Claim Missing Document
Check
Articles

Found 16 Documents
Search

Effect of umbilical cord-mesenchymal stem cells on skin tensile strength in pressure ulcers: a rat model study Aulia, Indri; Dilogo, Ismail Hadisoebroto; Prasetyono, Theddeus Octavianus Hari; Pawitan, Jeanne Adiwinata; Kekalih, Aria; Siregar, Nurjati Chairani; Whulanza, Yudan; Hasibuan, Lisa
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.268222

Abstract

BACKGROUND Stem cell therapy has emerged as a promising alternative for the management of chronic wounds, including pressure ulcers. Tensile strength, which reflects the biomechanical integrity of the skin, serves as an objective measure of wound healing. This study aimed to evaluate the effect of locally administered umbilical cord-mesenchymal stem cells (UC-MSCs) on the tensile strength of healing 3rd-degree pressure ulcers in a Sprague Dawley rat model. METHODS 21 adult male Sprague Dawley rats were divided into 3 groups: normal rats without ulcers, untreated pressure ulcer as control, and pressure ulcers treated with UC-MSCs. The treatment group received locally injected 4 × 10⁶ UC-MSCs at the ulcer site. On day-21, the tensile strength parameters (rupture point, elongation at break, and elastic modulus) of the dorsal skin were assessed using the Universal Testing System. RESULTS When expressed relative to normal skin tensile strength, the UC-MSC group exhibited higher tensile parameters that were higher than the controls by 2.08% for rupture point, 3.29% for elongation at break, and 8.42% for elastic modulus. Although these differences between the UC-MSCs and control groups across all tensile strength parameters were not statistically significant, a clear trend toward improved tensile strength parameters were observed in the UC-MSCs group. CONCLUSIONS Local UC-MSCs administration showed a consistent trend toward improved tensile strength in healing 3rd-degree pressure ulcers, albeit without statistically significant differences compared to controls. These findings support the further exploration of UC-MSCs as a potential treatment for promoting biomechanical restoration in healing pressure ulcers.
Addressing Fire Safety, Ground Impact Resistance, and Thermal Management in Composite EV Battery Enclosures: A Review Sunarto Kaleg; Danardono Agus Sumarsono; Yudan Whulanza; Alexander Christantho Budiman
Automotive Experiences Vol. 7 No. 3 (2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ae.12540

Abstract

Lithium-ion batteries are fundamental to modern electric vehicles, offering high energy density, long cycle life, and low self-discharge rates. However, thermal runaway—a critical safety issue involving uncontrolled temperature increases—can lead to fire or explosion. Ensuring flame retardancy is crucial in accidents where battery packs are exposed to external fires. Additionally, battery packs are susceptible to mechanical stresses and potential damage from ground impacts like debris or uneven road surfaces. Effective thermal management significantly impacts capacity and longevity. This review emphasizes the importance of researching flame retardancy, ground impact resistance, and thermal management, especially in composite battery enclosures. Composites serve as a lightweight alternative to metals and help overcome one of the main constraints of EVs, which is weight. Ground impact refers to the physical force battery packs endure during collisions, hitting potholes, debris, or accidents. Therefore, understanding the effects of ground impact on battery enclosures is crucial for design considerations. Effective thermal management is also essential, as it directly affects the performance and safety of Lithium-ion battery packs in EVs.
Ramie-PLA Composite Hollow Sections for EV Chassis: Development and Static Bending Test Mustasyar Perkasa; Tresna Priyana Soemardi; Djoko Wahyu Karmiadji; Yudan Whulanza; Arief Setyawan; Rizky Pratama Mulyana; Arga Agung Nugroho; Wahyu Sulistiyo; Masripah Masripah; Ridho Dwimansyah; Makmuri Makmuri; Wely Pasadena; Olivier Polit
Automotive Experiences Vol. 8 No. 3 (2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ae.14960

