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All Journal Disease Prevention and Public Health Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik Journal of Innovation in Community Empowerment (JICE) Jurnal Farmasi Sains dan Praktis Jurnal Farmasi SYIFA Journal of Pharmaceutical (JOP) Antigen: Jurnal Kesehatan Masyarakat dan Ilmu Gizi Journal of Health Research and Technology Indonesian Journal of Pharmacology and Therapy
Titami, Arina
Universitas Jenderal Achmad Yani Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences

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PRINCIPLES OF DOSE ADJUSTMENT IN PATIENTS WITH CHRONIC KIDNEY FAILURE Mende, Juniarto; Kartikawati, Nurfina Dian; Titami, Arina; Mahmuda, Hartati
Jurnal Farmasi Sains dan Praktis Vol 11 No 2 (May-August 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i2.9687

Abstract

Chronic renal disease is a kidney illness marked by a progressive decline in kidney function over months or years. The usage of medications in this condition is a crucial aspect of managing kidney disease patients. When done correctly, pharmacotherapy can halt disease development and minimize morbidity and mortality. In patients with kidney illness, decreasing kidney function can drastically change the pharmacokinetics and pharmacodynamics of many medications, increase the risk of drug toxicity if not well treat. Many of these changes must be expected and mitigated by changing the medicine dosage. Complications of chronic kidney disease (CKD) that go untreated can cause significant early morbidity and mortality, as well as aggravate its progression. This literature review is based on a review of the literature and articles related to CKD to determine the principles of dose adjustment in CKD patients. Classification of drugs in CKD patients includes antifungals, anticoagulants, antidiabetics, antihypertensives, antibiotics, and analgesics. The administration of these drugs should be considered for kidney function in CKD patients. The presence of multidisciplinary interventions reduces the risk of progression of CKD severity. Adjustment of the dosage regimen in CKD patients is carried out for certain drugs that have a significant relationship between drug concentration and clinical outcomes in patients.
Drug-related problems (DRPs) on antibiotic therapy in pediatric patients: a review Titami, Arina; Mende, Juniarto; Nurfina Dian K.
Indonesian Journal of Pharmacology and Therapy Vol 3 No 2 (2022)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.2692

Abstract

Drug-related problems (DRPs) is event that can interfere with the outcome of therapy. It can occur in various patient populations and ages. The DRPs in pediatric patients is found to be significantly frequent due to their vulnerable features. Many factors such as age, weight, body surface area should be considered during drug therapy in pediatric patients. The organs development continues for many years and the organs responsible for drug metabolism and elimination have not yet full capacity in pediatric patients. Antibiotics are often prescribed to pediatric patients. Several studies concerning DRPs on antibiotic therapy have been conducted in some countries. This review summarizes types, factors and impacts to the occurrence of DRPs on antibiotic therapy in pediatric patients.
Co-Authors Afrizal Wahyu Darma Syahyeri Chairun Wiedyaningsih Doni saputra Doni Saputra I Dewa Putu Pramantara Juniarto Mende Kartikawati, Nurfina Dian Mahmuda, Hartati Novela, Silvia Nadia Novia Ariani Dewi Nurfina Dian K. Nurfina Dian K. Pratama, I Dewa Putu Pujilestari, Mardiana Sugiyono T. N. Saifullah Sulaiman Widane, Made Yuni Andriani