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All Journal Science and Technology Indonesia Jurnal SOLMA Jurnal Ilmu Kefarmasian Indonesia Makara Journal of Science Bulletin of Chemical Reaction Engineering & Catalysis Indonesian Journal of Material Research
Najma Annuria Fithri, Najma Annuria
Department of Pharmacy, Faculty of Mathematic and Natural Sciences, Sriwijaya University, Kampus UNSRI Indralaya, Jl. Palembang Prabumulih Km 32 Ogan Ilir 30662, South Sumatera
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Other

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Green-Modified Ni/Al LDH with Camellia sinensis Bioactives: A Sustainable Strategy for Ceftriaxone Removal Amri, Amri; Fithri, Najma Annuria; Said, Muhammad; Lesbani, Aldes
Bulletin of Chemical Reaction Engineering & Catalysis 2026: BCREC Volume 21 Issue 1 Year 2026 (April 2026)
Publisher : Masyarakat Katalis Indonesia - Indonesian Catalyst Society (MKICS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.9767/bcrec.20513

Abstract

Ceftriaxone (CEF) is a β-lactam antibiotic widely used in the medical field to treat various bacterial infections in both humans and animals. The high usage of CEF has the potential to cause environmental pollution and antimicrobial resistance, necessitating effective treatment methods. In this study, the adsorption method is proposed using Ni/Al layered double hydroxide (LDH) and Camellia sinensis extract-modified material (Ni/Al-CSe) as a sustainable bio-modification approach. The results show the optimal adsorption pH for Ni/Al LDH is 3 and for Ni/Al-CSe is 5, with the adsorption isotherms following the Freundlich model and the kinetics conforming to pseudo-first order (PFO). The maximum adsorption capacity (Qm) significantly increased from 28.818 mg.g-1 (Ni/Al LDH) to 111.111 mg.g-1 (Ni/Al-CSe). Thermodynamic analysis revealed that adsorption on both materials proceeds spontaneously, while the consistently more negative ΔG values and predominantly exothermic behavior of Ni/Al-CSe confirm its superior thermodynamic favorability associated with more specific surface interactions. Regeneration tests up to four cycles showed that Ni/Al-CSe was more stable than Ni/Al LDH. Overall, modifying Ni/Al LDH with Camellia sinensis extract was proven to enhance adsorption capacity, spontaneity, and stability, providing an effective and environmentally friendly solution for antibiotic treatment. Copyright © 2026 by Authors, Published by BCREC Publishing Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).
Ethanolic extract of Parkia speciosa Hassk leaves innovation of gastroretentive tablet: standardization and optimization Nurfitriyana, Nurfitriyana; Fitriya, Fitriya; Fithri, Najma Annuria; Putri, Dwi Kurnia; Lestari, Siti Marwah; Waluyo, Dyah Ayuwati; Syarif, Hardiyanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1461

Abstract

Parkia speciosa ethanol leaves extract contains flavonoid, tannin, and terpen as ulcus peptic remedy. These compounds exhibit limited activity in the stomach due to the short gastric residence time following oral administration. The formulation of gastroretentive tablets can overcome this limitation. This research aims to control the prolonged release of drugs in the stomach to increase bioavailability and characterize the ethanol leaves extract. Extraction was carried out by maceration using ethanol, followed by standardization based on specific and non-specific parameters extract. Gastroretentive tablet was formulated with combination of HPMC-K4M and chitosan using factorial design 22. Effects of compositional factors and their interactions on gastroretentive tablet was observed on hardness, friability, floating lag/duration time, swelling index, and mucoadhesive time. Results standardization extract showed that extract met the required criteria for both specific parameters (organoleptic properties and phytochemical screening) and non-specific parameters (moisture content, loss on drying, water/ethanol-soluble extract content). Based on with DX®10 analysis, the optimum formulation was achieved with 20.25% of HPMC-K4M and 10.26% of chitosan. The analysis of the optimum formulation characteristics was as follows: friability (0.22%), hardness (29.53 N), mucoadhesive time (22.86 hours), floating lag/duration time (27.54 minutes; 12 hours), and swelling index (312.82%). Result revealed that gastroretentive tablets formulated with ethanol extract of Parkia speciosa leaves improve gastric residence duration and promote better bioavailability.
Cogon Grass Mesoporous Silica Nanoparticles Loaded with Uncaria gambir Extract and Photosensitizer for Photothermal Induced Anti-MRSA Activity: Formula Optimization and In Silico Exploration Mardiyanto; Sabrina, Tia; Alhafizh, M. Faris; Kota, Natacha Brigida; Ramadhona, Sheza Inayah; Valenia, Novella; Amrullah, M. Ammar; Zulda, Daghfal Rafataqwa; Marrisca, R.D. Nindi; Alisyahbana, Sutan Satya; Fadilah, Ade; Pratiwi, Aisyah; Fithri, Najma Annuria
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.311-322

