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All Journal BALI MEDICAL JOURNAL (BMJ) Jurnal Berkala Epidemiologi Jurnal NERS Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal Orthopaedi and Traumatology Surabaya (JOINTS) Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology Narra J The Hip and Knee Journal
Mouli Edward
Department Of Orthopaedic And Traumatology, Faculty Of Medicine, Universitas Airlangga – Dr. Soetomo General Hospital, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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QUALITY OF LIFE COMPARATION IN METASTATIC BONE DISEASE PATIENT BEFORE AND AFTER SURGERY IN DR. SOETOMO GENERAL HOSPITAL Ferdiansyah Mahyudin; Mouli Edward; Muhammad Hardian Basuki; Rizky Agung Satria
Journal Orthopaedi and Traumatology Surabaya Vol. 7 No. 2 (2018): October 2018
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v7i2.2018.132-138

Abstract

Background: Metastatic bone disease is bone pathologic process caused by spread of primary tumor. The incidence of metastatic bone disease varies between 20-75% corresponds to the primary site of the malignancy. Surgery in metastatic bone disease aim to cure or palliate the morbidity caused by the disease. Operative treatment could reduce pain, improve function, control metastatic focus of the malignancy, and provide mechanical stabilization. Based on those benefits, operative treatment is important to improve quality of life in patients with metastatic bone disease. Purpose:  Proved that there was a difference in the quality of life MBD patients before and after surgery.Methods: This research was a retrospective cohort on MBD patients which undergone surgery, and never given any other treatment in the course of the disease. The research was conducted in Dr. Soetomo General Hospital, Surabaya. Patient sampling was done using consecutive sampling. Karnofsky score was taken from the medical record before the procedure and direct interview via phone or completing questionnaire. Data analysis was done descriptively and analytically. Statistical tests were done using Wilcoxon test.Results: 146 patients enrolled in the research. The mean age of the sample was 48.77 ± 13.34 years. The mean of Karnofsky score before and after the procedure was 53.69±13.07 and 75.54±13.69 with statistical result of p<0.001.Conclusion: The Karnofsky score in MBD patients was higher after the surgery compared to before the surgery.
ANALYSIS OF IMMUNITY IN OSTEOSARCOMA AS A BASIS FOR DEVELOPMENT FOLLOWING THERAPY Ferdiansyah Mahyudin; Mouli Edward; Muhammad Hardian Basuki; Kadek Seta Prawira
Journal Orthopaedi and Traumatology Surabaya Vol. 7 No. 2 (2018): October 2018
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v7i2.2018.139-148

Abstract

Background: Osteosarcoma is a malignant bone disease. Predictors which used to determine osteosarcoma from non-invasive (stage IIB) to invasive (stage III), through the ratio of macrophages-1 (M-1) which are pro-inflammatory (anti-cancer) with macrophages-2 (M-2) which have anti-inflammatory characteristic (pro cancer) is not clear yet.Purpose: To elaborate the role of M-1 ratio with M-2 in the development of non-invasive osteosarcoma become invasive, in effort to obtain predictors that can be used to the selection of neoadjuvant therapy time.Methods: An observational study with cross sectional analytic study design. The sample of this research were all of paraffin blocks containing osteosarcoma patient tissue, collected within 5 years. The number of samples that met the inclusion criteria was 26 samples, and then divided into two groups, namely group-I as many as 13 stages IIB and group-II as many as 13 samples of stage III. The measured variables are the number of macrophages that express TNF-α and those that express IL-10 by immunohistochemical methods.Results: Analysis of the data using a Mann-Whitney test, and the results were obtain is the number of macrophages expressing TNF-α in group-I was greater than in group-II (p <0.05). Likewise, macrophages that expressed IL-10 in group I were smaller than in group-II (p <0.05).Conclusion: The M-1 ratio which reflected by TNF-α expression cells with M-2 as reflected by IL-10 expression cells in the non-invasive group is 5: 1.Whereas in the group that develops to invasive is 1:6.
MODIFIED LAUTENBACH TECHNIQUE AND EXTERNAL FIXATION AS A TREATMENT FOR INFECTED NON-UNION OF THE SUBTROCHANTER FEMUR: A CASE REPORT Mouli Edward; Teddy Heri Wardhana; Erfan Nasrullah
Journal Orthopaedi and Traumatology Surabaya Vol. 8 No. 1 (2019): April 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v8i1.2019.25-34

