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All Journal Medikora: Jurnal Ilmiah Kesehatan Olahraga Jurnal Kesehatan Lingkungan indonesia Majalah Kedokteran Bandung e-Journal Pustaka Kesehatan Indonesian Journal of Urology Journal of Agromedicine and Medical Sciences Majalah Obat Tradisional UNEJ e-Proceeding Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Majalah Kedokteran Andalas
septa surya wahyudi, septa surya
Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Jember
Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health Other

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The Effects of Giving Coconut Milk on Aortic Wall Thickness of Rats (Rattus norvegicus strain Wistar) Fed with High Fat Diet (HFD) Firdaus, Jauhar; Prasetyo, Aris; Wahyudi, Septa Surya; Haniefah, Yumna Rifda
Majalah Obat Tradisional Vol 28, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.84939

Abstract

Atherosclerosis is a chronic disease due to fat accumulation in the blood vessel walls. Atherosclerosis is the leading cause of cardiovascular disease. Indonesian people’s habit of consuming coconut milk is suspected of causing dyslipidemia, a risk factor for atherosclerosis, by increasing low-density lipoprotein (LDL). However, other studies suggest that coconut milk can increase high-density lipoprotein (HDL), an antioxidant that prevents atherosclerosis. Because of the different findings, this study aims to determine the effects of coconut milk administration on the aortic wall thickness of rats (Rattus norvegicus strain Wistar) fed a high-fat diet (HFD). This true experimental study used samples of 28 male Wistar rats divided into seven groups. These groups consisted of the normal group (N), the negative control group (Kn), and five treatment groups that received coconut milk at various doses, including 2, 5, 3.75, 5, 7. 5, and 10 ml/kgBW/day. The results obtained were then analyzed using SPSS. The statistical tests used are the independent t-test, one-way ANOVA, LSD post hoc, Pearson correlation test, and regression test. Based on this study, the results showed that giving HFD for 45 days could cause the aortic wall to thicken. Meanwhile, giving an HFD accompanied by coconut milk for 45 days can prevent the thickening of the aortic wall, with the maximum effective dose that can be given being 9.75 ml/kg BW/day.
Shallot (Allium cepa L.) Peel Infusion Ameliorates Kidney Histopathological Damages in Diazinon-Induced Wistar Rats Bi’izzyk, Avie Baldana; Helianti, Dina; Wahyudi, Septa Surya; Dewi, Rosita
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3307

Abstract

Diazinon, an organophosphate pesticide, is used extensively in agricultural sector. Consumption of agricultural products containing diazinon residue may lead to harmful health consequences. Among these is nephrotoxicity, which includes lipid peroxidation, that can damage the kidney. Flavonoids in shallot peel can scavenge free radicals, inhibit necrosis, and activate bone marrow-derived cells for cell regeneration. This study aimed to determine the correlation between shallot peel infusion (SPI) dose and kidney damage amelioration to establish the maximum effective dose of SPI to ameliorate kidney histopathological damage in diazinon-induced rats. This study was performed at the Pharmacology Laboratory, Faculty of Medicine, University of Jember, Indonesia, in April 2021, on 35 rats that were divided into 7 groups—normal, diazinon, and five treatment groups. Diazinon 40 mg/kgBW was administered on day 1-7, while SPI 125, 250, 500, 1,000, 2,000 mg/kgBW were administered on day 8–14 according to the treatment group. Kidney histopathological slides with hematoxylin-eosin (H.E.) staining were assessed using Kocoglu scoring and Kidney damage scores of the treatment groups were analyzed using Pearson test. The maximum effective dose was determined using regression test. The damages found in diazinon-induced rats were tubular degeneration, necrosis, and inflammation with a higher damage score than normal rats (p<0.05). Pearson test showed moderate correlation (coefficient -0.594). Higher SPI doses presented lower kidney damage scores, with 1,359 mg/kgBW being the maximum effective dose. SPI dose and the kidney damage amelioration are moderately correlated with a SPI maximum effective dose to ameliorate kidney damage in diazinon-induced rats of 1,359 mg/kgBW.
INTRACAVERNOSAL INJECTION OF PLATELET-RICH PLASMA AS AN ALTERNATIVE TREATMENT OF ORGANIC ERECTILE DYSFUNCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS Rayyan, Muhammad Isra Rafidin; Kholid, Akbar Fakhrudin; Wahyudi, Septa Surya
Indonesian Journal of Urology Vol 32 No 3 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i3.967

