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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Mandala Pengabdian Masyarakat AMMA : Jurnal Pengabdian Masyarakat Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat
Niluh Puspita Dewi
Departments Of Pharmacology And Clinical Pharmacy, STIFA Pelita Mas Palu, Central Sulawesi, 94111, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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MACROSCOPIC AND MICROSCOPIC GASTROPROTECTIVE ACTIVITY OF MUCOADHESIVE GRANULE FORMULATIONS OF CLOVE LEAF ETHANOL EXTRACT Dhitania Ivana Harliwong; Ayu Wulandari; Niluh Puspita Dewi; Sririzqi Muthmainnah; Joni Tandi; Putu Intan
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8949

Abstract

Gastric ulcers can be triggered by excessive HCl secretion, and the regenerative capacity of mucosal cells can be weakened by high alcohol levels and anti-inflammatory drugs, including NSAIDs. Gastrin functions to stimulate the secretion of gastric juice, particularly HCl and pepsinogen This study aims to evaluate the macroscopic and microscopic gastroprotective activity of clove leaf ethanol extract mucoadhesive granule formulations. The study used 25 rats divided into five groups: normal control, negative control, positive control, clove leaf ethanol extract group, and mucoadhesive granule formulation of clove leaf ethanol extract group. All groups except the normal control were administered acetylsalicylic acid. Treatments were conducted over 9 days, with surgical examination and observations performed macroscopically and microscopically on day 10. Macroscopic assessments revealed ulcer damage improvement in the positive control, extract, and mucoadhesive granule groups, all scored at 1. Microscopic assessments also indicated a significant difference between the negative control and the positive control, extract, and mucoadhesive granule groups, showing better gastric repair, scored at 0.5. Therefore, it can be concluded that the administration of the mucoadhesive granule formulation of clove leaf ethanol extract exhibits gastroprotective activity comparable to that of the clove leaf ethanol extract.
Effect of Purple Leaf (Graptophyllum pictum (L.) Griff) Emulsion on the Histological Parameters of Streptozotocin-Induced Diabetic Rats Niluh Puspita Dewi; Komang Dewik; Syafika Alaydrus; Athia Kurnia Kasim; Nani Astria Polontalo; Wayan Wirawan; Dian Andini; Irma Irma; Imelda Synthia Fatu
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.14172

Abstract

Damage to vital organs such as the liver, kidneys, and pancreas is a common complication of diabetes mellitus, characterized by chronic hyperglycemia due to pancreatic cell dysfunction. Graptophyllum pictum (purple leaf) is a potential herbal therapy containing bioactive compounds with antioxidant and organ-protective effects. This study aimed to evaluate the effect of purple leaf emulsion on blood glucose levels and the histopathological features of diabetic rats induced by streptozotocin. Rats were divided into six groups: normal control, negative control, positive control (glibenclamide), and three doses of purple leaf emulsion (100, 200, and 300 mg/kg BW). After 28 days of treatment, the emulsion significantly reduced blood glucose levels and improved the histological structures of the liver, kidneys, and pancreas. The 200 mg/kg BW dose was most effective for pancreatic protection, while 300 mg/kg BW provided optimal hepatoprotective and renoprotective effects. These findings highlight the potential of purple leaf as a natural antidiabetic and organ-protective agent.
Co-Authors Athia Kurnia Kasim Ayu Wulandari Darmayanti Dhitania Ivana Harliwong Dian Andini Giska Putri Agustina I Made Dipayana Imelda Synthia Fatu Indah Kurnia Utami Indah Kurnia Utami Irma Irma Joni Tandi, Joni Komang Dewik Magfira Maramis Mariyani Meike Rachmawati Nadila Nadila Nani Astria Nani Astria Polontalo Nur Azizah Putu Intan Ratna Ika Yususf Rivani Tampang Sri Wahyuni Khalik Sririzqi Muthmainnah Syafika Alaydrus Syafika Alaydrus Syafika Alaydrus Viani Anggi Wayan Wirawan Yuliet Yuliet Yunira Wardani