Abstract

Infected non-union is still a challenging orthopedic case to treat. Up until present day, there is no any established protocol to treat infected non-union of femur. Infection at subtrochanter femur specifically poses extra challenge as aforementioned location is affected by great tension and compression force. In this report, we present a 20-yo woman with infected subtrochanter femur following open reduction internal fixation (ORIF)with angle blade plate (ABP) 95o. One stage surgery was performed involving implant removal, debridement, definite external fixation, and antibiotic delivery using modified Lautenbach technique. Four years after trauma, the patient was capable of independent mobilization without aid. No infection recurrence was found, and Haris Hip Score was 91 (excellent). Based on the result of this case, definite external fixation and modified Lautenbach technique in one stage surgery can be a viable option in treating infected non-union of subtrochanter femur.
ANTERIOR TALOFIBULAR LIGAMENT (ATFL) RECONSRUCTION WITH MODIFIED BROSTROM-GOULD TECHNIQUE USING FIBER WIRE Andre Triadi Desnantyo; Mouli Edward; Asyumaredha Asyumaredha
Journal Orthopaedi and Traumatology Surabaya Vol. 8 No. 2 (2019): October 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v8i2.2019.93-103

Abstract

Background: The incident of ankle sprain reported 1 of 10.000 case each day. The most incident was male about 22-24 year and sport active. We reported 2 cases (15 years old female and 21 years old male) both of them played routine basketball and futsal.Case: We reported 2 cases, male 21 years old and female 15 years old, both of them suffered from anterior talofibular ligament rupture, with AOFAS score fair (below 80 point) from the MRI there is rupture of ATFL.Discussion: The patient administered to the hospital after injury at sport. By physical examination (fair at AOFAS score) and radiological finding, they was decided underwent rupture anterior talofibular ligament and prepared for reconstruction with modified Brostrom-Gould technique using fiber wire. After + 3 month, the evaluation from physical diagnostic, radiology and we got an excellent AOFAS score, which means the 2 patient got really satisfaction and has no limitation at doing daily activities.Conclusion: ATFL is one of the lateral ligament of the ankle which protect the foot while moving at plantar flexion. Modified Brostrom-Gould technique using fiber wire gave good result for reconstruction ATFL rupture for these 2 patients.
Giant Cell Tumor of The Proximal Phalanx of The Index Finger of The Hand: A Rare Case Report Mouli Edward; Ferdiansyah Mahyudin; Muhammad Hardian Basuki; Yunus Basrewan; Caesar Haryo Bimoseno
Journal Orthopaedi and Traumatology Surabaya Vol. 11 No. 2 (2022): October 2022
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v11i2.2022.49-55

Abstract

Background: Giant cell tumor (GCT) of bone is a relatively common type of benign tumor involving the epiphyseal region of tubular bones, but GCT rarely occurs at hand (1–4% of all GCT). GCT within the hand tends to be more aggressive and recurs more rapidly in hand than in other locations. Most authors prefer curettage or resection with reconstruction to maintain anatomical and functional integrity.Case Report: A 27-year-old man with a chief complaint of an enlarged lump and pain in the index finger of his left hand. These lumps appeared three months ago. Plain radiographs showed lytic, eccentric, geographic lesions with well-defined borders and narrow transition zones. Magnetic resonance imaging (MRI) showed a primary aggressive bone tumor with extension to the surrounding soft tissue. Fine Needle Aspiration Biopsy (FNAB) revealed the lesion as a Bone Giant Cell Tumor. The patient then underwent local resection and reconstruction using an allograft. Range of movement (ROM) measurements and DASH scores were evaluated.Discussion: Radiographic and MRI examinations showed characteristic cortical breach, and FNAB showed multinucleated giant cell spread. After treatment, the patient was found to be pain-free, have an improved ROM, and reduced disability. There was no recurrence observed. Conclusion: Despite the tendency for hand GCT to be more aggressive, local resection and reconstruction using an allograft with adjuvant hydrogen peroxide can reduce recurrence and disability.
Clinical Outcome Evaluation in Anterior Cruciate Ligament Reconstruction using Transportal Technique Augmented with Platelet Rich Plasma (PRP) Injection Steesy Benedicta; Mouli Edward; Lukas Widhiyanto; Dwikora Novembri Utomo; Kukuh Dwiputra Hernugrahanto
The Hip and Knee Journal Vol 1, No 1 (2020): August
Publisher : Indonesian Hip and Knee Society (IHKS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1108.929 KB) | DOI: 10.46355/hipknee.v1i1.21

