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Aktivitas Antidiabetes Kombinasi Ekstrak Etanol Daun Sirih Merah (Piper crocatum) dan Buah Mahkota Dewa (Phaleria macrocarpa) Pada Tikus Diinduksi Streptozotosin-Nikotinamid C. Teodhora; Agung Endro Nugroho; Gunawan Pamudji Widodo
SAINSTECH FARMA Vol 10 No 2 (2017): Sainstech Farma Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Sirih merah (Piper crocatum) dan mahkota dewa (Phaleria macrocarpa) merupakan tanaman yang dapat digunakan untuk mengatasi penyakit diabetes mellitus tipe II. Penelitian ini bertujuan untuk mengetahui aktivitas antidiabetes kombinasi ekstrak etanol daun sirih merah dan ekstrak etanol buah mahkota dewa pada tikus yang diinduksi streptozotosin-nikotinamid. Penelitian dilakukan menggunakan hewan uji tikus Wistar (Rattus norvegicus) yang digunakan dibagi menjadi 5 kelompok uji. Kelompok 1: kontrol normal; kelompok 2: kontrol negatif (Na-CMC); kelompok 3: kontrol positif (glibenklamid 0,5 mg/kg BB); kelompok 4 dan 5 adalah kelompok kombinasi : ekstrak etanol kelompok dosis 50:100 dan 100:200 mg/kg BB. Hewan uji dibuat diabetes mellitus dengan induksi streptozotosin 50 mg/kg BB dan nikotinamid 110 mg/kg BB secara intraperitonial. Penetapan kadar glukosa puasa menggunakan reagen kit. Hasil penelitian menunjukkan bahwa ekstrak sirih merah dosis 50 mg/kg BB dan ekstrak mahkota dewa 100 mg/kg BB (kombinasi I) dalam waktu 14 hari telah memberikan persentase daya hipoglikemik sebesar 24,32±2,07.

Hubungan Tingkat Pengetahuan Dan Sikap Masyarakat Terhadap Penggunaan Obat Tradisional di Kelurahan Sukamaju Baru Kecamatan Tapos Kota Depok Ainun Wulandari; Ni’matul Khoeriyah; Teodhora Teodhora
SAINSTECH FARMA Vol 14 No 2 (2021): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v14i2.975

Penggunaan obat tradisional akan bermanfaat bagi kesehatan apabila digunakan secara tepat. Pengetahuan dan sikap merupakan faktor yang mempengaruhi tindakan pemilihan pengobatan seseorang. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan dan sikap terhadap penggunaan obat tradisional di Kelurahan Sukamaju Baru, Kecamatan Tapos, Kota Depok. Jenis penelitian yang digunakan yaitu observasional yang bersifat deskriptif analitik dengan rancangan penelitian potong lintang (cross sectional) menggunakan instrumen penelitian berupa kuesioner. Pengambilan sampel dilakukan dengan teknik purposive sampling terhadap 153 responden dan diperoleh 149 responden yang memenuhi kriteria inklusi dan kriteria eksklusi. Analisis data dilakukan menggunakan uji chi-square. Hasil penelitian menunjukkan bahwa masyarakat yang mempunyai tingkat pengetahuan baik (69,1%), cukup (23,5%), dan kurang (7,4%). Hasil penelitian sikap yaitu 84,6% mempunyai sikap positif dan 15,4% mempunyai sikap negatif. Sebanyak 71,8% masyarakat menggunakan obat tradisional dengan tepat dan 28,2% masyarakat menggunakan obat tradisional tidak tepat. Hasil penelitian menunjukkan ada hubungan yang signifikan antara tingkat pengetahuan terhadap penggunaan obat tradisional (p value = 0,000) dan ada hubungan yang signifikan antara sikap terhadap penggunaan obat tradisional (p value = 0,000). Pengetahuan dan sikap merupakan faktor yang mempengaruhi tindakan pemilihan pengobatan seseorang, termasuk penggunaan obat tradisional.

