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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Diponegoro Herb-Medicine Journal

V. Rizke Ciptaningtyas

Department Of Microbiology, Faculty Of Medicine, Diponegoro University/Diponegoro National Hospital

Author-ID : 472059

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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PENGARUH ASAP CAIR BERBAGAI KONSENTRASI TERHADAP VIABILITAS STAPHYLOCOCCUS AUREUS Reynata Adhiasari; Oedijani Santoso; V. Rizke Ciptaningtyas
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 8, No 1 (2019): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar Belakang : Plak gigi terbentuk melalui tiga tahap, yaitu proses pembentukkan pellicle, kolonisasi primer, serta kolonisasi sekunder dan maturasi. Apabila dibiarkan, plak gigi dapat menyebabkan gingivitis dan periodontitis. Salah satu bakteri yang dapat melakukan kolonisasi pada pellicle gigi adalah Staphylococcus aureus. Disamping itu, Staphylococcus aureus juga dapat memperberat kejadian periodontitis dengan masuk ke dalam periodontal pocket yang terbentuk karena adanya kedalaman sulkus gingiva yang tidak normal. Peneliti menggunakan asap cair berbagai konsentrasi untuk mengetahui Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimum (KBM) terhadap pertumbuhan Staphylococcus aureus. Kandungan fenol, asam asetat, dan karbonil diharapkan mampu menghambat maupun membunuh bakteri ini. Tujuan : Mengetahui pengaruh pemberian asap cair berbagai konsentrasi terhadap viabilitas Staphylococcus aureus. Metode : Penelitian ini merupakan penelitian eksperimental dengan post test only control group design. Sampel yang digunakan adalah bakteri Staphylococcus aureus yang diberi perlakuan menggunakan lima macam konsentrasi asap cair (100%, 50%, 25%, 12,5%, dan 6,25%) dan dilakukan pengulangan sebanyak lima kali untuk masing-masing konsentrasi. Analisis data yang dilakukan adalah Kruskal Wallis dilanjutkan dengan uji Mann Whitney. Hasil : Uji Kruskal Wallis pada analisis data KHM menunjukkan adanya perbedaan bermakna (p=0,000), begitu pula pada analisis data KBM (p=0,000). Selanjutnya dilakukan uji Mann Whitney yang menyatakan bahwa terdapat signifikansi pada kelompok P3 (25%) untuk uji KHM dan pada kelompok P2 (50%) untuk uji KBM. Kesimpulan : Nilai Kadar Hambat Minimum (KHM) asap cair terhadap Staphylococcus aureus adalah 25%, sementara nilai Kadar Bunuh Minimum (KBM) asap cair terhadap bakteri ini adalah 50%.Kata Kunci : Asap cair, Staphylococcus aureus, Plak, KHM, KBM

KUALITAS PENGGUNAAN ANTIBIOTIK PADA KASUS BEDAH SEBELUM DAN SESUDAH KAMPANYE PENGGUNAAN ANTIBIOTIK SECARA BIJAK DI SEBUAH RUMAH SAKIT PENDIDIKAN DI INDONESIA Catharina Catharina; V. Rizke Ciptaningtyas; Winarto Winarto; Endang Sri Lestari
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 8, No 4 (2019): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar belakang : Penggunaan antibiotik yang tidak bijak merupakan penyebab utama terjadinya resistensi antibiotik. Kampanye penggunaan antibiotik secara bijak merupakan salah satu upaya yang dapat dilakukan rumah sakit untuk meningkatkan kualitas penggunaan antibiotik di kalangan tenaga medis. Tujuan : Mengevaluasi kualitas penggunaan antibiotik pada pasien kasus bedah di sebuah Rumah Sakit Pendidikan di Pulau Jawa (RS. A) sebelum dan sesudah kampanye penggunaan antibiotik secara bijak. Metode : Penelitian merupakan quasy experimental one group pre-test and post-test dengan 68 sampel berupa catatan medik pasien kasus bedah yang memenuhi kriteria inklusi dan ekslusi di RS. A. Data yang dibutuhkan untuk menilai kualitas penggunaan antibiotik didapat dari catatan medik, kemudian dilakukan review oleh Tim PPRA RS. A untuk menentukan kategori kualitas penggunaan antibiotik menurut Van der Meer dan Gyssens. Analisis data menggunakan uji Chi-square. Hasil : Penggunaan antibiotik bijak sebelum dan sesudah kampanye pada pasien kasus bedah di RS. A sebesar 8.7% dan 14%. Penggunaan antibiotik yang tidak bijak sebelum dan sesudah kampanye adalah sebesar 91.3% dan 86%. Terdapat peningkatan penggunaan antibiotik bijak, namun tidak signifikan. Kesimpulan : Kualitas penggunaan antibiotik pada pasien kasus bedah di RS. A setelah kampanye penggunaan antibiotik mengalami peningkatan, namun masih belum sesuai dengan yang diharapkan.Kata kunci : Kualitas Penggunaan Antibiotik, Pasien Bedah, Kriteria Van der Meer & Gyssen

