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All Journal e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi SOSIOLOGI NUSANTARA UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Journal Of Vocational Health Studies Majalah Biomorfologi (Biomorphology Journal) Denta: Jurnal Kedokteran Gigi Cakradonya Dental Journal
Atik Kurniawati
Bagian Biologi Oral, Fakultas Kedokteran Gigi Universitas Jember, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Library & Information Science Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Uji Daya Hambat Ekstrak Metanol Daun Ungu (Graptophillum pictum (L.) Griff) terhadap Pertumbuhan Bakteri Saluran Akar Gigi (Inhibition Test of Purple Leaf (Graptophillum pictum (L.) Griff) Methanol Extract toward Root Canal Bacteria's Growth) Resti Ayu Indriana; Pudji Astuti; Atik Kurniawati
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Background: Root canal bacteria in necrotizing pulp are dominated by polymicrobial bacterial colonization. Bacteria control were performed by using antribacterial irrigation. Purple leaf methanol extract contains triterpenoids, alkaloids, flavonoids, glycosides, saponins, and tanins which are to own antibacterial capability. Objective: To determine a wide range of consentrations, the minimal concentration of purple leaf methanol extract which able to inhibit the growth of root canal bacteria, and how much is the concentration of the purple leaf methanol extract which is equivalent to 2.6% sodium hypochlorite. Methods: The method was used well diffusion. Antibacterial test was indicated by the existance of the inhibition zone around the well hole. Total samples used were 56 samples for  each 7 group treatment, which are concentration 100%, 50%, 25%, 12,5%, 6,25% of purple leaf methanol extract, 2.6% of sodium hypochlorite, and sterile water. The results of the study was then tested by the statistical parametric one way ANOVA and LSD. Results and Conclusion: The concentration of purple leaf methanol extract which ables to inhibit the growth of root canal bacteria is 12,5%, 25%, 50%, and 100% also the minimum concentration is 12,5%, and the concentration of purple leaf methanol extract which is equivalent to 2.6% of sodium hypochlorite is concentration of 25%.Keywords: Antibacterial, Root Canal Bacteria, Purple Leaf Methanol Extract, Graptophillum pictum (L.) Griff
CLINICAL MANIFESTATION OF ORAL TUBERCULOSIS Atik Kurniawati; Ni Made Mertaniasih; Mangestuti Agil
UNEJ e-Proceeding 2016: Proceeding The 1st International Basic Science Conference
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Tuberculosis (TB) is chronic infectious disease caused by Mycobacterium tuberculosis. According to WHO report, it infected almost one third people and Indonesia has been 5th position in the world. Tuberculosis is classified clinically as Pulmonary and Extra Pulmonary. Extra pulmonary tuberculosis can occur in the lymph nodes, meninges, kidneys, bone, skin and even oral cavity that we called oral tuberculosis. The oral tuberculosis may manifest in various form : ulcer, gingivitis, nodules, granulomatous, tuberculoma and osteomyelitis. The purpose of this paper to explain the clinical manifestation of oral tuberculosis.
The microbiological detection of Mycobacterium tuberculosis from oral lesion Atik Kurniawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 40 No. 3 (2007): September 2007
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (636.571 KB) | DOI: 10.20473/j.djmkg.v40.i3.p127-130

Abstract

Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis. The oral manifestations of tuberculosis have been reported. The objectives of this study was to detect Mycobacterium tuberculosis from oral lesions by swabbing. Samples were received from collected primary data on annually clinical report status and then clinical intra oral examination was performed. Oral lesions were swabbed and cultured using Lowenstein Jensen media, Middlebrook 7H9 and Middlebrook 7H10. Positive culture were recorded and observed everyday until 8 weeks. From 66 samples, there were 2 patients with ulcer as an oral clinical manifestation with location on the tongue. Culture examination revealed 2 positive samples. It was inferred that Mycobacterium tuberculosis could be detected in oral lesion by swabbing.
Pengaruh Kumur Ekstrak Daun Ungu Terhadap Jumlah Bakteri dalam Saliva Atik Kurniawati
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 15 No 2 (2018)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v15i2.25225

