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All Journal Jurnal Kesehatan Hesti Wira Sakti Program Kreativitas Mahasiswa - Penelitian Health Sciences Journal Jurnal Riset Kefarmasian Indonesia HERBAPHARMA : Journal of Herb Farmacological Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS Medfarm: Jurnal Farmasi dan Kesehatan PROFESSIONAL HEALTH JOURNAL Jurnal Farmasi Tinctura Pharmademica: Jurnal Kefarmasian dan Gizi JURNAL JAMU KUSUMA JURNAL INSAN CENDEKIA Journal of Medicine and Clinical Pharmacy
Beta Herilla Sekti
Institut Teknologi, Sains, Dan Kesehatan RS DR. Soepraoen Kesdam V/Brw Malang
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN UNGU (Graptophyllum pictum L. Griff) MENGGUNAKAN METODE DPPH (1,1-DIPHENYL-2-PICRYHYDRAZYL) Beta Herilla Sekti; Rakhmadani Gadis A; Nurfitria Nurfitria
Jurnal Insan Cendekia Vol 9 No 2 (2022): Jurnal Insan Cendekia September 2022
Publisher : STIKES Insan Cendekia Medika Jombang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35874/jic.v9i2.982

Abstract

Pendahuluan: Beberapa senyawa yang terkandung dalam Daun ungu (Graptophyllum pictum L.Griff) antara lain flavonoid, alkaloid, tanin, triterpenoid, fenol dan saponin. Flavonoid berfungsi sebagai antioksidan dengan menstabilkan radikal bebas sehingga dapat mengurangi kerusakan sel karena inflamasi, maka dilakukanlah pengujian aktivitas antioksidan pada ekstrak daun ungu. Tujuan :untuk mengetahui IC50 pada ekstrak daun ungu sebagai antioksidan. Metode : Jenis penelitian ini merupakan penelitian eksperimental. Perhitungan IC50 menggunakan metode spektrofotometri UV-Visibel dengan 1,1-Diphenyl-2-picryhydrazyl (DPPH) pada Panjang gelombang 518 nm dengan standart yang digunakan adalah asam ascorbat. Konsentrasi yang digunakan pada pengujian aktivitas antioksidan ekstrak daun ungu sebesar 105µg/mL, 115µg/mL, 125µg/mL, 135µg/mL, 145µg/mL.Hasil :Pada hasil pengukuran aktivitas antioksidan ekstrak daun ungu diperoleh data berdasarkan nilai IC50 pada konsentrasi 84,91μg/mL. Hasil IC50 yang diperoleh dibandingkan dengan nilai inhibisi larutan Asam Ascorbat dengan variasi konsentrasi sebesar 10μg/mL, 12 μg/mL, 14 μg/mL, 16 μg/mL, 18 μg/mL. Kesimpulan : aktivitas antioksidan dari ekstrak daun ungu tergolong kuat.
GAMBARAN PENGGUNAAN OBAT DIABETES MELLITUS TIPE 2 DENGAN KOMPLIKASI HIPERTENSI PADA PASIEN GERIATRI DI PUSKESMAS PAKISAJI Sekti, Beta Herilla; Ardyanto, Muhammad Reza; Ardianto, Nanang
Journal Medicine And Clinical Pharmacy Vol. 1 No. 1 (2024): MedClip Vol 1 No 1, 2024
Publisher : Institut Teknologi, Sains, dan Kesehatan RS.DR. Soepraoen Kesdam V/BRW

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47794/medclip.v1i1.3

Abstract

Hipertensi dan Diabetes Mellitus adalah dua penyakit yang memiliki kaitan sangat erat. Lebih dari 50% penderita DM tipe 2 mengalami hipertensi. Pengaruh usia memegang peranan yang sangat penting karena merupakan salah satu faktor penyebab terjadinya Hipertensi dan Diabetes Melitus Tujuan penelitian ini bertujuan untuk mengetahui penggunaan obat Diabetes Melitus tipe 2 disertai Komplikasi Hipertensi yang diberikan untuk pasien geriatri di Puskesmas Pakisaji Malang. Penelitian Ini merupakan penelitian non eksperimental yang bersifat deskriptif. Hasil dari penelitian yang dilakukan menunjukkan Distribusi pasien berdasarkan usia dan jenis kelamin adalah 13 pada laki laki dan 46 pada perempuan. Antidiabetik paling banyak digunakan untuk pasien geriatri yaitu golongan biguanid dengan persentase (91%). Antihipertensi paling banyak digunakan yaitu Amlodipine dengan persentase (94%). Obat terapi kombinasi antdiabetik dan antihipertensi paling banyak digunakan yaitu kombinasi (Metformin + Glimepirde + Amlodipine) dengan persentase (40,6%). Penggunaan obat yang digunakan berdasarkan bentuk sediaan di Puskesmas Pakisaji adalah obat oral (Tablet) dengan persentase (100%).
GAMBARAN TINGKAT PENGETAHUAN IBU HAMIL TERHADAP PENTINGNYA ASAM FOLAT PADA KEHAMILAN DI RSIA MUHAMMADIYAH MALANG Wardana, Fendi Yoga; Mukholifah, Siti; Sekti, Beta Herilla
Journal Medicine And Clinical Pharmacy Vol. 1 No. 1 (2024): MedClip Vol 1 No 1, 2024
Publisher : Institut Teknologi, Sains, dan Kesehatan RS.DR. Soepraoen Kesdam V/BRW

