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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Abdul Aziz Rani
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Medicine & Pharmacology

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Expression of Cyclooxygenase Enhances Tumor Invasion and Metastasis in Human Gastric Carcinoma Murdani Abdullah; Abdul Aziz Rani; Daldiyono Hardjodisastro; Hiroyuki Otsuka; Tadashi Sato; Yuichiro Kojima; Masayuki A Fujino
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 5, ISSUE 2, August 2004
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/52200443-47

Abstract

Background: Expression of COX-2 in vitro has been shown to have a number of cellular effects including increasing proliferation, reducing apoptosis promoting angiogenesis, decreasing E-cadherin expression and increasing invasive/metastatic potential. Aims: To determine the role of COX-2 in the development and metastasis potential of gastric carcinoma in human subjects. Methods: Tissue samples were obtained from surgically removed specimens of 48 patients with primary gastric adenocarcinoma who underwent gastrectomy from January 1998 to December 1999. The specimens were stained for HE while COX-2 expressions in cancer fold and antrum site were evaluated immunohistochemically. Expression of COX-2 was defined as positive when either one of cancer lesion or antrum site showed immunoreactivity. Results: Preliminary result from 12 out of 48 cases, COX-2 immunoreactivity was detected in 50% (6 of 12 specimens). Expression of COX-2 were more frequent in tumor with serosal invasion (5 of 6 specimens), lymph node metastases (3 of 3 specimens), tumor size more than 4 cm and were significant, statistically (p0.05). The expression of COX-2 in well differential carcinoma type was similar with in poorly differentiated carcinoma type. Conclusion: COX-2 expression in gastric carcinoma tissue is correlated closely with tumor size, serosal invasion and lymph node metastases, indicating that COX-2 is involved in the growth and metastases of gastric carcinoma. Keywords: Gastric carcinoma, cyclooxygenase-2, invasion, immunochemistry
Gastric Amyloidosis Achmad Fauzi; Fajar Raditya; Ari Fahrial Syam; Abdul Aziz Rani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 7, ISSUE 3, December 2006
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/73200686-89

Abstract

Amyloidosis occurs as secondary to rheumatoid arthritis, inflammatory bowel disease and other diseases and also associated with familial Mediterranean fever. Outcomes are worse if there are cardiac or gastrointestinal manifestations. A 57 year-old female was admitted to our hospital with clinical manifestations of nausea, vomiting, epigastric pain, odynophagia, dysphagia and chronic diarrhea. She has also history of rheumatoid arthritis for 10 years. Upper gastrointestinal endoscopy revealed hyperemia in the whole region of gastric mucosa and lower gastrointestinal endoscopy showed hyperemia with erosion in colonic and ileal mucosa. Histopathologic examination of the gastric biopsy showed the deposition of amyloid materials in the mucosa. We report a case of gastric amyloidosis secondary to rheumatoid arthritis. Keywords: gastric amyloidosis, rheumatoid arthritis, dyspepsia
The Role of Esophageal pH-metri Test on Gastro-Esophageal Reflux Disease Diagnosis Katharina Setyawati; Murdani Abdullah; Ari Fahrial Syam; Achmad Fauzi; Dadang Makmun; Marcellus Simadibrata; Chudahman Manan; Abdul Aziz Rani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 3, December 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/93200891-97

Abstract

Gastro-esophageal reflux disease is a pathological condition of esophagus which is caused by gastric content reflux into esophagus. There is an increased prevalence of gastro-esophageal reflux disease. The roles of esophageal pH-metry in clinical application include looking for abnormal acid exposure on esophagus with no abnormality found in endoscopy; evaluating patients following the anti-reflux surgery who are being suspected for abnormal esophageal reflux; evaluating patients with normal endoscopic result but still having refractory reflux symptoms against proton pump inhibitor medication; detecting refractory reflux in patients chest pain following the heart evaluation; evaluating patients with otolaryngologic manifestations (laryngitis, pharyngitis, chronic cough) of the esophageal reflux disease after therapeutic failure of 4-weeks proton pump inhibitor treatment; and looking for correlation between adult onset gastro-esophageal reflux disease and non-allergic asthma. Keywords: gastro-esophageal reflux disease, esophagus pH-metry, symptoms-reflux correlation
Prevalence of Crohnƒs Disease in Endoscopic Unit Cipto Mangunkusumo Hospital Nata Pratama; Murdani Abdullah; Dolly Dolven Kansera; Jane Estherina; Rizki Yaruntradhani; Fransiska Hardi; Raden Nur Ista; Marcellus Simadibrata; Achmad Fauzi; Daldiyono Daldiyono; Abdul Aziz Rani; Diah Rini Handjari; Pamela Abineno
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 2, August 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (504.343 KB) | DOI: 10.24871/122201185-88

