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All Journal e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Journal of Dentomaxillofacial Science Masyarakat Telematika Dan Informasi : Jurnal Penelitian Teknologi Informasi dan Komunikasi Padjadjaran Journal of Dental Researchers and Students Prosiding Seminar Nasional Teknik Mesin INSERT: Information System and Emerging Technology Journal Indonesian Journal of Visual Culture, Design, and Cinema (IJVCDC) Odonto dental journal Aksa : Jurnal Desain Komunikasi Visual Sungging
Budi Yuwono
Fakultas Kedokteran Gigi Univeritas Jember Jl. Kalimantan 37 Jember
Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Kadar Serum Glutamic Oxaloacetic Transaminase (SGOT) pada Tikus Wistar (Rattus norvegicus) Jantan yang Dipapar Stresor Rasa Sakit Electrical Foot Shock selama 28 Hari (The Level of Serum Glutamic Oxaloacetic Transaminase (SGOT) in Male Wistar Rat (Ratt Nur Lely Yaumil Qodriyati; Erna Sulistyani; Budi Yuwono
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

  Stress is a natural reaction that allows the human compelled to face the difficulties. Stimuli that causes stress can be physical and psychological. Physical stressors can occur continuously or sustained, which causes pathological processes in the body. This pathological process may be occur in liver and heart. One of parameter to assess characteristics of tissue can use Serum Glutamic Oxaloacetic transaminase (SGOT). The aim of this study was to prove differences level of SGOT in male Wistar rats (Rattus norvegicus) that exposed and control group were not exposed by pain stressor electrical foot shock for 28 days. Blood sampling was carried out on day 28 in intracardiac then tested the levels of SGOT. Statistical analysis showed that there was no significant change (p≤0,05) between control and treatment group. Liver damage from stressors may be not cause necrosis of liver cells. SGOT was not a single biomarker that was specific and sensitive for the diagnosis of liver disease because SGOT was also found in the heart.   Keywords: electrical foot shock, SGOT, stress
Pengaruh Pemberian Ekstrak Propolis Terhadap Kadar Kolesterol Darah Tikus Wistar Jantan Setelah Dipapar Sidestream Cigarette Smoke (Effect of Propolis Extract on Blood Cholesterol Level in Male Wistar Rats After Being Exposed to Sidestream Cigarette Smoke Chusna Sekar Wardani; Roedy Budirahardjo; Budi Yuwono
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Smoking is one of environment factors which caused a bad effect for health. TheSidestream Cigarette Smoke (SCS) contained in smoke produce free radicals highly andincrease total cholesterol levels. Elevated levels of total cholesterol can be treated withmedicine of statins, but its use in the long term cause side effects. Therefore, at thistime medicine has been developed from natural a substance which is expected haveless side effects, one of which is propolis. This research aims to determine whether thereis a decrease in total cholesterol levels in male Wistar rats (Rattus norvegicus) whichwas given extracts of propolis and exposed SCS. The research is experimentallaboratory with post test control group design. This research uses 12 rats which consistof 2 groups (1 control and 2 groups of treatment). The first treatment group is exposedby SCS. The second one is exposed by SCS and given the extract of propolis 2 times aday for 8 days. The total blood cholesterol level is measured by usingspectrophotometer with enzymatic colorimetric methods. The results of data analysisusing One Way Anova test shows there is a significant difference in total bloodcholesterol level means of male Wistar rats (p <0.05). While the Tukey HSD test showsthere is a significant difference in total cholesterol level means between groups, exceptbetween the control group and the second treatment group. Conclusion of thisresearch is that the propolis extract can lower total cholesterol levels of male Wistar ratswhich given exposure of Sidestream Cigarette Smoke.Keywords: blood cholesterol levels, propolis extract, sidestream cigarette smoke
Efektivitas Seduhan Daun Yakon (Smallanthus sonchifolius) terhadap Kadar Low Density Lipoprotein (LDL) dan High Density Lipoprotein (HDL) pada Tikus Diabetik yang Diinduksi Streptozotocin (The Efectivity of  Yacon Leaves (Smallanthus sonchifolius) Infusion to Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) Level in Diabetic Rats Induced by Streptozotocin) Vitta Permata Sarie; Roedy Budirahardjo; Budi Yuwono
