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All Journal Medicina E-Jurnal Medika Udayana Paediatrica Indonesiana ISM (Intisari Sains Medis) : Jurnal Kedokteran Archives of Pediatric Gastroenterology, Hepatology, and Nutrition

Ni Nyoman Metriani Nesa

Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran Universitas Udayana/RS Universitas Udayana

Author-ID : 518794

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Accuracy of modified simple pediatric nutritional risk score to detect in-hospital malnutrition Ni Nyoman Metriani Nesal; Gusti Lanang Sidiartha; Endy Paryanto Prawirohartono; Kompiang Gede Suandi
Paediatrica Indonesiana Vol 50 No 5 (2010): September 2010
Publisher : Indonesian Pediatric Society

Background In-hospital malnutrition is malnutrition that occurs during hospitalization. Approximately 70% patients with in-hospital malnutrition are not identified. Only few nutritional screening tools are widely used among children , one of those is the modified risk score.Objective To determine cutoff point and accuracy of risk scores using the modified simple nutritional risk score to detect in-hospital malnutrition.Methods A diagnostic study on 1 month-12 year old children hospitalized at Sanglah Hospital Denpasar was conducted between September-December 2008. The subjects were collected using consecutive sampling method and were assessed using the modified simple pediatric nutritional risk score. Inô€€¿hospital malnutrition was defined days), 5% (length of stay 8-30 days), or 10% (length of stay >30 days). The statistical analyses done were sensitivity, specificity, positive/negative predictive value (PPV /NPV), positive/negative likelihood ratio (PLR/NLR), and post-test probability.Results This study recruited 310 children. Based on ROC curve, the cutoff point \\lith combination of the highest sensitivity and spesificity the sensitivity was 79%, spesificity was 92%, positive likelihood ratios was 2.71, negative likelihood ratio was 0.29 , and post test probality was 47%.Conclusion The modified simple pediatric nutritional risk score can be used as a screening tool to detect inô€€¿hospital malnutrition.

Liver function in children with human immunodeficiency virus infection before and after 6 months of highly active antiretroviral therapy Eva Jacomina Jemima Sapulete; I Gusti Ngurah Sanjaya Putra; Ketut Dewi Kumara Wati; Hendra Santoso; I Putu Gede Karyana; Komang Ayu Witarini; Ni Nyoman Metriani Nesa
Paediatrica Indonesiana Vol 58 No 4 (2018): July 2018
Publisher : Indonesian Pediatric Society

Background Highly active antiretroviral therapy (HAART) has resulted in dramatic decreases in morbidity and improved survival rate in human immunodeficiency virus (HIV)-infected patients. Although the risk of morbidity has decreased, it has been replaced by other long-term complications, such as hepatotoxicity. Hepatotoxicity is often reflected in biochemical abnormalities of liver function, such as elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and aspartate aminotransferase-to-platelet ratio index (APRI). Objective To compare liver function spectrum (AST, ALT, and APRI) in HIV-infected children before and after at least 6 months of HAART. Methods This observational study (before and after) was conducted in pediatric patients with HIV infection who received HAART for at least 6 months at Sanglah Hospital, Denpasar. Data were collected from medical records. Results Forty-nine patients were observed in this study. The mean AST, ALT, and APRI levels before HAART were higher than after at least 6 months of HAART. Anti-tuberculosis treatment and fluconazole therapy were not confounding factors for AST, ALT, and APRI. Conclusion Liver function spectrum enzyme levels of AST, ALT, and APRI are improved after at least 6 months of HAART.

Cystatin C level and amikacin use in neonatal sepsis Putu Diah Pratiwi; I Wayan Dharma Artana; Ni Putu Veny Kartika Yantie; Hendra Santoso; I Gusti Ngurah Sanjaya Putra; Gusti Ayu Putu Nilawati; Ni Nyoman Metriani Nesa
Paediatrica Indonesiana Vol 60 No 1 (2020): January 2020
Publisher : Indonesian Pediatric Society

Background Amikacin is the antibiotic of choice for eradicating bacteria in neonatal sepsis because of its effectiveness against Gram-negative bacteria. However, this drug has nephrotoxic effects. Monitoring kidney function in neonates is very important because amikacin can interfere with development of the kidney. Several studies have shown that serum cystatin C levels were closer to glomerular filtration rate (GFR) values â€‹â€‹compared to serum creatinine levels. Objective To evaluate cystatin C levels before and after administration of amikacin in neonates with sepsis. Methods This prospective cohort study was conducted in one group with a pretest and posttest design. Thirty neonatal sepsis patients who received amikacin therapy at Sanglah General Hospital, Denpasar, Bali, were included by consecutive sampling. Their cystatin C levels were measured before and after receiving amikacin therapy. Data were normally distributed and analyzed by paired T-test, with a value of P<0.05 considered to be significant. Results The mean difference was 0.23 [1.57 (SD 0.29) vs. 1.80 (SD 0.28)] mg/L with P value < 0.001. There was different value of cystatin c level before and after amikacin therapy with deviation standard 0.25 with P<0.001 (alfa 5%). Conclusion Cystatin C levels are significantly higher in neonates with sepsis after administration of amikacin.

Co-Authors Ayu Setyorini Mestika Mayangsari Bagus Setyoboedi Carissa Lidia Della Sabrina Marta Dewi Sutriani Mahalini Endy Paryanto Prawirohartono Eva Jacomina Jemima Sapulete Gusti Ayu Putu Nilawati Hendra Santoso Hendra Santoso I Dewa Made Satrianjaya I Gusti Istri Agung Widnyani I Gusti Lanang Sidiartha I Gusti Ngurah Sanjaya Putra I Made Darmajaya I Made Pramana Dharmatika I Made Yullyantara Saputra I Nyoman Budi Hartawan I Putu Gede Danika Adikarya I Putu Gede Karyana I Wayan Dharma Artana Kadek Deddy Arianta Kadek Deddy Ariyanta Kadek Deddy Ariyanta Ketut Dewi Kumara Wati Komang Ayu Witarini Kompiang Gede Suandi Luh Wayan Puspa Ningsih Made Darmajaya Made Dharmajaya Made Refika Widya Apsari Tangkas Made Sukmawati Martono Tri Utomo Melinda Masturina Muhammad Reza NP Veny Kartika Yantie Putu Diah Pratiwi Rendi Aji Prihaningtyas Sanjaya Putra Sjamsul Arief

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