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Molecular Docking Senyawa Caboxamycin Pada Mycobacterium tuberculosis Polyketide Synthase 13 (Pks13) Puspitasari, Lia; Nur Aripin, Iis Sumiyati; Setyaningsih, Erwi Putri
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 15 No 2 (2022): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v15i2.1265

Senyawa caboxamycin merupakan antibiotik baru yang termasuk dalam kelompok benzoxazole yang diproduksi oleh Streptomyces sp. NTK 937 (marine strain). Penelitian ini bertujuan untuk mengetahui mekanisme penghambatan senyawa caboxamycin terhadap Mycobacterium tuberculosis polyketide synthase 13 (Pks13) secara in silico dengan metode molecular docking. Tahapan molecular docking dimulai dengan optimasi struktur senyawa caboxamycin dan streptomisin (kontrol positif) 3D, preparasi protein Pks13, validasi metode, serta docking senyawa caboxamycin dan streptomisin yang teroptimasi pada protein Pks13. Hasil docking protein Pks13 pada ligan standar adalah -144,0 kkal/mol, pada streptomisin adalah -101,7 kkal/mol, dan pada caboxamycin adalah -75,9 kkal/mol. Streptomisin dan caboxamycin memiliki ikatan hidrogen yang sama terhadap residu asam amino protein Pks13 yaitu ASN-1640 dan HIS-1664, sehingga caboxamycin memiliki mekanisme kerja dalam menghambat Pks13 pada M.tuberculosis secara in silico. Senyawa caboxamycin memiliki mekanisme molekuler dalam menghambat protein Pks13 yang ditunjukkan dengan adanya pembentukkan ikatan hidrogen, sehingga senyawa caboxamycin berpotensi sebagai antituberkulosis secara in silico.

Etnobotani Tanaman Obat Sebagai Imunomodulator di Desa Adi Luhur Kecamatan Panca Jaya Provinsi Lampung Setyaningsih, Erwi Putri; Febriyanti, Risma
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1606

An ethnobotanical study was conducted to see the interaction of local people with their environment and to study the relationship between humans and their surrounding plants. The people in Adi Luhur Village have used traditional medicinal plants for a long time as evidenced by the existence of a women's farmer group in Adi Luhur Village. Each house has a family of medicinal plants to meet the needs of herbal medicines that can be used to prevent or treat disease. This study aims to determine the types of immunomodulatory plants used by the people in Adi Luhur Village, Panca Jaya District, Lampung Province. The type of research was observational using descriptive qualitative research methods. Sampling was carried out in the community of Adi Luhur Village, Panca Jaya District, Lampung Province by purposive sampling. The sample was determined based on the similarity between characteristics and inclusion criteria including the people of Adi Luhur Village who are willing to be respondents and fill out a questionnaire, people who have consumed herbal medicine in the last one month, and people in the age range of 20-75 years. Filling out the questionnaire involved a respondent of 110 people. Determination of the number of samples based on Lameshow calculations of the total population of 1.989 people. Based on the results of the study, information was obtained that in Adi Luhur Village 5 plants were cultivated and could be used as immunomodulators, namely sambiloto, turmeric, ginger, lempuyang, and finger root which are consumed by boiling and then drinking. The part of the plant that was taken for the leaves is sambiloto, while the parts for the rhizome were ginger, turmeric, lempuyang, and finger root.

Antibacterial Activity of Ethanol, Ethyl Acetate, and n-Hexane Extracts of Bidara Laut Lignum (Strychnos lucida R.Br) against Staphylococcus aureus and Escherichia coli Setyaningsih, Erwi Putri; Bahri, Saiful; Nurjanah, Rindang
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.283

Strychnos lucida is empirically believed to have efficacy in treating various diseases such as fever, malaria, toothache, and stomachache and to treat wounds. The secondary metabolite of Strychnos lucida has various polarity. The purpose of this study was to compare the inhibitory activity of Strychnos lucida extracts against E. coli and S. aureus bacteria. The test was carried out by measuring the Diameter of the Inhibitory Region (DIR) using the disc diffusion method on a concentration of 90%, 75%, 60%, 45%, 30%, and 15%. The Minimum Inhibitory Concentration (MIC) was carried out by agar dilution method on a concentration of 15%, 12.5%, 10%, 7.5%, 5%, and 2.5%. The positive control was 1% ampicillin, and the negative control was 10% DMSO. The ethyl acetate extract showed the highest DIR of 14.30 mm against S. aureus and E. coli on a concentration of 45%, ethanol extract was 8,38 mm against S. aureus and 8.71 mm against E. coli, and n-hexane had no inhibitory activity on a concentration 45%. The result of the MIC test for ethanol and ethyl acetate extract for both bacteria was found at a concentration of 15%, while n-hexane extract against Staphylococcus aureus was found at a concentration of 90% and a concentration of 75% against Escherichia coli.