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47794/medclip.v1i1.4

Abstract

Asam folat (vitamin B9) sangat penting selama kehamilan, dan merupakan satu-satunya vitamin yang kebutuhannya selama hamil berlipat dua. Pemberian asam folat pada ibu hamil diketahui untuk mencegah terjadinya cacat tabung saraf terutama tulang belakang tidak menutup sempurna otak janin tidak terbentuk. Penelitian ini merupakan penelitian deskriptif menggunakan metode observasional cross-sectional dengan pengamatan pada bulan Juni 2023. Pengumpulan data pada penelitian ini dilakukan dengan membagikan lembar kuesioner pada responden yang berkenan menjadi responden, sebelum analisis data melakukan data tabulating yaitu dengan memasukan data dalam tabel berdasarkan tujuan penelitian agar memudahkan data tabulating, maka perlu dibuat dummy tabel yaitu tabel kosong yang akan digunakan untuk mengkajikan hasil penelitian. Pengetahuan ibu hamil tentang pentingnya asam folat dalam kehamilan sebagian besar termaksud dalam kategori cukup dengan persentase sebesar 47,82% (33 orang) sisanya tergolong dalam kategori pengetahuan baik sebesar 47,82% (34 orang) dan pengetahuan kurang sebesar 2,90% (2 orang).
FORMULASI DAN UJI STABILITAS FISIK FACIAL WASH  EKSTRAK ETANOL DAUN MELINJO (Gnetum gnemon L.) DENGAN VARIASI PERBANDINGAN EMULGATOR Sekti, Beta Herilla; Gadis Aprilianti, Rakhmadani
Journal Medicine And Clinical Pharmacy Vol. 1 No. 2 (2024): MedClip Vol 1 No 2, 2024
Publisher : Institut Teknologi, Sains, dan Kesehatan RS.DR. Soepraoen Kesdam V/BRW

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47794/medclip.v1i2.9

Abstract

Soap is a mixture of sodium compounds with fatty acids used as a body cleansing agent, solid, foam, with or without other additives and does not cause irritation to the skin. One of the soaps often used by the community is facial wash to get rid of acne. One plant that is often used is melinjo leaf (Gnetum gnemon L.). Melinjo leaves contain flavonoid compounds that function as antioxidants that will interfere with the metabolic functions of microorganisms such as bacteria. This study was conducted to determine the physical stability test of melinjo leaf ethanol extract facial wash with variations in emulgator ratio. The emulgators used were Stearate Acid, Na CMC, and Trietylamine. The test results show that the comparison of emulgator variations can affect the stability of the preparation. The physical stability tests carried out include organoleptic test, viscosity test, specific gravity test, pH test, foam height test, and homogeneity test. The test results of Formulation I have met all these requirements, in Formulation II and Formulation III the preparation has not met the requirements of the specific gravity test and viscosity test.  
ANALISIS KEPUASAN KONSUMEN TERHADAP PELAYANAN KEFARMASIAN DI APOTEK PUSPA INDAH FARMA DENGAN MENGGUNAKAN METODE IMPORTANCE PERFORMANCE ANALYSIS (IPA) Ardianto, Nanang; Sekti, Beta Herilla
Journal Medicine And Clinical Pharmacy Vol. 1 No. 2 (2024): MedClip Vol 1 No 2, 2024
Publisher : Institut Teknologi, Sains, dan Kesehatan RS.DR. Soepraoen Kesdam V/BRW

