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All Journal Jurnal Sain Veteriner International Journal of Integrated Health Sciences Jurnal Kebijakan Kesehatan Indonesia Althea Medical Journal Indonesian Journal of Cancer Chemoprevention Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Pengabdian Pada Masyarakat Jurnal Gizi Klinik Indonesia Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Veterinary Biomedical and Clinical Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan
Eko Fuji Ariyanto
Department Of Biomedical Sciences, Research Center For Medical Genetics, Faculty Of Medicine, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary Other

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Effect of Citronella (Cymbopogon nardus) Aromatherapy Inhalation on Hematology Profile in Mice (Mus musculus) Shafa Azizah; Eko Fuji Ariyanto; Khairani, Shafia
Veterinary Biomedical and Clinical Journal Vol. 7 No. 1 (2025): Vol. 7 No. 1 2025
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2025.007.01.2

Abstract

Citronella (Cymbopogon nardus) is a widely distributed herbal plant throughout Indonesia, known for its aromatic essential oils that possess various biological properties such as antimicrobial, anti-inflammatory, and insect-repellent effects. Despite its widespread traditional use, limited studies have evaluated the systemic safety profile of citronella essential oil when administered via inhalation, especially its impact on hematological parameters, which are critical indicators of physiological and immune status. This study aimed to investigate the effects of inhaled citronella essential oil on the hematological profile of Swiss webster mice to assess its potential hematotoxicity and systemic safety. Citronella essential oil was extracted using steam-water distillation and characterized through phytochemical screening. Mice were divided into five groups: a negative control, a positive control treated with Diazepam (0.012 mg/kg), and three treatment groups exposed to citronella essential oil vapor for 30 minutes (P1), 60 minutes (P2), and 90 minutes (P3). Each dose consisted of 500 µL of essential oil diluted 1:1 with pyrogen-free water, corresponding approximately to 445 mg of essential oil per administration, with an estimated concentration of about 44.5% w/v based on typical oil density. Hematological parameters, including red and white blood cell counts, hemoglobin concentration, hematocrit, and platelet levels, were analyzed using the Kruskal-Walli’s test. The results showed no statistically significant differences between the citronella-exposed groups and controls, indicating that inhalation exposure at the given dose and duration did not induce hematological toxicity or adverse systemic effects. These findings suggest that citronella essential oil, when administered by inhalation under the tested conditions, is safe in Swiss webster mice and supports its continued use in aromatherapy and related applications. Further studies are recommended to explore long-term effects and other physiological parameters.
UPAYA PENINGKATAN KESADARAN MASYARAKAT TERHADAP PENTINGNYA IMUNISASI DI DESA IBUN, KECAMATAN IBUN, KABUPATEN BANDUNG, JAWA BARAT Ariyanto, Eko Fuji; Oktavia, Nandina; Refilianty, Alia; Damayanti, Erly Puji; Danil, Abdan Syakura
DHARMAKARYA: Jurnal Aplikasi Ipteks untuk Masyarakat Vol 14, No 1 (2025): Dharmakarya
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v14i1.41790

