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All Journal JURNAL RISET AKUNTANSI DAN AUDITING JAAKFE UNTAN ( (Jurnal Audit Dan Akuntansi Fakultas Ekonomi Universitas Tanjungpura) Jurnal Manajemen dan Bisnis Indonesia JST ( Jurnal Sains Terapan ) JURNAL AKUNTANSI DAN BISNIS : Jurnal Program Studi Akuntansi Akuntabel : Jurnal Ekonomi dan Keuangan Forum Ekonomi : Jurnal Ekonomi, Manajemen dan Akuntansi Inovasi : Jurnal Ekonomi, Keuangan, dan Manajemen JSHP (Jurnal Sosial Humaniora dan Pendidikan) Equilibrium: Jurnal Ekonomi-Manajemen-Akuntansi Jurnal Abdi Masyarakat Ilmu Ekonomi [J.A.M.I.E.] Jurnal GeoEkonomi Al-Bayan: Jurnal Ilmu al-Qur'an dan Hadist Jurnal Akun Nabelo : Jurnal Akuntansi Netral, Akuntabel, Objektif Abdimas Universal Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Current : Jurnal Kajian Akuntansi dan Bisnis Terkini Jurnal Ekonomi dan Manajemen Economics and Digital Business Review International Journal of Trends in Accounting Research TAFSE: Journal of Qur'anic Studies Literasi: Jurnal Pendidikan Guru Indonesia MEDIA RISET EKONOMI International Journal of Trends in Accounting Research Journal of Social Work and Science Education Jurnal Ilmu Ekonomi, Pendidikan dan Teknik (IDENTIK) Journal of Ekonomics, Finance, and Management Studies Jurnal Akuntansi Istifkar: Media Transformasi Pendidikan Journal of Biomedical Sciences and Health
Hairul Anam
Universitas Balikpapan, Indonesia
Religion Humanities Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Cytotoxic Activity of Chromolaena odorata Leaf Extract on WiDr Colon Cancer Cells Anam, Hairul; Aswad, Hijral; Irma, Ade; Wahdaniar
Journal of Biomedical Sciences and Health Vol. 3 No. 1 (2026)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v3.i1.300

Abstract

Background: Colorectal cancer (CRC) remains the third most commonly diagnosed cancer and the second leading cause of cancer-related mortality worldwide. In 2020, CRC accounted for approximately 1.9 million new cases and over 935,000 deaths globally. Conventional chemotherapy is frequently limited by systemic toxicity and drug resistance, necessitating the identification of novel plant-derived bioactive compounds. Chromolaena odorata (Asteraceae), a tropical medicinal plant, has demonstrated pharmacological properties including wound healing and anti-inflammatory activity; however, its antiproliferative potential against colorectal cancer cells remains insufficiently explored. Objective: This study aimed to evaluate the cytotoxic and antiproliferative effects of C. odorata n-hexane leaf extract on WiDr human colorectal adenocarcinoma cells using an in vitro MTT assay. Methods: Dried leaves of C. odorata were extracted via n-hexane maceration. WiDr cells were cultured in DMEM supplemented with 10% FBS and antibiotics. Cells were treated with graded extract concentrations (62.5–1000 μg/mL) for 24 hours in triplicate. Cell viability was assessed by the MTT assay and the half-maximal inhibitory concentration (IC₅₀) was determined via nonlinear regression analysis. Results: The extract exhibited concentration-dependent cytotoxicity against WiDr cells. The highest mean inhibition rate (94.3 ± 10.7%) was observed at 1000 μg/mL. The calculated IC₅₀ value was 149.09 ± 20.91 μg/mL, indicating moderate cytotoxic potency consistent with the National Cancer Institute (NCI) classification for biologically active crude extracts (IC₅₀ < 200 μg/mL). Conclusion: Chromolaena odorata n-hexane leaf extract demonstrates significant in vitro antiproliferative activity against WiDr colorectal cancer cells. The cytotoxic activity likely involves lipophilic bioactive compounds, including terpenoids. These findings support further bioassay-guided fractionation, mechanistic investigation, and in vivo validation as potential candidates for anticancer drug development.
Co-Authors Abd Syakur Abu Bakar Ade Irma Afrohah Afrohah Aprilia Kurnia Putri aswad, hijral Bani Anhar Budiyanto Budiyanto Butet Wulan Trifina D, Vino Darsono Darsono Didik Hadiyatno Dika Karlinda Sari Dika Karlinda Sari Dika Karlinda Sari Diong Liong Akbar Dirmayani, R. D. Dwi Susilowati Elisabeth Elisabeth Elisabeth Elisabeth Elvina Julianti Fajar, Ichsan Faza Muraya Zuhru Felita Oktavia Tenggara Firdaus, Dzaky Hendika SL Hendra Hendra Ika Makherta Sutadji Juwari Kusumawati, W L.W. Liyanto Lia Ardillah Liyanto, L.W. M. NaufalSani Manalu, Raja Vanaldo Boang Mayana Asid, Gatik Miswaty Miswaty Moh Hasan Noviani, Nurlita Novita Tri Utami Noviyanti Nita Nur Afni Laela Nurhayati Nurhayati Olbaroh Nikida Romadhoni Presilia Virji Raja Vanaldo Boang Manalu Raja Vanaldo Boang Manalu Raja Vanaldo Boang Manalu Rama Pramudia, Dimas Ramlah Ramlah Raudatul Zannah Rubiyanti, Desi Safira Istiqomah Sari, Dika Karlinda Sholeh A Silmi Fitriana Srie Hartutie Moehaditoyo sugeng pujileksono, sugeng Syafi’i, Imam Tamzil Yusuf Taufik Rohman, Dwi Tenggara, Felita Oktavia Tutik Yuliani, Tutik Verlia Justine Prabowo Vino D Virji, Presilia W Kusumawati Wahdaniar Wianda Faza Imelba Wijaya, Herman Wiwik Saraswati, Wiwik Yanzil Azizil Yudaruddin Yeye Suhaety Yuliana Rezki