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All Journal Jurnal Ilmiah Farmasi JURNAL PHARMASCIENCE MPI (Media Pharmaceutica Indonesiana) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmasetika Borneo Journal Of Pharmascientech Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Global Pharma Technology
Suci Hanifah
Department Of Pharmacy, Universitas Islam Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Stability and beyond-use date of anesthetic agents used in surgical procedures: a review: Stability and Beyond-Use Data of Anesthesia Wijayanti, Shofia; Hanifah, Suci; Fudholi, Dhomas Hatta
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art4

Abstract

Background: Anaesthesia drugs are often divided into other syringes to be soluted or mixed with other medications to share with other patients for the sake of efficiency. Objectives: This study aims to know the stability of anesthetic agents and the compatibility with co-simultaneous drugs used. Methods: This review was conducted by searching literature through the following databases: PubMed, Science Direct, and Google Scholar. The keywords used in the search for articles were "stability," "beyond use date," "anesthetic drug," and "intravenous."Results: The data showed that mixing fentanyl with levo-bupivakain or epinefrin is relatively stable up to one month, but it decreases only for 72 hours in dextrose 5% or normal saline (NS). Pethidin can be mixed with acetaminophen and metoclopramide using dextrose, NS, or water and stored up to 24 hours. Midazolam diluted in dextrose 5% (D5) or mixed with other medications maintains stability for up to 14 days or more. Stability of ketamine is 24 hours longer whether it is mixed in solvent or acetaminophen. Mixing with propofol induces instability because of the emulsion form of propofol. Conclusion: In general, the anesthetic drugs of fentanyl, pethidine, midazolam, and ketamine are stable and safe for preparation and administration in more than 24 hours. These four medications are compatible with NS and D5 and all tested medications during 24 hours.
Effect of Levonorgestrel Implant on Lactation and Infant Growth: A Review: Review : Pengaruh Implan Levonorgestrel pada Laktasi dan Pertumbuhan Bayi Febrianti, Yosi; Hanifah, Suci; Febrian, M. Pandoman; Annisa, Lily; Azza, Lintang Prava; Mafruhah, Okti Ratna; Medisa, Dian; Sari, Chynthia Pradiftha
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.17045

Abstract

Background: Family Planning is a way to regulate the number of children born and the spacing of pregnancies through information, education, and the use of contraceptives. Postpartum contraception is important to obtain an optimal interpregnancy interval. Postpartum contraception should be initiated early; one of which is Long-Acting Reversible Contraception (LARC). Levonorgestrel can be used to prevent pregnancy because it interferes with ovulation, implantation, and fertilization. Objectives: This study aimed to assess the efficacy and effects of using levonorgestrel implants on breastfeeding and infant growth. Methods: Primary data were in the form of research papers obtained from PubMed®, and Google Scholar® published from the period 2010-2018. The keywords for the searches included: “levonorgestrel”, “levonorgestrel (LNG)-releasing implant”, “levonorgestrel on lactogenesis”, “levonorgestrel on infant growth”, and “levonorgestrel on breastfeeding”, which were used alone or in combination. Results: The 20 selected articles were reviewed based on five identified phrases. Levonorgestrel subdermal implants were shown to be a good choice for women who wanted effective contraception. When used by breastfeeding mothers, levonorgestrel subdermal implants affected neither infant growth (0-1 year of age) nor lactation duration. Conclusions: Levonorgestrel subdermal implants can be effective long-term contraception. These implants are safe for breastfeeding mothers and do not affect infant growth.
Update on pharmacist role in sterile compounding in hospital Albesht, Hanan; Hanifah, Suci; Abukres, Salem
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art8