Abstract

Objective: To evaluate the effectiveness and safety of intracavernosal injections of platelet-rich plasma (PRP) as an alternative therapy for the treatment of erectile dysfunction. Material & Methods: We conducted a comprehensive literature search on Pubmed, Cochrane Library, ScienceDirect, Scopus, and Proquest databases for randomized controlled clinical trials (RCTs) until April 2023. The study protocol has been registered in the International Prospective Register of Systematic Reviews (PROSPERO CRD42023424586). Results: Our results showed that PRP could improve MCID in IIEF-EF score (OR: 4.64; 95% CI: 2.20, 9.79; p < 0.0001; I2 = 77%) and PSV (MD: 9.63; 95% CI: 1.17, 18.09; p = 0.03; I2 = 73%). In addition, PRP administration was shown to be relatively safe, and there was no significant difference in post-injection VAS pain scores when compared to controls (MD: -0.09; 95% CI: -0.49, 0.31; p = 0.66; I2 = 84%). Conclusion: This systematic review and meta-analysis showed promising results regarding the effects of PRP administration on erectile dysfunction. However, due to the lack of quality and number of studies, these findings should be interpreted carefully, and further investigations are still needed. Keywords: Platelet-Rich Plasma, Intracavernosal Injection, Erectile Dysfunction, IIEF-EF, Meta-Analysis.
ANALYSIS OF THE EFFECT OF EXPOSURE TO CHLORPYRYPHOS, CARBOFURAN, AND CYPERMETHRIN ON SPERMATOGENESIS IN ADOLESCENT RAT Janu, Libri Wira Indra; Wahyudi, Septa Surya; Sofiana, Kristianningrum Dian
Indonesian Journal of Urology Vol 30 No 2 (2023)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v30i2.803

Abstract

Objective: To investigate the effect of exposure to chlorpyryphos, carbofuran, and cypermethrin on spermatogenesis in adolescent rat. Material & Methods: This study is an experimental study with a post-test only control group design. In this study, 30 adolescent rats aged 30-45 days were randomly divided into 5 groups. Group I was a normal control or without treatment for 21 days (K0), group II was a solvent control group, namely DMSO 5% which was administered subcutaneously for 21 days (KI), group III was a group that received chlorpyrifos 20 mg/kgBW dissolved with DMSO 5% subcutaneously for 21 days (P1), group IV was the group that received carbofuran 0.2 mg/kgBW dissolved with DMSO 5% subcutaneously for 21 days (P2), group V was the group that received cypermethrin 20 mg/kg. kgBW dissolved with 5% DMSO subcutaneously for 21 days (P3). Ipsilateral testicular orchidectomy was performed on all rats to remove the left testicular organ for preparation with Haematoxylin Eosin staining. The spermatogenesis score was calculated based on the Johnsen score in 5 seminiferous tubule visual fields. Data were analyzed using Kruskal Wallis followed by Mann Mitney test. The difference was considered significant at p<0.05. Results: There was a significant decrease in spermatogenesis scores between P1, P2, and P3 against K0 and K1 (p<0.05). On the other hand, there was no significant difference in the decrease in spermatogenesis scores between P1 and P2, P1 and P3, P2 and P3 and K0 and K1 (p>0.05). Conclusion: Exposure to chlorpyrifos, carbofuran, and cypermethrin had an effect on reducing spermatogenesis scores in adolescent rats.
HYPERTENSION IS ASSOCIATED WITH BIGGER PROSTATE VOLUME AMONG BPH PATIENTS AT dr. SOEBANDI GENERAL HOSPITAL, JEMBER Radiva Eryadana, Aqshal; Wahyudi, Septa Surya; Febianti, Zahrah
Indonesian Journal of Urology Vol 30 No 3 (2023)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v30i3.811