Lung Tuberculosis with Multi Drug Resistant Risk in Tertiary Hospital in Middle Java Ratna Wulan Febriyanti; Winarto Winarto; Mujahidah Mujahidah; Endang Sri Lestari; Purnomo Hadi; Vincentia Rizke Ciptaningtyas
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 2 (2021): Herb-Medicine Journal April 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i2.10352

World TB report from World Health Organization (WHO) in 2017 informed that Indonesia was second country with TB case. Multi Drug Resistance pulmonary infection’s case in Indonesia were 12.000. Kariadi hospital is one of tertiary hospital for pulmonary MDR-TB treatment but, there is no study about risk factor of it yet, so it needed to find risk factors of MDR-TB pulmonary infection in Kariadi hospital. Cross Sectional design using secondary data from Medical Record from January 1st - December 31, 2017 with result of Mycobacterium tuberculosis on GeneXpert sputum examination. Bivariate analysis with Chi square test and multivariate analysis was done by multiple logistic regression. The p value was considered significant if <0.05, all analyzes were 2-tailed. Totally 110 patients were obtained during periode, 55 samples for case and 55 samples for control. There were correlation between smoking habit OR = 3,1 (CI 95% 1,1-8,7), malnutrition OR = 2,9 (CI 95% 1,3-6,3), contact with patient with MDR pulmonary TB infection OR = 12,0 (CI 95% 1,5-97,3), past treatment OR = 81,7(CI 95% 23,4-285,2) and ≥6months past treatment OR = 94,5 (CI 95% 12,1-736,2. Risk factor that could influence together were contact with patient with MDR pulmonary TB infection OR = 34,5 (CI 95% 2,6-464,5), past treatment OR = 39,4 (CI 95% 8,3-186,3) and ≥ 6months past treatment OR = 12,4 (CI 95% 1,3-117,7). Risk factors for the incidence of pulmonary MDR TB infection are past contact with patient with MDR pulmonary TB infection, past treatment and ≥ 6months past treatment.

PENGARUH PEMBERIAN ASAP CAIR PADA BERBAGAI KONSENTRASI TERHADAP PERTUMBUHAN Streptococcus mutans PENYEBAB KARIES GIGI Meiliza Ariesti C. Hutauruk; Gunawan Wibisono; V. Rizke Ciptaningtyas
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 1 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Background: The main requirement for the forming of caries is the plaque on the mouth. Bacteriahave a vital role in causing caries and periodontal. Streptococcus mutans is considered to have a vital role in causing caries. This research used liquid smoke solution which has antibacterial effect.Aim: Knowing the effect of the application of liquid smoke solution at various concentrations on the growth of S. mutans and determining the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC).Methods: This research is experimental research with post test only control group design. The sample used the colony of S. mutans. In this research, there were six sample groups and one control group.The sample’s given was by applying the liquid smoke solutions with 100%, 50%, 25%, 12,5%, 6,25%, and 0% concentration levels towards the research samples.The data was obtained by visually observing the growth of S. mutans colonies in each sample groups. Statistical test was using Kruskal-Wallis test and continued with Mann-Whitney test.Results: Result from the research shows the role of liquid smoke solutions in hindering the growth of S.mutans through its chemical components. Giving smoke liquid solution on 6,25 concentration can hold the growth of S.mutans bacteria and on 12,5 % concentration can kill the growth of S. mutans bacteria.Conclusion: Giving the smoke liquid solution on any concentration can give effect for the growth of S.mutans.