Abstract

Background: Sterile compounding, a critical aspect of pharmaceutical practice, involves the preparation of customized medications in a sterile environment. Pharmacists play a pivotal role in ensuring the safety and efficacy of compounded sterile products (CSPs), making their involvement integral to the healthcare system. Objective: This article aims to describe the role of pharmacists in sterile compounding based on literature. Method: Articles from Medline/PubMed, guidelines, reports, and databases related to sterile compounding have been searched and compiled. This review collected the qualitative data and identified the critical point for continuous quality improvement initiatives in sterile compounding.Results: This comprehensive narrative review explores the multifaceted responsibilities of pharmacists in sterile compounding, drawing insights from various studies and databases. However, the study related to the pharmacist's role in sterile compounding practices is very limited. Recent articles that mention the pharmacist's role in sterile compounding commonly come from the guidelines or government documents. In general, CSP needs a commitment to comply with regulatory standards for achieving patient safety using the integration of technology and healthcare collaboration. Continuous professional development is a crucial contributor to keeping the quality of compounded sterile products. Conclusion: The findings from various journals underscore the complexity of their responsibilities and emphasize the need for a holistic approach to ensure the integrity and safety of compounded sterile products in diverse healthcare settings.
POLA PENGGUNAAN OBAT UNTUK PENDERITAGAGAL GINJAL AKUT DI INSTALASI RAWAT INAP RUMAH SAKIT UMUM PUSAT (RSUP) DR. SARDJITO YOGYAKARTA TAHUN 1997-2001 Hanifah, Suci
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTDrug Utility Review for ARF’ patients of Internal Unit, Sardjito’s hospital was examed. Itinvolved 109 ARF’s patients. Medical Record Unit reported that this number was 0,12% of alldisese i.e. 93.445 case in 2001. The level was 93rdfrom 945 kind of disease. It was studied bynonanalitical descriptive design. using notes of Medical Record system. Collecting of data byretrospektive methode. This research was aimed to study the Drug Utility Review for ARF’spatients, especially to study ; drug variation included kind and class of drugs, route ofadministration, variation drug number, length of stay, and regimen dosage of drugs. To complete it,mortality persentaged was reported. The result of the study showed that ARF’s patients got somany variation of drugs. Using of antibiotic, diuretic, and electrolit was the most case. It conformedto Health Care Standard in Sardjito’s hospital. The others was aimed to simptomatical drugs i.e.antihypertensi, cardioasculer drugs, analgetic, antiemetic, multivitamin, laxan etc. It depended onsymptoms and complication of patients. Variation of number between 1-24. The average numberwas 7,7 drugs. It tended to use new generation of antibiotic and combinatins antibiotic, as indicatorof extravagant prescibing. Route of administratin by orally in most case and 38 % by injection.Injection route so indicate extravagant prescibing except on emergency care. The others used bysublingual and suppositoria. Length of stay averaged 12,52 days. Mortality persentaged was 22%.Key words : Drug Utility Review, ARF, Medical Record,Extravagant Prescribing
Ethylene Glycol Toxicity and Its Therapy Management: A Literature Review Kurniawan, Robi; Hanifah, Suci
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.81552

Abstract

Background: Ethylene glycol (EG) is an antifreeze substance commonly used as an additive for syrup preparations. One of the detrimental effects caused by EG toxicity is acute renal failure (ARF) and death, assuming therapy and management are delayed. Presently, there are limited studies on toxicity of EG and therapy. Therefore, this study aimed to provide an overview of EG toxicity levels, clinical manifestations, arising reactions, and therapy management methods.Objectives: A narrative review design was employed with data collected from PubMed and Google Scholar. The strategy used keywords such as “ethylene glycol toxicity” and "acute renal" with the assistance of Boolean operators including AND and OR.Methods: The result showed that the minimum EG level for toxicity was at 22 mg/dL, followed by metabolic acidosis with an increased anion gap (>10mmol/L). Based on case reports from one experimental study, the clinical manifestations of patients experiencing EG poisoning included decreased consciousness, tachycardia, and coma, with ARF occurring after 24-72 hours.Results: Write study findings in this section.Conclusion: EG poisoning could cause kidney damage in the form of ARF and lead to death, assuming therapy was delayed. Presently, the most effective therapy for EG poisoning was fomepizole.
The Study of Drug Storage Behavior in Indonesia: A Scoping Review: Studi Perilaku Penyimpanan Obat di Indonesia: Scoping Review Richard, Tricia Andini; Hanifah, Suci; Susanto, Yuliet
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 11 No. 2 (2025): October 2025
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2025.v11.i2.17817

