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All Journal Jurnal Teknologi Dan Industri Pangan Teknotan: Jurnal Industri Teknologi Pertanian Jurnal AGROTEKNOLOGI e-Journal Pustaka Kesehatan Agrointek Jurnal Penelitian Pascapanen Pertanian Jurnal Pangan dan Agroindustri Jurnal Keteknikan Pertanian Tropis dan Biosistem Jurnal Teknologi Pertanian Indonesian Journal of Pharmaceutical Science and Technology agriTECH Warta IHP (Warta Industri Hasil Pertanian) UNEJ e-Proceeding Industria: Jurnal Teknologi dan Manajemen Agroindustri Jurnal Pemberdayaan Masyarakat Madani (JPMM) JURNAL PANGAN J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Food ScienTech Journal Narra J Berkala Penelitian Hayati Jurnal Teknik Pertanian Terapan
Achmad Subagio
Jurusan Teknologi Hasil Pertanian Universitas Jember Jl. Kalimantan 37 Kampus Bumi Tegal Boto Kotak Pos 159 Jember 68121, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Journal : e-Journal Pustaka Kesehatan

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Pengaruh Pemberian Galaktomanan dari Daging Kelapa Lokal (Cocos nufitera L) terhadap Kadar Glucagon Like Peptide-1 (GLP-1) pada Tikus Wistar Jantan yang Hiperkolesterolemia Inayatul Aulia; Achmad Subagio; Aris Prasetyo
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Hypercholesterolemia is a condition characterized by high cholesterol concentration in blood. This is a risk factor for many diseases. Glucagon Like Peptide-1 (GLP-1) is an incretin hormone that affects cholesterol and other diseases with hypercholesterolemia as a risk factor. Drug that widely used for hypercholesterolemia is simvastatin which can increase GLP-1. GLP-1 also can be increased by high fibrous foods consumption, one of which is galactomannan which can be found in coconut as much as 61%. This study aimed to determine the effect of galactomannan on GLP-1 and compared with simvastatin. Wistar rats were induced into hypercholesterolemia and than treated with galactomannan 70 mg/200gBW/day and 140 mg/200gBW/day and simvastatin 0,1 mg/200gBW/day. After 28 days, GLP-1 levels was measured. The result showed that GLP-1 in 140 mg/200gBW/day group was the highest and in 70 mg/200gBW/day group was the lowest. Data analysis revealed no significant difference between 140 mg/200gBW/day and simvastatin group. In conclusion, galactomannan 140 mg/200gBW/day had the same potency as simvastatin 0,1 mg/200gBW/day.   Keywords: Hypercholesterolemia, GLP-1, Galactomannan, Simvastatin
Co-Authors -, Giyarto Agafatmi, Izzun Agustin Akhiriani, Resti Agustin Akhiriani, Resti Ahmad Nafi Ahmad Nafi Ahmad Nafi Ahmad Nafi’ Ainur Rofiah, Alif Alif Ainur Rofiah Alshammari, Fanar Hamad Amelia Puspitasari Aminah Abdullah Amini, Stefia A. Ancah Caesarina Novi Marchianti Andri Pamungkas Ararinda Kusweni, Nelfi Arifah, Naila Zanuba Asmak Afriliana Aulanni'am, Aulanni'am Aulanni’am Aulanni’am AUNUR ROFIQ Aunur Rofiq Azkiyah, Lailatul Bambang Piluharto Denik Setiawati Djamali, R. Abdoel Dwiyanti, Inayatus Nur EKA RURIANI Fahmi, Dafiq Kurniawan Fambudi, Stela S. Fatimah Wahyu Firdaus, Lutfi Gita Vindy, Pradiska Giyarto Giyarto Gustika Umiyati Herlina Herlina Herry Purnomo, Bambang Heru Widyatmoko Iguchi, Miyuki Inayatul Aulia Indarto Indarto indarto indarto Irsyam, Mahrus Jauhar Firdaus Lindrianasari Liony Dwi Yulianti Lutfi Firdaus Marchianti, Ancah CN. Maryanto - Mohammad Mardiyanto Mukhamad Fauzi Mukhammad Fauzi Nafi', Ahmad Nanto, Mai nFN Maryanto Nia Ariani Putri Nia Ariani Putri Nugraha Yuwana Nugraha Yuwana Nur Aini Nur Lutfian Sari, Riri Nurhayati Nurhayati Nurud Diniyah Nurul Isnaini Fitriyana Pradiska Gita Vindy Pradiska Gita Vindy Ganesha Prasetyo, Aris Puspita Sari Puspita Sari Putri, Dhiani E. Riri Nur Lutfian Sari Riri Nur Lutfian Sari Sakinah, Elly N. Shahira, Silvia Faradjdilara Sih Yuwanti SIMON BAMBANG WIDJANARKO Siti Windrati, Wiwik Subekah Nawa Kartikasari Subekah Nawa Kartikasari Tri Susanto Wiwik Siti Windrati Wiwik Siti Windrati Wiwik Siti Windrati Wiwik Siti Windrati Yoshino, Tomoyuki Yuli Wibowo Yuli Witono Yulianti, Liony Dwi