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septa surya wahyudi, septa surya
Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Jember
Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health Other

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THE EFFECT OF CONSUMPTION OF YOUNG COCONUT (COCOS NUCIFERA L) ON CHOLESTEROL LEVELS IN HEALTHY PEOPLE Aris Prasetyo; Alif Kufari; Septa Surya Wahyudi; Jauhar Firdaus; Adelia Handoko; Kristianingrum Dian Sofiana; Pipiet Wulandari
UNEJ e-Proceeding 2022: E-Prosiding Kolokium Hasil Penelitian dan Pengabdian kepada Masyarakat
Publisher : UPT Penerbitan Universitas Jember

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Abstract

High blood cholesterol levels are risk factors that cause an increase in Low Density Lipoprotein (LDL) that it can form clots and plaque in the vascular which will result in the formation of atherosclerosis. Galactomannan is a natural ingredient that can reduce blood cholesterol levels by inhibiting its absorption and forming hydrogen bonds with cholesterol. In Indonesia, a potential source of galactomannan is coconut (Cocos Nucifera L). This study aims to determine the effect of consumption of young coconuts on cholesterol levels in healthy people. This research is an experimental clinical trial study with a pretest-posttest design. The sample of this study was twenty healthy people aged 18-25 years consisting of 10 men and 10 women. The treatment is in the form of consumption of coconut with 250 gram coconut meat and 150 mL coconut water with administration once a day for 14 days. The beginning and the end of the treatment blood cholesterol level were examined. after the treatment of coconut, consumption obtained a decrease in blood cholesterol levels by 17 participants and 3 participants with an increase in blood cholesterol levels. it can be concluded that there is a significant influence on the consumption of young coconuts to reduce blood cholesterol levels in healthy people. Keywords: cholesterol, coconut, galactomanan
The Effects of Giving Coconut Milk on Aortic Wall Thickness of Rats (Rattus norvegicus strain Wistar) Fed with High Fat Diet (HFD) Firdaus, Jauhar; Prasetyo, Aris; Wahyudi, Septa Surya; Haniefah, Yumna Rifda
Majalah Obat Tradisional Vol 28, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.84939

Abstract

Atherosclerosis is a chronic disease due to fat accumulation in the blood vessel walls. Atherosclerosis is the leading cause of cardiovascular disease. Indonesian people’s habit of consuming coconut milk is suspected of causing dyslipidemia, a risk factor for atherosclerosis, by increasing low-density lipoprotein (LDL). However, other studies suggest that coconut milk can increase high-density lipoprotein (HDL), an antioxidant that prevents atherosclerosis. Because of the different findings, this study aims to determine the effects of coconut milk administration on the aortic wall thickness of rats (Rattus norvegicus strain Wistar) fed a high-fat diet (HFD). This true experimental study used samples of 28 male Wistar rats divided into seven groups. These groups consisted of the normal group (N), the negative control group (Kn), and five treatment groups that received coconut milk at various doses, including 2, 5, 3.75, 5, 7. 5, and 10 ml/kgBW/day. The results obtained were then analyzed using SPSS. The statistical tests used are the independent t-test, one-way ANOVA, LSD post hoc, Pearson correlation test, and regression test. Based on this study, the results showed that giving HFD for 45 days could cause the aortic wall to thicken. Meanwhile, giving an HFD accompanied by coconut milk for 45 days can prevent the thickening of the aortic wall, with the maximum effective dose that can be given being 9.75 ml/kg BW/day.
Shallot (Allium cepa L.) Peel Infusion Ameliorates Kidney Histopathological Damages in Diazinon-Induced Wistar Rats Bi’izzyk, Avie Baldana; Helianti, Dina; Wahyudi, Septa Surya; Dewi, Rosita
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3307

