Article Per Year (5 Year)
p-Index From 2020 - 2025
1.431
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Kesehatan Ar-Rum Salatiga PUBLIKASI PENELITIAN TERAPAN DAN KEBIJAKAN Eastasouth Journal of Impactive Community Services Riset Informasi Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Bioteknologi & Biosains Indonesia (JBBI) Strada Jurnal Ilmiah Kesehatan (SJIK)
Jaka Seprianto Lepangkari
STIKes Ar Rum Salatiga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 7 Documents
Search

 1 
Uji Aktivitas Antihipertensi Ekstrak Etanol Daun Matoa (Pometia pinnata J.R. Forster & G. Forster) pada Tikus Jantan yang Diinduksi Angiotensin II dengan Parameter Blood Flow Jaka Seprianto Lepangkari; Novi Elisa; Irvan Charles Seran Klau
Publikasi Penelitian Terapan dan Kebijakan Vol 6 No 1 (2023): Publikasi Penelitian Terapan dan Kebijakan
Publisher : Badan Penelitian dan Pengembangan Daerah Provinsi Sumatera Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46774/pptk.v6i1.532

Abstract

Hipertensi adalah naiknya tekanan darah sistolik dan diastolik lebih dari 140/90. Salah satu tanaman yang berpotensi sebagai antihipertensi adalah matoa yang mengandung senyawa Quercetin-3-O-rhamnoside dan Kaemferol 3-O-rhamnoside yang diyakini berpotensi sebagai antihipertensi. Pada penelitian ini, peneliti ingin mengetahui persentase penurunan blood flow pada tikus jantan yang diinduksi angiotensin II menggunakan ekstrak etanol daun matoa. Pengerjaan ini dimulai dengan membuat ekstrak etanol dari daun matoa dan membaginya dalam 3 variasi dosis, yaitu 75 mg/kgBB, 150 mg/kgBB, dan 300 mg/kgBB, kemudian diberikan perlakuan ke hewan uji yang telah diinduksi angiotensin II. Hasil penelitian menunjukkan bahwa variasi 3 dosis ekstrak etanol daun matoa dengan dosis 75 mg/kgBB, 150 mg/kgBB, dan 300 mg/kgBB, menunjukkan hasil berbeda. Ekstrak etanol daun matoa dengan dosis 75 mg/kgBB memiliki persentase penurunan 44.47%. Ekstrak etanol daun matoa dengan dosis 150 mg/kgBB memiliki persentase penurunan 53.36%. Ekstrak etanol daun matoa dengan dosis 300 mg/kgBB memiliki persentase penurunan 67.35%. Disimpulkan bahwa ekstrak terbaik yang berpotensi dalam menurunkan sirkulasi aliran darah atau blood flow adalah ekstrak etanol daun matoa dosis 300 mg/kgBB.
Pemberdayaan Ekonomi dan Peningkatan Kapasitas Perempuan Melalui Pelatihan Pembuatan Sabun Batang Bersama Aliansi Peduli Perempuan Sukowati (APPS) dan Jaringan Perempuan Usaha Kecil (JARPUK) Ngete, Ani Florida; Wibowo, Teguh Setiawan; Lepangkari, Jaka
Eastasouth Journal of Impactive Community Services Vol 3 No 02 (2025): Eastasouth Journal of Impactive Community Services (EJIMCS)
Publisher : Eastasouth Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58812/ejimcs.v3i02.321

Abstract

Kegiatan pengabdian kepada masyarakat merupakan salah satu Tridharma Perguruan Tinggi dan sebagai upaya perguruan tinggi untuk menjalin kerjasama dengan masyarakat. Perguruan Tinggi bersama Aliansi Peduli Perempuan Sukowati (APPS) dan Jaringan Perempuan Usaha Kecil (JarPUK) fokus pada pemanfaatan potensi bunga telang dan serai sebagai bahan alami dalam pembuatan sabun. Peserta diajarkan mengenai khasiat bunga telang untuk kesehatan kulit, serta manfaat antibakteri dan aromaterapi dari serai. Selain teori, peserta juga melakukan praktik langsung pembuatan sabun, mulai dari persiapan bahan hingga pengemasan produk akhir. Melalui kegiatan Pengabmas ini, peserta diharapkan dapat memproduksi sabun alami berkualitas dan memiliki peluang usaha baru untuk meningkatkan ekonomi keluarga.
Hypertension Profile of Angiotensin Receptor Blocker From Matoa Leaves Extract (Pometia Pinnata J.R. Foster & G. Foster) In Angiotensin II Induced-Male Rat With Blood Volume Parameter Novi Elisa; Fransiskus Xaverius Sulistiyanto Wibowo Sutardjo; Jaka Seprianto Lepangkari
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 2 (2020): November
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i2.595

