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All Journal e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi ODONTO Dental Journal UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Journal Of Vocational Health Studies Majalah Biomorfologi (Biomorphology Journal) Denta: Jurnal Kedokteran Gigi Cakradonya Dental Journal Odonto dental journal
Atik Kurniawati
Bagian Biologi Oral, Fakultas Kedokteran Gigi Universitas Jember, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Library & Information Science Medicine & Pharmacology Neuroscience Public Health

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COWHIDE GELATIN NANOPARTICLES AND TITANIUM-PREPARED PLATELET-RICH FIBRIN POTENTIAL IN PERIODONTITIS HEALING PROCESS Atik Kurniawati; Dwi Riski Saputra; Dewi Yunita Sari; Indhi Cinthiya Amanitha; Siti Nurul Masruroh Hariyati
ODONTO : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.1.73-81

Abstract

Introduction: Based on epidemiological data, the periodontitis prevalence in Indonesia reached 96.58%. Periodontitis is a periodontal disease caused by specific microorganisms causing attachment loss, alveolar bone resorption, and periodontal pocket. The pocket which is more than 6 mm couldn’t be carried out using standard care. Therefore bone grafting is needed to fix the bone defect. Cowhide Gelatin nanoparticle (GNPs) combined with Titanium-Prepared Platelet-Rich Fibrin (T-PRF) is an innovative healing of periodontitis. Objective: To review the potential of cowhide gelatin nanoparticles combined with titanium-prepared platelet-rich fibrin (T-PRF) as an innovation in the healing of periodontitis defects. Literature review: Cowhide GNPs are the main ingredients for the bone replacement, which are nano-sized, biocompatible, bioactive, osteoconductive, non-toxic, and have a porous structure that supports the drug-delivery process. T-PRF contains platelets, fibrin, growth factors that can stimulate bone regeneration. Discussion: GNPs support the attachment and proliferation of osteoblast cells and the formation of mineralized bone matrix. The contents of T-PRF, which are fibrin, platelets, and growth factors, one of TGF-β1 will produce bone formation and periodontal healing in the large number. Moreover, T-PRF has leukocyte-fibrin, which may give an antibacterial effect. Thus, GNPs combined with T-PRF have more potent properties that support each other in carrying out their functions to stimulate the healing process. Conclusion: The combination of cowhide gelatin nanoparticles (GNPs) and titanium-prepared platelet-rich fibrin (T-PRF) has the potential to be effective in bone regeneration in periodontitis defects.
CACAO SEED (THEOBROMA CACAO L.) EXTRACT GEL EFFECT ON THE NEUTROFIL NUMBER AFTER TOOTH EXTRACTION Atik Kurniawati; Dwi Riski Saputra; Zainul Cholid; Hendito K. Putra
ODONTO : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.1.60-67

Abstract

Uji Daya Hambat Ekstrak Metanol Daun Ungu (Graptophillum pictum (L.) Griff) terhadap Pertumbuhan Bakteri Saluran Akar Gigi (Inhibition Test of Purple Leaf (Graptophillum pictum (L.) Griff) Methanol Extract toward Root Canal Bacteria's Growth) Resti Ayu Indriana; Pudji Astuti; Atik Kurniawati
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Background: Root canal bacteria in necrotizing pulp are dominated by polymicrobial bacterial colonization. Bacteria control were performed by using antribacterial irrigation. Purple leaf methanol extract contains triterpenoids, alkaloids, flavonoids, glycosides, saponins, and tanins which are to own antibacterial capability. Objective: To determine a wide range of consentrations, the minimal concentration of purple leaf methanol extract which able to inhibit the growth of root canal bacteria, and how much is the concentration of the purple leaf methanol extract which is equivalent to 2.6% sodium hypochlorite. Methods: The method was used well diffusion. Antibacterial test was indicated by the existance of the inhibition zone around the well hole. Total samples used were 56 samples for  each 7 group treatment, which are concentration 100%, 50%, 25%, 12,5%, 6,25% of purple leaf methanol extract, 2.6% of sodium hypochlorite, and sterile water. The results of the study was then tested by the statistical parametric one way ANOVA and LSD. Results and Conclusion: The concentration of purple leaf methanol extract which ables to inhibit the growth of root canal bacteria is 12,5%, 25%, 50%, and 100% also the minimum concentration is 12,5%, and the concentration of purple leaf methanol extract which is equivalent to 2.6% of sodium hypochlorite is concentration of 25%.Keywords: Antibacterial, Root Canal Bacteria, Purple Leaf Methanol Extract, Graptophillum pictum (L.) Griff
CLINICAL MANIFESTATION OF ORAL TUBERCULOSIS Atik Kurniawati; Ni Made Mertaniasih; Mangestuti Agil
UNEJ e-Proceeding 2016: Proceeding The 1st International Basic Science Conference
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Tuberculosis (TB) is chronic infectious disease caused by Mycobacterium tuberculosis. According to WHO report, it infected almost one third people and Indonesia has been 5th position in the world. Tuberculosis is classified clinically as Pulmonary and Extra Pulmonary. Extra pulmonary tuberculosis can occur in the lymph nodes, meninges, kidneys, bone, skin and even oral cavity that we called oral tuberculosis. The oral tuberculosis may manifest in various form : ulcer, gingivitis, nodules, granulomatous, tuberculoma and osteomyelitis. The purpose of this paper to explain the clinical manifestation of oral tuberculosis.
The microbiological detection of Mycobacterium tuberculosis from oral lesion Atik Kurniawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 40 No. 3 (2007): September 2007
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (636.571 KB) | DOI: 10.20473/j.djmkg.v40.i3.p127-130