Pengaruh Konsentrasi Hpmc Sebagai Basis Gel Ekstrak Ciplukan Terhadap Aktivitas Antibakteri Teodhora Teodhora
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 7 No. 2 (2020)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v7i2.5633

Physalis angulata L. merupakan tanaman yang dapat digunakan untuk mengatasi infeksi yang disebabkan oleh bakteri Staphylococcus aureus dan Pseudomonas aeruginosa. Penelitian ini bertujuan untuk meneliti pengaruh penggunaan HPMC sebagai basis dalam beberapa variasi konsentrasi terhadap mutu fisik gel dan aktivitas sebagai antibakteri Staphylococcus aureus dan Pseudomonas aeruginosa. Hasil penelitian menunjukkan bahwa gel ekstrak daun Physalis angulata L. pada penggunaan variasi basis HPMC tidak mempengaruhi mutu fisik organoleptik, homogenitas, pH dan aktivitas antibakteri terhadap bakteri Pseudomonas aeruginosa dan mempengaruhi mutu fisik viskositas, dan aktivitas antibakteri terhadap bakteri Staphylococcus aureus. Gel ekstrak daun Physalis angulata L. dengan menggunakan konsentrasi HPMC 4% menghasilkan gel dengan mutu fisik dan aktivitas antibakteri yang optimal terhadap bakteri Staphylococcus aureus dan Pseudomonas aeruginosa, dengan daya hambat yang diperoleh yaitu sebesar 12,7 mm dan 12,9 mm.

GAMBARAN TERAPI DIABETES DENGAN PENYAKIT PENYERTA HIPERLIPIDEMIA DI RUMAH SAKIT Refdanita Refdanita; Lili Musnelina; Teodhora Teodhora; Hirim Hotma Uli Aprianis
Jurnal Endurance Vol. 6 No. 1 (2021): Jurnal Endurance : Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

Diabetes mellitus and cholesterol disorders are a lethal combination that places patients with diabetes 2-4 times more at risk for developing macrovascular and microvascular complications. Risk factors for Diabetes with Hyperlipidemia include age, sex, lifestyle, metabolic conditions that affect the metabolism of plasma lipoproteins, insulin deficiency. This study aims to know determine demographic data (age, sex, and length of stay), to know results of the laboratory tests and to know description of the therapy. The study was conducted descriptive with a cross sectional design, retrospective data collection methods from patients medical records of diabetic with hyperlipidemia at the hospital inpatient installation in January-December 2019, with 130 sample patients medical record. Result presented as a percentage table. The mean results of the study based on the highest patients demographics were at age 51-60 years as 40%, the highest gender was females 56%, based on the highest length of stay was 3 days 54%. Initial fasting glucose examination with the highest percentage >126 mg / dl of 78.5%. Total cholesterol examination with the highest percentage >200 mg / dl was 84.6%, triglycerides with the highest percentage >150 mg / dl was 15.4%, LDL with the highest percentage >100 mg / dl 79.3%. The highest use of oral antidiabetic was 52.30%, long-acting insulin was 40.70% and oral antihyperlipidemia was 77.60%. The statin class has been shown to have an effect in preventing complications in patients with type 2 diabetes mellitus

EFFECTIVENESS OF BAKUNG EXTRACT (CRINUM ASIATICUM L) AS AN ANALGESIC IN ACETIC ACID-INDUCED MICE Teodhora Simangunsong; Elzius Fransiscus Lumban Gaol; Sister Sianturi
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.3806

Crinum asiaticum L. leaves is a plant that has a pharmacological effect, which is to relieve pain. The purpose of this study was to determine the effect of the ethanol extract of daffodils as an analgesic effect on male mice DDY. The extract was obtained through the maceration extraction method and was administered by oral administration with three dose variations, namely 200 mg/kg BW, 400 mg/kg BW, and 800 mg/kg BW. Ibuprofen 52 mg/kgBW was used as a positive control and Na-CMC 0,5% as a negative control. 30 minutes after induced with 1% acetic acid the amount of stretching was observed every 5 minutes to 60 minutes. The results showed the best analgesic effect at dose III 800 mg/kg BW with the percentage of analgesic protection of 80,66%. The results of effectiveness at dose III 800 mg/kg BW of 99,37% which is almost the same as the effectiveness of Ibuprofen at a dose of 52 mg/kgBW of 100%

