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All Journal Jurnal Teknologi Dan Industri Pangan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences El-Hayah : Jurnal Biologi Alchemy : Journal of Chemistry Agrointek Prosiding SNATIF Jurnal Pangan dan Agroindustri Jurnal Teknologi Pertanian agriTECH Jurnal Ilmu Pangan dan Hasil Pertanian Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Teknik Pertanian Lampung (Journal of Agricultural Engineering) Jurnal Ilmiah Inovasi Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Jurnal Ilmu Peternakan Terapan Berkala Penelitian Hayati Jurnal Ilmiah Agritas
Dr.Ir. Yunianta, DEA
Department Of Food Science And Technology, Faculty Of Agricultural Technology, Brawijaya University, Malang, Indonesia, 65145
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics Public Health Veterinary Other

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Journal : Alchemy : Journal of Chemistry

 1 
Potential Use of Compounds from Neem Leaves (Azadirachta indica Juss) as PPARg and ERa Inhibitors to Control Breast Cancer Cell Growth In Silico Model Supriyanto, Supriyanto; Rifa'i, Muhaimin; Yunianta, Yunianta; Widjanarko, Simon Bambang
ALCHEMY Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.121 KB) | DOI: 10.18860/al.v8i1.9863

Abstract

Treatment using herbs is currently growing rapidly. Compounds in herbal plants can cure various degenerative diseases. The study aims to analyze the potency of nimbin, deacetylnimbin, salanin, and deacetylsalanin compounds in the neem leaves extract to inhibit target proteins namely PPARg and ERa. PPARg is the main regulator of the function of adipose tissue microvascular endothelial cells (aMVECs) while ERa is a protein that mediates all estrogen effects and it is important in the growth of prostate and breast cancer. Inhibition of ERa can prevent the proliferation and growth of breast cancer cells by affecting the performance of estrogen which binds to hormonal receptors and causes inhibition of breast cancer cell proliferation. The results of in silico analysis show that deacetylnimbin can inhibit ERa protein. The docking analysis shows that deacetylnimbin has the potential to replace tamoxifen as a breast cancer drug. The other studies such in vitro and in vivo are needed to validate in silico study.
Potential Use of Compounds from Neem Leaves (Azadirachta indica Juss) as PPARg and ERa Inhibitors to Control Breast Cancer Cell Growth In Silico Model Supriyanto Supriyanto; Muhaimin Rifa'i; Yunianta Yunianta; Simon Bambang Widjanarko
ALCHEMY:Journal of Chemistry Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.121 KB) | DOI: 10.18860/al.v8i1.9863

Abstract

Treatment using herbs is currently growing rapidly. Compounds in herbal plants can cure various degenerative diseases. The study aims to analyze the potency of nimbin, deacetylnimbin, salanin, and deacetylsalanin compounds in the neem leaves extract to inhibit target proteins namely PPARg and ERa. PPARg is the main regulator of the function of adipose tissue microvascular endothelial cells (aMVECs) while ERa is a protein that mediates all estrogen effects and it is important in the growth of prostate and breast cancer. Inhibition of ERa can prevent the proliferation and growth of breast cancer cells by affecting the performance of estrogen which binds to hormonal receptors and causes inhibition of breast cancer cell proliferation. The results of in silico analysis show that deacetylnimbin can inhibit ERa protein. The docking analysis shows that deacetylnimbin has the potential to replace tamoxifen as a breast cancer drug. The other studies such in vitro and in vivo are needed to validate in silico study.
Co-Authors . Harijono Achmad Fauzie Wahyunanto, Achmad Fauzie Aji Sutrisno Anna Ingani Widjajaseputra Apriliastuti Apriliastuti Aulani'am Baharudin, Ahmad Ferry Bella Ayu Shafira Budi Satriyanto Darnawi Darnawi Dedi Dedi Dego Yusa Ali Della Rosalita, Della Dhian Imani Prihardhani, Dhian Imani Driska Arnanto Elya Putri Pane Erryana Martati Estri Laras Arumingtyas Evi Setiawati Fadiyah Safitri Fadiyah Safitri Gilang Drajat Maulana Hariadi Subagja Ida Ayu Putu Sri Widnyani Ida Ayu Ulifah Indria Purwantiningrum Indria Purwantiningrum Jaya Mahar Maligan Joni Kusnadi Kurnia Rahmawati, Kurnia Lukman Azis M, Rifa'i Maemunah Maemunah Mawardi, Nanang Kusuma Moh. Sui Muhaimin Rifa'i Muhaimin Rifa'i Ni Made Ayu Octaviana, Ni Made Ayu Ni Made Wartini Nur Ida Panca Nugrahini Pane, Elya Putri Rahmani Rahmani Resti, Arin Riyanti Rifa'i, Muhaimin Rizka Aulia Rahma Rofiq Sunaryanto Rurini Retnowati SATRIYAS ILYAS Shinta Chandra Rahmawati, Shinta Chandra Simon B. Widjanarko Simon Bambang Widjanarko SIMON BAMBANG WIDJANARKO Simon Bambang Widjanarko Siti Narsito Wulan Sri Widata Sudarma Dita Wijayanti Sudrajat, Ignatius Suprih Supriyanto Supriyanto Supriyanto Supriyanto Supriyanto, Supriyanto Suryayuliana, Ifan Dwi Sutendi, Faktori Syarifah Rohaya Teti Estiasih Teti Estiasih Tri Sulistyo Tri Susanto Wahyu Setya Ratri, Wahyu Setya WB, Simon WB, Simon wulansari, angela Yenny Risjani Zamroni Zamroni Zohan Efendi