Keterlibatan Dosen Farmasi Dalam Pemeriksaan Kesehatan Dasar Di Apotek Byel Farma Sebagai Bagian Dari Pengabdian Masyarakat Teodhora, Teodhora; Syafriana, Vilya; Febriani, Amelia; Wulandari, Ainun; Veryanti, Putu Rika; Rachmatiah, Tiah; Sholikha, Munawarohthus; Herdini, Herdini; Akhatik, Nurul; Subaryanti, Subaryanti; Kusuma, Ika Maruya; Setyaningsih, Erwi Putri; Putri, Elvina Triana; Siswati, Siswati; Andini, Issri Mila Nova; Jaya, Rendy Indra
MESTAKA: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 5 (2024): Oktober 2024
Publisher : Pakis Journal Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58184/mestaka.v3i5.430

This health check-up program aims to increase public understanding of preventive measures and healthy lifestyles. The free health check-up conducted at Byel Farma Pharmacy involved simple checks such as uric acid, cholesterol, blood glucose, and blood pressure. This activity was attended by 50 residents as participants. The results of the examination showed that blood pressure (hypertension) was the most common health problem, with 25 residents showing uncontrolled results, followed by uncontrolled fasting blood glucose in 14 residents, uncontrolled cholesterol in 10 residents, and uncontrolled uric acid in 5 residents. Lecturers involved in this activity also provided education on the correct use of medication, including the correct dosage and frequency of administration. Residents were reminded not to change or add medication without first consulting a doctor or pharmacist. It is hoped that residents in RW 04 Semanan Alas Tua, West Jakarta will continue to maintain their health, reduce the risk of worsening diseases, and undergo routine checks for hypertension, cholesterol, and uric acid.

Deteksi dan Kuantifikasi Rhodamin B pada Tiga Jenis Kosmetik tanpa Nomor Izin BPOM yang Beredar di Pasar Tradisional Kota Depok Setyaningsih, Erwi Putri; Manullang, Cindy; Subaryanti, Subaryanti
Jurnal Riset Sains dan Kesehatan Indonesia Vol. 2 No. 1 (2025): Jan-Feb
Publisher : CV. Science Tech Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69930/jrski.v2i1.283

Perona bibir, perona mata, dan perona pipi tanpa nomor izin BPOM banyak diperjualbelikan terutama di pasar tradisional. Warna yang menarik dan beragam pada kosmetik tersebut menjadi daya tarik bagi konsumen, namun produk tersebut patut diwaspadai karena dapat mengandung bahan kimia berbahaya seperti Rhodamin B. Tujuan dari penelitian ini untuk mendeteksi kandungan dan mengetahui kadar rhodamin B pada perona bibir, perona pipi, dan perona mata tanpa nomor izin BPOM yang beredar di pasar Tradisional Kota Depok. Penelitian ini menggunakan metode analisis kualitatif menggunakan Kromatografi Lapis Tipis dengan fase gerak etil asetat : n-butanol : amonia (60:20:20) dan analisis kuantitatif secara Spektrofotometri UV-Vis pada panjang gelombang 530 nm. Proses ekstraksi untuk menarik rhodamin B atau zat pewarna pada sampel dengan cara menambahkan HCl 4M dan metanol. Hasil penelitian menunjukkan dari 15 sampel yang diuji, terdapat 4 sampel yang positif mengandung Rhodamin B dengan kode S4, S10, S12, dan S14 dengan kadar Rhodamin B pada sampel kode S4 sebesar 0,27158 mg/g, kode S10 sebesar 0,48093 mg/g, kode S12 sebesar 0,29712 mg/g, kode S14 sebesar 0,36881 mg/g.

