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All Journal Jurnal Ilmiah Farmasi JURNAL PHARMASCIENCE Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JOPS (Journal Of Pharmacy and Science) Majalah Farmasetika Borneo Journal Of Pharmascientech Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Global Pharma Technology Eduvest - Journal of Universal Studies Pharmacon: Jurnal Farmasi Indonesia ASEAN Journal for Science and Engineering in Materials
Suci Hanifah
Department Of Pharmacy, Universitas Islam Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences

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PENGGUNAAN OBAT GOLONGAN PROTON PUMP INHIBITTOR PADA PASIEN RAWAT INAP DI RUMAH SAKIT PKU MUHAMMADIYAH GAMPING YOGYAKARTA Sari, Chynthia Pradiftha; Rachman, Chintia Khairunnisa; Hanifah, Suci; Mutmainah, Isti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.575

Abstract

Proton pump inhibitor (PPI) is a drug with a good safety profile and effectiveness for patients with various conditions, so it is routinely prescribed around the world, one of them at PKU Muhammadiyah Gamping Yogyakarta. The aim of this study is to find out the profile of PPI drug use and the appropriate doses of the PPI group of drugs in hospitalized patients. This study is a descriptive observational study with a cross-sectional design. Data collection through secondary data is 200 patient medical records retrospectively. The results of the study showed the highest diagnosis of PPI drug use for gastro (60.50%) and non-gastro (39.50%). There are drugs that are given to patients at risk of gastrointestinal bleeding: NSAIDs (88.4%), glucocorticosteroids (8.97%), and anticoagulants (2.56%). The types of PPI used are pantoprazole injections 40 mg, lansoprazole tablets 30 mg, and lansoprazole injections 30 mg. The accurate dosage appropriate of PPI use is 100%.
Stability and beyond-use date of anesthetic agents used in surgical procedures: a review: Stability and Beyond-Use Data of Anesthesia Wijayanti, Shofia; Hanifah, Suci; Fudholi, Dhomas Hatta
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art4

Abstract

Background: Anaesthesia drugs are often divided into other syringes to be soluted or mixed with other medications to share with other patients for the sake of efficiency. Objectives: This study aims to know the stability of anesthetic agents and the compatibility with co-simultaneous drugs used. Methods: This review was conducted by searching literature through the following databases: PubMed, Science Direct, and Google Scholar. The keywords used in the search for articles were "stability," "beyond use date," "anesthetic drug," and "intravenous."Results: The data showed that mixing fentanyl with levo-bupivakain or epinefrin is relatively stable up to one month, but it decreases only for 72 hours in dextrose 5% or normal saline (NS). Pethidin can be mixed with acetaminophen and metoclopramide using dextrose, NS, or water and stored up to 24 hours. Midazolam diluted in dextrose 5% (D5) or mixed with other medications maintains stability for up to 14 days or more. Stability of ketamine is 24 hours longer whether it is mixed in solvent or acetaminophen. Mixing with propofol induces instability because of the emulsion form of propofol. Conclusion: In general, the anesthetic drugs of fentanyl, pethidine, midazolam, and ketamine are stable and safe for preparation and administration in more than 24 hours. These four medications are compatible with NS and D5 and all tested medications during 24 hours.
Effect of Levonorgestrel Implant on Lactation and Infant Growth: A Review: Review : Pengaruh Implan Levonorgestrel pada Laktasi dan Pertumbuhan Bayi Febrianti, Yosi; Hanifah, Suci; Febrian, M. Pandoman; Annisa, Lily; Azza, Lintang Prava; Mafruhah, Okti Ratna; Medisa, Dian; Sari, Chynthia Pradiftha
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.17045

