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All Journal Pharmascience SAINTIFIK@ : Jurnal Pendidikan MIPA As-syifaa Jurnal Farmasi JURNAL PengaMAS Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat Jurnal Farmasi Higea JURNAL FARMASIMED (JFM) Journal Of Khairun Community Services Kieraha Medical Journal Jurnal Riset Farmasi Jurnal Farmasi Indonesia Jurnal Pengabdian Harapan Ibu (JPHI) Journal of Pharmaceutical and Sciences. BARAKATI: Journal of Community Service Pharmacon: Jurnal Farmasi Indonesia
Ermalyanti Fiskia
Prodi Farmasi, Fakultas Kedokteran, Universitas Khairun
Religion Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Immunomodulatory Potential of Ethanolic Extract of Blue Butterfly Pea Flower (Clitoria ternatea) on Non-Specific Immune Mechanisms Fiskia, Ermalyanti; Karim, Muhammad Azhar A; Hi Yusuf, Muhammad Fakhrur Rajih; Azzahra, Rufaidah; Rahman, Ismail
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/s67fbc03

Abstract

The immune system is a complex mechanism consisting of cells, tissues, and organs that work in coordination to protect the body from exposure to pathogens. However, pathogens also possess strategies to counteract immune defenses, thereby necessitating external substances to support immune enhancement. One such substance is antioxidants. Butterfly pea flower (Clitoria ternatea) is a potential candidate as an immunomodulator due to its high antioxidant content, which functions to prevent lipid peroxidation and combat free radicals. This study aims to investigate the immunomodulatory potential of the ethanol extract of butterfly pea flower using the carbon clearance test in mice. The research method was experimental, employing 30 BALB/c mice as test animals, which were divided into six groups: Butterfly Pea Flower Extract (EBTB) at doses of 150, 300, and 600 mg/kg BW, levamisole 25 mg and methylprednisolone 4 mg as comparison groups, and sodium CMC as the negative control group. The substances were administered orally for seven consecutive days, followed by intravenous induction of carbon ink on day 8. The obtained serum was measured for absorbance using UV-Vis spectrophotometry at 650 nm. Parameters observed included the phagocytic index (PI) and lymphoid organ index (liver, spleen, and thymus). Based on the phagocytic index calculation, EBTB at doses of 150 and 300 mg/kg BW yielded values of 2.990 and 2.929, respectively, indicating strong immunostimulant activity, while BPFE at 600 mg/kg BW showed moderate immunostimulant activity with a PI value of 1.423. Results for the lymphoid organ index in the BPFE 150 group did not show significant differences (P > 0.05) compared to the control group. In conclusion, the ethanol extract of butterfly pea flower demonstrates potential as an immunomodulator for nonspecific immune responses.
Co-Authors Amran Nur Azzahra, Rufaidah Bambang Tjiroso Bambang Tjiroso, Bambang Cindhany Darmaria Faridha Utami Mala Cindhany Darmaria Faridhah Utami Mala Eri Marwati Febrianty, Marisca Handayani, Sri Windi Karim, Muhammad Azhar A Marhamah Marhamah Meswara, Arfani Nuruladha Muhammad Fakhrur Rajih Hi. Yusuf Muhammad Subhan A Sibadu Muhammad Zulfian A. Disi Mursin, Nita P.H, Dian Pramana rahman, ismail S. Somadayo, Nur Asma Sadik, Fahmi Safriani Rahman, Safriani Saleh, Rahmat Dian Septian Dwi Rahmat