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NURHAYU MALIK, NURHAYU
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Effects of gamal leaf extract (Gliricidia sepium Jacq.) on body weight and internal organ performance of mice (Mus musculus L.) Harlis, Wa Ode; Malik, Nurhayu; Luvita, Luvita; Resman, Resman
Jurnal Pijar Mipa Vol. 18 No. 6 (2023): November 2023
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v18i6.5730

Abstract

Gamal leaves (Gliricidia sepium Jacq.) contain toxic compounds that have the potential to act as vegetable rodenticides, such as alkaloids, tannins, dicumerol, and hydrogen cyanic acid (HCN). Coumarin compounds can bind vitamin K, disrupt the circulatory system, and damage liver cells. The compounds dicumerol and warfarin are used as rat poison because of their anticoagulant properties, which prevent blood clots in the heart. Alkaloid and tannin compounds can damage liver cells through liver necrosis and bleeding in the digestive system. This study aims to determine the effect of Gamal leaf extract on body weight and internal organ performance in mice (Mus musculus L.). The experimental research method is based on a Completely Randomized Design (CRD) pattern. A total of 16 mice weighing 20-22 grams consisting of 4 treatments, namely A0 (water control), A1 (extract 10 mg/g BW), A2 (extract 15 mg/g BW) and A3 (extract 20 mg/g BW). The extract was given orally for 14 days, and body weight was measured every 3 days to obtain data on changes in body weight (PBB). At the end of the treatment, the mice were sacrificed using chloroform and then dissected to observe the performance of the liver, kidney and heart organs in color appearance and organ weight. Quantitative data were analyzed using one-way ANOVA and further DMRT test α=0.05. The research showed that mice's mean change in body weight (PBB) decreased significantly as the dose of Gamal leaf extract increased. The percentage of liver organ weight (BOH), kidney organ weight (BOG), and heart organ weight (BOJ) decreased as the dose of Gamal leaf extract increased. The research results concluded that Gamal leaf extract caused color changes in the internal organs of mice and significantly affected the percentage change in body weight (PBB) and internal organ weight (BOD) of mice along with increasing doses of Gamal leaf extract.
Effect of White Ginger Rhizome Extract (Zingiber officinale var. amarum) on Pregnancy in Mice (Mus musculus L.) Early Post-implantation Stage Harlis, Wa Ode; Salwinda, Salwinda; Malik, Nurhayu; Resman, Resman
Jurnal Pijar Mipa Vol. 19 No. 4 (2024): July 2024
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v19i4.6932

Abstract

White ginger (Zingiber officinale var. Amarum) contains compounds in the antifertility group, namely flavonoids, terpenoids, and essential oils (gingerol and shogaol). Flavonoids can interfere with zygote division and implantation, while terpenoids and essential oils disrupt sperm transport and cause sperm to clot in male animals. This study aims to determine the effect of white ginger (Zingiber officinale var. Amarum) rhizome extract on the mouse (Mus musculus L.) early post-implantation stage. This research type is experimental and structured using a Completely Randomized Design (CRD) pattern. A total of 16 female mice weighing 20-30 g aged 2-3 months were divided into four treatments, namely K1 (control), K2 (0.7 mg/g BW), K3 (1.4 mg/g BW), and K4 (2.8 mg/g BW) white ginger rhizome extract. The extract is given orally at 0.5 mL/head/day on the 4th to 8th day of pregnancy. The mother's body weight is weighed every three days. On the 18th day of pregnancy, mice were sacrificed using chloroform and dissected to observe early post-implantation pregnancy parameters. Data were analyzed using Analysis of Variance (ANOVA) and Duncan's follow-up test with a confidence level of 95%.   The research showed that white ginger rhizome extract significantly reduced the percentage of implantation (IM) and the percentage of live fetuses (FH), causing fetal growth to be hampered. The rate of implantation (IM) is K1 (1.8%), K2 (0.52%), K3 (0.49%). The percentage of live fetuses (FH) was K1 (1.06%), K2 (0.48%), and K3 (0.30%), while no fetus was found in K4. K3 treatment (1.4mg/g) causes fetal growth to be hampered. White ginger rhizome extract, on average, increases post-implantation mortality (KPI) and percentage of embryo resorption (ER) and reduces fetal weight. Based on the results of this study, it is concluded that white ginger extract has antifertility properties in female animals because it causes pregnancy disorders, so it is hoped that the use of white ginger in early pregnancy will be reduced.
KONTRIBUSI DAN MOTIVASI IBU RUMAH TANGGA PEMBUAT KUE TRADISIONAL DALAM MENINGKATKAN PENDAPATAN EKONOMI KELUARGA DI KABUPATEN KONAWE SALEH, Leni; Malik, Nurhayu
JURNAL NUSANTARA Vol 1 No 2 (2018): EDISI 2 AGU 2018
Publisher : AKPARDA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63986/nsn.v1i2.6

Abstract

Penelitian ini bertujuan : 1) Bagaimana kontribusi pendapatan ibu rumah tangga pada kegiatanmembuat makanan kue tradisional, terhadap pendapatan keluarga, 2). Apa motivasi ibu rumah tanggamelakukan pekerjaan membuat makanan kue tradisional. Penentuan daerah penelitian ini dilakukansecara sengaja (purposive sampling) dengan pertimbangan bahwa di Kelurahan Wawonggole banyakterdapat ibu rumah tangga yang bekerja membuat makanan kue tradisional untuk di jadikan jualansebagai salah satu upaya untuk meningkatkan pendapatan keluarganya. Teknik pengambilan sampeldilakukan dengan cara sensus yaitu dengan mengambil seluruh jumlah populasi yang ada di KelurahanWawonggole Kecamatan Unaaha Kabupaten Konawe, dengan menggunakan data sekunder dan primer. Berdasarkan hasil penelitian besarnya pendapatan wanita pembuat makanan kue tradisional adalahsebesar Rp. 8.850.000 atau rata-rata Rp. 804.545, pendapatan suami adalah sebesar Rp. 17.000.000 ataurata-rata Rp. 1.545.455 sedangkan pendapatan anggota keluarga lainnya adalah sebesar Rp. 3.600.000atau rata-rata Rp. 327.273. Dari uraian tersebut dapat diketahui total pendapatan keluarga wanitapembuat makanan kue tradisional di Kelurahan Wawonggole Kecamatan Unaaha Kabupaten Konaweadalah sebesar Rp. 29.450.000 atau rata-rata Rp. 2.677.273. Dengan kontribusi pendapatan usahawanita pembuat makanan kue tradisional terhadap total pendapatan keluarga yaitu 37 %. Motivasiresponden ibu rumah tangga untuk membuat makanan kue tradisional adalah untuk menambahpendapatan keluarga, untuk mengisi waktu luang.
Co-Authors Alhadi, Syahrul Amirullah -, Amirullah Febrianto Febrianto, Febrianto Harlis Harlis Harlis, Wa Ode Leni Saleh, Leni Luvita, Luvita Musadar Mappasomba Nelpiani, Nelpiani Niya, Wa Ode Nur Rela, Iskandar Zainuddin Reni Yunus, Reni Resman, Resman Rosmaya, Rosmaya Salahuddin Salahuddin Salwinda, Salwinda Susilawati, Fidar Taufik, Yani