Abstract

Hypertension is a problem of cardiovascular disease that occurs in many people. The leaves of matoa, which have another name, Pometia pinnata, are one of the plants used as traditional medicine for the treatment of hypertension. The active compounds of matoa leaves are flavonoids. This study aimed to observe the hypertension profile of the Angiotensin Receptor Blocker class. The test animals used in this study were 45 male Wistar rats. Each group consisted of 5 rats induced by angiotensin II, divided into groups, namely normal control, negative control, positive control, a dose of 75g/kgBW, 150g/kgBW, and 300g/kgBW, and observation were done for 14 days. The hypertension profile observed in this study was the blood volume of rats. The percentage reduction in blood volume of rats given the best matoa leaves extract was 300 mg/kgBW, extract which showed mean difference in negative control group with a significance value of <0.05
FORMULASI DAN UJI MUTU FISIK SEDIAAN LIP BALM DARI FRAKSI ETIL ASETAT KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) DENGAN VARIASI KONSENTRASI CERA ALBA Reza Noviani; Aditya Nuryanto Saputro; Jaka Lepangkari
Jurnal Ilmiah Kesehatan Ar-Rum Salatiga Vol 9, No 2 (2025)
Publisher : STIKES Ar-Rum Salatiga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36409/jika.v9i2.254

Abstract

Lip Balm merupakan salah satu kosmetik bibir yang memiliki kandungan zat pelembab untuk pelindung tambahan pada bibir. Komponen utama pada sediaan lip balm adalah basis lilin seperti cera alba untuk menstabilkan dan menjaga konsistensi sediaan lip balm. Penelitian ini untuk mengetahui konsentrasi cera alba yang dapat menstabilkan sediaan lip balm menggunakan kulit buah naga merah (Hylocereus polyrhizus) sebagai zat aktifnya. Fraksi kulit buah naga merah (Hylocereus polyhizus) memiliki kandungan antioksidan seperti flavonoid yang bermanfaat untuk melembabkan bibir. Penelitian ini menggunakkan metode eksperimental dengan variasi konsentrasi cera alba pada F1, 5%, F2, 10%, F3, 15% dan F4, 20% kemudian dilakukan uji mutu fisik sediaan lip balm pada penyimpanan suhu ruang selama empat minggu dengan pengujian setiap tujuh hari sekali. Hasil uji mutu fisik menunjukkan bahwa sediaan lip balm memenuhi persyaratan uji organoleptik, tidak mengalami perubahan dari bentuk, warna dan bau. Pada uji homogenitas sediaan tidak terdapat partikel atau butiran kasar, uji pH yang sesuai dengan kulit bibir berkisaran antara 4,0-6,5, uji daya sebar memenuhi persyaratan diameter penyebaran 5-7 cm dan uji daya lekat memenuhi persyaratan yaitu lebih dari 4 detik. Penambahan cera alba dapat menjadi sediaan lip balm yang stabil.
EXTRACT AND FRACTIONS EXPLORATION OF DAYAK ONION (Eleutherine America-na Merr.) WITH ANTIOXIDANTS POTENTIAL USING GC-MS and FTIR METHODS Elisa, Novi; Advistasari, Yustisia Dian; Lepangkari, Jaka Seprianto; Hidayatullah, Muhammad Haqqi
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9209