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Diabetes mellitus (DM) is a metabolic disorder characterized by elevated level of blood glucose abnormalities associated with the metabolism of carbohydrates,lipids and proteins. Lipids metabolism disorder can increase LDL and lower HDL level. One of plants in Indonesia, that has potential as antihyperglycemic and hypolipidemic agent is yakon (Smallanthus sonchifolius) containing chlorogenic acid (CGA). This study aimed to determine the effect of yacon leaves infusion to LDL and HDL level in diabetic rats induced by streptozotocin (STZ). This study was an experimental research laboratories with the post test only control group design. Rats checked the blood glucose early then induced by STZ with dose 65 mg / kg BW. At 3 days post injection, they were checked the blood glucose. Then the rats were divided into 2 groups the control and treatment group. The treatment group was given yacon leaves infusion ( 3.6 ml/200 g BB rats ) for 14 days. Then they were checked LDL and HDL level by using electrospectrofotometer. Statistical analysis showed that there were significant differences in LDL level and no significant difference in HDL level. It could be concluded that the yacon leaves infusion could lower LDL level in diabetic rats induced by STZ, while HDL level had not change. Keywords: Diabetic, HDL, LDL, yacon
Pengaruh Daun Katuk (Sauropus androgynus (L.) Merr.) terhadap Waktu Perdarahan (Bleeding Time) pada Tikus Wistar Jantan sebagai Alternatif Obat Antitrombotik (The Effect of Star Gosseberry (Sauropus androgynus (L.) Merr.) to bleeding time of Male Wistar Selvia Magdalena; Budi Yuwono; Agustin Wulan Suci Dharmayanti
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Background: Cardiovascular disease can be treated with synthetic or traditional antithrombotic drugs (herbal). Synthetic antithrombotic drugs have a lot of side effects, so as an alternative antithrombotic is used traditional drugs, star gosseberry. Star gosseberry have many active compounds which are suspected to inhibit platelet aggregation. Objective: to know the effect of star gosseberry on bleeding time of male Wistar rats as an alternative antithrombotic drugs. Methods of research: this study was experimental laboratory research with post-test only control group design. The research samples were 24 male wistar rats and divided into 4 groups: negative control (distilled water), positive control (aspirin 5,85 mg dose), treatment 1 (star gosseberry 4,5 mg/g dose), and treatment 2 (star gosseberry 2.25 mg/g dose). The treatment was given for 8 days then the tail of samples were cut by 0.5 cm from the tip of the tail. Every 30 seconds the blood that dripped out was absorbed on absorbent papers until the bleeding stops. Bleeding time was measured from initial point of bleeding until the cessation of the bleeding point. Result: star gosseberry dose 4,5 mg/g had the same effect as aspirin that was prolonged bleeding time. Conclusion: star gosseberry could be prolonged bleeding time so it can be used as an alternative antithrombotic drugs. Keywords: Katuk leaf, bleeding time, antithrombotic, platelet
The effect of caffeine on osteoblast proliferation after tooth extraction in Wistar rats Budi Yuwono
Dental Journal (Majalah Kedokteran Gigi) Vol. 39 No. 1 (2006): March 2006
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (98.953 KB) | DOI: 10.20473/j.djmkg.v39.i1.p32-34

Abstract

Caffeine is the most well-known substance which consumed by most people daily. Behind its popularity as favorable drinks and food, this substance also known can inhibit the post extraction wound healing by decreasing the proliferation of osteoblast cells through the increase of intracellular cyclic Adenosine Mono Phosphate (cAMP). The objective of this study was done to observe the effect of caffeine intake toward the number of osteoblast cells during the wound healing of post dental extraction in Wistar’s rats. This study was an experimental laboratory research and the post test-only control group design was used for the statistical evaluation. The samples used were 24 healthy 3 months old male Wistar’s rats, with approximately 200 grams of body weight and devided into 4 groups. Three groups were taken and represented as a treated group (P) and the rest of one group was used as a control group (KO). Caffeine diet with a dosage of 3.78 mg/100 ml grams of body weight/cc was given for 7 days in group P1, P2 for 14 days, and 21 days in group P3 and the diet was given orally using an oral sonde. Teeth extractions of the right first molar in the lower jaw were done in all groups according to the interval time had been scheduled. Seven days of post-extraction time was waiting in all groups before the sample being decapitated for further histological examination in the post extracted sites. A Hematoxillin and Eosin staining was used and the number of osteoblast cells were counted under light microscopy with 400 times magnification. One-way ANOVA and Least Significant Difference (LSD) test were used for the statistical evaluation. The result of the study shown a significant decrease of the number of osteoblast cells in caffeine consumed group of 7, 14, and 21 days observed (p < 0.05). This study conclude that the duration time of caffeine consumed had been interfered significantly with the osteoblast cell proliferation during the wound healing after teeth extractions in Wistar’s rats.
Laporan Kasus : Abses Gingiva Akibat Traumatik Oklusi pada Pasien Pasca Kehamilan Nidha Tuhu Respati Karno; Dewi Muflikhah; Budi Yuwono
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 15 No 1 (2018)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v15i1.17906

