Article Per Year (5 Year)
p-Index From 2021 - 2026
1.497
P-Index
This Author published in this journals
All Journal Science and Technology Indonesia Jurnal Ilmu Kefarmasian Indonesia Makara Journal of Science Bulletin of Chemical Reaction Engineering & Catalysis Indonesian Journal of Material Research
Najma Annuria Fithri, Najma Annuria
Department of Pharmacy, Faculty of Mathematic and Natural Sciences, Sriwijaya University, Kampus UNSRI Indralaya, Jl. Palembang Prabumulih Km 32 Ogan Ilir 30662, South Sumatera
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Cogon Grass Mesoporous Silica Nanoparticles Loaded with Uncaria gambir Extract and Photosensitizer for Photothermal Induced Anti-MRSA Activity: Formula Optimization and In Silico Exploration Mardiyanto; Sabrina, Tia; Alhafizh, M. Faris; Kota, Natacha Brigida; Ramadhona, Sheza Inayah; Valenia, Novella; Amrullah, M. Ammar; Zulda, Daghfal Rafataqwa; Marrisca, R.D. Nindi; Alisyahbana, Sutan Satya; Fadilah, Ade; Pratiwi, Aisyah; Fithri, Najma Annuria
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.311-322

Abstract

In recent years antimicrobial resistance (AMR) has grown to become a massive concern for the global community due to their lack of successful prevention and low recovery rates. One of methods with high efficiency in reducing AMR is photodynamic and photothermal therapy (PDPT), due to their independency from chemical mechanism of antimicrobial efficacy. Mesoporous silica nanoparticle (MSN) is an excellent carrier for potential alternative for AMR including photosensitizers and natural based active ingredients. Herein, we explored the use of various sources as silica precursors as well as optimization based on method of fabrication and coating agent to stabilize and load the active ingredients. We additionally incorporated Uncaria gambir extract and phycocyanin to increase MSN antimicrobial effect and photosensitizing ability. Cogon grass-based MSN (CG-MSN) has yet to be explored extensively and in this research, we compared their characteristics to a more established precursors such as tetraethyl orthosilicate (TEOS) and sodium silicate. Based on the results obtained, cogon grass-based precursors produced the highest yield, with entrapment efficiency of Uncaria gambir and phycocyanin as high as 98%. Furthermore, CG-MSN produced one of the highest photothermal increase and adsorption rate comparable to that of TEOS. From in silico exploration Uncaria gambir contained Gambiriin and Roxburghin as two of the most active phytoconstituents that influenced its antimicrobial activity. Based on this research we were able to synthesize a new precursor of silica from natural based product, cogon grass, and incorporate it as carrier for phytocompounds in the management of AMR.
Co-Authors Aisyah Pratiwi, Aisyah Aldes Lesbani Alhafiz, Muhammad Faris Alhafizh, M. Faris Alisyahbana, Sutan Satya Amrullah, M. Ammar Annisa, Novilia Megi Azzahra, Farah Daffa Budi Untari Dwi Kurnia Putri Dyah Ayuwati Waluyo Fadilah, Ade Fitriya, Fitriya Fitrya . Jefri Jefri Kota, Natacha Brigida Kurniawan, Gilang Maharani, Nabila Puan Mardiyanto Mardiyanto Mardiyanto Mardiyanto, Marrisca, R.D. Nindi Mawaddah, Zahrul Mulyani, Laida Neti Nurfitriyana Nurfitriyana Rahmah, Asfaraeni Ramadhan, Navinda Ramadhona, Sheza Inayah Risfidian Mohadi Sabrina, Tia Satrio, Fakhri D. Shaum Shiyan Siti Marwah Lestari Sofia Sandi SUMIATI, Syarif, Hardiyanti Valenia, Novella Zulda, Daghfal Rafataqwa