Abstract

Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis. The oral manifestations of tuberculosis have been reported. The objectives of this study was to detect Mycobacterium tuberculosis from oral lesions by swabbing. Samples were received from collected primary data on annually clinical report status and then clinical intra oral examination was performed. Oral lesions were swabbed and cultured using Lowenstein Jensen media, Middlebrook 7H9 and Middlebrook 7H10. Positive culture were recorded and observed everyday until 8 weeks. From 66 samples, there were 2 patients with ulcer as an oral clinical manifestation with location on the tongue. Culture examination revealed 2 positive samples. It was inferred that Mycobacterium tuberculosis could be detected in oral lesion by swabbing.
Pengaruh Kumur Ekstrak Daun Ungu Terhadap Jumlah Bakteri dalam Saliva Atik Kurniawati
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 15 No 2 (2018)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v15i2.25225

Abstract

Caries is the most problem in oral health. The main etiology of the disease dominated by bacterial colonization, can be found in saliva. Bacteria control were performed by using antibacterial agent. Purple leaves extract (Graphtophyllum pictum L.Griff) contains of antibacterial agent namely flavonoid, triterpenoid, alkaloid, glycoside, saponin and tannin. The objective of this study was to examine the effect of gargling with 10% purple leaves extract on bacteria’s count in saliva. In this study 15 subjects were divided randomly into 3 groups (treatment, positive and negative control). Each of groups consist of 5 persons. Treatment group gargled with 10% purple leaves extract, while positive control group gargled with 0,2% Chlorhexidine gluconate and negative control group gargled with aquadest for 1 minute consecutively. Before and after treatment saliva samples were collected in sterile container, incubated, cultivated on Brain-Heart Infusion Agar (BHIA) for 2 x 24 hours and counted bacteria’s colony in saliva by using colony counter. Analyzing data with Anova and LSD test. The results showed that 10% purple leaves extract decreased bacteria’s count in saliva (p<0,05). There was no significant difference between the number of bacteria’s colony in samples who gargled with 10% purple leaves extract and 0,2% Chlorhexidine gluconate(p>0.05). In conclusion, gargling with 10% purple leaves extract may decrease bacteria’s count in saliva and hassimilar potency as 0,2% Chlorhexidine gluconate
MECHANISM OF COCOA SEEDS (Theobroma cacao, L) TO REDUCE THE INFILTRATION OF LYMPHOCYTES IN THE REGIONAL OF TOOTH EXTRACTION OF RATS Atik Kurniawati; Zainul Cholid; Budi Yuwono
UNEJ e-Proceeding 2022: E-Prosiding Kolokium Hasil Penelitian dan Pengabdian kepada Masyarakat
Publisher : UPT Penerbitan Universitas Jember

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Abstract

The act of removing a tooth from the alveolar bone socket is known as tooth extraction. Tooth extraction causes inflammation around the extraction area. Inflammation after tooth extraction will result in an increase in lymphocyte cells. This increase in the number of lymphocytes is too high due to continued inflammation can cause tissue damage around the socket. Cocoa beans contain chemical compounds that have anti-inflammatory and antioxidant properties that can help the post-extraction inflammation process so that wound healing is faster. Objective: to analyze the mechanism of cocoa bean extract (Theobroma cacao, L) on the decrease in the number of lymphocytes in the socket after tooth extraction of male Wistar rats. Methods: including laboratory experimental research with the post-test control group design. The results of the One-way Anova test showed that the number of lymphocytes decreased in all groups with a significant difference (p<0.05). LSD post hoc test results showed that the overall group was significantly different. Results and Conclusions: 8% cocoa bean extract gel (Theobroma Cacao, L) had an effect on reducing the number of lymphocyte cells in the socket after tooth extraction of male wistar rats compared to those not treated. Keywords: Cocoa, lymphocyte, tooth extraction.
The Effect of Purple Leaf Extract (Graptophyllum pictum L. Griff) to The Amount of Fibroblast in Gingiva Rat Wistar induced by Porphyromonas gingivalis Savira Aulia Rachim; Atik Kurniawati; Pudji Astuti
Denta Journal Kedokteran Gigi Vol 14 No 2 (2020): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v14i2.7