Abstract

Gingival abcess is apurulent inflamation that localized in periodontium. Clinically manifested start with toothache, swelling and redness gingiva, fistule gingiva, which can include malaise and headache. Woman during pregnancy could have gingivitis more easily and getting worse with traumatic occlusion. A women 27 years old came with the swelling chin since ± 3days ago. The swelling is painful, with toothache, swelling dan redness gingiva, fistule gingiva, andmalaise. The final diagnose in this case is gingival abcess.
The effectiveness of proanthocyanidins cacao pods (theobroma cacao l) on increasing socket epithelial thickness post toothextraction in wistar rats Yani C. Rahayu; Budi Yuwono; Alifia Wandansari
Journal of Dentomaxillofacial Science Vol. 5 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (599.405 KB) | DOI: 10.15562/jdmfs.v5i1.963

Abstract

Objective: The aim of this study was examine theeffectivenessof proanthocyanidins cacaopods (Theobroma cacao L) extract on increasing socketepithelialthicknessposttooth extractionin Wistar Rats. Proanthocyanidins has benefis as antiinflammation, antioxidant and antibacteria agent. Post-extraction wound can cause complication, which can make long the healing process. This is where anti-inflammatory is needed to prevent infection, so that it can avoid bacterial contamination and can shorten the inflammatory process. Material and Methods:These study was an experimental laboratory research on thickness of socket epithelium of Wistar rats given proanthocyanidins cacao pod extract post extraction. A total of 24 male Wistar rats was divided into 3 group; which was treated with 100 mg/ml proanthocyanidins cocoa pod extract as treatment group, distilled placebo gel as negative control group and alvogyl as positive control group. On day 7 and day 14 the sampel was sacrified and tissue processing was made. The gingival epithelial thickness was determined by software image raster on light microscopy. Results:Analysisof One way Anova showed there was a significant difference0.001 between groups. The epithelium oftreatment group, was thicker than the control group significantly.Conclusion:Proanthocyanidins cocoa pods (Theobroma cacao L)  extract effectiveincreasing the thickness of socket epithelium postextraction in Wistar rats.
Pengaruh pajanan radiasi sinar x dari radiografi periapikal terhadap penurunan jumlah fibroblas pada soket pencabutan gigi tikus wistar Ghina Lady Salsabila; Swasthi Prasetyarini; Budi Yuwono
MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Vol 6, No 1 (2020)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mkgk.58241