Antibacterial Activity of Ethanol, Ethyl Acetate, and n-Hexane Extracts of Bidara Laut Lignum (Strychnos lucida R.Br) against Staphylococcus aureus and Escherichia coli Setyaningsih, Erwi Putri; Bahri, Saiful; Nurjanah, Rindang
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.283

Strychnos lucida is empirically believed to have efficacy in treating various diseases such as fever, malaria, toothache, and stomachache and to treat wounds. The secondary metabolite of Strychnos lucida has various polarity. The purpose of this study was to compare the inhibitory activity of Strychnos lucida extracts against E. coli and S. aureus bacteria. The test was carried out by measuring the Diameter of the Inhibitory Region (DIR) using the disc diffusion method on a concentration of 90%, 75%, 60%, 45%, 30%, and 15%. The Minimum Inhibitory Concentration (MIC) was carried out by agar dilution method on a concentration of 15%, 12.5%, 10%, 7.5%, 5%, and 2.5%. The positive control was 1% ampicillin, and the negative control was 10% DMSO. The ethyl acetate extract showed the highest DIR of 14.30 mm against S. aureus and E. coli on a concentration of 45%, ethanol extract was 8,38 mm against S. aureus and 8.71 mm against E. coli, and n-hexane had no inhibitory activity on a concentration 45%. The result of the MIC test for ethanol and ethyl acetate extract for both bacteria was found at a concentration of 15%, while n-hexane extract against Staphylococcus aureus was found at a concentration of 90% and a concentration of 75% against Escherichia coli.

Penentuan Aktivitas dan Potensi Senyawa Kalkon Daun Jambu Air (Eugenia aquea Burm f) Terhadap Sel T47D Kanker Payudara Secara In Silico Setyaningsih, Erwi Putri; Dari, Resti Wulan; Manalu, Rosario Trijuliamos
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol. 18 No. 1 (2025): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v18i1.2196

Breast cancer is a malignant tumor caused by excessive expression of one or all three estrogen (ER) and progesterone (PR) proteins and Human Epidermal Growth Factor Receptor (HER2). Current breast cancer treatment generally uses chemotherapy, radiotherapy, hormone therapy, and surgery. The increasing need for new drugs with high selectivity, low toxicity, and good metabolic stability against breast cancer has led many researchers to explore Indonesia's natural resources to obtain drugs that have anticancer activity. Chalcone is a secondary metabolite of the flavonoid group with pharmacological activity as an anticancer. Four chalcone compounds in jambu air leaves (Eugenia aquea Burm f) have met the requirement Breast cancer is a malignant tumor caused by excessive expression of one or all three estrogen (ER) and progesterone (PR) proteins and Human Epidermal Growth Factor Receptor (HER2). Current breast cancer treatment generally uses chemotherapy, radiotherapy, hormone therapy, and surgery. The increasing need for new drugs with high selectivity, low toxicity, and good metabolic stability against breast cancer has led many researchers to explore Indonesia's natural resources to obtain drugs that have anticancer activity. Chalcone is a secondary metabolite of the flavonoid group with pharmacological activity as an anticancer. Four chalcone compounds in jambu air leaves (Eugenia aquea Burm f) have met the requirements for drug similarity testing. In silico research is the initial step in designing new drug discoveries because it is relatively faster and can handle thousands of compounds. This study aimed to determine the activity and potential of jambu air (Eugenia aquea Burm f) leaf chalcone compounds in inhibiting the target protein of breast cancer T47D cells in silico and its ADMET prediction. The research method is in silico, with molecular docking techniques using the YASARA View, Marvinsketch, PubChem, PLANTS, and Discovery Studio 2021 applications. The results of the molecular docking analysis of the target protein, namely, Myrigalon-b have the potential to inhibit HER2 protein, Myrigalon-g has the potential to inhibit ERÎ±, and phloretin has the potential to inhibit ERÎ². The ADMET prediction results of the Myrigalon-g and phloretin compounds have the best values.

Pelatihan Pembuatan Jamu Kunyit Asam dan Beras Kencur Instan di SMK Harapan Massa Depok Wenas, Desy Muliana; Setyaningsih, Erwi Putri; Kusuma, Ika Maruya; Pratiwi, Ritha Widya; Hasanah, Kurniatul; Bahri, Saiful
Jurnal SOLMA Vol. 14 No. 3 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i3.20282

Background: Jamu is an ancestral heritage of the Indonesian people that has important health benefit. Kunyit Asam (turmeric and tamarind) and Beras Kencur (rice and aromatic ginger) are two types of jamu that can help maintain and improve the health of adolescent students. This community service activity aims to help the students of SMK Harapan Massa understand how to make turmeric-tamarind and rice-kencur instant herbal drinks, as well as to grasp their uses and benefits. Method: Fifty-eight respondents participated in a training session focused on making instant kunyit asam and beras kencur. The questionnaire is used as a benchmark to measure the knowledge level of the students at SMK Harapan Massa. Results: There was an increase in questionnaire scores, indicating an improvement in the knowledge of respondents who completed both the pre-test and post-test, such as 87% (pre-test) menjadi 90% (post-test). Conclusions: The jamu workshop had enhance the students' knowledge and understanding of the benefits, preparation, production, and safe consumption methods of jamu.

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