Abstract

Caries is the most problem in oral health. The main etiology of the disease dominated by bacterial colonization, can be found in saliva. Bacteria control were performed by using antibacterial agent. Purple leaves extract (Graphtophyllum pictum L.Griff) contains of antibacterial agent namely flavonoid, triterpenoid, alkaloid, glycoside, saponin and tannin. The objective of this study was to examine the effect of gargling with 10% purple leaves extract on bacteria’s count in saliva. In this study 15 subjects were divided randomly into 3 groups (treatment, positive and negative control). Each of groups consist of 5 persons. Treatment group gargled with 10% purple leaves extract, while positive control group gargled with 0,2% Chlorhexidine gluconate and negative control group gargled with aquadest for 1 minute consecutively. Before and after treatment saliva samples were collected in sterile container, incubated, cultivated on Brain-Heart Infusion Agar (BHIA) for 2 x 24 hours and counted bacteria’s colony in saliva by using colony counter. Analyzing data with Anova and LSD test. The results showed that 10% purple leaves extract decreased bacteria’s count in saliva (p<0,05). There was no significant difference between the number of bacteria’s colony in samples who gargled with 10% purple leaves extract and 0,2% Chlorhexidine gluconate(p>0.05). In conclusion, gargling with 10% purple leaves extract may decrease bacteria’s count in saliva and hassimilar potency as 0,2% Chlorhexidine gluconate
MECHANISM OF COCOA SEEDS (Theobroma cacao, L) TO REDUCE THE INFILTRATION OF LYMPHOCYTES IN THE REGIONAL OF TOOTH EXTRACTION OF RATS Atik Kurniawati; Zainul Cholid; Budi Yuwono
UNEJ e-Proceeding 2022: E-Prosiding Kolokium Hasil Penelitian dan Pengabdian kepada Masyarakat
Publisher : UPT Penerbitan Universitas Jember

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Abstract

The act of removing a tooth from the alveolar bone socket is known as tooth extraction. Tooth extraction causes inflammation around the extraction area. Inflammation after tooth extraction will result in an increase in lymphocyte cells. This increase in the number of lymphocytes is too high due to continued inflammation can cause tissue damage around the socket. Cocoa beans contain chemical compounds that have anti-inflammatory and antioxidant properties that can help the post-extraction inflammation process so that wound healing is faster. Objective: to analyze the mechanism of cocoa bean extract (Theobroma cacao, L) on the decrease in the number of lymphocytes in the socket after tooth extraction of male Wistar rats. Methods: including laboratory experimental research with the post-test control group design. The results of the One-way Anova test showed that the number of lymphocytes decreased in all groups with a significant difference (p<0.05). LSD post hoc test results showed that the overall group was significantly different. Results and Conclusions: 8% cocoa bean extract gel (Theobroma Cacao, L) had an effect on reducing the number of lymphocyte cells in the socket after tooth extraction of male wistar rats compared to those not treated. Keywords: Cocoa, lymphocyte, tooth extraction.
The Effect of Purple Leaf Extract (Graptophyllum pictum L. Griff) to The Amount of Fibroblast in Gingiva Rat Wistar induced by Porphyromonas gingivalis Savira Aulia Rachim; Atik Kurniawati; Pudji Astuti
Denta Journal Kedokteran Gigi Vol 14 No 2 (2020): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v14i2.7

Abstract

Background: The prevalence of periodontal disease ranks second in dental and oral diseases after caries. Periodontitis is inflammation with bacteria infecting the host and involving all parts of the periodontal tissue. If this condition is left untreated, it can lead to fibrosis and irreversible damage. Various types of periodontitis therapy have not been able to provide optimal results in healing periodontitis and that therapy can cause side effects. Because of this background, the researchers wanted to carry out research on alternative treatments for periodontitis with purple leaves as an anti-inflammatory with an indicator of an increase in the number of fibroblast cells in inflamed areas. The use of purple leaves has been used since ancient times for the treatment of wounds and inflammation. Objective: To determine the effect of purple leaf extract (EDU) on increasing the number of fibroblast cells in the gingiva of Wistar rats infected by Porphyromonas gingivalis (Pg). Methods: 30 Wistar rats were divided into 5 groups, namely the normal group (KN), the control group Pg induced (K +) and the treatment group using EDU 2.5% (P1), EDU5% (P2), EDU10% (P3 ). All groups were induced by Pg except KN. EDU administration once a day for 7 days. On the 7th day the rats were decaputed and their gingivae were taken to make preparations and HE staining was carried out. Results readings in 3 different viewpoints were averaged and analyzed by one-way ANOVA. Results: The results showed that the K + group, 2.5% EDU, 5% EDU and 10% EDU groups increased the number of fibroblast significantly when compared to the Pg group (p < 0.05). Conclusion: EDU can increase the number of fibroblasts in Pg-induced mice
PERAN EKSTRAK DAUN WUNGU (GRAPTOPHYLLUM PICTUM L. GRIFF) TERHADAP ADHESI STREPTOCOCCUS MUTANS PADA NEUTROFIL Atik Kurniawati; Sulistiyani -; Arina Nur Rahmah
Cakradonya Dental Journal Vol 11, No 2 (2019): Agustus 2019
Publisher : FKG Unsyiah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.421 KB) | DOI: 10.24815/cdj.v11i2.16156