Abstract

Background: Family Planning is a way to regulate the number of children born and the spacing of pregnancies through information, education, and the use of contraceptives. Postpartum contraception is important to obtain an optimal interpregnancy interval. Postpartum contraception should be initiated early; one of which is Long-Acting Reversible Contraception (LARC). Levonorgestrel can be used to prevent pregnancy because it interferes with ovulation, implantation, and fertilization. Objectives: This study aimed to assess the efficacy and effects of using levonorgestrel implants on breastfeeding and infant growth. Methods: Primary data were in the form of research papers obtained from PubMed®, and Google Scholar® published from the period 2010-2018. The keywords for the searches included: “levonorgestrel”, “levonorgestrel (LNG)-releasing implant”, “levonorgestrel on lactogenesis”, “levonorgestrel on infant growth”, and “levonorgestrel on breastfeeding”, which were used alone or in combination. Results: The 20 selected articles were reviewed based on five identified phrases. Levonorgestrel subdermal implants were shown to be a good choice for women who wanted effective contraception. When used by breastfeeding mothers, levonorgestrel subdermal implants affected neither infant growth (0-1 year of age) nor lactation duration. Conclusions: Levonorgestrel subdermal implants can be effective long-term contraception. These implants are safe for breastfeeding mothers and do not affect infant growth.
Nature of Precipitation Resulted from Intravenous Drugs Incompatibility Hanifah, Suci; Ball, Patrick A.; Kennedy, Ross A.
ASEAN Journal for Science and Engineering in Materials Vol 4, No 2 (2025): AJSEM: Volume 4, Issue 2, September 2025
Publisher : Bumi Publikasi Nusantara

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Abstract

In critical care, the co-administration of intravenous drugs often leads to physical incompatibilities, resulting in harmful precipitates. This study evaluated the nature of drug-induced precipitation in terms of size, shape, and quantity. Twelve drugs previously reported to be incompatible were tested with infusion fluids. Particle detection was conducted using an Olympus CX41 microscope with a 1 µm detection limit, enhanced by darkfield microscopy for better sensitivity. Particle size was analyzed using Feret’s diameter via the Optilab imaging system. Precipitates ranged from 5–150 µm, with smaller particles (<10 µm) seen in furosemide and subvisible particles (10–50 µm) in cefotaxime, chloramphenicol, and paracetamol. Visible particles were noted in acyclovir, ampicillin, meropenem, phenobarbital, and phenytoin. Most macro-precipitates were acicular, while micro-precipitates tended to be irregular. Particle counts ranged from 80 to 2,000 particles/mL. The findings highlight the clinical risk of particulate contamination due to drug incompatibilities, emphasizing the need for careful medication management.
Update on pharmacist role in sterile compounding in hospital Albesht, Hanan; Hanifah, Suci; Abukres, Salem
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art8

Abstract

Background: Sterile compounding, a critical aspect of pharmaceutical practice, involves the preparation of customized medications in a sterile environment. Pharmacists play a pivotal role in ensuring the safety and efficacy of compounded sterile products (CSPs), making their involvement integral to the healthcare system. Objective: This article aims to describe the role of pharmacists in sterile compounding based on literature. Method: Articles from Medline/PubMed, guidelines, reports, and databases related to sterile compounding have been searched and compiled. This review collected the qualitative data and identified the critical point for continuous quality improvement initiatives in sterile compounding.Results: This comprehensive narrative review explores the multifaceted responsibilities of pharmacists in sterile compounding, drawing insights from various studies and databases. However, the study related to the pharmacist's role in sterile compounding practices is very limited. Recent articles that mention the pharmacist's role in sterile compounding commonly come from the guidelines or government documents. In general, CSP needs a commitment to comply with regulatory standards for achieving patient safety using the integration of technology and healthcare collaboration. Continuous professional development is a crucial contributor to keeping the quality of compounded sterile products. Conclusion: The findings from various journals underscore the complexity of their responsibilities and emphasize the need for a holistic approach to ensure the integrity and safety of compounded sterile products in diverse healthcare settings.
Antibiotics in Children with Pneumonia: a Review Kurniasih, Fatimah Intan; Hanifah, Suci
Pharmacon: Jurnal Farmasi Indonesia Volume 22, No 1 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i1.8491

