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Machrumnizar Machrumnizar
Departemen Parasitologi Fakultas Kedokteran Universitas Trisakti, Jakarta, Indonesia
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Berat Badan Lahir Rendah pada Bayi Wanita Terinfeksi Plasmodium falciparum Saat Hamil Machrumnizar -
Cermin Dunia Kedokteran Vol 42, No 6 (2015): Malaria
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i6.999

Abstract

Plasmodium falciparum dapat memodifikasi permukaan eritrosit terinfeksi dengan membentuk knobs oleh protein yang dikenal sebagai Plasmodium falciparum Erythrocyte Membrane Protein-1 (PfEMP-1) dan dikode oleh famili gen var. Pembentukan knobs menyebabkan sel darah merah mudah melekat dan menggumpal di sel endotelial sehingga mengganggu mikrosirkulasi organ, termasuk plasenta. Gangguan invasi trofoblas menyebabkan penyumbatan mekanik sehingga terjadi insufisiensi plasenta dan fetal growth retardation (FGR). Antigen parasit malaria juga mampu menginduksi imunitas seluler oleh limfosit T dan imunitas humoral oleh limfosit B. Sitokin yang diduga banyak berperan pada patologi malaria adalah TNF-alfa karena meningkatkan ekspresi molekul adhesi pada sel-sel endotel kapiler. Semua hal tersebut menyebabkan gangguan aliran darah plasenta dan akhirnya gangguan nutrisi janin, yang dapat menyebabkan retardasi pertumbuhan janin sehingga bayi memiliki berat badan rendah.Plasmodium falciparum can modify the surface of infected erythrocytes with knobs formed by proteins known as Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) and encoded by var gene family. Formation of knobs causes red blood cells clumping and attachment to endothelial cells, affecting microcirculation in organs including placenta. Invasion of trophoblast causes mechanical obstruction resulting in placental insufficiency and Fetal Growth Retardation (FGR). Malaria parasite antigens are also able to induce cellular immunity by T lymphocytes and humoral immunity by B lymphocytes. TNF-alpha has a suspected role in the pathology of malaria, because it increases molecule adhesion in capillary endothelial cells. Plasmodium falciparum infection in pregnant women is associated with disruption of placenta microcirculation and trophoblast parasites invasion, as well as immune response that may increase cytoadherence of infected red blood cells. These mechanisms lead to placental blood flow disruption andmay ultimately cause fetal nutritional disorders resulting in fetal growth retardation and low birth weight.
Penyuluhan Tentang Demam Berdarah Dan Pencegahannya Yuliana; Machrumnizar; Suriyani; Arleen Devita
JURNAL ABDIMAS KESEHATAN TERPADU Vol. 1 No. 2 (2022): Jurnal Abdimas Kesehatan Terpadu
Publisher : Fakultas Kedokteran Gigi, Universitas Trisakti bekerjasama dengan Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (363.647 KB) | DOI: 10.25105/jakt.v1i2.15477

Abstract

Dengue hemorhagic fever (DHF) is an infection caused by dengue virus. Dengue is a virus that is transmitted from Aedes Spp mosquito, the fastest growing mosquito in the world and has transmitted dengue virus. The prevalence of DHF until July 2020 has reached 71.633 in Indonesia, and 4.227 cases only in DKI Jakarta province. We usually don’t find new case on July, but this year we still find new cases on July. This should increase our vigilance, especially at this time when there is a pandemic of COVID-19 cases. The purpose of this activity is to increase public knowledge about dengue fever so that they can prevent dengue fever in their area. This activity is carried out through seminar using the zoom application because conditions in the field do not allow offline activities to be held. The activity will be held on Saturday, April 23, 2022. The results obtained through this PKM activity is an increase in the level of participants' knowledge about DHF as evidenced by an increase in post-test scores after attending the seminar. The conclusion of this PKM activity went well because of the support from all related parties from institutions, solid teams, and partners who actively participated. The shortage of this PKM activity is that the activities are carried out online because the conditions are still not conducive to do an offline activity. The advice we can give is to carry out PKM activities again with the same partner with different health topics according to the conditions that exist in the partners.
Penyuluhan Tentang Kesehatan Gigi Dan Mulut Pada Anak Sekolah Dasar Suriyani Tan; Machrumnizar Machrumnizar
AMMA : Jurnal Pengabdian Masyarakat Vol. 1 No. 05 (2022): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