Abstract

Background: The cumulative number of inflammatory bowel disease patients in Asia has raised three times since early 1990s, although Crohn’s disease is still less common than ulcerative colitis. The objective of this study was to provide clinical and demographic data of Crohn’s disease patients seen in Endoscopic Unit Cipto Mangunkusumo Hospital and compare the Results with other Asian countries. Method: This study was done retrospectively cross-sectional descriptive from medical records of all patients underwent colonoscopy at Endoscopic Unit, Cipto Mangunkusumo Hospital, and histological evaluation in the Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, between 2007 and 2008. Data was analyzed using SPSS version 17. Results: Of 921 patients who underwent colonoscopy, 19 (2.1%) patients were diagnosed with Crohn’s disease. There was no sex preponderance. The mean age was 47.7 years with a peak age at presentation between 51 and 60 years. The main clinical complaints were diarrhea (42.1%), lower gastrointestinal bleeding (36.8%), abdominal pain (10.5%) and upper gastrointestinal bleeding (5.3%). Colonoscopic findings were hyperemia in 94.7%, edema in 57.9%, erosions in 63.2%, ulcerations in 89.5%, pseudopolyp in 31.6%, fragile lesion in 10.5%, stenosis, fistulation, and cobblestone appearance in 5.3%. Involvement of isolated left colon was 26.3%; other manifestations were isolated right colon (10.5%), pancolitis (57.9%), ileitis (5.3%), ileocolitis (36.8%) and skip lesion (5.3%). Conclusion: The prevalence of Crohn’s disease in this study was similar to the findings in previous studies in Asian countries, with diarrhea as the main clinical complaint, and pancolitis as the dominant finding in colonoscopy examination. Keywords: Crohn’s disease, prevalence, clinical complaints, colonoscopy description
Co-Authors Aan Santi ACHMAD FAUZI Ahmad Fauzi Ahmad Soefyani Ahmar Abyadh Ali Imron Yusuf Ari Fahrial Syam Bona Adhista Budi Tan Oto Chudahman Manan Dadang Makmun Daldiyono Daldiyono Daldiyono Hardjodisastro Deddy Gunawanjati Dedy Gunawanjati Sudrajat Dharmika Djojoningrat Diah Rini Handjari Djulzasri Albar Dolly Dolven Kansera DWI SURYANTO Ekowati Rahajeng Ellen Susanti Elli Arsita Endang Susalit Ening Krisnuhoni Fajar Raditya Fransiska Hardi Fumiaki Kitahara Gunawanjati Sudrajat Hiroyuki Otsuka Hotmen Sijabat Ina Susianti Timan Indra Marki Irsan Hasan Jacobus Albertus Jane Estherina Jeffri Gunawan Joseph JY Sung Julwan Pribadi Kaka Renaldi Katharina Setyawati Lianda Siregar Marcellus Simadibrata Masayuki A Fujino Masayuki A. Fujino Moch Ikhsan Mokoagow Murdani Abdullah Nata Pratama Novie Rahmawati Zirta Nur Rasyid Nurul Akbar Pamela Abineno Pamela Abineno Damaledo Paulus Kusnanto Pradana Suwondo Raden Nur Ista Ralph Girson Gunarsa Riahdo Saragih Rizki Yaruntradhani Ruswhandi Martamala Salius Silih Sedijono Sedijono Seri Mei Maya Ulina Siti Setiati Steven Sumantri Suhardjono Suhardjono Sumaryono Sumaryono Suryantini Suryantini Suzana Ndraha Tadashi Sato Tjahjadi Robert Tedjasaputra Unggul Budihusodo Widyasari Kumala Yuichiro Kojima