Abstract

ABSTRACT Objective: Hypertension is one of BPH (Benign Prostate Hyperplasia) risk factors. This study was to compare the prostate volume of hypertensive-BPH patient and normotensive-BPH patient at Soebandi General Hospital Jember. Material & Methods: This is an observational analytic study with cross-sectional design conducted at Soebandi General Hospital, Jember. The data (blood pressure and prostate volume) were obtained from the medical records of BPH patients visiting the Urology Department during December 2021 until January 2022. They were analyzed with Independent T-test. Result: The results showed that there was a significant difference in prostate volume between hypertensive-BPH patients and normotensive BPH patients (p-value: 0.013). Among the BPH patients, the hypertensive groups had a bigger prostate volume than the normotensive groups. Conclusion: This study proves that hypertension is associated with bigger prostate volume among BPH patients at Soebandi General Hospital, Jember. Keywords: Independent T-test, prostate volume, blood pressure.
The effects of consuming coconut milk on SGOT and SGPT levels of rats serum (Rattus norvegicus strain Wistar) fed with High Fat Diet (HFD) Sari, Yuhanita Tyara; Wahyudi, Septa Surya; Febianti, Zahra; Riyanti, Rini; Prasetyo, Aris
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 13 ISSUE 5, 2025
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2025.13(5).324-334

Abstract

ABSTRAK Latar Belakang: Pola makan tinggi lemak merupakan pemicu utama terjadinya obesitas dan penyakit kardiometabolik. Akumulasi lemak yang berlebihan menyebabkan peningkatan Reactive Oxygen Species (ROS) melalui hidrokarbon aromatik polisiklik (PAH), yang bermanifestasi dalam peningkatan kadar Serum Glutamic Oxaloacetic Transaminase (SGOT) dan Serum Glutamic Pyruvic Transaminase (SGPT). Santan mengandung kandungan polifenol yang dapat menghambat mekanisme ROS. Penelitian sebelumnya menyebutkan bahwa pemberian MCFA dan polifenol pada tikus Wistar yang diinduksi hiperkalori tidak memberikan efek hepatoprotektif dan mengindikasikan adanya peningkatan kadar SGOT dan SGPTTujuan: Penelitian ini bertujuan untuk membuktikan pengaruh pemberian santan terhadap kadar SGOT dan SGPT pada tikus yang diinduksi diet tinggi lemak (HFD).Metode: Penelitian ini merupakan penelitian true eksperimental dengan rancangan posttest control group design. Sampel terdiri dari 25 ekor tikus wistar (Rattus norvegicus) jantan dibagi menjadi 5 kelompok secara acak. Pengukuran SGOT dan SGPT dilakukan sesuai standarisasi IFCC (International Federation of Clinical and Chemistry and Medical Laboratory) dengan mengumpulkan sampel serum yang dilanjutkan dengan pemeriksaan menggunakan Spektrofotometer Biolyzer 100 untuk menganalisis kadar SGOT dan SGPT setelah 45 hari perlakuan. Analisis data menggunakan uji ANOVA.Hasil: Hasil penelitian menunjukkan bahwa, peningkatan dosis santan makin menurunkan kadar baik SGOT/SGPT. Hasil uji Anova menunjukkan hasil yang signifikan secara statistik. Perbandingan LSD Post-hoc antara kelompok K dan P3 menunjukkan signifikansi terhadap SGPT (0,276) dan SGOT (0,707). Pemberian santan dosis 10 mL/kg berat badan/ hari pada tikus yang diinduksi HFD secara statistik, dapat menghambat peningkatan SGOT dan SGPT.Kesimpulan : Berdasarkan hasil tersebut disimpulkan bahwa pemberian santan mampu mencegah peningkatan kadar SGOT dan SGPT.KATA KUNCI: diet tinggi lemak;santan kelapa;SGOT;SGPT ABSTRACTBackground: High-fat diets contribute to obesity and cardiometabolic diseases by increasing Reactive Oxygen Species (ROS)levels. Coconut milk's polyphenols may counteract ROS effects which manifests in increasing levels of Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). Coconut milk contains polyphenols which can inhibit the ROS mechanism. Previous research stated that administration of MCFA and polyphenols to Wistar rats induced by hypercalories did not provide a hepatoprotective effect and indicated an increase in SGOT and SGPT levels.Objectives: This study aimed to prove the influence of coconut milk administration on the levels of SGOT and SGPT in rats induced by High Fat Diet (HFD).Methods: The study was a true experimental research employing a posttest control group design. It involved 25 male Wistar rats (Rattus norvegicus) split into 5 randomly assigned groups. SGOT and SGPT measurements were carried out according to IFCC standards by collecting serum samples followed by examination using the photometric method to analyze SGOT and SGPT levels after 45 days of treatment. Data analysis used the ANOVA test using SPSS Statistics V21.0Results: The results of research on both SGOT and SGPT levels showed that increasing the dose further reduces both SGOT and SGPT levels. The Anova test results show statistically significant results. Post-hoc LSD comparison between groups K and P3 showed significance for SGPT (0.276) and SGOT (0.707).Conclusions: Based on these results, it can be concluded that high-dose coconut milk administration was able to prevent the increase in SGOT and SGPT levels KEYWORDS: coconut milk; high fat diet; SGOT; SGPT
ACUTE TOXICITY TEST OF RED ONION (Allium Cepa L) SKIN EXTRACT ON KIDNEY HISTOPATHOLOGY OF RATS (Rattus Norvegicus) Brahmantya Putra, Denny Christian; Helianti, Dina; Wahyudi, Septa Surya; Dewi, Rosita
Indonesian Journal of Urology Vol 33 No 2 (2026)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v33i2.1000