Sugary foods and drinks are defined as foods that contain high levels of sugar. The high sugar content in these foods or beverages generally comes from added sweeteners. Sugary foods and drinks affect human health. If sugary foods and drinks are consumed for a long period of time and in excessive proportions, health problems such as obesity, diabetes mellitus and dental and oral health can occur. School-aged children are consumers who consume a lot of sugary foods and drinks. The incidence of dental caries also often occurs in school children due to consumption of sugary foods and drinks. The purpose of this community service activity is to provide counseling to school children about the risks of consuming sugary foods and drinks, as well as provide education about dental and oral health.
Peningkatan Pengetahuan Tentang Infeksi Parasit Penyebab Diare dan Sanitasi Lingkungan Suriyani Tan; Machrumnizar Machrumnizar
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 2 (2023): AMMA : Jurnal Pengabdian Masyarakat (INPRESS)
Publisher : CV. Multi Kreasi Media

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Abstract

Diarrhea in one of the leading causes of child mortality worldwide. According to World Health Organization data, there are about 1,7 billion cases of diarrhea in children. Diarrhea due to parasitic infection is widespread throughout developing countries. This includes limited access to health services, socio-economic problems, population density, slum settlements, malnutrition, geographic factors, poor hygiene and waste management, including lack of access to clean water and sanitation.
SKORING CORONARY ARTERY CALSIUM PADA INDIVIDU USIA DEWASA AKHIR DAN LANSIA DENGAN HIPERTENSI Putu Suryabrata Adnyana; Machrumnizar Machrumnizar
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Vol. 8 No. 2 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v8i2.15556

Abstract

Hypertension causes an increase in coronary artery calcium (CAC), which is a strong predictor of new-onset hypertension and occurrences related to atherosclerotic cardiovascular disease in people either with or without hypertension. The medical application of CAC scoring to adjust hypertension management has received slight attention and is poorly defined. In Indonesia, research on the benefits of CAC assessment for hypertension is yet very limited. This study will show the association of hypertension with CAC rating, age, and gender. This cross-sectional study used secondary data in the form of medical records from 163 patients (88 men, 75 women; range 40-70 years) at Siloam Hospital TB Simatupang. Sample collection was carried out using consecutive nonrandom sampling. Only medical records with complete physical examination results and CAC scoring will be further analyzed. The Mann-Whitney statistical test was carried out using the SPSS 25.0 program to see the relationship between CAC scoring and hypertension, with a value of p=0.002 and a significance level of p<0.05. To assess the relationship between age and gender with the incidence of hypertension, a chi square test was carried out, with each value p = 0.011 and p = 0.141 (p <0.05). The results showed a relationship between CAC scoring and hypertension in late adulthood and elderly individuals.
Faktor – faktor yang berhubungan dengan gejala depresi di kalangan perempuan yang melakukan pernikahan dini Suryani Tan; Machrumnizar Machrumnizar; Rina Kusumaratna; Jipri Suyanto
Holistik Jurnal Kesehatan Vol 17, No 4 (2023)
Publisher : Program Studi Ilmu Keperawata Fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v17i4.11052