Abstract

In recent years antimicrobial resistance (AMR) has grown to become a massive concern for the global community due to their lack of successful prevention and low recovery rates. One of methods with high efficiency in reducing AMR is photodynamic and photothermal therapy (PDPT), due to their independency from chemical mechanism of antimicrobial efficacy. Mesoporous silica nanoparticle (MSN) is an excellent carrier for potential alternative for AMR including photosensitizers and natural based active ingredients. Herein, we explored the use of various sources as silica precursors as well as optimization based on method of fabrication and coating agent to stabilize and load the active ingredients. We additionally incorporated Uncaria gambir extract and phycocyanin to increase MSN antimicrobial effect and photosensitizing ability. Cogon grass-based MSN (CG-MSN) has yet to be explored extensively and in this research, we compared their characteristics to a more established precursors such as tetraethyl orthosilicate (TEOS) and sodium silicate. Based on the results obtained, cogon grass-based precursors produced the highest yield, with entrapment efficiency of Uncaria gambir and phycocyanin as high as 98%. Furthermore, CG-MSN produced one of the highest photothermal increase and adsorption rate comparable to that of TEOS. From in silico exploration Uncaria gambir contained Gambiriin and Roxburghin as two of the most active phytoconstituents that influenced its antimicrobial activity. Based on this research we were able to synthesize a new precursor of silica from natural based product, cogon grass, and incorporate it as carrier for phytocompounds in the management of AMR.
Edukasi Daun Jambu Air sebagai Penanggulangan Penyakit Sindrom Metabolik di Desa Burai, Ogan Ilir Fithri, Najma Annuria; Mulyani, Laida Neti; Sabrina, Tia; Humairoh, Siti; Akram, M.; Marrisca, Rumiyati Dwi Nindi; Ikhsana, Nadya Ramadhani
Jurnal SOLMA Vol. 15 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v15i1.20811

Abstract

Background: Desa Burai, Kecamatan Tanjung Batu, Kabupaten Ogan Ilir adalah kawasan wisata dengan produksi pertanian yang beragam, diantaranya adalah tanaman jambu air. Daun jambu air merupakan salah satu bahan alam yang memiliki sifat antioksidan tinggi, namun pemanfaatannya masih tergolong sedikit. Pengabdian ini bertujuan untuk meningkatkan pemanfaatan daun jambu air sebagai alternatif pengobatan sindrom metabolik. Metode: Upaya pencegahan ini dapat dilakukan secara tradisional menggunakan daun jambu air yang jarang dimanfaatkan dengan mengembangkannya menjadi teh dan saturasi untuk mendorong diversifikasi pemanfaatan tanaman herbal dan mengurangi efek samping yang ditimbulkan oleh penggunaan medikasi sintetik. Edukasi dan pelatihan dilakukan dengan metode pemberdayaan melalui pembinaan, pendampingan, dan pelatihan keterampilan membuat produk kaya antioksidan. Hasil: Dari hasil proses pembuatan teh, produk yang dihasilkan memiliki rasa yang tidak pahit, yang menandakan produk teh dan saturasi dapat dibuat dengan baik. Proses pendampingan masyarakat dalam pelatihan menunjukkan hasil yang positif berdasarkan nilai post test yang dilakukan setelah pelatihan. Kesimpulan: Masyarakat Desa Burai mampu menangkap pelatihan yang diberikan dan dapat menjelaskan manfaat minuman teh dan saturasi daun jambu air sebagai penanggulangan sindrom metabolik.
Co-Authors Aisyah Pratiwi, Aisyah Akram, M. Aldes Lesbani Alhafiz, Muhammad Faris Alhafizh, M. Faris Alisyahbana, Sutan Satya Amri Amri Amrullah, M. Ammar Annisa, Novilia Megi Azzahra, Farah Daffa Budi Untari Dwi Kurnia Putri Dwi Kurnia Putri Dyah Ayuwati Waluyo Fadilah, Ade Fitriya, Fitriya Fitrya . Ikhsana, Nadya Ramadhani Jefri Jefri Kota, Natacha Brigida Kurniawan, Gilang Maharani, Nabila Puan Mardiyanto Mardiyanto Mardiyanto Mardiyanto, Marrisca, R.D. Nindi Marrisca, Rumiyati Dwi Nindi Mawaddah, Zahrul MUHAMMAD SAID Mulyani, Laida Neti Nurfitriyana Nurfitriyana Rahmah, Asfaraeni Ramadhan, Navinda Ramadhona, Sheza Inayah Risfidian Mohadi Sabrina, Tia Satrio, Fakhri D. Shaum Shiyan Siti Humairoh, Siti Siti Marwah Lestari Sofia Sandi SUMIATI, Syarif, Hardiyanti Valenia, Novella Zulda, Daghfal Rafataqwa