Abstract

Pneumonia is one of the most common infections in children; at the same time, it's also a case that consumes lots of days in hospitals with antibiotics. Essentially, antibiotics are medicines that specifically combat infection produced by bacteria, turning out to be some of the important discoveries in the entire history of medicine. This review aims to analyze the types of sensitive and resistant antibiotics in the management of pneumonia in children. Antibiotic resistance is one of the most dangerous health hazards facing the global community, which has grave consequences economically. The literature search in this study is adopted from both Google Scholar and PubMed. While on Pubmed, the keyword used includes "pneumonia", "antibiotics", "children", "PICU"; on Google Scholar, the word used is antibiotics, pneumonia, pediatric, and intensive care joined by using "AND" or "OR". The inclusion criteria in this literature search include published literature within less than 10 years, between 2014 and 2024; antibiotic articles on use scheme in the PICU; literatur of pneumonia in pediatric; and study review about bacterial type examinations. Thus, other articles were excluded that did not represent any empirical data regarding the study of antibiotics, or those that focused only on one kind of antibiotic sine the contextualization of its usage design. From the outcome of the review, the following bacteria types have been identified to be present in pneumonia patients: M. pneumoniae, Acinetobacter baumannii, Staphylococcus, Pseudomonas, and K. pneumoniae. Tetracycline and fluoroquinolone groups are effective choices of antibiotic classes. Mycoplasma pneumoniae, a common bacteria in pneumonia patients with CAP, is resistant to macrolides, leading to the recommendation of combination therapy or tetracycline antibiotics. Meropenem, widely used in VAP patients, is now limited and recommended for other types.
POLA PENGGUNAAN OBAT UNTUK PENDERITAGAGAL GINJAL AKUT DI INSTALASI RAWAT INAP RUMAH SAKIT UMUM PUSAT (RSUP) DR. SARDJITO YOGYAKARTA TAHUN 1997-2001 Hanifah, Suci
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTDrug Utility Review for ARF’ patients of Internal Unit, Sardjito’s hospital was examed. Itinvolved 109 ARF’s patients. Medical Record Unit reported that this number was 0,12% of alldisese i.e. 93.445 case in 2001. The level was 93rdfrom 945 kind of disease. It was studied bynonanalitical descriptive design. using notes of Medical Record system. Collecting of data byretrospektive methode. This research was aimed to study the Drug Utility Review for ARF’spatients, especially to study ; drug variation included kind and class of drugs, route ofadministration, variation drug number, length of stay, and regimen dosage of drugs. To complete it,mortality persentaged was reported. The result of the study showed that ARF’s patients got somany variation of drugs. Using of antibiotic, diuretic, and electrolit was the most case. It conformedto Health Care Standard in Sardjito’s hospital. The others was aimed to simptomatical drugs i.e.antihypertensi, cardioasculer drugs, analgetic, antiemetic, multivitamin, laxan etc. It depended onsymptoms and complication of patients. Variation of number between 1-24. The average numberwas 7,7 drugs. It tended to use new generation of antibiotic and combinatins antibiotic, as indicatorof extravagant prescibing. Route of administratin by orally in most case and 38 % by injection.Injection route so indicate extravagant prescibing except on emergency care. The others used bysublingual and suppositoria. Length of stay averaged 12,52 days. Mortality persentaged was 22%.Key words : Drug Utility Review, ARF, Medical Record,Extravagant Prescribing
Ethylene Glycol Toxicity and Its Therapy Management: A Literature Review Kurniawan, Robi; Hanifah, Suci
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.81552

Abstract

Background: Ethylene glycol (EG) is an antifreeze substance commonly used as an additive for syrup preparations. One of the detrimental effects caused by EG toxicity is acute renal failure (ARF) and death, assuming therapy and management are delayed. Presently, there are limited studies on toxicity of EG and therapy. Therefore, this study aimed to provide an overview of EG toxicity levels, clinical manifestations, arising reactions, and therapy management methods.Objectives: A narrative review design was employed with data collected from PubMed and Google Scholar. The strategy used keywords such as “ethylene glycol toxicity” and "acute renal" with the assistance of Boolean operators including AND and OR.Methods: The result showed that the minimum EG level for toxicity was at 22 mg/dL, followed by metabolic acidosis with an increased anion gap (>10mmol/L). Based on case reports from one experimental study, the clinical manifestations of patients experiencing EG poisoning included decreased consciousness, tachycardia, and coma, with ARF occurring after 24-72 hours.Results: Write study findings in this section.Conclusion: EG poisoning could cause kidney damage in the form of ARF and lead to death, assuming therapy was delayed. Presently, the most effective therapy for EG poisoning was fomepizole.
Profile of Oral Corticosteroid Use in Patients in Madiun City Pharmacies Anggani, Herninggar Aulia; Hanifah, Suci; Hermawatiningsih, Oktaviarika Dewi
Eduvest - Journal of Universal Studies Vol. 4 No. 9 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i9.6268