Abstract

Background: In general, the role of the mother in family life is to be responsible for taking care of the family. Mother has to handle all aspects of household management, including childcare, money management, food preparation, etc. Requires mental readiness to carry out its role which has the potential to cause depression.Purpose: To identify factors correlated with depression symptoms among women in early married.Method: Using a stratified random sampling procedure, 488 participants were selected for the interview and questionnaire in this cross-sectional study. Married women experience pressure because of the condition of their marriage, especially those who marry at a young age. The dependent variable, depression, was divided into two groups: the group with depressive symptoms with a score range of >60, and the group without depressive symptoms with a score range of 0 to 60. The fourteen independent variables were age of marriage, religion, education, ethnicity, area of residence in Bengkulu Province, occupation, place of residence, household income per month, poor living conditions, social influence on depression, family influence on depression, and stress. This study also includes three types of tests: univariate, logistic regression, and multiple logistic regression. Logistic regression and multiple logistic regression were used as data analysis to find the relationship between the independent factors and the dependent variable.Results: The prevalence of depression was 77.87% (95% CI: 73.95-81.34). The factors that are significantly related to depression are; < 18 years (AOR = 6.19; 95% CI: 2.98 - 12.88), household income < Rp. 122.72.000 (OR = 7.01; 95% CI: 3.62 - 13.57), poor living conditions (OR = 2.16; 95% CI: 1.11 - 4.18), have a community influence on depression (OR = 3.68; 95% CI: 1.91 - 7.06) and experience stress (OR = 9.85; 95% CI: 5.24 - 18.24).Conclusion: Marriage age, household income, poor living conditions, community depression, and stress are all associated with depression among married women in Bengkulu Province.Keywords: Depression; Early Married; Stress; WomenPendahuluan: Karena wanita dianggap lebih sensitif daripada pria, ini adalah masalah hak bagi mereka. Mayoritas penduduk berpikir bahwa wanita harus menangani semua aspek manajemen rumah tangga, termasuk pengasuhan anak, pengelolaan uang, persiapan makanan, dll. Mereka mungkin mengalami berbagai masalah mental sebagai akibat dari penyakit ini, yang dapat menyebabkan depresi.Tujuan: Untuk mengidentifikasi faktor-faktor yang berhubungan dengan gejala depresi pada wanita menikah dini.Metode: Dengan menggunakan prosedur sampel acak bertingkat, 488 partisipan dipilih untuk wawancara dan kuesioner dalam penelitian cross-sectional ini. Perempuan yang sudah menikah adalah salah satu responden. Perempuan yang sudah menikah berada di bawah tekanan karena kondisi pernikahan mereka, terutama mereka yang menikah di usia muda. Variabel dependen, depresi, dibagi menjadi dua kelompok: mereka yang memiliki gejala depresi dengan rentang skor >60, dan mereka yang tidak memiliki gejala depresi dengan rentang skor 0 hingga 60. Empat belas variabel independen adalah usia pernikahan, agama, pendidikan, etnis, wilayah tempat tinggal di Provinsi Bengkulu, pekerjaan, tempat tinggal, pendapatan rumah tangga per bulan, kondisi tempat tinggal yang buruk, pengaruh komunitas terhadap depresi, pengaruh keluarga terhadap depresi, dan stres. Penelitian ini juga mencakup tiga jenis uji yang berbeda: univariat, regresi logistik, dan regresi logistik berganda. Regresi logistik dan regresi logistik berganda digunakan sebagai data analisis untuk menemukan hubungan antara faktor independen dan variabel dependen.Hasil: Prevalensi depresi adalah 77,87% (95% CI: 73,95-81,34). Faktor-faktor yang secara signifikan berhubungan dengan depresi adalah; < 18 tahun (AOR = 6,19; 95% CI: 2,98 - 12,88), memiliki pendapatan rumah tangga < Rp. 122.72.000 (OR = 7,01; 95% CI: 3,62 - 13,57), kondisi tempat tinggal yang buruk (OR = 2,16; 95% CI: 1,11 - 4,18), memiliki pengaruh komunitas terhadap depresi (OR = 3,68; 95% CI: 1,91 - 7,06) dan mengalami stres (OR = 9,85; 95% CI: 5,24 - 18,24). Simpulan: Usia pernikahan, pendapatan rumah tangga, kondisi kehidupan yang buruk, depresi di masyarakat, dan stres semuanya berhubungan dengan depresi di antara perempuan yang sudah menikah di Provinsi Bengkulu.
Monosodium Glutamat (MSG) dan Gambaran Histologis Otak: Implikasi terhadap Pembentukan Otak Mencit Suriyani Tan; Machrumnizar Machrumnizar; Muhamad Andanu Yunus Slamet
Sanus Medical Journal Vol. 5 No. 1 (2023): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v5i1.11335

