Article Per Year (5 Year)
p-Index From 2021 - 2026
1.325
P-Index
This Author published in this journals
All Journal Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Jurnal Bios Logos AGRIVITA, Journal of Agricultural Science BERITA BIOLOGI Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Biologi Tropis Babali Nursing Research Journal La Lifesci Makara Journal of Science
KRISTIANTO NUGROHO, KRISTIANTO
Balai Besar Penelitian dan Pengembangan Bioteknologi dan Sumber Daya Genetik Pertanian, Jl. Tentara Pelajar 3A, Bogor 16111 Indonesia Telp. (0251) 8337975
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Immunology & microbiology Medicine & Pharmacology Nursing

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Biopharmaceutical potential of indonesian husk tomato (Physalis angulata L.): genetic diversity, metabolite biosynthesis, and breeding for enhanced fruit quality Shoidah, Fajriyatus; Fadillah, Muhammad Asya; Martasari, Chaireni; Nugroho, Kristianto; Wulandari, Dyah Retno; Kosmiatin, Mia; Husni, Ali; Waluyo, Budi; Budiarto, Kurniawan; Yusuf, Hadi Mokhamad
AGRIVITA Journal of Agricultural Science Vol 48, No 3 (2026): October 2026 (IN PRESS)
Publisher : Faculty of Agriculture University of Brawijaya in collaboration with PERAGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17503/agrivita.v48i3.5055

Abstract

The Husk Tomato (Physalis angulata L.) has been valued as a medicinal plant due to its rich secondary metabolites. These compounds include physalins, which exhibit antitumor activity; withanolides, recognized as potent anti-inflammatory agents; and other components such as flavonoids, phenolic acids, alkaloids, and carotenoids. Despite its therapeutic potential, the commercial utilization of P. angulata remains limited by inconsistent fruit quality. This review summarizes current knowledge on Indonesian P. angulata germplasm, focusing on its botany, growth characteristics, genetic diversity, and metabolite profiles. Previous reviews mainly discussed botanical and pharmacological properties, whereas this review emphasizes Indonesian germplasm diversity and breeding perspectives. We critically evaluate several breeding strategies aimed at improving fruit quality, including the utilization of genetic resources, hybridization, mutation breeding, polyploidization, and in vitro techniques. Furthermore, we highlight the application of genetic engineering, particularly the overexpression of the squalene synthase (SQS) gene, suggesting that this approach could efficiently enhance the biosynthesis of squalene derivatives, such as physalins and withanolides. By evaluating the achievements and challenges of these strategies in P. angulata and other Solanaceae species, this review offers a roadmap for future research, aiming to maximize fruit quality and unlock the extensive biopharmaceutical applications of the Indonesian Husk Tomato.
Co-Authors . REFLINUR Agus Purwito Ali Husni Apriliani, Elisa Arlies Zenitha Victoria Auliya, Novisa Ismi Budi Waluyo Chaireni Martasari Dewi Sukma Dwi Widyajayantie Eka Rosyida Fadillah, Muhammad Asya HABIB RIJZAANI Ifa Manzila Ishthifaiyyah, Sayyidah Afridatul Kurniawan Budiarto Maemunah Maemunah Mastur Mia Kosmiatin Muhamad Syukur Nurwijayanti PUJI LESTARI PUJI LESTARI Putri, Fitria Mahardika Raden Mohamad Herdian Bhakti REFLINUR REFLINUR RERENSTRADIKA T. TERRYANA, RERENSTRADIKA T. Rerenstradika Tizar Terryana, Rerenstradika Tizar Samliok Ndobe Shoidah, Fajriyatus TRI JOKO SANTOSO Tri Puji Priyatno Trikoesoemaningtyas Triyani Dewi Wulandari, Dyah Retno Yusuf, Hadi Mokhamad Zakirah Raihani Ya’la