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ANALISIS KADAR PARASETAMOL GENERIK DIBANDINGKAN BERMEREK DAGANG Mariyani; Patala, Recky; Awilia, Nurkhaliza
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 1 (2023): Vol. 7 No. 1, September Tahun 2023
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i1.1483

Abstract

Paracetamol is a substance that can reduce the fever (antipyretic) and relieve the pain (analgesic). Analysis of the levels of generic and branded paracetamol tablets was carried out to determine whether the levels of the active substance in the preparations met the requirements or not by using the High Performance Liquid Chromatography method. The paracetamol quantitative test obtained the results of the levels in sample A = 94.306%, sample B = 99.986%, sample C = 95.296% and sample D = 94.904%. These results indicate that the level of the active substance paracetamol in each sample still meets the requirements of the Indonesian Pharmacopoeia Edition IV, namely not less than 90% and not more than 110%. Statistical analysis using the t-student test, the results of t-count < t-table (0.026 < 2.35) at a significant level of 5%, with the conclusion that there is no significant difference between generic paracetamol and branded paracetamol were analyzed using High Performance Liquid ChromatographyIV, namely not less than 90% and not more than 110%. Statistical analysis using the t-student test, the results of t-count < t-table (0.026 < 2.35) at a significant level of 5%, with the conclusion that there is no significant difference between generic paracetamol and branded paracetamol were analyzed using High Performance Liquid Chromatography.
Peningkatan Pengetahuan Masyarakat Terkait Bahaya Penggunaan Kortikosteroid yang Tidak Rasional Budiawan, Erick; M, Mariyani; Lagaga, Adidtya Prasetia
Jurnal Malikussaleh Mengabdi Vol 2, No 1 (2023): Jurnal Malikussaleh Mengabdi, April 2023
Publisher : LPPM Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jmm.v2i1.10674

Abstract

Kortikosteroid merupakan salah satu golongan obat keras yang hanya bisa didaptkan dengan resep dokter. Masalah yang sering muncul dimasyarakat terkait dengan steroid hingga saat ini adalah masarakat sering mendapatkan serta mengkonsumsi kortikosteroid secara bebas tanpa memiliki pengetahuan yang cukupo tentang cara penggunaan obat-obat steroid yang rasional. Jika tidak digunakan secara rasional, obat-obat steroid dapat menyebabkan efek yang sangat merugikan, apalagi dalam penggunaan jangka panjang. Kegiatan pengabdian kepada masyarakat ini dilaksanakan di Desa Lampo, Kec. Banawa Tengah, Kab. Donggala, Sulawesi Tengah. Pelaksanaan kegiatan Pengabdian Kepada Masyarakat ini dilakukan dalam bentuk pemberian edukasi berupa pemberian materi serta diskusi tanya jawab terkait bahaya pengguaan steroid yang tidak rasional. untuk mengukur tingkat pengetahuan masyarakat terkait materi yang diberikan dilakukan pembagian kuisioner yang wajib diisi oleh peserta sebelum pemberian materi (pre-test) dan setelah pemberian materi (pre-test). Berdasarkan hasil yang didapatkan terlihat bahwa terjadi peningkatan pengetahuan masyarakat terkait dampak penggunaan steroid yang tidak rasional.
Analysis Pork Contamination in Beef Meatballs through Polymerase Chain Reaction in Palu City Tresya J. Polibaon; Mariyani; Joni Tandi; Tien Wahyu Handayani; Rahmawati Salsa Dinurrosifa; Ikhsan Hi. Amir Sene
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.9006

Abstract

The need for halal products is essential, particularly among various processed beef products like meatballs, which are popular among nearly the entire community. These products are susceptible to issues of meat counterfeiting for greater economic gain. This study aims to determine the smallest DNA concentration that can still be detected and to assess whether there is any pork contamination in meatballs circulating in Palu City using Polymerase Chain Reaction (PCR). This test uses four DNA samples obtained from fresh meat to test the specificity of the primer: wild boar, rat, and goat DNA samples as comparisons, and pig DNA as a positive control. The presence of DNA bands in the agarose gel electrophoresis visualization results indicates that DNA amplification has occurred, meaning that the sample can be detected. The analysis results showed that the primer used (Cyt-b) had good specificity for detecting pork DNA, while the absolute pork DNA concentration of 0.01 ng/µL and the reference meatball DNA with a concentration of 0.01% are the smallest limits that can still be detected using PCR. Of the four meatball samples from Palu City, one sample produced a DNA band, indicating that the sample contains or is contaminated with pig DNA. This method is valid as it meets the specificity test and demonstrates a good detection limit.