Abstract

Background: Anterior cruciate ligament (ACL) injury is a common injury in the athlete with an incidence of 30-78 cases per year. PRP injection can be applied to enhance graft healing and help patient return to sports faster. Transportal placement is a newer technique and believed can handle this problem. No perspective surveillance system has been made to monitoring the outcome of ACL surgery using the transportal technique and PRP injection in our hospital.Materials and Methods: A total data of 157 patients using medical records in our hospital between 1 January 2014 and 31 December 2018 were evaluated. All patients underwent ACL reconstruction surgery using the transportal technique and additional platelet rich plasma (PRP) intraarticular, with the exclusion of multiple ligament and meniscal injuries. The values evaluated in this study were clinical examination, SF-12 Daily Living Score, Knee Injury and Osteoarthritis Outcome Score (KOOS), Oxford knee Score (OKS), Tegner Lysholm score and Cincinnati score. Patients were followed up from a minimum of 6 months to 4 years after surgery.Results: We found male-dominant (82.8%) patients with the mean age is 25.59 ± 7.61 years old. MOI mostly sports-related activity (78,9%). Anterior drawer and Lachman test post-surgery showed significant improvement. SF-12 showed increasing post-op with mean 80.94. Mean Tegner Lysholm and Cincinnati post-operative was 87.30 and 378.57. OKS pre and post-op mean was 23.56 and 43.82. No significant difference in KOOS score with p0.0001.Conclusions: The ACL reconstruction augmentation with PRP injection with the transportal technique showed significant satisfaction and function restored to normal.
Role of preservation methods using deep-freezing and liquid nitrogen in bone allograft characteristics: An in vitro study Lisan, Rizal A.; Mahyudin, Ferdiansyah; Edward, Mouli; Buwana, Dewan S.
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.757

Abstract

Bone grafting has emerged as a key solution in bone defect management such as allograft, graft of bone from another individual. However, bone allografts usually undergo rigorous preparation to eliminate immune-triggering elements. The deep-freezing methods may delay graft use, while cryopreservation using liquid nitrogen allows rapid freezing but may alter graft characteristics. The aim of this study was to investigate the post-preservation changes in bone allograft characteristics and to compare the effectiveness of deep-freezing and liquid nitrogen methods using animal model. An experimental study using a post-test only control group design was conducted. Fresh-frozen femoral cortical bone was obtained from male New Zealand white rabbits. Preservation by deep-freezing involved placing bone samples in a -80°C freezer for 30 days. For liquid nitrogen preservation, bone grafts were immersed in liquid nitrogen for 20 min, followed by a 15-min rest at room temperature and a final immersion in 0.9% sodium chloride at 30°C for 15 min. Bone samples then underwent evaluation of cell viability, compression, and bending tests. Cell viability test employed the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and the compression and bending tests used the Universal Testing Machine (UTM). Independent Student t-test or Mann-Whitney U test were used to compare the methods as appropriate. Our study found that the use of deep-freezing and liquid nitrogen resulted in similar outcomes for cell viability, compression, and bending tests, with p-values of 0.302, 0.745, and 0.512, respectively. Further exploration with larger sample sizes may help to optimize the methods for specific applications.
Conventional Radiological Profile of Metastatic Bone Disease Based on Its Histopathological Results: A 3-Year Experience Armando, Braven; Setiawati, Rosy; Edward, Mouli; Mustokoweni, Sjahjenny
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.76-82

Abstract

Highlights:1. The incidence of MBD tends to be more frequent in older ages and in female patients.2. The radiological appearance of a lesion tends to differ depending on its primary tumor.3. Pathological fracture was present in 55.37% of the cases. AbstractIntroduction: Metastasis commonly occurs in the bone, termed metastatic bone disease (MBD). Early diagnosis and intervention are important to prolong and increase the quality of life. Although conventional radiology is less sensitive for diagnosing this disease, it remains the most cost and time-efficient screening method. This study aimed to describe the radiological profile of patients diagnosed with MBD based on its histopathological result.Methods: This was a descriptive retrospective study using medical records and digital radiological data of patients diagnosed with MBD from 2019-2021 in Dr. Soetomo General Academic Hospital, Surabaya. Variables in this study include gender, age, histopathological result, location of metastases, number of lesions, lesion density, and pathological fracture.Results: 51 patients were diagnosed with MBD during the period of the study and sorted into 121 cases based on metastases location. MBD is more frequent in older female patients, where lesion mostly originates from the breast, thyroid, and lungs, with adenocarcinoma as the most common histology. Vertebrae were the most common location of metastases. Most lesion tends to be multiple and osteolytic. However, certain lesions from different primary tumor had different predilections. Pathological fracture was present in 55.37% of cases.Conclusion: MBD needs to be suspected in patients with cancer from the breast, thyroid, and lungs as its incidence is higher. More studies about MBD profiles on a larger scale should be conducted to better represent this disease in the general population.
The Clinical and Radiological Outcome of Bovine Hydroxyapatite (Bio Hydrox) as Bone Graft Arifin; Mahyudin, Ferdiansyah; Edward, Mouli
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 9 No. 1 (2020): April 2020
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v9i1.2020.9-16