Abstract

Streptococcus mutans (S. mutans) merupakan bakteri utama penyebab karies gigi yang mampu mendemineralisasi email, menginvasi dentin yang dapat berlanjut menjadi inflamasi pulpa (pulpitis). Streptococcus mutans menginvasi inang diawali dengan melakukan adhesi (perlekatan). Proses ini merupakan langkah awal dalam proses inflamasi. Oleh karena itu, adhesi Streptococcus. mutans pada sel inang perlu dicegah agar tidak terjadi infeksi oleh bakteri. Neutrofil merupakan sel pertahanan pertama yang datang pada proses inflamasi. Salah satu upaya untuk mencegah terjadinya adhesi tersebut bisa menggunakan bahan alami yang bersifat anti-inflamasi, salah satunya yaitu daun wungu. Penelitian ini bertujuan untuk  mengetahui pengaruh pemberian ekstrak daun wungu (EDW) terhadap adhesi  bakteri  Streptococcus. mutans pada neutrofil dan perbedaan indeks adhesi dalam berbagai konsentrasi dengan eksperimental laboratoris menggunakan the post test only control group design. Sampel terbagi menjadi 5 kelompok (klp): klp I/kontrol (tanpa inkubasi EDW), klp II (EDW 3,125%), klp III (EDW 6,25%), klp IV (EDW 12,5%), dan klp V (EDW 25%). Isolat neutrofil diinkubasi dengan EDW selama 3 jam, kemudian dipapar S. mutans selama 4 jam. Indeks adhesi dihitung berapa rata-rata jumlah S. mutans  yang menempel pada 100 neutrofil. Simpulan penelitian menunjukkan bahwa ekstrak etanol daun wungu berpotensi menurunkan indeks adhesi Streptococcus mutans. Kata kunci: adhesi, S. mutans, neutrophil, daun wungu
POTENSI EKSTRAK DAUN UNGU DALAM MENURUNKAN JUMLAH SEL OSTEOKLAS TIKUS YANG DIINDUKSI PORPHYROMONAS GINGIVALIS Atik Kurniawati; Melok Aris Wahyukundari; Syafira Dwi Astuti
Cakradonya Dental Journal Vol 12, No 2 (2020): Agustus 2020
Publisher : FKG Unsyiah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (656.069 KB) | DOI: 10.24815/cdj.v12i2.18436

Abstract

Periodontitis merupakan penyakit inflamasi pada jaringan periodontal. Porphyromonas gingivalis merupakan salah satu bakteri patogen pemicu periodontitis. Respons awal inflamasi dipicu oleh faktor virulen P.gingivalis antara lain lipopolisakarida (LPS) yang berlanjut pada kerusakan ligamen periodontal sehingga memicu resorpsi tulang alveolar yang diperankan oleh sel osteoklas. Ekstrak daun ungu (Graptophyllum pictum L. Griff) diketahui dapat menghambat P.gingivalis secara in vitro, namun kemampuannya sebagai antiinflamasi dalam menurunkan jumlah sel osteoklas pada kejadian periodontitis belum diketahui. Penelitian ini bertujuan untuk mengevaluasi potensi ekstrak daun ungu (EDU) dalam menurunkan jumlah sel osteoklas pada tikus wistar yang diinfeksi dengan P.gingivalis. Penelitian dilakukan pada tikus wistar yang terdiri atas 6 kelompok. Masing-masing kelompok terdiri dari 5 tikus wistar. Enam kelompok yang terdiri dari kelompok normal (KN): tanpa perlakuan, kelompok kontrol negatif (K-): diinfeksi P.gingivalis (Pg), kelompok kontrol positif (K+): Pg + Tantum Verde, dan 3 kelompok perlakuan yaitu: KP2,5% (Pg + EDU 2,5%), KP5% (Pg + EDU 5%) serta KP10% (Pg + EDU10%). Pemeriksaan histologi dengan pengecatan Haematoxylin-Eosin (HE), jumlah sel osteoklas pada jaringan gingiva, ditentukan dengan menghitung jumlah rata-rata dari 3 lapang pandang tiap potongan jaringan. Analisis data dengan One Way Anova dilanjutkan LSD. Kesimpulan penelitian ini adalah ekstrak daun ungu berpotensi menurunkan jumlah sel osteoklas pada jaringan gingiva tikus wistar (p0,05).
Uji Aktivitas Antijamur Ekstrak Kulit Buah Kakao (Theobroma cacao L.) terhadap Candida albicans Desy Sofyah Hartina; Yani Corvianindya Rahayu; Atik Kurniawati
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 20 No 2 (2023)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v20i2.44006

