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Journal : PAMERI : Pattimura Medical Review

UJI AKTIVITAS ANTIOKSIDAN ALGA COKELAT Saragassum sp. DENGAN METODE 1,1- DIFENIL-2-PIKRIHIDRASIL (DPPH) Anugrah P.M.D. Kamoda; Maria Nindatu; Indrawanti Kusadhiani; Eka Astuty; Halidah Rahawarin; Elpira Asmin
PAMERI Vol 3 No 1 (2021)
Publisher : Fakultas Kedokteran Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.698 KB) | DOI: 10.30598/pamerivol3issue1page60-72

Abstract

Antioxidants are chemical compounds that are naturally present in the human body, which can donate hydrogen atoms to free radicals, resulting in chain reactions and converting free radicals into stable forms. Based on the source, antioxidants can be divided into 2 namely natural antioxidants and synthetic antioxidants that can overcome the formation of free radicals. One of the natural ingredients that can overcome the formation of free radicals is the brown algae Sargassum sp. The purpose of this study was to test antioxidant activity using the 1,1-Diphenyl-2-Pikrihydrasil (DPPH) method. This research is a type of experimental laboratory research. The research methodology included and prepared ingredients, extract preparation, and antioxidant activity testing using the DPPH method. Data analysis in this study was carried out by calculating the percent (%) of activity obtained from the absorbance of the data from each concentration. After obtaining the percent (%) antioxidant activity data for each absorbance sample, the IC50 value is calculated using a non-linear regression equation by substituting y = ax + b which states the relationship between log concentration and percent (%) antioxidant activity (inhibition). The results showed 50% concentration inhibition (IC50) of brown algae Sargassum sp. is 5,864. So it can be conclude that the algae Sargassum sp. has a very active antioxidant activity.
HUBUNGAN RASIO KOLESTEROL TOTAL TERHADAP HIGH DENSITY LIPOPROTEIN DENGAN KEJADIAN SINDROM KORONER AKUT DI RSUD DR. M. HAULUSSY AMBON TAHUN 2018-2019 Nurul H D J F Ahmad; Irwan Irwan; Eka Astuty; Zulkarnain Zulkarnain; Indrawanti Kusadhiani; Is Ikhsan Hataul
PAMERI Vol 3 No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.811 KB) | DOI: 10.30598/pamerivol3issue2page43-62

Abstract

Cardiovascular disease is one of the leading causes of death in the world. The primary cause of death in cardiovascular disease around the worldis acute coronary syndrome (ACS). Based on data from the World Health Organization (WHO) in 2015, cardiovascular disease causes 17.5 million deaths or about 31% of all deaths globally, and due to acute coronary syndrome is 7.4 million. This disease is estimated to reach 23.3 million deathsby 2030. ACS is an emergency heart disease that occurs due to rupture or erosion of the atherosclerotic plaque in the coronary arteries. The ratio of total cholesterol to high density lipoprotein (HDL) cholesterol or also known as the Cardiac Risk Ratio is a comparative number that can be used to detect the risk of developing ACS.The purpose of this study was to determine the relationship between the ratio of total cholesterol to high density lipoprotein and the incidence of ACS in RSUD dr. M. Haulussy Ambon in 2018-2019. This research was an observational analytic study with a cross sectional design. Using total sampling method there were 80 peoples included to the sample. The instrument used was medical record data. Datas were analyzed using the SPSS application with the chi square test. Theresult showed p=0,032 (p<0,05). Based on the data analysis, there wassignificant relationship between theratio of total cholesterol to high density lipoprotein (HDL) and the incidenceof acute coronary syndrome in RSUD dr.M. Haulussy Ambon in 2018-2019