Diagnostic Study on Identification Method of Enterobacteriaceae Directly from Blood Culture Ciptaningtyas, V. Rizke; Hapsari, Rebriarina; Kristina, Tri Nur; Winarto, Winarto
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 2 (2015): July-December 2015
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Introduction: The provision of rapid diagnosis results from positive blood cultures is important for clinical management of sepsis. Using conventional method as a reference method in laboratory, time needed for bacterial identification are 24 hours longer because it has to deal with primary isolation step. Objectives: This study investigated the accuracy of direct inoculation technique of bacteria from positive blood culture vials to biochemical test tubes without primary isolation step to identify Enterobacteriaceae, second most common causative agent of sepsis.Methods: The study was conducted at the Microbiology Laboratory Medical Faculty of Diponegoro University. This is a diagnostic study. As the study sample, blood cultures in BACTEC bottles from Dr. Kariadi General Hospital Semarang with bacterial growth in it. Inclusion criteria was Gram-negative rod bacteri, staining results from BACTEC blood culture bottles, and as a exclusion criteria, there are more than one colony found on blood agar and Mac Conkey agar and showed positive result in oxidation test. Identification of bacteria based on biochemical table of Enterobacteriaceae. Data were analyzed with a 2x2 table.Results: Thirty two samples included in this study. Ten samples (31%) were excluded. Twenty one from twenty two (95%) study samples accurately identified to the genus level by direct inoculation method.Conclusion: The results showed that the direct inoculation method provides an acceptable genus identification, with a potential saving of 24 hours compared with conventional methods.

Pseudomonas aeruginosa Resistance in Southeast Asia Ciptaningtyas, Vincentia Rizke; Lestari, Endang Sri; Wahyono, Hendro
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 10, No 2 (2019): December 2019
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

INTRODUCTION: The increasing number of multidrug-resistant Pseudomonas aeruginosa worldwide need to be continuously monitored to prevent its transmission. This study reviewed multidrug-resistant Pseudomonas aeruginosa in Southeast Asia.METHODS: Pubmed database was searched (January 2013-March 2018) for relevant articles using specific names of all eleven Southeast Asian countries. The articles retrieved were screened and analyzed to meet the inclusion criteria.RESULTS: A total of 17 articles met the inclusion criteria. Vietnam had the most published data included in this study, East Timor, Cambodia, and Laos had none. There are variations among Pseudomonas aeruginosa resistance in Southeast Asia. Thailand had complete data on antibiotic resistance and had the highest resistance rate of almost all antibiotics. Colistin had the lowest resistance rate among all antibiotics.CONCLUSIONS: Colistin had the lowest resistance rate among all antibiotics. Another study with more extensive data should be done to validate this study. Future research should be explicitly providing detail data results for antimicrobial resistance analyses.

Age Krisniawati, Nia; Ciptaningtyas, Vincentia Rizke; Reki, Winarto
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022): June 2022
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Most blood culture contaminants are coagulase-negative staphylococci (CoNS), which are also the leading cause of nosocomial bloodstream infections. To date, no research in Indonesia has analyzed the potential causes of a CoNS infection in the bloodstream. The goal of this research was to better understand who is at risk for developing a CONS-related bloodstream infection while in a hospital setting. Secondary data from the CONS blood culture results at Dr. Kariadi Hospital Semarang were used in this retrospective cross-sectional study conducted between January 1 and December 31, 2016. The Vitek-2 Compact System (Biomerieux, USA) and the Kirby Bauer method (Clinical & Laboratory Standards Institute (CLSI) of the USA) were used for the antibiotic identification and sensitivity testing, respectively. Multivariate with multiple logistic regressions and the Chi-Square test for categorical variables were used in the analysis. Among the study's 272 participants, 158 (58.1%) developed CONS-related bloodstream infections. Risk factors for central nervous system (CNS) bloodstream infection in 18-year-olds include preterm birth, low birth weight (LBW), compromised immunity, malnutrition, immunosuppressive therapy, and peripheral intravenous use. Age >=18, malnutrition, and immunosuppression therapy all ranked high as risk factors in a multivariate analysis. Risk factors for CONS-causing bloodstream infections in people aged 18 include malnutrition and immunosuppressant therapy.

Diagnostic Value of Direct Antibiotic Susceptibility Test for Faster BacterialSusceptibility Reporting in Bacteremia Hapsari, Rebriarina; Ciptaningtyas, Vincentia Rizke; Masfiyah, Masfiyah
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Background: Rapid and accurate information on susceptibility of bacteria causing bacteraemia is very helpful in sepsis management. Blood culture is the gold standard for bacteraemia diagnosis. Standard antibiotic susceptibility testing needs at least three days for completion while direct method can give the result a day earlier. The aim of this study was to investigate the diagnostic value of direct antibiotic susceptibility testing in blood culture.Methods: Bloods from positive BACTEC bottles which met inclusion and exclusion criteria were put into sterile tubes and centrifuged. The pellets were then used to make 0.5 McFarland bacterial suspensions and directly used for antibiotic susceptibility testing. Interpretations of direct method were compared to standard method to count sensitivity, specificity, sensitive predictive value, resistant predictive value, accuracy, and kappa value.Results: From 58 samples (containing 22 gram negative, 36 gram positive bacteria), there were 309 total antibiotic susceptibility tests. Direct method showed sensitivity, specificity, sensitive predictive value, resistant predictive value, accuracy, and kappa value of 89.3%, 92.9%, 93.8%, 87.8%, 86.4%, and 0.82, respectively.Conclusion: Direct antibiotic susceptibility testing has a good agreement with the standard method so it can aid faster antibiotic susceptibility reporting in bacteraemia (Sains Medika, 4(2):174-181).

