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All Journal Medula Jurnal Ilmu Kedokteran dan Kesehatan JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Rekha Nova Iyos, Rekha Nova
Bagian Anatomi, Fakultas Kedokteran, Universitas Lampung
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Medula

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Penggunaan OAINS sebagai Faktor Risiko Dispepsia Wahidah, Putri Kamila; Wardani, Dyah Wulan Sumekar Rengganis; Iyos, Rekha Nova
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1414

Abstract

Dyspepsia is a syndrome characterized by a collection of symptoms such as epigastric discomfort, burning sensation, nausea, vomiting, bloating and satiety. These symptoms can be chronic and recur frequently, requiring long-term therapy. If left untreated, dyspepsia can interfere with daily activities and increase medical costs. In Indonesia, the prevalence of dyspepsia is increasing significantly, with major risk factors including irregular diet, alcohol consumption, stress, and the use of non-steroidal anti-inflammatory drugs (NSAIDs). Long-term use of NSAIDs can damage the gastric mucosa, increase gastric acid production, and cause gastrointestinal complications such as peptic ulcers and gastrointestinal bleeding. The main mechanism of NSAID side effects involves inhibition of the COX-1 enzyme which reduces the production of protective prostaglandins in the gastric mucosa. In addition, some patients with a history of gastric disease are more susceptible to side effects due to NSAIDs. Therefore, preventive strategies such as the use of selective COX-2 inhibitors and the combination of NSAIDs with proton pump inhibitors (PPIs) are effective approaches in reducing the risk of dyspepsia and related complications. The impact of dyspepsia is not only physical but also affects mental, social and emotional aspects. Sleep disturbances and anxiety are common in people with chronic dyspepsia, which can reduce productivity and quality of life.
Peran Terapi Farmakologi dan Non-Farmakologi dalam Pengelolaan Dry Eye Disease Sitanggang, Grety; Himayani, Rani; Iyos, Rekha Nova; Mutiara, Hanna
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1469

Abstract

Dry Eye Disease (DED) is a multifactorial disorder of the ocular surface characterized by tear system imbalance, inflammation, and tissue damage, often leading to discomfort, visual disturbances, and a decline in quality of life. Managing DED requires a holistic approach that integrates both pharmacological and non-pharmacological therapies to alleviate symptoms while addressing underlying causes. Pharmacological treatments, such as artificial tears, anti-inflammatory agents (corticosteroids and cyclosporine), diquafosol tetrasodium, and oral pilocarpine, aim to restore ocular surface homeostasis. Non pharmacological approaches, including punctal plugs, lifestyle modifications, intense pulsed light (IPL) therapy, and nutritional supplementation with vitamin D and omega-3, are increasingly recognized for their supportive role in treatment. A comprehensive understanding of these therapeutic strategies is expected to improve DED management, enhance patients' quality of life, and prevent further complications.
Co-Authors Anggraeni Janar Wulan, Anggraeni Janar Chandrasatria, Rony Mario Dyah Wulan Sumekar Dyah Wulan Sumekar Rengganis Wardani Endamatriza, Gadih Ranti Erwin Mulia Fattimah, Eliza Techa Handayani, Riana Hanna Mutiara, Hanna Jausal, Anisa Nuraisa Krisnandi, Charles KRISNAWATI, DWI Marta, Annisa Tiara Masfufah, Indy Meriedlona, Nuka Muhammad Maulana Nasruddin, Sigit Pratama Iustitia Nurhayati, Senja Rani Himayani Sitanggang, Grety Sulya, Hana Tanto, Ines Vidal Terrance Ransun Trisnawati, Niputu Alit Wahidah, Putri Kamila Wardhana, Muhammad Fitra Yulistiawati, Novitri