Abstract

Abstract BACKGROUND The sodium salt of glutamic acid, monosodium glutamate (MSG), is a white crystalline compound (glutamic acid). MSG was first produced in large quantities in early 1963 by Korea and Japan which then spread to other countries, including Indonesia. The medical profession is concerned about the detrimental consequences of MSG because of its widespread and uncontrolled consumption. The histological differences between the cerebellum of MSG-treated and MSG-free rats are of interest to researchers. METHOD The Post Test-Only Control Group design was used in this study and used data collected for 14 days. This study used 30 male mice of the Swiss Webster type (Mus Musculus) which were reared as pure strains through inbreeding. Mice taken were 8 weeks old weighing 20 – 40 grams and divided into three groups, each consisting of nine mice with one tail in reserve for each group. One group as a control and two groups will receive MSG orally, each at a dose of 3 mg and 8 mg. Termination of mice was carried out by means of dislocation of the cervical vertebrae and continued with preparation of mice brain tissue preparations. Data analysis, which was obtained from observing the histological appearance of the mouse brain, used the Paired-Sample T test in the SPSS (Statistical Product and Service Solutions) version 20.0 for Windows with a significance level of 0.05. RESULTS In this study, there was no difference in the histological appearance of the brain cerebellum of mice in the control group and the administration of 3 mg and 8 mg of MSG. However, there was a greater increase in body weight in mice given 3 mg of MSG compared to the group given 8 mg of MSG and controls, the average weight gain was 2.87 mg. CONCLUSION After observing through a microscope on the brain preparations of control mice, MSG 3 mg and MSG 8 mg, no difference in histological appearance was found. But giving MSG to mice affects weight gain.   Abstrak LATAR BELAKANG Garam natrium dari asam glutamat, monosodium glutamat (MSG), adalah senyawa kristal putih (asam glutamat). MSG pertama kali diproduksi dalam jumlah besar pada awal tahun 1963 oleh Korea dan Jepang yang kemudian menyebar ke negara lain, termasuk Indonesia. Profesi medis prihatin dengan konsekuensi merugikan dari MSG karena konsumsinya yang meluas dan tidak terkendali. Perbedaan histologis antara otak kecil tikus yang diberi MSG dan bebas MSG adalah hal yang menarik untuk diketahui. METODE Desain Post Test-Only Control Group digunakan dalam penelitian ini dan menggunakan data yang terkumpul selama 14 hari. Penelitian ini menggunakan 30 ekor mencit jantan jenis Swiss Webster (Mus Musculus) yang dipelihara sebagai galur murni melalui perkawinan sedarah. Mencit yang diambil berumur 8 minggu dengan berat 20 – 40gram dan dibagi menjadi tiga kelompok, masing-masing terdiri atas sembilan ekor mencit dengan cadangan satu ekor untuk setiap kelompok. Satu kelompok sebagai kontrol dan dua kelompok akan menerima MSG secara oral, masing-masing dengan dosis 3 mg dan 8 mg. Terminasi mencit dilakukan dengan cara dislokasi vertebra servikal dan dilanjutkan pembuatan preparat jaringan otak mencit. Analisis data, yang diperoleh dari pengamatan gambaran histologis otak mencit, menggunakan Paired-Sample T test pada program SPSS (Statistical Product and Service Solutions) versi 20.0 for Windows dengan tingkat kemaknaan 0,05. HASIL Pada penelitan ini tidak ditemukan adanya perbedaan pada gambaran histologis cerebellum otak mencit pada kelompok kontrol dan pemberian MSG 3 mg dan 8 mg. Namun, terdapat peningkatan berat badan lebih banyak pada mencit yang diberikan MSG 3 mg dibandingkan dengan kelompok yang diberikan MSG 8 mg dan kontrol, rata-rata kenaikan berat badan sebesar 2,87 mg. KESIMPULAN Setelah dilakukan pengamatan melalui mikroskop pada preparat otak mencit kontrol, MSG 3 mg dan MSG 8 mg, belum ditemukan perbedaan gambaran histologis. Tetapi pemberian MSG pada mencit mempengaruhi pertambahan berat badan.
Penyuluhan Kesehatan Demam Berdarah Dengue di Masa Pandemi COVID-19 Machrumnizar Machrumnizar; Suriyani Tan; Yuliana Yuliana; Arleen Devita
AMMA : Jurnal Pengabdian Masyarakat Vol. 1 No. 11 (2022): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