Abstract

Background: The prevalence of periodontal disease ranks second in dental and oral diseases after caries. Periodontitis is inflammation with bacteria infecting the host and involving all parts of the periodontal tissue. If this condition is left untreated, it can lead to fibrosis and irreversible damage. Various types of periodontitis therapy have not been able to provide optimal results in healing periodontitis and that therapy can cause side effects. Because of this background, the researchers wanted to carry out research on alternative treatments for periodontitis with purple leaves as an anti-inflammatory with an indicator of an increase in the number of fibroblast cells in inflamed areas. The use of purple leaves has been used since ancient times for the treatment of wounds and inflammation. Objective: To determine the effect of purple leaf extract (EDU) on increasing the number of fibroblast cells in the gingiva of Wistar rats infected by Porphyromonas gingivalis (Pg). Methods: 30 Wistar rats were divided into 5 groups, namely the normal group (KN), the control group Pg induced (K +) and the treatment group using EDU 2.5% (P1), EDU5% (P2), EDU10% (P3 ). All groups were induced by Pg except KN. EDU administration once a day for 7 days. On the 7th day the rats were decaputed and their gingivae were taken to make preparations and HE staining was carried out. Results readings in 3 different viewpoints were averaged and analyzed by one-way ANOVA. Results: The results showed that the K + group, 2.5% EDU, 5% EDU and 10% EDU groups increased the number of fibroblast significantly when compared to the Pg group (p < 0.05). Conclusion: EDU can increase the number of fibroblasts in Pg-induced mice
Efektivitas Ekstrak Biji Kakao (Theobroma Cacao L.) terhadap Penyembuhan Luka Pencabutan Gigi pada Sel Makrofag Atik Kurniawati; Zainul Cholid; Melati Harum Pertiwi
Denta Journal Kedokteran Gigi Vol 13 No 2 (2019): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Abstract

Background: Tooth extraction is a choice procedure that is often carried out in the field of dentistry. Tooth extraction can cause a cavity in the form of a tooth socket and tooth extraction wounds on the tissue around the socket followed by the body's response through wound healing. One of the process of wound healing namely the inflammatory phase. Macrophages are the most dominant cells in inflammation with the highest number on days 2 to 3. Polyphenols in cocoa beans have an active compound in the form of anti-inflammatory and antioxidants that are effective in accelerating the healing of wounds. Purpose: To determine the effect of giving the cocoa bean extract gel to the number of macrophage cells in the socket after tooth extraction male wistar rat on the 1st, 3th and 5th day. Material and method: This type of research is experimental laboratories. The samples used were 24 male Wistar rats which were then divided into 2 groups, namely the control group (sockets not given any treatment) and treatment groups (sockets were given 8% cocoa bean extract) on the 1st, 3th and 5th day post tooth extraction will be carried out decaputation. Results: The 8% cocoa bean extract gel had the potential to influence the number of macrophage cells in the socket after the tooth extraction of male Wistar rat on the 1st, 3th and 5th day caused an active compound in the cocoa Conclusions: the most effectiveness of the cocoa bean extract gel toward tooth extraction healing on the number of macrophage cells on the 3ath day
The Influence of Ethanol Extract Graptophyllum pictum L. Griff toward Phagocytic Activity of Monocyte Exposed by Candida albicans Atik Kurniawati
Denta Journal Kedokteran Gigi Vol 12 No 2 (2018): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Abstract

Background: Candidiasis is one of oral infectious disease caused by Candida albicans.The role of C. albicans as pathogen opportunistic in oral infection can affected by immune system. Phagocytosis has contributed in immune system against C. albicans infection, which is the role of monocytes. Grapthophyllum L. Griff has been proved to increase macrophage’s phagocytic activity, but the effect of violet leaves ethanol extract (EEDU) to increase monocyte’s phagocytic activity on C. albicans is unknown. Objectives: To determine the effect of violet leaves extract on monocyte’s phagocytic activity on C. albicans. Methods: This research was acted in vitro on human monocyte cell culture. There was 5 groups: negative control group, positive control group (incubated in Isoprinosine) and treatment groups was incubated in EEDU 2,5%, 5%, 10%. The percentage of activated monocytes was counted. Result: The result showed that incubation of EEDU 2,5%, 5% and 10% could increase monocyte’s phagocytic activity significantly (p<0,05) compared to control groups. The number of monocyte’s phagocytosis on C. albicans incubated with EEDU 2,5%, 5% and 10% is 65%, 60,5%, and 58,75%. The optimal concentration of EEDU to increase monocyte’s phagocytic activity was 2,5%. Conclusion: The study showed that EEDU can increase monocyte’s phagocytic activity on C. albicans.
Co-Authors Arina Nur Rahmah Budi Yuwono Desy Sofyah Hartina Dewi Yunita Sari Dwi Riski Saputra Dwi Riski Saputra Erawati Wulandari Falah, Pilar Menara Hendito K. Putra Indhi Cinthiya Amanitha Indriyani Chusnadia, Shafira Mangestuti Agil Melati Harum Pertiwi Melok Aris Wahyukundari Ni Made Mertaniasih Pertiwi, Melati Harum Pudji Astuti Resti Ayu Indriana Sari Setyaningsih Savira Aulia Rachim Siti Nurul Masruroh Hariyati Sulistiyani . Syafira Dwi Astuti Yani Corvianindya Rahayu Yani Corvianindya Rahayu Yudha Nurdian Zainul Cholid