Abstract

Radiografi periapikal adalah radiografi intraoral yang mencakup gigi geligi dan jaringan sekitarnya. Penggunaannya menimbulkan efek negatif bagi tubuh yaitu adanya kerusakan seluler. Salah satu sel yang memiliki radiosensitif tinggi adalah fibroblas. Fibroblas merupakan agen utama dalam proses penyembuhan luka pasca pencabutan. Penelitian ini bertujuan untuk mengetahui pengaruh pajanan radiasi sinar x dari radiografi periapikal terhadap penurunan jumlah fibroblas pada soket pencabutan gigi tikus wistar. Jenis penelitian yang digunakan yaitu penelitian eksperimental laboratoris dengan rancangan posttest only control group design. Sampel 12 tikus wistar jantan yang dipilih berdasarkan kriteria inklusi dan eksklusi. Dibagi menjadi 3 kelompok: kelompok kontrol (Kk), kelompok perlakuan 1 (Kp1), dan kelompok perlakuan 2 (Kp2). Pajanan radiasi menggunakan unit radiografi periapikal dengan dosis 1,54 mGy. Pencabutan dilakukan pada gigi molar satu kiri rahang bawah. Pemeriksaan jumlah fibroblas dilakukan pada hari ke-3 menggunakan mikroskop binokuler dengan perbesaran 400x. Hasil penelitian menunjukkan nilai rata rata tertinggi adalah Kk (351) dan terendah Kp2 (197). Analisis statistik dengan uji One-Way Annova dan LSD terdapat perbedaan yang bermakna antar kelompok perlakuan (α <0,05). Kesimpulan: Terdapat pengaruh pajanan radiasi sinar x dari radiografi periapikal terhadap penurunan jumlah fibroblas.
MECHANISM OF COCOA SEEDS (Theobroma cacao, L) TO REDUCE THE INFILTRATION OF LYMPHOCYTES IN THE REGIONAL OF TOOTH EXTRACTION OF RATS Atik Kurniawati; Zainul Cholid; Budi Yuwono
UNEJ e-Proceeding 2022: E-Prosiding Kolokium Hasil Penelitian dan Pengabdian kepada Masyarakat
Publisher : UPT Penerbitan Universitas Jember

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Abstract

The act of removing a tooth from the alveolar bone socket is known as tooth extraction. Tooth extraction causes inflammation around the extraction area. Inflammation after tooth extraction will result in an increase in lymphocyte cells. This increase in the number of lymphocytes is too high due to continued inflammation can cause tissue damage around the socket. Cocoa beans contain chemical compounds that have anti-inflammatory and antioxidant properties that can help the post-extraction inflammation process so that wound healing is faster. Objective: to analyze the mechanism of cocoa bean extract (Theobroma cacao, L) on the decrease in the number of lymphocytes in the socket after tooth extraction of male Wistar rats. Methods: including laboratory experimental research with the post-test control group design. The results of the One-way Anova test showed that the number of lymphocytes decreased in all groups with a significant difference (p<0.05). LSD post hoc test results showed that the overall group was significantly different. Results and Conclusions: 8% cocoa bean extract gel (Theobroma Cacao, L) had an effect on reducing the number of lymphocyte cells in the socket after tooth extraction of male wistar rats compared to those not treated. Keywords: Cocoa, lymphocyte, tooth extraction.
Pengaruh ekstrak bagian dalam kulit durian terhadap waktu perdarahan pada luka potong ekor mencit: Studi eksperimental in vitro Maisyatul Ihsaniyah; Budi Yuwono; Roedy Budirahardjo
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 35, No 2 (2023): Agustus 2023
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v35i2.37978

