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All Journal JFIOnline Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Jurnal Kefarmasian Indonesia
Joshita Djajadisastra, Joshita
Faculty of Pharmacy, Universitas Indonesia
Chemistry Health Professions Medicine & Pharmacology

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Uji Aktivitas Antioksidan dan Penghambatan Tirosinase serta Uji Manfaat Gel Ekstrak Kulit Batang Taya (Nauclea subdita) terhadap Kulit Charissa, Meiliana; Djajadisastra, Joshita; Elya, Berna
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2924

Abstract

Dayak women in Borneo treat their skin with natural ingredients, one of which is taya cortex (Nauclea subdita). Flavonoids that can be found in natural ingredients have antioxidant effect and can inhibit the activity of tyrosinase in melanogenesis process. The research objectives were to measure the antioxidant activity and the inhibition of tyrosinase of taya cortex extract, to obtain a stable formulation of taya cortex extract gel, and to determine the safety and efficacy on human skin. The method used for antioxidant activity test was DPPH method. The inhibition of tyrosinase was conducted with kojic acid as control. The safety and efficacy test were conducted to healthy women ages 35-50 with healthy and normal skin. The results show IC50 value of 568.58 µg/mL in L-tyrosine and 1374.69 µg/mL in L-DOPA for inhibiton of tyrosinase. Antioxidant activity assay of the extract shows IC50 value of 48.78 µg/mL and can be categorized as a powerful antioxidant (
Formulasi dan Uji Penetrasi Sediaan Gel Transfersom yang Mengandung Kojyl 3 Amino Propil Fosfat sebagai Pencerah Kulit Andini, Septia; Jufri, Mahdi; Djajadisastra, Joshita
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2948

Abstract

Kojyl 3 APPA is a compound used for skin lightening. Kojyl 3 APPA has a good solubility in water. This causes the hydrophilic nature kojyl 3 APPA difficult to penetrate through the skin. Transfersom is a carrier system that can improve the effectiveness of drug penetration. This study aims to formulate, characterize and evaluate transfersom preparations containing kojyl 3 APPA. Further more transfersom formulated in a gel formulation. Preparation gel was tested its physical stability and in vitro penetration test against non transfersom kojyl 3 APPA. Transfersom gel formulation is physically proven stable at room temperature, low temperature and high temperature storage. In vitro penetration tests showed that kojyl 3 APPA penetration loaded in transfersom gel was 11,16% while for non transfersom gel 8,02%
Potensi Ekstrak Biji Coklat (Theobroma cacao Linn) sebagai Inhibitor Tirosinase untuk Produk Pencerah Kulit Kurniasari, Aprilia; Anwar, Effionora; Djajadisastra, Joshita
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 1, FEBRUARI 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i1.3723

Abstract

Hyperpigmentation is a condition of excessive skin pigments production. The skin colour is strongly influenced by the presence of melanin that marked by the melanin tyrosinase enzyme activity. Cocoa (Theobroma cacao Linn) is one of the ingredients which are rich in flavonoids include polyphenolic compounds that used as antioxidants and a tyrosinase inhibitor. The aim of this study is to examine the potential of the cocoa bean extract as a tyrosinase inhibitor for skin lightening active ingredients. The method of the study was experimental laboratories, among others: total flavonoid and tyrosinase inhibitory activity assay. The result of this research was ethanol extract of cocoa had tyrosinase inhibitor activity. The inhibitory activity could be seen from the IC50 for monophenolase activity were 352.05 μg mL-1 and for diphenolase activity 836.20 μg mL-1 respectively. This value is greater than kojic acid, for monophenolation was 2.38 μg mL-1 and diphenolation was 10.74 μg mL-1. The total flavonoids content was 0.05% w/w so that the ethanol extract of the cocoa bean is a natural product that potential to be used in the formulation of skin lightening cream in the pharmaceutical sciences.
Co-Authors Abdul Munim Adilla Novitasari, Adilla Anton Bahtiar Ariestanti, Donna Maretta Arry Yanuar Berna Elya Bevina D Handari Charissa, Meiliana Christye Aulia, Christye Denny Riama Silaban Effionora Anwar Elfrida Ratnawati Etik Mardliyati, Etik Fadhila, Redhalfi Hasan Rahmat, Hasan Hutami, Riska Amalia Putri Ilma Nugrahani Indah, Rosari James, Richard Johari Juheini Amin Kurniasari, Aprilia Ledy Maya, Ledy Mahdi Jufri MARIA BINTANG Mun'im, Abdul Munâ??im, Abdul Mun’im, Abdul Ninin Kartika Juwita, Ninin Kartika NP, Dessy NP, Dessy Nurzaman, Fulka Octaviarini Hidayah, Octaviarini Septia Andini Sugindro, Sugindro Sutriyo Sutriyo, Sutriyo Zuraida Syafara Dzuhro, Zuraida Syafara