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All Journal Medical Journal of Indonesia Indonesian Journal of Biotechnology Jurnal Kimia Riset Journal of Energy, Mechanical, Material and Manufacturing Engineering Jurnal Teknik Mesin Jurnal Teknik Mesin Indonesia Journal of Integrated and Advanced Engineering (JIAE) Automotive Experiences Journal of Biomedical Science and Bioengineering Poltekita: Jurnal Ilmu Kesehatan Prosiding SNTTM
Yudan Whulanza
Departemen Teknik Mesin, Fakultas Teknik, Universitas Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology

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Effect of umbilical cord-mesenchymal stem cells on skin tensile strength in pressure ulcers: a rat model study Aulia, Indri; Dilogo, Ismail Hadisoebroto; Prasetyono, Theddeus Octavianus Hari; Pawitan, Jeanne Adiwinata; Kekalih, Aria; Siregar, Nurjati Chairani; Whulanza, Yudan; Hasibuan, Lisa
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.268222

Abstract

BACKGROUND Stem cell therapy has emerged as a promising alternative for the management of chronic wounds, including pressure ulcers. Tensile strength, which reflects the biomechanical integrity of the skin, serves as an objective measure of wound healing. This study aimed to evaluate the effect of locally administered umbilical cord-mesenchymal stem cells (UC-MSCs) on the tensile strength of healing 3rd-degree pressure ulcers in a Sprague Dawley rat model. METHODS 21 adult male Sprague Dawley rats were divided into 3 groups: normal rats without ulcers, untreated pressure ulcer as control, and pressure ulcers treated with UC-MSCs. The treatment group received locally injected 4 × 10⁶ UC-MSCs at the ulcer site. On day-21, the tensile strength parameters (rupture point, elongation at break, and elastic modulus) of the dorsal skin were assessed using the Universal Testing System. RESULTS When expressed relative to normal skin tensile strength, the UC-MSC group exhibited higher tensile parameters that were higher than the controls by 2.08% for rupture point, 3.29% for elongation at break, and 8.42% for elastic modulus. Although these differences between the UC-MSCs and control groups across all tensile strength parameters were not statistically significant, a clear trend toward improved tensile strength parameters were observed in the UC-MSCs group. CONCLUSIONS Local UC-MSCs administration showed a consistent trend toward improved tensile strength in healing 3rd-degree pressure ulcers, albeit without statistically significant differences compared to controls. These findings support the further exploration of UC-MSCs as a potential treatment for promoting biomechanical restoration in healing pressure ulcers.
A Compact oxygen concentrator for premature infants: Integrating portability and performance in the third-generation prototype Vianney, Cornelia Christiani; Koestoer, Raldi Artono; Whulanza, Yudan; Hakim, Imansyah Ibnu
Prosiding SNTTM Vol 23 No 1 (2025): SNTTM XXIII October 2025
Publisher : BKS-TM Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71452/zs2cbg95

Abstract

Oxygen concentrators are vital devices in medical oxygen therapy. It provides supplemental oxygen, extracted from the environmental air, to patients suffering from hypoxemia or other clinical conditions characterized by low blood oxygen saturation. The need for oxygen therapy extends across various patient populations, including adults, children, and neonates, especially premature infants. However, commercially available concentrators are usually designed for adults, making them unsuitable for premature infants whose delicate, underdeveloped organs can be harmed by high oxygen levels. Meanwhile, field observations from the Indonesian Incubator Team indicate frequent demand for supplemental oxygen following hospital discharge. To meet the urgent need for a suitable device, especially for premature infants discharged from hospitals, this study describes the design and development of a compact, portable, and neonatal-specific oxygen concentrator. A reverse engineering approach was adopted through a three-phase prototyping process. The first prototype verified the feasibility of the pressure swing adsorption (PSA) principle as the main process of the oxygen concentrator. The second prototype integrated a complete system to evaluate performance by measuring flow rate and oxygen concentration and adjusting components to achieve optimal results. The final, third prototype refined the design to improve compactness and portability. The device achieved an oxygen concentration of about 40% oxygen purity with a steady flow rate of 2 L/min. This developed oxygen concentrator presents a significant step forward in neonatal care, providing a tailored and accessible solution that can support widespread use in home-based infant healthcare programs.
Development of a microfluidic paper based with portable system for glucose concentration colorimetric analysis Irwansyah, Ridho; Herdian, Muhammad Bintang; Whulanza, Yudan
Prosiding SNTTM Vol 23 No 1 (2025): SNTTM XXIII October 2025
Publisher : BKS-TM Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71452/2eqhby13