Ekspresi Glukosa Transporter-2 di Sel Beta Pankreas dan Sel Hepatosit Tikus yang Diinduksi Diabetes Mellitus teodhora teodhora
Pharmaceutical Journal of Indonesia Vol. 6 No. 2 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.006.02.9

Diabetes Mellitus (DM) is an incurable disease that can be prevented clinically from worsening. This disease is based on classification related to pancreatic damage in total or partial so that the impact on insulin production. Glucose transporter is a protein that can glucose uptake from outside cell into cell and provides an important role in the body's glucose homeostasis. Glucose transporter-2 (GLUT-2) is found in the pancreas, liver, and kidney. Parameters used are the expression and amount of GLUT-2 density in pancreatic Î² cells and in hepatocyte cells in normal and diabetic Rat. Used Wistar strain male white rats. An immunohistochemistry (IHC) staining technique was performed to observe the expression of GLUT-2 and the macbiophotonics image J program to determine total density of GLUT-2. GLUT-2 is marked in brown in the cell nucleus surrounded by cytoplasm. The results showed an increased in GLUT-2 expression in hepatocyte cells with a total density of 25,447,052 and a decreased in GLUT-2 expression in pancreatic Î² cells with a total density of 5,074,544 by Streptozotocin 50 mg/kg BB-Nicotinamide 100 mg/kg BB (STZ-NA) Intraperitonial routes in induced DM rat. STZ-NA induced triggers damage in pancreatic Î² cells and significantly influences the expression of GLUT-2 protein. High blood glucose levels give different GLUT-2 activity in hepatocyte cells due to the effects of induced agent.

Ekspresi Glukosa Transporter-2 di Sel Beta Pankreas dan Sel Hepatosit Tikus yang Diinduksi Diabetes Mellitus teodhora teodhora
Pharmaceutical Journal of Indonesia Vol. 6 No. 2 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.006.02.9

Diabetes Mellitus (DM) is an incurable disease that can be prevented clinically from worsening. This disease is based on classification related to pancreatic damage in total or partial so that the impact on insulin production. Glucose transporter is a protein that can glucose uptake from outside cell into cell and provides an important role in the body's glucose homeostasis. Glucose transporter-2 (GLUT-2) is found in the pancreas, liver, and kidney. Parameters used are the expression and amount of GLUT-2 density in pancreatic Î² cells and in hepatocyte cells in normal and diabetic Rat. Used Wistar strain male white rats. An immunohistochemistry (IHC) staining technique was performed to observe the expression of GLUT-2 and the macbiophotonics image J program to determine total density of GLUT-2. GLUT-2 is marked in brown in the cell nucleus surrounded by cytoplasm. The results showed an increased in GLUT-2 expression in hepatocyte cells with a total density of 25,447,052 and a decreased in GLUT-2 expression in pancreatic Î² cells with a total density of 5,074,544 by Streptozotocin 50 mg/kg BB-Nicotinamide 100 mg/kg BB (STZ-NA) Intraperitonial routes in induced DM rat. STZ-NA induced triggers damage in pancreatic Î² cells and significantly influences the expression of GLUT-2 protein. High blood glucose levels give different GLUT-2 activity in hepatocyte cells due to the effects of induced agent.

