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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Biomedical Engineering Jurnal Sains dan Teknologi Farmasi Majalah Obat Tradisional Majalah Farmaseutik Jurnal Ilmu Kefarmasian Indonesia Majalah Farmasetika
Ngatidjan Ngatidjan
Departement Of Pharmacology And Therapy, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Pengaruh Pemberian Ekstrak Akar Pasak Bumi Terstandar terhadap Gambaran Histopatologik Testis dan Konsentrasi Testosteron pada Tikus FARIDA HAYATI; SITARINA WIDYARINI; LUKMAN HAKIM; NGATIDJAN NGATIDJAN; MUSTOFA MUSTOFA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1918.329 KB)

Abstract

The root of pasak bumi (Eurycoma longifolia, Jack) is one of plant from Indonesia known as aphrodisiac. This study was conducted to evaluate the influence of pasak bumi standardized extract to testosterone level and histopathological changes of the testes in male Wistar rats. Sample were 50 adult male rats aged 3 4 months were divided into 5 groups. Group I (control) was given distilled water, group II (positive control), was given testosterone (Andriol ®), group III, IV, and V were each given a standardized extract of the roots of pasak bumi doses of 50, 100, and 200 mg/kg of body weight, respectively. The extract was given orally twice a day for six days and forty nine days and then testes was taken out on 7th and 50th day. Testosterone level was assayed on 7th and 50th day by the ELISA methods. The results were analyzed using one way ANOVA, and post hoc Dunnet (2-sided) (p < 0.05). The data of this study shows that treatment with water extract of pasak bumi root influence the number of Leydig cells that would also increase the concentration of testosterone in Wistar male rats positively at a dose of 100 mg/kg and 200 mg/kg body weight.
Penurunan Laktat Dehidrogenase Plasmodium falciparum strain D10 pada pemberian Fraksi Tithonia diversifolia (Hemsley) Rul Afiyah Syarif; Mae Sri Hartati Wahyuningsih; Mustofa Mustofa; Ngatidjan Ngatidjan
Majalah Farmaseutik Vol 17, No 1 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v17i1.57817

Abstract

Penelitian terdahulu menunjukkan bahwa fraksi ke-6 (F6) merupakan fraksi aktif (F-akt) daun Tithonia diversifolia (Hemsley) A.Gray yang menghambat pertumbuhan Plasmodium. Pertumbuhan parasit ini memerlukan energi yang diperoleh dari aktivitas laktat dehidrogenase (LDH). Penelitian ini bertujuan mengkaji aktivitas antiplasmodium fraksi aktif T. diversifolia terhadap kadar LDH kultur P. falciparum. Kultur Plasmodium falciparum strain D10 stadium cincin dibagi menjadi kelompok eritrosit tidak terinfeksi (KTI), eritrosit terinfeksi (KI), dan eritrosit terinfeksi Plasmodium yang diberi F6 (F-akt) T. diversifolia (KI+F-akt) konsentrasi 9,38-150 µg/mL. Kultur diinkubasi 48 jam. Media kultur diukur kadar LDH-nya secara enzimatik. Adanya perbedaan LDH antar kelompok dianalisa dengan Anova. Penghambatan aktivitas LDH (IC50) ditetapkan dengan analisa probit. Kadar LDH kelompok KI (362,33 ± 133,18 U/L) lebih tinggi daripada KTI (270,33 ± 65,85 U/L) (p>0,05). Pemberian F-akt pada KI menyebabkan kadar LDH parasit lebih rendah daripada KI. Kadar LDH parasit yang diberi F-akt konsentrasi 9,38; 18,75; 37,50; dan 150 µg/mL secara berturut-turut adalah 365,5 ± 129,5; 210,5 ± 1,5; 195,5 ± 81,5; dan 111,5 ± 53,5 U/L. Tidak ada perbedaan kadar LDH antar kelompok penelitian (p>0,05). F-akt  T. diversifolia mampu menghambat LDH P. falciparum strain D10 dengan nilai IC50 = 39,22 µg/mL.Kata kunci: Tithonia diversifolia, laktat dehidrogenase, Plasmodium falciparum
Co-Authors Afifah Afifah Aryan Morita Dewi, Lucia Vita Inandha Dwi Aris Agung Nugrahaningsih Endang Mahati Erna Kristin Eti Nurwening Sholikhah FARIDA HAYATI Indra Bramanti Jarir At Thobari Lukman Hakim Lukman Hakim Mae Sri Hartati Wahyuningsih Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Ni Made Dwi Sandhiutami Nur Arfian Pratiwi, Woro Rukmi Rul Afiyah Syarif Setyo Purwono Setyo Purwono Sismindan Sismindan Sitarina Widyarini Soni Prabowo Putra Yuniyanti, Mia Munawaroh