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All Journal Ulul Albab: Jurnal Studi Islam CAUCHY: Jurnal Matematika Murni dan Aplikasi El-HARAKAH : Jurnal Budaya Islam Indonesian Journal of Cancer Chemoprevention Journal of Islamic Pharmacy Journal of Islamic Medicine The Avicenna Medical Journal Jurnal Riset Mahasiswa Matematika Kitaba : Journal of Interdisciplinary Arabic Learning
Ach. Nashichuddin
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Public Health Other

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Exposure of Murattal Al-Quran Audio Enhances Cisplatin Activity on Growth Inhibition and Cell Cycle Modulation on Hela Cells Mutiah, Roihatul; Mustofa, Muhammad Ragib; Indrawijaya, Yen Yen Ari; Hakim, Abdul; Annisa, Rahmi; Susanti, Nurlaili; Nashichuddin, Ach; Zainuddin, Muhammad
Indonesian Journal of Cancer Chemoprevention Vol 10, No 2 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss2pp71-79

Abstract

Cancer is a disease characterized by abnormal cell mechanisms. The development of alternative cancer treatments is still needed. One of them is the music therapy. The music therapy uses sound vibrations to improve healing. Al-Quran, the Holy book of muslims, recites with measured recitation produces beautiful tones. Reading and recitating of Al-Quran is an important form of worship for which a Muslim can expect reward and benefit in the Hereafter. Al-Fatihah is one of surahs in Al-Qur'an that is often read by Muslims and used as a prayer for healing. The purpose of this study was to determine the effect of cytotoxic activity and cell cycle modulation on Hela cells with exposure of murattal Al-Quran and cisplatin combination. Audio exposure murattal Al-Fatihah and its combination with cisplatin to HeLa cells were tested using the MTT method assay. Induction of apoptosis and modulation of cell cycle evaluated by flow cytometry method. Treatment used 30 minutes Audio Murattal (AM), Cisplatin 10 µg/mL (Cis), and the combination of AM + Cis caused a decrease in the viability of HeLa cells respectively 80.14%, 69.86%, and 64.32%. The results of flow cytometry explained that in treatment of AM there was inhibition in the G2-M phase and induction of apoptosis in the M5 phase. Whereas in treatment AM + Cis inhibition occurs in the S, G2-M phase, and induction of apoptosis in the M5 phase. Audio Murattal Al-Quran presents cytotoxic effects on HeLa cells and to provide a synergistic impact on cisplatin so that disclosure therapy murattal can be recommended for supporting therapy in the treatment of cancer (supportive therapy).Keywords: Al-Quran, Audio murottal, HeLa Cells, Cell Viability, Flow cytometry
Digital Natives and the Call for Innovation in Arabic Language Education Nashichuddin, Achmad; Taufiqurrochman, R.; Salam, Nur
Kitaba Vol 3, No 3 (2025): KITABA
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/kitaba.v3i3.36997

Abstract

Abstract: Today’s graduate students in Arabic language education are unmistakably digital natives—predominantly young women (70.6%) aged 21–25, graduates of Islamic higher education institutions across Indonesia, and deeply embedded in digital culture. This study explores their research interests, academic expectations, and aspirations through a structured survey of 51 newly enrolled master’s students at Maulana Malik Ibrahim State Islamic University (UIN Malang). Findings reveal a decisive shift in scholarly orientation: 37.3% identified “technology and media in Arabic language education” as their primary research interest, far surpassing traditional domains like linguistics or literature. Their call for innovation is not merely technological but pedagogical—they seek curricula that integrate digital tools, emphasize practical application, and align with 21st-century competencies. Simultaneously, a significant academic preparedness gap emerges: 72.5% requested intensive training in scholarly writing, and 64.7% demanded access to international journals, signalling a need for methodological scaffolding. Global aspirations are equally strong, with multiple students explicitly advocating for student exchange programs to Saudi Arabia, Malaysia, and Madinah. Thematic analysis of open-ended responses yielded five strategic priorities: (1) strengthening academic capacity, (2) advancing internationalization, (3) ensuring curriculum relevance in the digital era, (4) improving internal management, and (5) nurturing an Islamic scholarly vision that fuses linguistic mastery with civilizational mission. This study argues that the voices of digital-native students are not peripheral feedback but central diagnostic data for transforming Arabic language education into a dynamic, responsive, and globally engaged discipline in the Global South.
The Impact of Neem Leaf Extract (Azadirachta indica) on renal hypoxia in Balb/C Mice Infected with Plasmodium berghei Rahmah, Zainabur; Religious, Tafakur Bagus; Akbar, Putri Wulan; Kosbandhono, Erryk; Amiruddin, Muhammad; Nashichuddin, Ach
The Avicenna Medical Journal Vol. 6 No. 2 (2025): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v6i2.46488

Abstract

Background: Millions of people die from malaria every year in tropical areas, making it a severe public health concern. Plasmodium, a genus of protozoa with several species, is the main cause of the disease. Humans contract malaria when bitten by female Anopheles sp. mosquitoes. Malaria is one of the world's deadliest diseases. The WHO's 2020 World Malaria Report indicates that there were 229 million cases of malaria globally in 2019, with 409,000 fatalities resulting from the disease. In nine Southeast Asian countries, malaria is endemic. After India, Indonesia is the second most endemic region. Transcription factors such as the HIF-1α protein are produced by hypoxic cells. Patients with malaria have a blockage of the cytoaderenal pathway. Hypoxia occurs due to vascular disorders that prevent oxygen flow to the kidney tissue. Antimalarial drugs are developed in response to the lethal consequences of hypoxia.  Methods: BALB/c mice aged sixteen weeks were infected with the Plasmodium berghei ANKA strain. For six days, the neem leaf 96% ethanol extract was administered orally at doses of 8 mg, 12 mg, and 16 mg. As comparisons, negative, positive, and healthy controls were also included. The kidneys were isolated, and the mice were surgically removed on the seventh day. HIF-2α expression in kidney tissue, which was measured immunohistochemically using Abcam's anti-HIF-2α (H1α67) ChIP Grade antibody, was a characteristic of kidney hypoxia. One-way ANOVA, post-hoc LSD, and Pearson correlation tests were used to assess the hypotheses. Results: Treatment with neem leaf extract significantly decreased oxygen levels (p<0.000).  The correlation test showed a very strong relationship between neem leaf extract and HIF-2α expression in the kidney (r=16.057). Conclusion: Twelve milligrams of neem leaf extract can reduce the risk of renal hypoxia. Keywords: Neem leaves, malaria, degree of parasitemia, hypoxia, Azadirachta indica
Co-Authors Abdul Hakim Abdussakir Abdussakir Anggraini, Resti Dwi Anita Andriya Ningsih Arief Suryadinata Erryk Kosbandhono Handrini Rahayuningtyas, Handrini Karawid, Galih Elsy Khoiri, Muhammad Imamul Ma'arif, Burhan Mohammad Nafie Jauhari Muhammad Amiruddin Muhammad Zainuddin Mustofa, Muhammad Ragib Muti'ah, Roihatul Nur Salam Nur Toifah Nurlaili Susanti Putri Wulan Akbar R. Taufiqurrochman Rahmi Annisa Religious, Tafakur Bagus Resti Dwi Anggraini Roihatul Mutiah Salsabillah, Natasya Thalia Sri Harini Usman Pagalay Yen Yen Ari Indrawijaya Yulianti, Silviyatus Zainabur Rahmah