Abstract

ABSTRAKPendahuluan: Pencabutan gigi mengakibatkan perdarahan pada gingiva dan mukosa rongga mulut yang dapat menyebabkan komplikasi. Perdarahan dapat diminimalisir dengan suatu zat untuk hemostasis. Kulit durian mengandung beberapa senyawa aktif yang digunakan untuk mempercepat hemostasis yang dapat mempengaruhi waktu perdarahan. Sehingga diperlukan penelitian untuk menganalisis pengaruh ekstrak bagian dalam kulit durian (durio zibethinus murr.) terhadap waktu perdarahan luka potong ekor mencit (mus musculus). Tujuan penelitian untuk menganalisis pengaruh pemberian ekstrak bagian dalam kulit durian terhadap waktu perdarahan pada luka potong ekor mencit. Metode: eksperimental laboratoris dengan rancangan post-test only control group design. Sampel adalah 20 ekor mencit yang dibagi 4 kelompok yaitu, kelompok kontrol negatif ( aquades steril), kelompok kontrol positif (asam traneksamat), dan dua kelompok perlakuan (ekstrak bagian dalam kulit durian dengan dosis 100 dan 200 mg/kg BB). Tahap selanjutnya pemotongan ekor mencit, kemudian dilakukan perhitungan waktu perdarahan dan analisis data. Data hasil penelitian diuji normalitasnya menggunakan uji Shapiro Wilk dan uji homogenitas menggunakan Levene test. Selanjutnya uji One Way Anova dan uji LSD. Hasil: Waktu perdarahan kelompok kontrol negatif yaitu 7 menit, kelompok kontrol positif yaitu 2,5 menit, kelompok perlakuan satu yaitu 4,9 menit, dan pada kelompok perlakuan dua yaitu 3 menit. Hasil uji One Way Anova terdapat perbedaan waktu perdarahan pada semua kelompok. Hasil uji LSD terdapat perbedaan yang bermakna antara kelompok perlakuan. Hasil uji terlihat bahwa semakin tinggi dosis yang diberikan maka waktu perdarahan semakin pendek. Simpulan: pemberian ekstrak bagian dalam kulit durian (Durio zibethinus Murr.) dapat memperpendek waktu perdarahan. Kata kunci: hemostasis, ekstrak bagian dalam kulit durian, waktu perdarahan Effect of durian skin extract on bleeding time in mice tail cut wounds: in vitro experiment studyABSTRACT Introduction: Tooth extraction often leads to gingiva and oral mucosa bleeding, which may give rise to complications. To mitigate bleeding, hemostatic agents are employed. The inner bark of the durian fruit (Durio zibethinus murr.) contains several active compounds known to accelerate hemostasis and influence bleeding time. Thus, there is a need for research to analyze the impact of the extract obtained from the inner bark of durian on the bleeding time of cut wounds on the tails of mice (Mus musculus). Purpose: To examine the impact of administering extracts from the inner portion of the durian peel on the bleeding time in tail incisions of mice. Methods: This study employed a laboratory experiment with a posttest-only control group design. The sample size consisted of 20 mice, divided into four groups: the negative control group (treated with sterile distilled water), the positive control group (treated with tranexamic acid), and two treatment groups (administered with extract from the inner portion of the durian peel at doses of 100 and 200 mg/kg BW). The subsequent steps involved tail incisions on the mice, followed by the measurement of bleeding time and subsequent data analysis. The collected research data underwent normality assessment using the Shapiro-Wilk test and homogeneity assessment using the Levene test. Subsequently, the One-Way ANOVA test and the LSD test were employed for further data analysis. Results: The bleeding time for the negative control group was 7 minutes; for the positive control group, it was 2.5 minutes; for the first treatment group, it was 4.9 minutes; and for the second treatment group, it was 3 minutes. The outcomes of the One-Way ANOVA test demonstrated variations in bleeding time across all groups. The results from the LSD test indicated notable distinctions between the treatment groups. The test outcomes suggest that a higher dose corresponds to a shorter bleeding time. Conclusion: The administration of the extract from the inner bark of durian (Durio et al.) can reduce the bleeding time.Keywords : hemostatic,the inner extract of the durian peel, bleeding time
Co-Authors Agustin Wulan Suci Dharmayanti Alfiansyah, Muhammad Abi Alifia Wandansari Ariek Sulistyowati, Ariek Arinanda, Aditya Atik Kurniawati Aviandi, Ivano Azevie, Umarta Rizky Chusna Sekar Wardani Daniel, Faisal Bramantyo Desi Sandra Sari Dessy Rachmawati Dewi Muflikhah Erna Sulistyani Febryane, Zarrina Eltri Ghani, Oktaviani Ghina Lady Salsabila I Nyoman Sujana Kumala, Efa Ayu Ratnaning Leonardo, Vande Maisyatul Ihsaniyah Mei Syafriadi Muhammad Nasri Muhammad Nurul Amin Mulia Widya Winiswara Muttaqin, Muhammad Hasan Nidha Tuhu Respati Karno Nugraha, Rinaldi Pratama Nur Indrawati, Nur Nur Lely Yaumil Qodriyati Rekimsa, Anugrah Yusuf Rina Sutjiati Rizki, Alifka Dimas Robbiya, Maiya Arsya Roedy Budirahardjo Rohim, Fatur Ruslam, Reza Zulfikar Safira Niza Ulfita Saputra, I Nyoman Sujana Saputra, Tedi Selvia Magdalena Siti Aisyah Swasthi Prasetyarini Triputra, Rein Nusa Vijaya, Annas Vitta Permata Sarie Winny Adriatmoko Yani C. Rahayu Yani Corvianindya Rahayu Zainul Cholid