Abstract

Diazinon, an organophosphate pesticide, is used extensively in agricultural sector. Consumption of agricultural products containing diazinon residue may lead to harmful health consequences. Among these is nephrotoxicity, which includes lipid peroxidation, that can damage the kidney. Flavonoids in shallot peel can scavenge free radicals, inhibit necrosis, and activate bone marrow-derived cells for cell regeneration. This study aimed to determine the correlation between shallot peel infusion (SPI) dose and kidney damage amelioration to establish the maximum effective dose of SPI to ameliorate kidney histopathological damage in diazinon-induced rats. This study was performed at the Pharmacology Laboratory, Faculty of Medicine, University of Jember, Indonesia, in April 2021, on 35 rats that were divided into 7 groups—normal, diazinon, and five treatment groups. Diazinon 40 mg/kgBW was administered on day 1-7, while SPI 125, 250, 500, 1,000, 2,000 mg/kgBW were administered on day 8–14 according to the treatment group. Kidney histopathological slides with hematoxylin-eosin (H.E.) staining were assessed using Kocoglu scoring and Kidney damage scores of the treatment groups were analyzed using Pearson test. The maximum effective dose was determined using regression test. The damages found in diazinon-induced rats were tubular degeneration, necrosis, and inflammation with a higher damage score than normal rats (p<0.05). Pearson test showed moderate correlation (coefficient -0.594). Higher SPI doses presented lower kidney damage scores, with 1,359 mg/kgBW being the maximum effective dose. SPI dose and the kidney damage amelioration are moderately correlated with a SPI maximum effective dose to ameliorate kidney damage in diazinon-induced rats of 1,359 mg/kgBW.
INTRACAVERNOSAL INJECTION OF PLATELET-RICH PLASMA AS AN ALTERNATIVE TREATMENT OF ORGANIC ERECTILE DYSFUNCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS Rayyan, Muhammad Isra Rafidin; Kholid, Akbar Fakhrudin; Wahyudi, Septa Surya
Indonesian Journal of Urology Vol 32 No 3 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i3.967

Abstract

Objective: To evaluate the effectiveness and safety of intracavernosal injections of platelet-rich plasma (PRP) as an alternative therapy for the treatment of erectile dysfunction. Material & Methods: We conducted a comprehensive literature search on Pubmed, Cochrane Library, ScienceDirect, Scopus, and Proquest databases for randomized controlled clinical trials (RCTs) until April 2023. The study protocol has been registered in the International Prospective Register of Systematic Reviews (PROSPERO CRD42023424586). Results: Our results showed that PRP could improve MCID in IIEF-EF score (OR: 4.64; 95% CI: 2.20, 9.79; p < 0.0001; I2 = 77%) and PSV (MD: 9.63; 95% CI: 1.17, 18.09; p = 0.03; I2 = 73%). In addition, PRP administration was shown to be relatively safe, and there was no significant difference in post-injection VAS pain scores when compared to controls (MD: -0.09; 95% CI: -0.49, 0.31; p = 0.66; I2 = 84%). Conclusion: This systematic review and meta-analysis showed promising results regarding the effects of PRP administration on erectile dysfunction. However, due to the lack of quality and number of studies, these findings should be interpreted carefully, and further investigations are still needed. Keywords: Platelet-Rich Plasma, Intracavernosal Injection, Erectile Dysfunction, IIEF-EF, Meta-Analysis.
Co-Authors A.A. Ketut Agung Cahyawan W Adelia Handoko Al Munawir Alfina kamelia fakhriyah Alif Kufari Ancah Caesarina Novi Marchianti Aris Prasetyo Aziz, Ayu Munawaroh Bagus Hermansyah Bagus Indra Kusuma Bi’izzyk, Avie Baldana Cholis Abrori, Cholis Dhiemas Trisyuananda Eniestama Diayu Putri Akhita Dina Helianti Dini Agustina Doddy M Soebadi Edy Junaidi El Milla, Kardiana Izza ENNY SUSWATI Haniefah, Yumna Rifda Heni Fatmawati I Nyoman Insan Parisudha Ika Rahmawati Sutejo Inke Kusumastuti Insani, Ain Yuanita Jauhar Firdaus Kholid, Akbar Fakhrudin Kristianingrum Dian Sofiana Kurnia Putra, Prayoga Triyadi Laksmi Indreswari Made Devi Desyana Arisandi Miftakhul Huda Muhammad Aqib Husni Fadhli Muhammad Hasan Pipiet Wulandari Pralampita, Pulong Wijang Prasetyo, Aris Probosutiksna, Nuno Febrian Probosutiksna, Nuno Febrian Rahma Illa Putri Utami Rayyan, Muhammad Isra Rafidin Rosita Dewi Ryan Ravi Is Syahputra Soetojo Soetojo Sri Weli Teguh Pujo Sakti Suci Rizalah I Sunaryo Hardjowijoto Supangat Supangat Sutejo, Ika Rahmwati Tarmono Djojodimedjo Tristianti, Farmitalia Nisa Widjajana, Desy Pratiwi Winanda, Leony Agnes Savira Yuli Hermansyah Yunita Wulansari Zulfahmi Muslim