Abstract

Diabetes mellitus is a major health problem in Indonesia, with a prevalence of up to 20.4 million people in 2024 according to the International Diabetes Federation (IDF). Early detection of blood sugar is hampered by expensive and difficult-to-access diagnostic tools. Microfluidic paper-based analytical devices (μPADs) are a potential solution because they are inexpensive, portable, and environmentally friendly, in accordance with WHO ASSURED standards. This study aims to develop a μPAD integrated with a portable detection system for colorimetric quantification of glucose concentration using Glucose Oxidase–Peroxidase Aminoantipyrine (GOD-PAP) reagent, which produces a color change proportional to glucose concentration. Initial testing was conducted on phosphate-buffered saline (PBS) and D-glucose solutions as test materials in glucose concentration research. The test materials will be validated using spectrophotometry. Next, the test materials will be applied to μPAD for colorimetric observation using an RGB sensor on a portable device. The quantification results show that the red ratio at 10 minutes of the colorimetric method has excellent linearity (R² = 0.96). Precision validation of the colorimetric method produced an RSD value of less than 5%. The paired t-test produced a p-value of 0.42 with a 95% confidence level, indicating that there was no significant difference between the glucose concentration quantification results obtained using the colorimetric method and the spectrophotometric method.
Design and fabrication of a lumbar interbody fusion spine cage combining titanium and PEEK materials Whulanza, Yudan
Prosiding SNTTM Vol 23 No 1 (2025): SNTTM XXIII October 2025
Publisher : BKS-TM Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71452/9j5vvz23

Abstract

Lower back pain (LBP) is a common condition that significantly affects patient quality of life. One of the pathological causes of LBP is degenerative disk disease (DDD), resulting from the degeneration of the intervertebral disc (IVD). A surgical option for addressing this is transforaminal lumbar interbody fusion (TLIF), which involves the use of an implant known as a spine cage to maintain spacing between vertebrae during bone fusion. Spine cages are commonly made from either polyether ether ketone (PEEK) or titanium, both of which have distinct advantages and limitations. PEEK exhibits a bone-like elastic modulus but limited osseoconductivity, whereas titanium offers good osseoconductivity but an elastic modulus much higher than bone. This study proposes a hybrid spine cage combining both materials: PEEK machined via computer numerical control (CNC) machining and titanium fabricated using selective laser melting (SLM). The cage features a banana shape, nose insertion, pins-and-holes connection system, and dimensions customized for the Indonesian lumbar morphometry. Realized prototype showed a maximum margin of 3.9% for titanium part and 2.14% for PEEK part. Further results showed a compressive elastic modulus of 1.36 GPa, indicating the current model followed mechanical property of titanium material.
Co-Authors Adella Josephin Adin, Mehmet Şükrü Aria Kekalih Basari Basari Budi Anna Keliat Budiman, Alexander Christantho Danardono Agus Sumarsono David N Vicarneltor Dhira, Pandya Eunike Thirza Hanita Christian Galih Rineksa Gatot Prayogo Hakim, Imansyah Ibnu Haryadi, Deni Herdian, Muhammad Bintang Herry Purnomo Herry Purnomo Indri Aulia Irfan Martiansyah Ismail Hadisoebroto Dilogo Jeanne Adiwinata Pawitan Jos Istiyanto Lisa Hasibuan Lischer, Kenny Mahfud Ibadi Mahfud Ibadi Misri Gozan Muhammad Imam Surya Nur Agustini Nurjati Chairani Siregar Praswasti Pembangun Dyah Kencana Wulan RA. Koestoer Ridho Irwansyah Setiawati, Santun Siti Fauziyah Rahman Siti Fauziyah Rahman Sugeng Supriadi, Sugeng Sunarto Kaleg Theddeus O. H. Prasetyono Tito Sitanggang, Tito Tresna P. Soemardi Uda Hashim Valmelina, Ersyi Arini Vianney, Cornelia Christiani Wanda , Dessie Wiguna Rahman