Abstract

Background: Poor home drug storage techniques can worsen the issue of antibiotic resistance, lower therapeutic efficacy, and raise the risk of toxicity. The purpose of this study was to use a scoping review technique to map the knowledge, attitudes, and practices of Indonesians with regard to drug storage. Home drug storage practices may be affected by Indonesians’ knowledge, attitudes, and habits regarding the storage of household pharmaceuticals using a scoping review methodology.Methods: This study uses a scoping review methodology. The study reviewed scientific literature that was obtained from the Google Scholar database, PLOS ONE, PubMed, Indonesia One Search, by using “Boolean.” Of the 615 records, twenty-six met the inclusion requirements.Results: According to the report, most Indonesian families keep up to five types of medications in their homes. Such as antibiotics, antipyretics, antiplatelet medications, anti-hypertensive medications, cough suppressants, antihistamines, and pain relievers. Misunderstanding was also present. The improper disposal of expired medications poses not only a health issue but also a safety one. Additionally, national programs have improved people’s awareness. During the period, education programs significantly improved drug use competence and education.Conclusion: Many Indonesian houses continue to store drugs improperly. The drug management staff are working on preventing the community from storing drugs inappropriately. Increasing education and educational initiatives are required. Indonesian families continue to face many drug-related problems; more education and training, particularly safety and more effective in the community, medical personnel, suitable storage facilities, and educational initiatives are required.
KEAMANAN PENGGUNAAN OBAT PADA KEHAMILAN DI RUMAH SAKIT SWASTA YOGYAKARTA Sari, Chynthia Pradiftha; Hanifah, Suci; Febrianti, Yosi; Sari, Azmi Fahma; Dwirahmania, Pipit
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2485

Abstract

Pregnancy is a special physiological condition in which the use of medication is often unavoidable. However, the risks of teratogenicity and drug safety require careful evaluation to minimize risks to both mother and fetus. This study aims to evaluate the safety of drug use based on FDA (Food and Drug Administration) categories in pregnant inpatients at a private hospital in Yogyakarta. The study uses a descriptive observational method with a cross- sectional design, analyzing 141 inpatient medical records from 2022. The analyzed data includes patient demographics, diagnoses, drug safety, and dosages. Inclusion criteria were pregnant inpatients treated with or without pregnancy emergencies; exclusion criteria were patients giving birth or experiencing abortion. Descriptive results (using Microsoft Excel) showed most pregnant inpatients were aged 20-35 years (80.14%), hospitalized during the first trimester (49.65%), had no comorbidities (90.07%), no emergency pregnancy conditions (82.27%), and a length of stay under 4 days (72.34%). The most common diagnosis was hyperemesis gravidarum (41.84%), with predominant use of multivitamins (16.18%) and antiemetics (14.91%). The safety of drugs in inpatients was categorized as A (18.80%), B (34.34%), C (36.86%), D (2.26%), and N (6.77%), with appropriate dosage usage (96,30%). The study concludes that drug use was dominated by category C, and no use of category X drugs was found. The most used drugs were folic acid multivitamins and iron supplements for increasing blood levels.
Pengetahuan dan Sikap Ibu Hamil terhadap Swamedikasi: Analisis Faktor Demografi dan Riwayat Penyakit Kronis Sari, Chynthia Pradiftha; Hanifah, Suci; Sasnada, Nesya Abeliza
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 2 (2025): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i2.7961