Prevalence of Influenza Viruses (Influenza Like Illness) In Regional Laboratory Avian Influenza Semarang Wahyutomo, Ridha; Ciptaningtyas, V. Rizke; Hadi, Purnomo
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 2 (2011): Juli-Desember 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Influenza is the major health threat worldwide causing illness and death every year. However, data on the epidemiology of influenza in tropical countries, including Indonesia, are still limited. Up dated data for its prevalence is needed to monitor its spreading and to evaluate its outbreak. Therefore a working regional laboratory in surveillance of ILI (Influenza Like Illness) was formed. This research was conducted to provide updated data on prevalence of ILI in regional laboratorium avian influenza Semarang.Design and Method: Data from patients examined in the regional laboratory of avian influenza Semarang from April 2009 until December 2010 was collected. Samples were obtained from Malang sentinel, Yogyakarta sentinel and Semarang sentinel. Samples were examined using PCR to detect influenza A, influenza B, and swine flu.Result: out 1367 patients tested, 279 patients (20.41%) were from Yogyakarta sentinel, 619 patients (45.28%) were from Malang sentinel, and 467 patients (34.16%) were from Semarang sentinel. Flu A virus was detected in 117 patients (8.5%). Influenza B virus was found in 39 patients (2.8%). H1 virus was detected in 5 patients (0.36%). H3 virus was detected in 45 patients (3.29%). Swine flu virus was detected in 3 patients in Malang.Conclusion: The highest prevalence of flu A and flu B examined in avian influenza regional laboratory Semarang was from Semarang sentinel, followed by Yogyakarta sentinel and Malang (Sains Medika, 3(2):157-161).

Sterility of Gauze Packed in One and Three Layer Layer Parchment Paper Putri, Saskia Biyakto; Lestari, Endang Sri; Ciptaningtyas, Vincentia Rizke
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (2017): June 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Intoduction: Sterile gauze is one of the medical devices that are often used to prevent infection. Several things, one of them is materials for packaging, can affect the sterility of gauze. Parchment paper is one of the packaging materials for sterilization. The study was done to analyze the sterility of gauze packed with parchment paper one layer and three layers on the growth of microorganism.Method: This study was an experimental study with a quasi-experimental design. Samples were 60 gauze packed with one layer parchment paper and 60 gauze packed with three layers of parchment paper. The sterility of sterile gauze tested at weeks 0, 2 and 4. Results: There was no significant difference in the sterility of gauze packed with 1 layer of parchment paper on the growth of microorganisms at 0, 2, 4 weeks (p = 0.126). No significant difference in the sterility of sterile gauze packed with 3 layers of parchment paper at 0, 2, 4 weeks (p = 0.675). There was a significant difference in the sterility of sterile gauze packed with parchment paper 1 layer and 3 layers on the growth of microorganisms (p = 0.002).Conclusion There is a significant difference of sterile gauze packed with parchment paper 1 layer and 3 layers against the growth of microorganisms. The sterility of the packaged sterile gauze with a layer of parchment paper is better than the three layers.

Co-Authors Annisa Septiningrum Ardiana Cahaya Imaniar Catharina Catharina Daniel, Yohanes Endang Sri Lestari Endang Sri Lestari Helmia Farida Hendro Wahyono indah lestari vidyahayati Ivana Shafira Putri Krisniawati, Nia Masfiyah Masfiyah, Masfiyah Meiliza Ariesti C. Hutauruk Mujahidah Mujahidah Muslimin Muslimin Nabila Adzhana Nathalia Tiara Mulia Kartika Nurwijayanti Oedijani Santoso Pramesti Darojah Purnomo Hadi Raden Mohamad Herdian Bhakti Rasyidia Laksmita Putri Ratna Wulan Febriyanti Rebriarina Hapsari Rebriarina Hapsari Reki, Winarto Reynata Adhiasari Ridha Wahyutomo Saskia Biyakto Putri, Saskia Biyakto Susanna Arie Kondo Tri Nur Kristina Wayan Dimas Yogiswara Winarto Winarto Winarto Winarto YL Aryoko Widodo S. Zaki Dewantoro

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