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POLA PERESEPAN ANTIBIOTIK UNTUK PENGOBATAN INFEKSI SALURAN PERNAFASAN ATAS (ISPA) DI KLINIK X KOTA SEMARANG Wulan Kartika Sari; Yustisia Dian Advistasari; Novi Elisa
Cendekia Journal of Pharmacy Vol 8, No 1 (2024): Cendekia Journal of Pharmacy
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v8i1.275

Abstract

Infeksi Saluran Pernafasan Atas (ISPA) merupakan 10 penyakit terbanyak di Indonesia. Penyakit ISPA diawali dengan gejala demam, batuk selama kurang lebih jangka waktu 2 minggu, pilek atau hidung tersumbat dan sakit tenggorokan. Penyebab ISPA dapat berasal dari berbagai mikroorganisme yakni bakteri dan virus. Beberapa faktor yang mempengaruhi penyebaran infeksi saluran pernafasan atas diantaranya faktor lingkungan, perilaku masyarakat yang kurang baik terhadap hygne dan sanitasi diri, keluarga, dapat pula dari kurangnya asupan makanan yang bergizi serta menurunnya imunitas tubuh  Penelitian ini dilakukan secara retrospektif dengan periode pengambilan data Januari hingga Juni 2023 yang bertempat di Klinik X di Kota Semarang, Jawa Tengah dengan periode pengambilan data Januari hingga Juni 2023. Subyek penelitian yang sesuai dengan kriteria inklusi sebanyak 3945 pasien. Karakteristik pasien dalam penelitian kemudian dikategorikan berdasarkan jenis kelamin diperoleh hasil  laki laki 46,24% dan perempuan 53,76%, perempuan lebih sigap, tanggap, cekatan serta memiliki kepekaan, kepedulian, perhatian yang lebih terhadap kesehatan dan lingkungan sekitarnya. Pasien dengan penderita ISPA banyak terjadi pada retang usia secara berturut turut 0 -12 th (34,63%), 13-25 th (15,59%), 26-38 th (17,79%), 39-51th (20,51%) dan 52-60 th (11,48%). Usia 0 sampai 12 tahun memiliki persentase tertinggi hal ini dikarenakan penyakit ISPA berhubungan dengan adanya kemampuan imunitas tubuh terhadap serangan bakteri atau virus. Bentuk sediaan antibiotik yang banyak diresepkan oleh dokter yakni syrup (12,09%), pulveres (21,88%), tablet (66.03%). Antibiotik yang banyak diresepkan oleh dokter yakni amoxycillin (54,90%), kloramfenikol (25,63%), thiamphenicol (8,04%), ciprofloxacin (10,70%) dan sefadroxil 0,74%). Pemilihan amoxycillin dalam terapi ISPA dikarenakan amoxycillin memiliki mekanisme kerja dalam kondisi tertentu sebagai bakteriostatik dapat pula bersifat bakterisid yakni dengan cara merusak dinding sel pada bakteri yang mengandung mucoprotein kompleks terhadap mikroba. Berdasarkan hasil penelitian diperoleh hasil bahwa pada klinik X penyakit ISPA banyak terjadi pada pasien perempuan dan antibiotik yang paling banyak diresepkan adalah amoxycillin tablet 500 mg.
Phytochemical Screening and Antioxidant Activity of Strawberry Juice (Fragaria ananassa Duchessne) Against Ureum Level, Creatinin, and Enzyme Catalase Activity In Isoniazid-Induced Wistar Male Rats Endang Sri Sunarsih; Ebta Narasukma Anggraeny; Patricia Sanggita Listyoputri Wibowo; Novi Elisa
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 2 (2020): November
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i2.510

Abstract

ROS increase can causes damage to the kidney so that urea and creatinine level increase in the blood and can be used as a marker of decreased kidney function. Excessive free radicals can cause a decrease in endogenous antioxidant activity, namely the catalase enzyme. This condition can be overcome by given exogenous antioxidants such as strawberry juice (Fragaria ananassa Duchessne). This study aimed to determine the effect of strawberry juice treatment against urea and creatinine levels in male Wistar rats Isoniazid-induced for 14 days divided into groups, namely normal control, negative control, positive control, strawberry juice dose of 3 g/kgBW, 6 g/ kgBW, and 9 g/kgBW. Data were collected on 1st, 15th, and 29th day. The results of the study concluded that strawberry juice had an effect in reducing levels of urea, creatinine and catalase enzyme activity in isoniazid-induced rats with an effective dose of 3g / kgBW
Hypertension Profile of Angiotensin Receptor Blocker From Matoa Leaves Extract (Pometia Pinnata J.R. Foster & G. Foster) In Angiotensin II Induced-Male Rat With Blood Volume Parameter Novi Elisa; Fransiskus Xaverius Sulistiyanto Wibowo Sutardjo; Jaka Seprianto Lepangkari
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 2 (2020): November
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i2.595

Abstract

Hypertension is a problem of cardiovascular disease that occurs in many people. The leaves of matoa, which have another name, Pometia pinnata, are one of the plants used as traditional medicine for the treatment of hypertension. The active compounds of matoa leaves are flavonoids. This study aimed to observe the hypertension profile of the Angiotensin Receptor Blocker class. The test animals used in this study were 45 male Wistar rats. Each group consisted of 5 rats induced by angiotensin II, divided into groups, namely normal control, negative control, positive control, a dose of 75g/kgBW, 150g/kgBW, and 300g/kgBW, and observation were done for 14 days. The hypertension profile observed in this study was the blood volume of rats. The percentage reduction in blood volume of rats given the best matoa leaves extract was 300 mg/kgBW, extract which showed mean difference in negative control group with a significance value of <0.05
The Effect of Pharmaceutical Care against Patient Loyalty with Intervening Variables of Patient Satisfaction at "X" Pharmacy, Sukoharjo Regency Fransiskus Xaverius Sulistiyanto Wibowo Sutardjo; Amor Sofandi; Novi Elisa
STRADA : Jurnal Ilmiah Kesehatan Vol. 10 No. 1 (2021): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v10i1.599

Abstract

This study aimed to determine whether there was an effect of pharmaceutical care on patient satisfaction, to find out whether there was an effect of pharmaceutical care on patient loyalty and to find out whether there was an effect of patient satisfaction in partially mediating the relationship between pharmaceutical care and patient loyalty. Data analysis obtained from testing was carried out by knowing whether there was an effect or not carried out by statistical tests, Anova test using the SPSS 16th version. The results showed that pharmaceutical care had a positive effect on patient satisfaction (sig 0.000 <0.05), pharmaceutical care had a positive effect on patient loyalty (sig 0.000 <0.05), patient satisfaction had a positive effect on patient loyalty (sig 0.000 <0.05), and patient satisfaction has an effect in partially mediating the relationship between pharmaceutical care and patient loyalty (sig 0.000 <0.05).