Abstract

Introduction: Shallots (Allium cepa L.) are known to contain quercetin, which is helpful as an antioxidant, but its accumulation in the body can be toxic. Objective: This study aims to determine the effect of administering red onion skin extract on histopathology and weight of the kidney, body weight, and clinical symptoms, as well as determining the LD50. Material & Methods: This research was conducted according to OECD guideline No. 420 Fixed Dose Procedures. Rats were allocated to a control group that was given 3% DMSO and a treatment group that was given red onion peel extract at a dose of 5000 mg/kgBW. Kidney histopathology slides with Hematoxylin-eosin staining were observed by two observers in five fields of view using Fiji ImageJ software and assessed based on the Kocoglu scoring. Kidney histopathology data was analyzed using the Mann-Whitney test, while kidney weight and body weight gain used the Independent Sample T-test. Results: The treatment group experienced significantly higher body weight gain than the control group. On the other hand, observations of the histopathological appearance and weight of the kidney did not show any significant differences. Observation of clinical symptoms showed normal results with no deaths. Conclusion: Administration of 5000 mg/kgBW red onion skin extract in the acute toxicity test had no effect on the histopathology and weight of kidney rats, but had a significant effect on body weight gain. The LD50 of red onion skin extract was found to be >5000 mg/kgBW. Keywords: Red onion skin extract, acute toxicity test, LD50, kidney histopathology.
Co-Authors A.A. Ketut Agung Cahyawan W Adelia Handoko Al Munawir Alfina kamelia fakhriyah Alif Kufari Ancah Caesarina Novi Marchianti Aris Prasetyo Aziz, Ayu Munawaroh Bagus Hermansyah Bagus Indra Kusuma Bi’izzyk, Avie Baldana Brahmantya Putra, Denny Christian Cholis Abrori, Cholis Cicih Komariah Desie Dwi Wisudanti Dhiemas Trisyuananda Eniestama Diayu Putri Akhita Dina Helianti Dini Agustina Doddy M Soebadi Dwisaraswati, Salma Aulia Edy Junaidi El Milla, Kardiana Izza Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Febianti, Zahra Haniefah, Yumna Rifda Heni Fatmawati I Nyoman Insan Parisudha Ika Rahmawati Sutejo Inke Kusumastuti Insani, Ain Yuanita Janu, Libri Wira Indra Jauhar Firdaus Kholid, Akbar Fakhrudin Kristianingrum Dian Sofiana Kristianningrum Dian Sofiana Kurnia Putra, Prayoga Triyadi Laksmi Indreswari Made Devi Desyana Arisandi Miftakhul Huda Muhammad Aqib Husni Fadhli Muhammad Hasan Pipiet Wulandari Pralampita, Pulong Wijang Prasetyo, Aris Probosutiksna, Nuno Febrian Probosutiksna, Nuno Febrian Radiva Eryadana, Aqshal Rahma Illa Putri Utami Rayyan, Muhammad Isra Rafidin Rini Riyanti Rosita Dewi Rumastika, Nindya Shinta Ryan Ravi Is Syahputra Sari, Yuhanita Tyara Sheilla Rachmania, Sheilla Soetojo Soetojo Sri Weli Teguh Pujo Sakti Suci Rizalah I Sunaryo Hardjowijoto Supangat Supangat Supangat Supangat Sutejo, Ika Rahmwati Tarmono Djojodimedjo Tristianti, Farmitalia Nisa Widjajana, Desy Pratiwi Winanda, Leony Agnes Savira Yuli Hermansyah Yunita Wulansari Zahrah Febianti Zulfahmi Muslim