This study examines the critical role of business characteristics in addressing the complexity of global challenges. The main objective is to identify and analyze key business characteristics that enhance resilience and adaptability in the face of international markets, technological advancements, and socio-political changes. Using a literature review method approach, this study seeks to further examine the critical role of business characteristics in addressing the complexity of its global challenges. The results of the analysis indicate that businesses that emphasize innovation, strategic planning errors, and strong stakeholder engagement are better equipped to manage global business. In addition, this study highlights the importance of cultural competence and sustainability practices as critical factors contributing to long-term success. These insights provide valuable guidance for businesses seeking to strengthen their competitive advantage and resilience in an increasingly connected world.