORDS: methanol intoxication, acute kidney injury, hydroxychloroquine, folinic acid, endothelin-1, NLRP3 inflammasome, experimental animal models, rabbits
Clinicopathologic Features of Carcinoma of the Cervix Uteri at Prof. Dr. I.G.N.G. Ngoerah Hospital in 2021-2022 Paramitha, Ni Made Laksmi Dewi; Dewi, I Gusti Ayu Sri Mahendra; Paskarani, Putu Erika; Winarti, Ni Wayan
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1328

Abstract

Background: Cervical cancer is a malignant tumor of the cervix with a high mortality rate, primarily identified by vaginal bleeding. Human papillomavirus (HPV) infection was found in 99.7% of cervical cancer cases. Other risk factors include age at first sexual intercourse, parity, smoking, weak immune system, use of oral contraceptives, and a high number of sexual partners. This study aims to analyze and describe the clinicopathological features of cervical carcinoma, including patient demographics, primary symptoms, histopathological types, and tumor staging, at Prof. Dr. I.G.N.G. Ngoerah Hospital from 2021 to 2022.Method: This study employs a descriptive research method with a retrospective approach, utilizing secondary data and comprising 283 samples. Inclusion criteria included patients diagnosed with cervical carcinoma confirmed by histopathological evaluation and complete medical records documenting age, primary complaints, histopathological classification, and TNM staging. Data were processed and presented using descriptive statistics. Results: The results showed that the age group with the highest number of cervical carcinoma cases was the 40-49 years age group (36.0%), the most common main complaint was bleeding (68.9%), the most common histopathological type was squamous cell carcinoma (78.8%), and the most common TNM stage was T1 (52 cases) and N0 (87 cases).Conclusion: This study highlights that cervical carcinoma predominantly affects women aged 40–49 years, with abnormal vaginal bleeding as the most common symptom. Squamous cell carcinoma was the most common histopathological type (78.8%), with the majority of cases staged at T1 (18.4%) and N0 (30.7%).
Intra-adrenal Paraganglioma and Paraaortic Paraganglioma in 15 Years Old Boys Butarbutar, Christine Rosalina; Maker, Luh Putu Iin Indrayani; Sumadi, I Wayan Juli; Winarti, Ni Wayan; Ariyanta, Kadek Deddy; Asih, Made Widhi
Majalah Patologi Indonesia Vol. 33 No. 1 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i1.631

Abstract

Intra-adrenal paraganglioma (also called pheochromocytoma) is a chromaffin cell tumor that arises in the adrenal medulla and produces excess catecholamines. Paraganglioma can also be located in the extra-adrenal area. The incidence rate of intra-adrenal and extra-adrenal paraganglioma is about 1 case per 2.500-6.500 population, highest incidence at 40-50 years old, and distribution is the same in males and females. Intra-adrenal paraganglioma in pediatrics is more familial, bilateral, multifocal, and malignant. In children, the incidence rate of these tumors was 8.86%, the ratio of boys to girls was 2:1, and the average age of 11. This article reports a case, of a 15 years old boy with severe headaches, recurrent seizures, and a hypertension crisis (143/103-220/110 mmHg). MSCT scan of abdominal showed solid mass heterogeneous with central necrotic multiple in the supero-anterior of the left and right kidneys and on the right anterolateral aorta as high as CV L2, impressive adrenal gland mass and extra-adrenal, suspect pheochromocytoma. Performed surgery, routine histopathological examination, and Immunohistochemistry. Macroscopic examination showed an oval round shape mass of left and right adrenal tumors as well as the paraaortic, a smooth outer surface of the capsular, with yellowish brown color mass tumor at cut surface, supple consistency. Microscopic examination showing adrenal gland and paraaortic tissue with fibrous capsule contains proliferation of neoplastic cells forming a nested alveolar (Zellballen) pattern with a round oval to polygonal cells, granular eosinophilic cytoplasm, round oval nuclei, surrounded by sustentacular cells. Chromogranin A and S-100 are positive. The case was concluded by clinical findings, histopathological, and immunohistochemistry as intra-adrenal paraganglioma and paraganglioma of paraaortic.
Co-Authors Anak Agung Ayu Ngurah Susraini Anak Agung Gde Putra Wiraguna annie minerva datui Ariyanta, Kadek Deddy Arlene Elizabeth Padang Astuti, Ida Ayu Jelantik Bambang Purwanto Butarbutar, Christine Rosalina Damayanti, Ni Kadek Ayu Maya Danastri, I Gusti Ayu Mahaprani Dewi, Ida Ayu Krisna Cantika Dewi, Ida Ayu Meilasari Diahningrum, Sylvi Fatri Idana Handayani, Ni Komang Tri Utami Henky, . Heriani, Ni Komang Herman Saputra Herman Saputra I Dewa Nyoman Wibawa I Gde Raka Widiana I Gusti Ayu Agung Elis Indira I Gusti Ayu Sri Mahendra Dewi I Ketut Agus Somia I Made Gotra I Made Muliarta I MADE MULIARTA . I Wayan Juli Sumadi Ida Ayu, Priandini Ida Bagus Nyoman Putra Dwija Ida Sri Iswari Kadek Agus Suhardinatha Putra Kadek Pramesti Dewi, Kadek Pramesti Ketut Suega Ketut Tuti Parwati Merati Limantoro, Joshua Lisanthoni, Johnathan Luh Putu Iin Indrayani Maker Made Dalika Nareswari Made Widhi Asih Made Yogi Oktavian Prasetia Maker, Luh Putu Iin Indrayani Nariswari, Ida Ayu Ista Nathaniela, Jocelin Ni Kadek Ayu Maya Damayanti Ni Made Dewi Dian Sukmawati Ni Putu Ekawati Ni Putu Sriwidyani Nicholas Wijayanto Noviana Indrawati Paramitha, Ni Made Laksmi Dewi Paskarani, Putu Erika Prayuda, Prayuda Putu Erika Paskarani Rahayu, Made Lely Reniati, Roselina Reny Setya Pratiwi Duarsa Santi Maya Lestari Siahaan Shalihaty Emy Sri Mahendra Dewi, I Gusti Ayu Yenny Kandarini