Abstract

The increasing demand for sustainable and lightweight materials in the transportation sector, particularly in the context of electric vehicles (EVs), has accelerated the exploration of bio-based composites as viable alternatives to conventional structural materials. This study investigates the mechanical performance of hollow structural components fabricated from polylactic acid (PLA)-based composites reinforced with natural ramie fibers, targeting their application as chassis elements in urban electric vehicles. Emphasis is placed on replacing commercial steel hollow sections with environmentally benign alternatives that maintain mechanical integrity while offering additional functional benefits such as electrical non-conductivity. Three-point bending tests were conducted to evaluate the composite specimens' flexural strength, stiffness, and failure behavior to assess structural viability. This method was selected for its relevance to real-world bending stresses encountered in vehicular chassis components and suitability for consistent evaluation across beam-like geometries. Results demonstrate that the ramie-PLA bio-composite exhibits promising flexural performance, with sufficient bendability and stiffness for potential structural integration. Furthermore, the non-conductive nature of the composite presents a significant advantage for reducing electromagnetic interference with sensitive electronic systems common in EV platforms. The findings support the feasibility of deploying natural fiber-reinforced PLA composites as a sustainable, cost-effective solution for lightweight automotive structures, particularly in emerging markets where urban EV adoption is rapidly expanding.
Influence of Electrode Shape and Spacing on Corona Discharge Phenomena using a Plasma Generator Jefri Dharmesta; Salma Aulia Rohimah; Yudan Whulanza; Ario Sunar Baskoro
INDONESIAN JOURNAL OF APPLIED PHYSICS Vol 15, No 1 (2025): April
Publisher : Department of Physics, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/ijap.v15i1.90553

Abstract

Electrical discharges that happen near high-voltage conductors are known as corona discharges. It will produce light and sound as it ionises the surrounding air. The purpose of this work is to investigate how conductor form and spacing affect the properties of corona discharge produced by a plasma generator. In this study, conductor shapes such as triangle, W-shaped wire, syringe (point), and L-shaped wire (horizontal) were experimented with, as well as the distance between conductors. The outcome demonstrates that conductor spacing affects the corona discharge's plasma intensity, with shorter distances producing stronger electric fields and greater discharge intensities. Furthermore, the dispersion of the plasma is greatly influenced by the conductor's shape, since every conductor shape results in a different pattern of plasma distribution. These findings offer important new information for the development and improvement of systems that make use of corona discharge events.
Development of a microfluidic paper based with portable system for glucose concentration colorimetric analysis Ridho Irwansyah; Muhammad Bintang Herdian; Yudan Whulanza
Prosiding SNTTM Vol 23 No 1 (2025): SNTTM XXIII October 2025
Publisher : BKS-TM Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71452/2eqhby13

Abstract

Diabetes mellitus is a major health problem in Indonesia, with a prevalence of up to 20.4 million people in 2024 according to the International Diabetes Federation (IDF). Early detection of blood sugar is hampered by expensive and difficult-to-access diagnostic tools. Microfluidic paper-based analytical devices (μPADs) are a potential solution because they are inexpensive, portable, and environmentally friendly, in accordance with WHO ASSURED standards. This study aims to develop a μPAD integrated with a portable detection system for colorimetric quantification of glucose concentration using Glucose Oxidase–Peroxidase Aminoantipyrine (GOD-PAP) reagent, which produces a color change proportional to glucose concentration. Initial testing was conducted on phosphate-buffered saline (PBS) and D-glucose solutions as test materials in glucose concentration research. The test materials will be validated using spectrophotometry. Next, the test materials will be applied to μPAD for colorimetric observation using an RGB sensor on a portable device. The quantification results show that the red ratio at 10 minutes of the colorimetric method has excellent linearity (R² = 0.96). Precision validation of the colorimetric method produced an RSD value of less than 5%. The paired t-test produced a p-value of 0.42 with a 95% confidence level, indicating that there was no significant difference between the glucose concentration quantification results obtained using the colorimetric method and the spectrophotometric method.
Design and fabrication of a lumbar interbody fusion spine cage combining titanium and PEEK materials Yudan Whulanza
Prosiding SNTTM Vol 23 No 1 (2025): SNTTM XXIII October 2025
Publisher : BKS-TM Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71452/9j5vvz23

Abstract

Lower back pain (LBP) is a common condition that significantly affects patient quality of life. One of the pathological causes of LBP is degenerative disk disease (DDD), resulting from the degeneration of the intervertebral disc (IVD). A surgical option for addressing this is transforaminal lumbar interbody fusion (TLIF), which involves the use of an implant known as a spine cage to maintain spacing between vertebrae during bone fusion. Spine cages are commonly made from either polyether ether ketone (PEEK) or titanium, both of which have distinct advantages and limitations. PEEK exhibits a bone-like elastic modulus but limited osseoconductivity, whereas titanium offers good osseoconductivity but an elastic modulus much higher than bone. This study proposes a hybrid spine cage combining both materials: PEEK machined via computer numerical control (CNC) machining and titanium fabricated using selective laser melting (SLM). The cage features a banana shape, nose insertion, pins-and-holes connection system, and dimensions customized for the Indonesian lumbar morphometry. Realized prototype showed a maximum margin of 3.9% for titanium part and 2.14% for PEEK part. Further results showed a compressive elastic modulus of 1.36 GPa, indicating the current model followed mechanical property of titanium material.