Abstract

Free radicals can cause various diseases in the body if not treated immediately. Large levels of free radicals may trigger damage to normally functioning tissues, lipid layers, blood vessels, DNA synthesis disturbances, and even destruction of cells. The objective is to evaluate the antioxidants potential of dayak onion extract and fractions. FTIR spectrophotometers, gas chromatography-mass spectrometry (GC-MS) and an antioxidants multimode reader are some of the research methods. The outcomes of this research are identifying plants that showed the dayak onion extract of the species Eleutherine Americana Merr. It contains compounds such as flavonoids, alkaloids, tannins, and saponins. In addition, the components found in the extract, water fraction, ethyl acetate fraction, and n-hexane fraction are octadecanoic acid 298 m/z, 9-octadecanoic acid 282 m/z, undecanoic acid 214 m/z, hexadecanoic acid 368 m/z, and nonadecanoic acid 326 m/z. Therefore, the antioxidants test using the DPPH method showed that the best IC50 value is for ethyl acetate with IC50 20.56 ppm.
INVENTORY OF MEDICINAL PLANTS AND THEIR UTILISATION BY THE COMMUNITY OF RENGEL SUB-DISTRICT, TUBAN DISTRICT Klau, Ivan Charles Seran; Ambari, Yani; Sulistiani, Vidia Dwi; Leki, Karol Giovani Battista; Oktadiana, Isma; Negara, Yohanes Adrian Kapri; Lepangkari, Jaka Seprianto
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.999

Abstract

Plant inventory is an activity aimed at documenting and classifying plant species within a specific area. This study investigated the utilization of traditional medicines in the Lengger District, Tuvan Province, focusing on the types of medicinal plants, their properties, uses, and the specific plant parts employed. A qualitative descriptive method was applied, and data were collected through observations and interviews. The sampling technique followed a snowball sampling approach, where key informants were identified based on predefined criteria, and additional informants were selected through recommendations. The findings revealed that the community in the Lengger District utilizes 54 types of medicinal plants for traditional healing practices. The conclusion of this research is that preserving traditional medicinal knowledge is very important to prevent the loss of information about the benefits and uses of medicinal plants that have been passed down from generation to generation. Further research is needed to reveal the bioactive content, effectiveness, and safety of medicinal plants so that they can be developed into scientifically based therapies. Given the community's dependence on medicinal plants, conservation efforts through sustainable cultivation and protection of natural habitats must be implemented to ensure their availability in the future and maintain ecosystem balance. Keywords: Inventory, Types of medicinal plants, Rengel District, Tuban Regency
Histopathological study of renal hypertension with avocado leaf extract and fractional in male wistar rats Novi, elisa; Advistasari, Yustisia Dian; Lepangkari, Jaka Sepriantor; Sari, Wulan Kartika
Riset Informasi Kesehatan Vol 13 No 1 (2024): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v13i1.823

Abstract

Background: The first of the cardiovascular diseases that may turn deadly is hypertension, which has elevated blood pressure. The causes of hypertension, which causes an average rise of 140/90 mmHg, are based on epidemiological factors such as stroke, heart failure, myocardial infarction, arterial fibrillation, and peripheral artery disease. Hypertension is also known as the silent killer. Objective: Known histopathology in kidney cells and avocado leaf compounds that could potentially inhibit hypertension. Methods: Methods that can be used in histopathological testing with hematoxylin and eosin (HE) dying and compound determination by analysis Gas Chromatography-Spectrometry Mass (GC-MS) Results: The study obtained GC-MS (Gas Chromatography-Spectrometry Mass) analysis results at an area of 36.50%, molecular weight 17,03 with 9-Octadecenoic acid compounds, and an area of 10,18%, molécular weight 2,54 with a compound of 9-Oktadecenosic acid (z)-methyl esters (CAS). An extract of 250 mg/kgBW has a slightly low renal cell damage value (138), and an effective avocado leaf fraction test is ethanol acetate 250 mg/kgBW, with a small renal cell damage value (146), where as a negative control has a high renal cell damage value (189).
Co-Authors Aditya Nuryanto Saputro Advistasari, Yustisia Dian Ambari, Yani Elisa, Novi Fransiskus Xaverius Sulistiyanto Wibowo Sutardjo Irvan Charles Seran Klau Klau, Ivan Charles Seran Leki, Karol Giovani Battista Muhammad Haqqi Hidayatullah Negara, Yohanes Adrian Kapri Ngete, Ani Florida Novi Elisa novi, Elisa Oktadiana, Isma Reza Noviani Sulistiani, Vidia Dwi Wibowo, Teguh Setiawan Wulan Kartika Sari