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47794/medclip.v1i2.10

Abstract

Pharmaceutical services are a benchmark for pharmaceutical technical personnel in services at pharmacies in order to improve quality of life, quality service and consumer satisfaction. The aim of this research to determine satisfaction with each item in pharmaceutical services at Puspa Indah Farma pharmacy. This research involved 100 consumers who purchased prescription drugs cash at Puspa Indah Farma Malang Pharmacy using Importance Performance Analysis (IPA) method. The research design used was descriptive quantitative "non-experimental". The results obtained in reliability dimension were all very satisfied category. The responsiveness dimension received scores that were all very satisfied category. The guarantee dimension received a score where all of them were in very satisfied category. From the empathy dimension, all of them were very satisfied category. From the direct evidence dimension, all scores were in the very satisfied category. Based on the science analysis of Cartesian diagram, there are no items included in quadrant I, quadrant II is occupied by items number 1,5,6,7,8,10,11,12,14,15 and 16, quadrant III item number 17,18, 19, and 20. Quadrant IV items number 2,3,4,9, and 12. From the results of the research conducted it can concluded that there are no items need to be improved, However, 11 items must maintained.
HUBUNGAN TINGKAT KEPATUHAN MINUM OBAT ANEMIA DENGAN KEBERHASILAN TERAPI PASIEN HEMODIALISA DI RS dr. SOEPRAOEN MALANG Maharani, Rizma Feby; Sekti, Beta Herilla; Fitri, Aldesra
Health Sciences Journal Vol. 8 No. 1 (2024): April
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/hsj.v8i1.2353

Abstract

Penyakit ginjal kronik ialah penyakit tak menular yang dapat mengancam nyawa juga penyakit serius dengan pasien terbanyak di Indonesia pada prevalensi sebesar 0,38% dari seluruh penduduk Indonesia. Pasien penyakit ini dapat mengalami komplikasi seperti anemia dan hipertensi ketika sedang menjalani hemodialisa. Komplikasi anemia yang terjadi disebut dengan anemia renal yang harus diperhatikan dengan serius agar dapat mencapai keberhasilan terapi yang didukung oleh kepatuhan pasien dalam minum obat. Penelitian ini memiliki tujuan dalam mengetahui hubungan antara tingkat kepatuhan minum obat anemia dengan keberhasilan terapi padi pasien hemodialisa di RS dr. Soepraoen Malang. Penelitian ini dilakukan secara kuantitatif non eksperimental dengan metode pendekatan cross sectional. Responden yang diambil sebanyak 65 pasien yang didapatkan melalui teknik purposive sampling. Didapatkan hasil bahwa mayoritas pasien memiliki kepatuhan minum obat anemia yang tinggi (60%) dan keberhasilan terapi yang baik (52,3%). Hubungan dari tingkat kepatuhan minum obat anemia dan keberhasilan terapi ini dianalisis melalui uji statistik Spearman rank dan mendapatkan hasil ρ = < 0,001 dan r = 0,884. Dapat ditarik kesimpulan bahwa terdapat hubungan searah yang sangat kuat antara tingkat kepatuhan minum obat anemia dengan keberhasilan terapi pada pasien hemodialisa di Rumah Sakit dr. Soepraoen Malang. Disarankan kepada pasien hemodialisa agar selalu menjaga kepatuhan minum obat untuk mempertahankan keberhasilan terapi yang optimal
Analisis Kandungan Formalin dalam Bumbu Giling Instan di Pasar Besar Kota Malang Fendi Yoga Wardana; Arnis Riawati; Beta Herilla Sekti
PROFESSIONAL HEALTH JOURNAL Vol. 4 No. 2 (2023): Juni
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v4i2.336

Abstract

Ground spices are food ingredients that can enrich the taste, aroma and taste of dishes and have a very limited service life. Many manufacturers use formalin as a preservative to overcome the short shelf life of ground spices. Formalin is a clear, colorless or almost colorless liquid with a pungent odor. The use of formalin as a food preservative is prohibited in the Regulation, because formaldehyde is toxic (poisonous). This study identified the formalin content in instant ground spices in the market of Malang City. The purpose of this study was to determine the content and levels of formaldehyde contained in five traders of instant ground spices in Market of Malang City. Five samples of instant ground spices that were analyzed were taken using the Purposive Sampling technique. Qualitative testing was carried out using the Test Kit and quantitative testing for the determination of formalin levels was carried out using the Spectrophotometry UV-VIS . The results showed that based on observations and qualitative tests, two samples of instant ground spices sold in Market were positive for formaldehyde. Meanwhile, the quantitative test results using the Spectrophotometry UV-Vis showed that of the five samples tested, two of them contained 0.378% formalin in Rendang instant ground spice and 0.516% instant curry spice. So the curry and rendang samples are not suitable for consumption because formaldehyde cannot be added to food at all.
Uji Stabilitas dan Mutu Fisik Nanoemulsi Ekstrak Kyllinga nemoralis BETA HERILLA SEKTI; Moh Firmansah
Tinctura Vol 7 No 1 (2025): Jurnal Farmasi Tinctura
Publisher : Program Studi S1 Farmasi Fakultas Ilmu Kesehatan Universitas Ibrahimy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35316/tinctura.v7i1.8093

