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All Journal Majalah Kesehatan FKUB PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Farmasi Komunitas Jurnal Kefarmasian Indonesia
Adeltrudis Adelsa Danimayostu, Adeltrudis Adelsa
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Formulation and Antioxidant Evaluation of Anti-Aging Moisturizer Containing Peperomia pellucida Extract Loaded Nanostructured Lipid Carrier Maulita, Silvia; Devianti, Siti; Laila, Nur; Hailiyah, Dini Siva; Sukmawati, Dian Ayu; Danimayostu, Adeltrudis Adelsa; Adianingsih, Oktavia Rahayu
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 2, JULY-DECEMBER 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Peperomia pellucida, commonly known as Chinese betel, contains antioxidants and anti-inflammatory compounds, which are potential candidates for active ingredients in anti-aging topical moisturizer formulations. However, its low lipid solubility requires a modified delivery system, such as nanostructured lipid carriers (NLC). This study aimed to determine the optimum lipid concentration and lipid phase ratio for NLC formulation, evaluate the anti-aging potential of Peperomia pellucida extract-loaded NLC, and assess the characteristics of the NLC-based moisturizer. NLC was prepared using the high shear homogenization method and then characterized for its physical properties. Antioxidant activity was evaluated using the DPPH method, while the stability of the moisturizer was assessed through a six-cycle storage cycling test. NLC F1, containing 5% total lipid with a solid-to-liquid lipid ratio of 3:2, had the smallest particle size among all formulations and was selected as the optimal formula. The antioxidant test of NLC F1 revealed a spheroidal morphology, confirmed by TEM, and an IC50 value of 113.45 ppm, indicating moderate antioxidant activity. When incorporated into a moisturizer, the formulation maintained stable organoleptic properties, homogeneity, pH, spreadability, and adhesiveness over six test cycles, despite a decrease in viscosity. The optimized lipid composition produced a stable NLC-based moisturizer loaded with Peperomia pellucida extract, showing moderate antioxidant activity and favorable physicochemical characteristics, supporting its potential as an anti-aging cosmeceutical product.
Co-Authors Almiahsari, Ashri ANISYAH ACHMAD Anugrah Elfa Yudita, Anugrah Elfa Asyiqin, Melfin Fakhrul Ayuk Lawuningtyas Hariadini Dahlia Permatasari, Dahlia Devianti, Siti Dini, Martina Hailiyah, Dini Siva Irsani, Intaha Kimiko Hikari Zuhria, Kimiko Hikari Leny Budhi Harti Lukitasari, Widya Maulana, Sulung Rival Isom Maulita, Silvia Moch Rijal Hadi, Moch Rijal Ni Luh Indah Puspayani, Ni Luh Indah NUR LAILA Oktavia Eka Puspita, Oktavia Eka Oktavia Rahayu Adianingsih Putra, Juanda Riztama Rahmi Nurdiani Siti Jazimah Iswarin Sukmawati, Dian Ayu