Abstract

Bulan Imunisasi Anak Nasional (BIAN) adalah upaya Kementerian Kesehatan RI untuk memperkecil kesenjangan imunitas kesehatan di masyarakat akibat dampak dari pandemi COVID-19 yang menyebabkan gangguan rantai pasokan vaksin, adanya aturan pembatasan kegiatan, jumlah tenaga kesehatan yang terbatas, dan membuat orang tua/wali asuh enggan ke fasilitas kesehatan karena khawatir tertular COVID-19. Berdasarkan data Kementerian Kesehatan, terdapat 1,7 juta anak Indonesia yang belum mendapatkan imunisasi dasar lengkap selama pandemi COVID-19. Hal ini akan berdampak pada peningkatan risiko penyakit-penyakit berbahaya pada anak akibat rendahnya imunisasi pasca pandemi COVID-19. Kegiatan Kuliah Kerja Nyata (KKN) Tematik Kesehatan telah dilaksanakan secara hybrid (bauran daring dan luring) dengan sasaran masyarakat di Desa Ibun, Kecamatan Ibun, Kabupaten Bandung, Provinsi Jawa Barat selama satu bulan, yaitu pada tanggal 4-31 Juli 2022. Pemilihan Desa Ibun sebagai tempat pelaksanaan KKN tematik kesehatan didasari pada rendahnya angka cakupan dasar imunisasi di desa tersebut. Pelaksanaan kegiatan dilakukan melalui beberapa program kerja berupa sosialisasi terkait BIAN secara luring (penyuluhan di posyandu, aula kantor desa, sekolah, dan kunjungan rumah) dan daring (melalui grup WhatsApp). Hasil yang dicapai dari keseluruhan program adalah meningkatnya kesadaran masyarakat tentang pentingnya imunisasi anak kepada orang tua, khususnya ibu, dan cara mengelola media sosial dengan bijaksana, khususnya siswa sekolah menengah. Dalam pelaksanaan program kerja tersebut, didapatkan respon yang positif dari aparat desa dan masyarakat setempat.
Machine Learning Based QSAR Model for Screening PPAR-gamma Stimulator Nirwana, Edwin; Nugraha, Gaga Irawan; Ariyanto, Eko Fuji; Sanjaya, Ardo
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.46916

Abstract

Type-2 diabetes (DM2) is still growing into a global problem. Decreased insulin sensitivity is the main mechanism causing DM2. PPAR-gamma has been shown to have a direct relationship with insulin sensitivity. This study aimed to develop a machine-learning model to evaluate phytochemical compounds’ activity as a PPAR-gamma agonist. The dataset used for modeling was procured from the ChEMBL database. A total of 3668 substances were retained after null and duplicate values were removed. Canonical SMILES were collected and described to generate an extended connectivity fingerprint, which was then used to predict the pEC50 value. The machine learning-generated model was then used to predict 2846 phytochemical compounds from the KEGG database. This study uses the Light gradient-based machine learning method. The performance of the model was evaluated using Root Mean Square Error (RMSE) and R-square (R2) of 0.63 and 0.73, respectively. Afterward, the model was used to predict phytochemical compounds. Five compounds with the lowest EC50 were obtained: Pedilstatin (60.05 nM), Gnididin (64.29 nM), Paclitaxel (98.93 nM), Vincristine (113.9 nM), and Camellidin II (129.72 nM). Further research regarding the direct effect of PPAR-gamma needs to be tested on these five compounds. Machine learning models will save time and resources for drug discovery or repurposing previously used drugs.
Rasio lingkar pinggang pinggul dan rasio lingkar pinggang tinggi badan pada penderita hipertensi Damayanti, Luthfiyah; Nugraha, Gaga Irawan; Ariyanto, Eko Fuji; Inayati, Iis; Ghozali, Mohammad; Fatimah, Siti Nur
Jurnal Gizi Klinik Indonesia Vol 21, No 4 (2025): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.99149

Abstract

Waist-hip ratio (WHR) and waist-height ratio (WHtR) in hypertension patientsBackground: Hypertension is a health problem characterized by systolic blood pressure ≥140 mmHg and/or diastolic pressure ≥90 mmHg. One risk factor for hypertension is central obesity, which can be indicated by the Waist-Hip Ratio (WHR) and Waist-Height Ratio (WHtR). Objective: This study aimed to determine WHR and WHtR in hypertensive patients. Methods: This research is a descriptive observational study with a cross-sectional approach, cross-tabulation, and Spearman analysis using secondary data in the form of hypertension patient data from the cardiometabolic working group study from January 2022 to July 2023 in Cibeber Village, which includes data on systolic and diastolic blood pressure, waist circumference, hip circumference, and body height. Consecutive sampling was used to obtain 173 subjects aged 46-65 years, comprising 116 women and 57 men. Results: Stage 1 hypertension was the most common category (38.7%). The average WHR is 0.90 (men) and 0.89 (women), while the average WHtR is 0.54 (men) and 0.59 (women). There are 134 subjects (77,5%) with high WHR and 147 subjects (85%) with high WHtR. The higher WHR and WHtR category was more frequently found in subjects with stage I hypertension. Conclusions: WHR and WHtR values above the cut-off are more common in subjects with hypertension.
Generating Paclitaxel-Resistant in Cervical Cancer HeLa Cell Line Bashari, Muhammad Hasan; Damara, Fachreza Aryo; Hardani, Isna Nisrina; Pradini, Gita Widya; Putri, Tenny; Ariyanto, Eko Fuji
Indonesian Journal of Cancer Chemoprevention Vol 11, No 2 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss2pp90-96