Abstract

Hyperglycemia induced by corticosteroid use depends on the dose, indication and setting of use. The type of corticosteroid that causes a greater degree of hyperglycemia is the use of Deksametasonor metilprednisolonrednisolone compared to prednisolone or hydrocortisone. High risk of hyperglycemia due to the use of oral corticosteroids, especially Deksametasonor metilprednisolonrednisolone. The aim of this study was to determine the profile of oral corticosteroid use in Madiun City pharmacies. This research is an observational study using retrospective data. Where data was obtained from profile data on the use of oral corticosteroids in one of the pharmacies in Madiun City. Then the data is analyzed, percentages are calculated and presented in the form of tables, graphs and diagrams. The results obtained were that the number of oral corticosteroids used in Madiun City pharmacies in 2022 was 44,270 tablets and increased in 2023, namely 50,680 tablets. Meanwhile, the type of oral corticosteroid that is widely used is metilprednisolonrednisone 4 mg, namely 13,090 tablets (29.57%) in 2022 and 14,950 tablets (29.50%) in 2023. The increase in the use of metilprednisolonrednisolone 4mg from 2022-2023 is 1,860 tablets . The conclusion of this research is that the use of oral corticosteroids in Madiun City pharmacies in 2022 and 2023 will increase and the most common type of corticosteroid is metilprednisolonrednisolone 4 mg.
The Study of Drug Storage Behavior in Indonesia: A Scoping Review: Studi Perilaku Penyimpanan Obat di Indonesia: Scoping Review Richard, Tricia Andini; Hanifah, Suci; Susanto, Yuliet
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 11 No. 2 (2025): October 2025
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2025.v11.i2.17817

Abstract

Background: Poor home drug storage techniques can worsen the issue of antibiotic resistance, lower therapeutic efficacy, and raise the risk of toxicity. The purpose of this study was to use a scoping review technique to map the knowledge, attitudes, and practices of Indonesians with regard to drug storage. Home drug storage practices may be affected by Indonesians’ knowledge, attitudes, and habits regarding the storage of household pharmaceuticals using a scoping review methodology.Methods: This study uses a scoping review methodology. The study reviewed scientific literature that was obtained from the Google Scholar database, PLOS ONE, PubMed, Indonesia One Search, by using “Boolean.” Of the 615 records, twenty-six met the inclusion requirements.Results: According to the report, most Indonesian families keep up to five types of medications in their homes. Such as antibiotics, antipyretics, antiplatelet medications, anti-hypertensive medications, cough suppressants, antihistamines, and pain relievers. Misunderstanding was also present. The improper disposal of expired medications poses not only a health issue but also a safety one. Additionally, national programs have improved people’s awareness. During the period, education programs significantly improved drug use competence and education.Conclusion: Many Indonesian houses continue to store drugs improperly. The drug management staff are working on preventing the community from storing drugs inappropriately. Increasing education and educational initiatives are required. Indonesian families continue to face many drug-related problems; more education and training, particularly safety and more effective in the community, medical personnel, suitable storage facilities, and educational initiatives are required.
Co-Authors Abukres, Salem Albesht, Hanan Anggani, Herninggar Aulia Anisa, Yuni Arnia Megasari, Azza, Lintang Prava Ball, Patrick A. Chynthia Pradiftha Sari, Chynthia Pradiftha Dwirahmania, Pipit Febrian, M. Pandoman Fudholi, Dhomas Hatta Hermawatiningsih, Oktaviarika Dewi Kennedy, Ross A. Khoiriyah, Umatul Kurniasih, Fatimah Intan Laksmy Anggun Larasati Lily Annisa, Lily Mafruhah, Okti Ratna Medisa, Dian Mutiara Herawati, Mutiara Mutmainah, Isti Nur Aini Mardea Pratiwi, Martania Rachman, Chintia Khairunnisa Richard, Tricia Andini Robi Kurniawan Rosdiana Rosdiana Rosdiana Rosdiana Saepudin Saepudin Sari, Azmi Fahma Susi Ari Kristina Vitarani Dwi Ananda Ningrum Wachidah Rahmawati Wijayanti, Shofia Yosi Febrianti, Yosi Yuliet Yuliet Yuni Anisa