Abstract

Jukut pendul (Kyllinga nemoralis) digunakan sebagai antioksidan, antiinflamasi, dan penyembuh luka. Nanoemulsi sebagai sistem pengiriman obat berukuran nano dapat meningkatkan stabilitas dan efektivitas ekstrak herbal. Penelitian ini bertujuan menilai karakteristik, stabilitas, serta mutu fisik nanoemulsi ekstrak jukut pendul yang diformulasikan menggunakan surfaktan Tween 80 pada konsentrasi 25%, 30%, dan 35%. Homogenizer dengan kecepatan 13.000 rpm digunakan dalam penelitian ini dengan waktu pengadukan 20 menit. Hasil menunjukkan bahwa Formula 3 dengan konsentrasi Tween 80 35% memiliki kualitas fisik dan stabilitas terbaik. Formula ini menunjukkan kejernihan tinggi dengan nilai transmisi ≥90%, stabilitas pH untuk kulit dalam rentang (4,5–6,5), dan viskositas yang sesuai (57,9 cP). Nilai transmisi tinggi 100% menunjukkan bahwa ukuran partikel dalam sistem telah mencapai skala nano. Kesimpulan yang diperoleh adalah bahwa nanoemulsi ekstrak jukut pendul dengan konsentrasi Tween 80 35% menunjukkan potensi terbaik sebagai sediaan topikal yang stabil, jernih, dan efektif.
Test Antioxidant Content In Herb Kyllinga nemoralis Extract With DPPH Method Firmansah, Moh.; Sekti, Beta Herilla; Arta, Alfa Frista
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.676

Abstract

Antioxidants are compounds capable of slowing or preventing oxidation, even in relatively low concentrations, thereby contributing to various physiological functions in the body. The antioxidant components found in plants act as free radical scavengers by transforming them into less reactive molecules. Jukut Pendul (Kyllinga nemoralis) contains several bioactive substances, including flavonoids, tannins, and alkaloids, which are recognized for their potential as natural antioxidants. Flavonoids, for instance, exhibit antioxidant activity by donating hydrogen atoms or through their metal-chelating properties. These compounds can be present as glycosides (with glucose moieties) or in the free form known as aglycones. This research aimed to evaluate the antioxidant capacity of Kyllinga nemoralis extract. The plant material was sourced from Banyuwangi, East Java. Extraction was performed using the maceration method with 70% ethanol as the solvent. The free radical scavenging activity was assessed using the DPPH (1 radical) method. Ascorbic acid was used as positive control. Measurement of absorbance was carried out through UV-Vis spectrophotometry. The extract was tested at concentrations of 20, 40, 60, 80, and 100 μg/mL. The findings revealed that the value of Kyllinga nemoralis extract was 11.351 μg/mL, whereas ascorbic acid exhibited an IC50 of 3.43 μg/mL. The antioxidant activity of Kyllinga nemoralis ethanol extract falls into the very strong category, ranging <50-100 μg/mL. These results suggest that although the antioxidant strength of Kyllinga nemoralis is lower than that of , the extract still possesses detectable radical-scavenging activity.
GAMBARAN INTERAKSI OBAT PENYAKIT JANTUNG KORONER DENGAN SINDROM METABOLIK PADA PASIEN RAWAT JALAN DI RS TK II DR. SOEPRAOEN MALANG Aprilianti, Rakhmadani Gadis; Sekti, Beta Herilla; Hidayati, Lilik Nur
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 1 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i1.222

Abstract

Drug interaction is the effect of a drug that is caused when there are two or more drugs that interact and affect the body's response to treatment. The method used in this study is a descriptive study using a cross-sectional observational method with retrospective observations in October - December 2020. Patient data collection was obtained from patient medical records using a purposive sampling technique with inclusion criteria. A total of 89 patients were taken as samples. Data analysis using MEDSCAPE and drugs.com applications. A total of 82 prescriptions have the potential for drug interactions, where the most significant level of drug interaction is moderate level (81.48%, these include aspirin with candesartan and bisoprolol with amlodipine. The most drug interaction is the interaction between aspirin and bisoprolol which is classified as a minor interaction (17.74%). The most frequently used type of drug is bisoprolol (22.18%) and the most frequently used drug class is beta blocker
Co-Authors Agung Permata Aldesra Fitri Alifia Putri Febriyanti Ardianto, Nanang Ardyanto, Muhammad Reza Arnis Riawati Arta, Alfa Frista Ayuning Siwi, Mayang Aditya Desie Suci Permata Sari Diana Lyrawati Ellen Natalia Firman Mulyo Wicaksono Gadis Aprilianti, Rakhmadani Hidayati, Lilik Nur Intan Riyanti Laila Muzdalifah Rahayu Maharani, Rizma Feby Mukholifah, Siti Neysa Oktadiva S. P Nurfitria Nurfitria Pratiwi, Yunita Eka Ratih Tyas Widara Susi Wijiastini Wardana, Fendi Yoga Yitania Sari