Abstract

Cervical cancer is one of the most leading causes of women death. Currently, paclitaxel is still one of the main therapeutic regimens for cervical cancer patients. However, some patients developed to be paclitaxel-resistant. Hence, studies to find out the novel strategies to resolve this problem are important. Generating resistant cancer cell lines can be utilized as the potent tool to evaluate the efficacy of any therapeutic agent toward cancer drug-resistant problems. Current studies describing the methods to establish chemoresistance are lacking. Moreover, study in Indonesia conducting chemoresistance in cell line is limited. This study was aimed to elaborate the characteristics of HeLa cells during generation of paclitaxel-resistant cervical cancer cells. The parental HeLa cells were exposed to an escalating concentration of paclitaxel for a long time period. Subsequently, cells were divided into two groups for the evaluation of resistance characteristics. The values of inhibitory concentration 50 (IC50) and inhibitory concentration 90 (IC90) were analyzed using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay. Our data showed that the longer exposing periods of paclitaxel, the higher IC50 and IC90 values of HeLa cells are. IC90 of paclitaxel in HeLa Pac RB was increased from 69 pM, 440 pM, 2,561 pM and 10,337 pM on 0th, 1st, 2nd, 3rd and 4th months, respectively. Interestingly, the resistant cells were recovered to be paclitaxel-sensitive when they were not being continuously exposed to paclitaxel. In addition, the paclitaxel resistant cells become less sensitive against 5-FU but not doxorubicin, cisplatin and etoposide. We were able to generate cervical cancer HeLa paclitaxel-resistant cell line. These cell line could potentially be utilized for further studies in order to understand the molecular mechanisms of drug resistance in cervical cancer and as a tool for cancer drug discovery.Keywords: cervical cancer, drug resistant cell line, paclitaxel resistant cells, stepwise escalating concentration.
Co-Authors Abdullah Firmansah Wargahadibrata Achadiyani Anisha Salmah Azhar Ardo Sanjaya Aziiz Mardanarian Rosdianto Bashari, Muhammad Hasan Bianda Putri Ramadhani Damara, Fachreza Aryo Damayanti, Erly Puji Damayanti, Luthfiyah Danil, Abdan Syakura Dany Muhammad Daffa David Firmansyah Dewi Marhaeni Diah Herawati Diza Raudya Tuzzahra Dwi Wahyudha Wira Fahmi Zacki Mubarak Fauzia Rahma Cahyani Gaga Irawan Nugraha Gita Widya Pradini Hardani, Isna Nisrina IIS HERAWATI Inayati, Iis Iqbal Anugrah Fitriyanto Khairani, Shafia Kurnia Wahyudi Lauditta Nurseptia Prihandhini Mohammad Ghozali Mohammad Ghozali, Mohammad Muhammad Abian Muhammad Hasan Bashari Muhammad Nurhalim Shahib Muhammad Raihan Ramdhan Nandina Oktavia Nikla Sekar Salsabila Nirwana, Edwin Nur Ramadani Meliani Syukri Nurjanah Sriyanti Nurul Qomarilla Putri Halleyana Rahman Putri, Tenny Refilianty, Alia Rima Destya Triatin Rizkiani Tri Ramdani Septiyani Septiyani Shafa Azizah Siti Nur Fatimah Sri Betha Putri Tenny Putri Yuni Susanti Pratiwi Yuni Susanti Pratiwi