Abstract

Background: Bone grafting is a surgical procedure that involves transplanting material to enhance bone healing through osteogenesis, osteoconduction, and osteoinduction. While autografting has long been considered the gold standard, it has limitations, including a restricted supply and donor site morbidity. These limitations, along with those associated with allografts, have led to the development of bovine hydroxyapatite (BHA) as a bone graft substitute. This study aimed to evaluate the clinical and radiological outcomes of BHA.Methods: This descriptive study used a consecutive sampling design, including all trauma patients who received BHA at our hospital between 2016 and 2018. The BHA was obtained from the tissue bank at our institution. The clinical and radiological outcomes were evaluated, and the data was tabulated and analyzed descriptively.Results: Of the 56 patients who underwent surgery with BHA, most (80.36%) had excellent outcomes, 12.5% had good outcomes, 3.57% had fair outcomes, and 3.57% had poor outcomes.Conclusion: Bovine hydroxyapatite can be considered an alternative bone graft to support the bone healing process.
Better Functional Outcomes in Plate Fixation of Midshaft Clavicle Fracture in Dr. Soetomo General Academic Hospital Edward, Mouli; Benedicta, Steesy; Wardhana, Teddy Heri
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 11 No. 1 (2022): April 2022
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v11i1.2022.10-15

Abstract

Background: Clavicle fractures are common, with treatment trends shifting from conservative to operative. While malunion often has minimal functional impact, nonunion rates and associated complications remain a concern. This study evaluates functional outcomes between plating and conservative approaches for midshaft clavicle fractures.Methods: A total of 531 cases with a midshaft clavicle fracture presented to the emergency room between January 1, 2014 and December 31, 2018 at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Patients with a head injury, multiple traumas, re-fracture, malunion, open fracture, and pathological fracture were excluded. 161 patients remained. A conservative group (84 patients) was treated using an arm sling, and an operative group (77 patients) with Open Reduction and Internal Fixation (ORIF) and S-plate. Clinical and functional scores were evaluated retrospectively a minimum of 6 months after treatment. Shoulder function was evaluated using the Constant Shoulder Score and Manual Muscle Test.Results: 117 (72.7%) patients were male, with a mean age of 35.4 ± 12.33 years old. The right side was dominantly injured. The Manual Muscle Test score in the operative group was five, and in the conservative group, four. The Constant Shoulder score in the operative group was 93.38 ± 7.529, and in the conservative group, 86.60 ± 7.560 (p < 0.001). The DASH score in the operative group was 10.05±6.98 and in the conservative group, 23.67±3.49 (p < 0.001).Conclusion: In our study, surgery on clavicle midshaft fractures showed significant improvement and satisfaction compared to conservative treatment. Patients gained better function.
Co-Authors Abdul Bari, Yunus Akbar, Kukuh Ali Ansari Rahman Ardana, Fahrizal Novan Arifin Arisvia Sukma Hariftyani Arius Suwondo Armando, Braven Asyumaredha Asyumaredha Bayu Antara Hadi Benedicta, Steesy Buwana, Dewan S. Caesar Haryo Bimoseno Deny Mory Aryawan Desnantyo, Andre Triadi Dwikora Novembri Utomo Erfan Nasrullah Fedik Abdul Rantam Ferdiansyah Mahyudin Fikri Rasikh Pritanto Henry Dominica Heri Suroto Hermina Novida, Hermina I Putu Gede Pradnyadewa Pradana Kadek Seta Prawira Kukuh Dwiputra Hernugrahanto Laskar Pradnyan Kloping, Laskar Pradnyan Lisan, Rizal A. Lukas Widhiyanto M Hardian Basuki Manyakori, Dionysius Bramta Putra Martanto, Tri Wahyu Mohammad Hardian Basuki Muhammad Dimas Arya Candra Permana, Muhammad Dimas Arya Candra Muhammad Hardian Basuki Muhammad Hardian Basuki Muhammad Hardian Basuki Muhammad Hardian Basuki P. Purwati, P. Perwira, Ferdiansyah Danang Putu Garry Rizky Agung Satria Rwahita Satyawati Dharmanta Setiawati, Rosy Sjahjenny Mustokoweni, Sjahjenny Steesy Benedicta Suyono, Rifki Effendi Wardhana, Teddy Heri Wardhani, Indrayuni Lukitra Yesa Suwandani Yunita Purnamasari, Yunita Yunus Abdul Bari Yunus Basrewan