GAMBARAN TERAPI DIABETES DENGAN PENYAKIT PENYERTA HIPERLIPIDEMIA DI RUMAH SAKIT Refdanita Refdanita; Lili Musnelina; Teodhora Teodhora; Hirim Hotma Uli Aprianis
Jurnal Endurance Vol. 6 No. 1 (2021): Jurnal Endurance : Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

Diabetes mellitus and cholesterol disorders are a lethal combination that places patients with diabetes 2-4 times more at risk for developing macrovascular and microvascular complications. Risk factors for Diabetes with Hyperlipidemia include age, sex, lifestyle, metabolic conditions that affect the metabolism of plasma lipoproteins, insulin deficiency. This study aims to know determine demographic data (age, sex, and length of stay), to know results of the laboratory tests and to know description of the therapy. The study was conducted descriptive with a cross sectional design, retrospective data collection methods from patients medical records of diabetic with hyperlipidemia at the hospital inpatient installation in January-December 2019, with 130 sample patients medical record. Result presented as a percentage table. The mean results of the study based on the highest patients demographics were at age 51-60 years as 40%, the highest gender was females 56%, based on the highest length of stay was 3 days 54%. Initial fasting glucose examination with the highest percentage >126 mg / dl of 78.5%. Total cholesterol examination with the highest percentage >200 mg / dl was 84.6%, triglycerides with the highest percentage >150 mg / dl was 15.4%, LDL with the highest percentage >100 mg / dl 79.3%. The highest use of oral antidiabetic was 52.30%, long-acting insulin was 40.70% and oral antihyperlipidemia was 77.60%. The statin class has been shown to have an effect in preventing complications in patients with type 2 diabetes mellitus

The relationship level of community's knowledge and attitude toward the use of antibiotics in Gandaria, South Jakarta Teodhora Teodhora; Eka Putri Maliawati
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.21117

Antibiotics will be beneficial and have the anticipated therapeutic effect if prescribed and administered as instructed. The purpose of this study was to evaluate community attitudes and knowledge levels regarding the use of antibiotics, as well as the relationship between these two variables. The sample size for this descriptive-analytic study was 95 respondents, and a cross-sectional design was used. The sampling technique utilized was purposeful sampling. Women made up the bulk of responses (65.3%), and their age range was 36 to 45 (44.2%). The latest educational levels indicated were high school (61.1%), antibiotic use in the past or present (100%), and housewife (38.1%). The respondent received scores of 62.1% for "excellent" knowledge, 3.5% for "adequate" learning, and 7.4% for "poor" expertise. In contrast, there were 0.0% of participants in a horrible disposition, 52.6% with an acceptable attitude, and 47.4% with an excellent attitude. The Chi-Square test findings showed a significant value of 0.097, or more significant than 0.05, between the variable amount of knowledge and attitudes against antibiotics. The p-value (> 0.05) indicates no correlation between the level of competence and perspectives regarding the use of antibiotics. Education, knowledge, and attitudes toward antibiotics were found to be correlated, with a p-value of (0.05). It was determined that the local population had a good and insightful understanding of antibiotics.

Penyembuhan Luka Diabetes dan Aktivitas Antimikroba dari Gel Ekstrak Melastoma malabathricum L. dan Psidium guajava L. pada Tikus Sprague Dawley Refdanita Refdanita; Tonny Cortis Maigoda; Firdaus Firdaus; Barakatun Nisak; Teodhora Teodhora
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1390

Diabetes mellitus (DM) is a degenerative disease characterized by abnormalities in carbohydrate, lipid, and protein metabolisms. This research was aimed at the gel’s pharmacological activity, the extract’s potential in treating diabetic wounds in male rats of Melastoma malabathricum L leaves (ML) and Psidium guajava L leaves (PL), as well as microbiological activity. Viscous extracts of ML and PL were prepared in gel dosage form with concentrations of 4% and 6%. Clindamycin was used as a positive control. This study was conducted using an experimental laboratory method, and the study population included white male rats. The pharmacological activity was tested in the form of a gel dosage formula, and the rats were made diabetic using alloxan. The potential of the extract was observed in healing diabetic wounds in male rats. ML and PL leaf extract gels affect wound healing in diabetic patients. This can be seen from the change in diameter. Wound swab examination revealed the presence of bacteria Klebsiella pneumoniae and Staphylococcus aureus. Secondary metabolites of flavonoids, tannins, steroids, and saponins help stimulate the regeneration of epithelial cells and tissues. The results for wound healing of 4% and 6% gel formulations were derived from maturation data on day 10.

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