Abstract

Swamedikasi pada wanita hamil memerlukan kehati-hatian karena dapat menimbulkan risiko bagi ibu maupun janin, sehingga pengetahuan dan sikap yang tepat sangat penting untuk memastikan keamanan penggunaan obat selama kehamilan. Penelitian bertujuan untuk mengetahui tingkat pengetahuan dan sikap wanita hamil terhadap swamedikasi di Kota Yogyakarta, serta faktor karakteristik yang berhubungan dengan keduanya. Desain penelitian dengan potong lintang pada 150 wanita hamil, menggunakan teknik accidental sampling. Pengambilan data menggunakan kuesioner terstruktur yang telah tervalidasi, dilakukan di RSKIA PKU Muhammadiyah Kotagede dan Klinik Puri Adisty Yogyakarta pada Maret–Mei 2024. Uji statistik menggunakan rank spearman (usia, usia kehamilan, pendidikan, pendapatan, dan jarak faskes) dan chi square (pekerjaan, riwayat penyakit kronis, jumlah kehamilan). Hasil menunjukkan mayoritas responden berusia 20–30 tahun (56%), trimester III kehamilan (53,33%), primigravida (54,67%), berpendidikan terakhir SMA/ sederajat (57,33%), tidak bekerja (64,67%), pendapatan keluarga >Rp3.000.000 (60%), jarak rumah ke faskes >2 km (54,67%), dan tidak memiliki penyakit kronis (77,33%). Responden memiliki tingkat pengetahuan tinggi (62,03%) dan sikap positif (84,81%) terhadap swamedikasi. Dapat disimpulkan bahwa wanita hamil di Kota Yogyakarta memiliki pengetahuan tinggi dan sikap positif terhadap swamedikasi, tidak ditemukan demografi yang berkorelasi dengan pengetahuan, namun sikap responden terbukti dipengaruhi secara signifikan oleh tingkat pendidikan (p=0,032) dan riwayat penyakit kronis (p=0,002). Self-medication during pregnancy requires caution due to potential risks to both the mother and fetus; therefore, appropriate knowledge and attitudes are crucial to ensure medication safety. This study aims to determine the level of knowledge and attitudes of pregnant women toward self-medication in Yogyakarta City, as well as to analyze the characteristic factors associated with them. This was a cross-sectional study involving 150 pregnant women selected using accidental sampling. Data collection was conducted using a validated structured questionnaire at RSKIA PKU Muhammadiyah Kotagede and Puri Adisty Clinic Yogyakarta from March to May 2024. Statistical analysis was performed using the Spearman Rank test (for age, gestational age, education, income, and distance to health facilities) and the Chi-Square test (for occupation, history of chronic disease, and number of pregnancies). The results showed that the majority of respondents were aged 20–30 years (56%), in the third trimester of pregnancy (53.33%), primigravida (54.67%), had a high school education or equivalent (57.33%), were unemployed (64.67%), had a family income >IDR 3,000,000 (60%), lived >2 km from health facilities (54.67%), and had no history of chronic disease (77.33%). Respondents demonstrated a high level of knowledge (62.03%) and a positive attitude (84.81%) toward self-medication. It can be concluded that pregnant women in Yogyakarta City possess high knowledge and positive attitudes toward self-medication. Although no demographic characteristics were found to correlate with knowledge, respondents attitudes were significantly influenced by education level (p=0.032) and history of chronic disease (p=0.002).
Co-Authors Abukres, Salem Albesht, Hanan Anisa, Yuni Arnia Megasari, Azza, Lintang Prava Chynthia Pradiftha Sari, Chynthia Pradiftha Dwirahmania, Pipit Febrian, M. Pandoman Fudholi, Dhomas Hatta Laksmy Anggun Larasati Lily Annisa, Lily Mafruhah, Okti Ratna Medisa, Dian Mutiara Herawati, Mutiara Mutmainah, Isti Nur Aini Mardea Rachman, Chintia Khairunnisa Richard, Tricia Andini Robi Kurniawan Rosdiana Rosdiana Rosdiana Rosdiana Saepudin Saepudin Sari, Azmi Fahma Sasnada, Nesya Abeliza Susi Ari Kristina Vitarani Dwi Ananda Ningrum Wachidah Rahmawati Wijayanti, Shofia Yosi Febrianti, Yosi Yuliet Yuliet Yuni Anisa