Demam Berdarah Dengue (DBD) disebabkan oleh virus dengue dan masih menjadi masalah kesehatan masyarakat saat ini, terutama pada daerah perkotaan.  Tingkat kematian yang disebabkan oleh penyakit ini sangat tinggi  jika tidak ditangani dengan segera.   Virus dengue terutama ditularkan oleh nyamuk betina Aedes aegypty dan Ae. albopictus. Nyamuk Aedes spp merupakan nyamuk yang mempunyai kemampuan untuk berkembang biak dengan cepat karena telur dari nyamuk ini bisa hidup dalam kondisi kering. Indonesia menerapkan program Jumantik (Juru Pemantau Jentik) sebagai salah satu cara pemberantasan nyamuk. Namun, dengan pemberlakuan PSBB (Pembatasan Sosial Berskala Besar) di DKI Jakarta saat ini, program ini menjadi sedikit sulit dilakukan. Penyuluhan ini dilakukan sebagai bagian dari peningkatan literasi masyarakat terhadap pemahaman akan demam berdarah dari gejala sampai pencegahan di tingkat rumah tangga., sehingga masyarakat menjadi waspada akan penyakit ini meskipun di tengah kondisi pandemi Covid-19. Penyuluhan dilakukan secara daring dan sebelum penyuluhan telah diadakan survey awal pemahaman tentang DBD dan survey akhir dilakukan setelah penyuluhan untuk menilai tingkat pemahaman masyarakat tentang DBD. Hasil yang dicapai berupa manfaat terutama untuk masyarakat, yaitu warga memahami tentang penyakit demam berdarah dan pencegahannya melalui pemberantasan jentik nyamuk di rumah masing-masing, yang pada akhirnya dapat menurunkan jumlah kasus DBD di Jakarta.
Edukasi Pemakaian Masker, Peningkatan Pengetahuan Tentang Penyakit Pernapasan, Dan Skrining Kesehatan Machrumnizar Machrumnizar; Suriyani Tan
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 12 : Januari (2024): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

More than four million people die each year from respiratory problems, which also affect hundreds of millions more. This disease has detrimental effects on the family, society, and the health and well-being of the patient. especially those living in low- and middle-income countries, where people are daily exposed to indoor air pollution from solid fuels used for cooking and heating. The biggest significant risk factor for respiratory disease in high-income countries is tobacco use. WHO data for 2020 shows that Lower Respiratory Infection Disease and Chronic Obstructive Pulmonary Disease rank number 3 and 4, at 6.1% and 5.8% respectively. There are eight lung diseases that are a public health problem in Indonesia and are included in the scope of the Indonesian Ministry of Health's environmental health and disease control program, including Tuberculosis, Acute Respiratory Infection (ARI), Bronchial Asthma, Lung Disease, Chronic Obstructive, Lung Cancer, Air Pollution and Climate Change, Combating Smoking Problems, Emerging & New Emerging Diseases (including COVID-19). Since WHO declared the COVID-19 pandemic in March 2020, Indonesia has carried out public interventions to stop the pandemic, including pharmaceutical and non-pharmaceutical actions (wearing masks, travel restrictions, closing schools, and postponing public events). Non-pharmaceutical interventions have a greater impact on infectious diseases than pharmaceutical interventions, despite the fact that pharmaceutical strategies can target specific organisms.
Peningkatan Kesadaran Masyarakat Tentang Infeksi Tuberkulosis Paru Pasca Covid-19 Suriyani Tan; Rina K. Kusumaratna; Yuliana Yuliana; Machrumnizar Machrumnizar
AMMA : Jurnal Pengabdian Masyarakat Vol. 3 No. 3 : April (2024): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

Pulmonary tuberculosis, often called TB, is a bacterial infection caused by Mycobacterium tuberculosis. Indonesia is one of eight countries that accounts for 2/3 of TB cases worldwide. This disease usually affects the lungs, but can also attack other organs in the body. TB symptoms can vary depending on the type of infection and the organs affected. During the COVID-19 pandemic, attention to other diseases, such as TB has decreased. The increasing risk of spreading TB after COVID-19 is a public health concern. Restrictions on social movement implemented during the COVID-19 pandemic may result in an increased risk of TB transmission among close contacts of TB sufferers. People who have had COVID-19, especially those who have had lung damage due to COVID-19 infection, may have a higher risk of developing TB due to a weakened immune system. This Community Service is carried out to increase public awareness of the dangers of TB that continue to lurk after COVID-19 and it is hoped that through this outreach and education, the public will become more aware of the symptoms of TB so they can check themselves at Primary Health Care.
Co-Authors Adang Bachtiar Devita, Arleen Hans Sutanto Utama Hans Utama Sutanto Hendra Kurniawan Jipri Suyanto Jipri Suyanto Mhd. Idham Khalif Muhamad Andanu Yunus Slamet Putu Suryabrata Adnyana Rina K. Kusumaratna Rina K. Kusumaratna Rina Kusumaratna Suriyani Suriyani Tan Suriyani Tan Suryani Tan Yuliana Yuliana Yuliana Yuliana, Yuliana