Abstract

Candidiasis is an opportunistic fungal infection caused by Candida albicans. The prevalence of candidiasis in Indonesia is around 20-25%, it can attack the skin, nails, hair, throat, and mouth. One of the fungal infections that occur in the oral cavity is oral candidiasis. Oral candidiasis is caused by overgrowth of Candida albicans species in the oral cavity which is dominated by Candida albicans as much as 85-95%. One of the treatments using herbal medicinal plants is cocoa peel containing active compounds including phenolics, flavonoids, tannins, and terpenoids which are thought to be antifungal. The aim was to determine the inhibition of cocoa peel extract on the growth of Candida albicans. This study used the disc diffusion method with 4 samples in each study group. The research group consisted of 5 treatment groups (10%, 20%, 40%, 80%, and 100% cocoa peel extract), positive control group (nystatin), and negative control group (sterile aquades). Data were analyzed using One Way Anova test and LSD (Least Significant Difference) test. Concentrations of extracts of cocoa pods 100% and 80% have the ability to inhibit the growth of Candida albicans.
MITIGATION OF SOIL-TRANSMITTED HELMINTHIASES RESURGENCE IN THE ERA OF COVID-19 DISRUPTION: A LITERATURE REVIEW Falah, Pilar Menara; Yani Corvianindya Rahayu; Atik Kurniawati; Yudha Nurdian
Majalah Biomorfologi Vol. 32 No. 2 (2022): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v32i2.2022.96-102

Abstract

Highlights: 1.    Prolonged interruptions and delays that accompany the COVID-19 pandemic have further increased the spread of STH in high-transmission areas.2.    Adaptations carried out in the context of a pandemic are able to strengthen efforts to sustain deworming programs based on primary health facilities and their integration into community-based platforms.3.    Community-based WASH activities must be continued by adjusting WASH messages to focus on preventing the transmission of COVID-19. Abstract: Background: Interruptions and postponements are influencing people's desire for soil-transmitted helminthiases (STH) services as all countries are fighting the Covid-19 pandemic. The risk of spreading STH in high-transmitting areas increases with increased disturbance. Indonesia is a compatible host country for STH because it is a tropical country. The STH impacts the population's nutrient status and disturbs their cognitive processes. Objective: To describe the issue and how best efforts had been made to mitigate the possibility of a resurgence of intestinal worms during the disruptions caused by the Covid-19 pandemic. Material and Method: Search for the most recent articles in a database of research in January 2022 on Google Scholar, Science Direct, and PubMed. Qualifying articles were then extracted and synthesized qualitatively. Discussion: The interference and postponement of the deworming control program due to COVID-19 had a tentative effect on the progress of achieving the elimination of STH as a public health problem by 2030. Conclusion: Best practices show that revitalization efforts to control STH by strengthening integrated interventions and collaborations through the expansion of POPM, PHBS, and STBM in line with COVID-19 prevention efforts with mitigation innovations shifting from controlling morbidity to terminate the transmission of STH.
Co-Authors Arina Nur Rahmah Budi Yuwono Desy Sofyah Hartina Erawati Wulandari Falah, Pilar Menara Indriyani Chusnadia, Shafira Mangestuti Agil Marista Christina Shally Kabelen Meila Riska Fitri Melati Harum Pertiwi Melok Aris Wahyukundari Ni Made Mertaniasih Pertiwi, Melati Harum Pudji Astuti PUDJI ASTUTI Resti Ayu Indriana Sari Setyaningsih Savira Aulia Rachim Sulistiyani . Syafira Dwi Astuti Yani Corvianindya Rahayu Yani Corvianindya Rahayu Yudha Nurdian Zainul Cholid Zainul Cholid