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All Journal snimed Jurnal Ilmiah Farmasi Media Penelitian dan Pengembangan Kesehatan Journal of Educational, Health and Community Psychology Disease Prevention and Public Health Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Kedokteran Sari Pediatri Universa Medicina Jurnal Ilmu Kefarmasian Indonesia Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Refleksi Pembelajaran Inovatif Jurnal Aisyah : Jurnal Ilmu Kesehatan Automata JK Unila (Jurnal Kedokteran Universitas Lampung) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Media Penelitian dan Pengembangan Kesehatan Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Ika Fidianingsih
Departemen Histologi, Fakultas Kedokteran, Universitas Islam Indonesia, Yogyakarta
Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Universa Medicina

 1 
Intermittent fasting decreases oxidative stress parameters in Wistar rats (Rattus norvegicus) Nurmasitoh, Titis; Utami, Shindy Yudha; Kusumawardani, Endah; Najmuddin, Abdulhalim Ahmad; Fidianingsih, Ika
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.31-38

Abstract

BackgroundChronic and degenerative diseases are closely related to modern lifestyles that tend to be deficient in physical activity but excessive in food intake. One method used to overcome this problem is dietary restriction through intermittent fasting. Intermittent fasting decreases the risk of chronic and degenerative diseases, e.g. by lowering oxidative stress. Oxidative stress can be determined from the malondialdehyde (MDA) levels and lipid profile in the blood. The present study aimed to determine the effect of intermittent fasting on plasma MDA levels and lipid profile of Wistar rats (Rattus norvegicus).MethodsThis research was a laboratory experimental research using a post test control group design. Twenty four male Wistar rats (Rattus norvegicus) were randomly assigned to 4 groups, ie control group (C), fasting group (F), non-fasting obese group (NFO), and fasting obese group (FO). Fasting treatment given in this research was intermittent fasting, comprising one day of fasting for 12 hours alternating with one day of normal feed ad libitum in the span of 8 weeks. After completion of treatment, blood was taken transcardially for examination of MDA levels and lipid profiles using spectrophotometry.ResultsThere were significant between-group differences in MDA levels and lipid profiles (p<0.05 for all parameters). Groups treated with intermittent fasting had lower levels of MDA, total cholesterol, triglycerides, and ow-density lipoprotein (LDL) than those without intermittent fasting. The high-density lipoprotein (HDL) levels were higher in the intermittent fasting group than the other groups.ConclusionIntermittent fasting has an effect on the oxidative stress parameters of Wistar rats (Rattus norvegicus).
Age-related changes of malondialdehyde, body weight and organ weight in male mice Ahsani, Dwi Nur; Fidianingsih, Ika
Universa Medicina Vol 37, No 2 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.115-126

Abstract

IntroductionAging is characterized by gradual impairment in all physiological functions. Increases in free radicals and changes in organ morphology occur with aging. The purpose of this study was to determine age-related changes in serum free radicals, body weight, organ weights, and relative organ weights in male mice. MethodsAn experimental animal study was performed on 25 male mice (Mus musculus), which were randomized into 5 groups according to age at termination, i.e. 12 (group K1), 24 (K2), 32 (K3), 40 (K4) and 48 weeks (K5), respectively. Retro-orbital venous blood was taken for examination of malondialdehyde (MDA) levels. After termination, liver, heart, kidneys, testes, brain, thymus and spleen were weighed using an analytical balance. ANOVA and Kruskal Wallis tests were used to analyze the data, with p<0.05 being considered significant. ResultsSignificant changes were found with age in serum MDA level (p=0.000), body weight (p=0.000), and weights of all organs except thymus (p>0.05) (liver p=0.023, heart p=0.000, kidneys p=0.002, testes p=0.000, brain p=0.012 and spleen p=0.006). Significant changes in relative weight of brain (p=0.001) and spleen (p=0.049) were also found with age. ConclusionThis study demonstrated increases in serum MDA levels, body weight, and weights of the liver, heart, kidneys, testes, brain and spleen with age. Peak increases in weights of kidneys and thymus were found earlier than those in MDA levels and weights of other organs.
Mild anxiety and depression related to elevated dopamine level Fidianingsih, Ika; Nurmasitoh, Titis; Arjana, Adika Zhulhi; Devita, Ninda; Khoiriyah, Umatul
Universa Medicina Vol 38, No 1 (2019)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (788.451 KB) | DOI: 10.18051/UnivMed.2019.v38.48-55

Abstract

BackgroundDopamine is an important neurotransmitter that plays a role in the pathogenesis of anxiety and depression. Dopamine secretion occurs when there is a pleasurable stimulus. Blood dopamine levels have the potential to be developed as biomarkers of depression or anxiety, but previous studies related to the relationship between dopamine levels and levels of anxiety and depression are still controversial. The purpose of this study was to determine the correlation between anxiety and depression score with dopamine level in young adults. MethodsThis was an observational cross sectional study. A total of 43 subjects aged 18 to 40 years were recruited by consecutive non-random sampling according to inclusion and exclusion criteria. Anxiety and depression were assessed using the Beck anxiety inventory and Beck depression inventory-II questionnaire. Dopamine plasma level was measured using the enzyme-linked immunosorbent assay (ELISA). The Spearman rho correlation test was used to analyze the data and p<0.05 was considered significant.Results The median dopamine levels in respondents with mild, moderate and severe anxiety were respectively: 77.79; 63.43; 62.51 ng/mL (p=0.043). The median dopamine levels in respondents with reasonable depression, mood disorder, moderate and severe depression were respectively: 79.2; 61,32; 62,51; 60.24 (p=0.001). Correlation test results showed a weak correlation between dopamine and anxiety (r=- 0.310) and a moderate correlation for depression (r=-0.505).ConclusionMild anxiety and depression were associated with elevated dopamine level in young adults. Further studies are required to confirm the role of dopamine metabolism in anxiety and depression in young adults.
Annona muricata aqueous extract suppresses T47D breast cancer cell proliferation Ika Fidianingsih; Ety Sari Handayani
Universa Medicina Vol. 33 No. 1 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.19-26

Abstract

BackgroundCancer is a dreadful disease caused by abnormal and uncontrolled cell division. Annona muricata L, also known as soursop, is useful as an anticancer herbal medication since its leaves, seeds and fruits contain active compounds called annonaceous acetogenins. The objective of this study was to scientifically justify the traditional application of soursop for anticancer treatment in the community, by comparing the antiproliferative effect of Annona muricata L leaf, seed and fruit aqueous extracts on T47D breast cancer cells. Methods     This study used an experimental post test trial with control group design. Infusions of soursop leaves, seeds, and fruits collected from Kaliurang, Sleman district, Yogyakarta were used for cytotoxicity tests on T47D cells, in comparison with tamoxifen as standard cancer therapy. Proliferative inhibition was determined by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide [MTT] assay. The parameter of proliferative inhibition was IC50 which is defined as 50% proliferative inhibition ability of soursop and tamoxifen. Significant differences between groups were determined at p<0.05 by Kruskal-Wallis test. ResultsThe leaves, fruits, and seeds Annona muricata and tamoxifen were proven to be able to inhibit T47D cell proliferation. The IC50 of Annona muricata leaf, seed, fruit aqueous extracts and tamoxifen were 31,384.21 µg/ml; 1.528,800 µg/ml; 329,194.81 µg/ml and 114.52 µg/ml, respectively (p=0.016). The IC50 of Annona muricata aqueous extract was significantly different from that of tamoxifen.ConclusionsThe proliferative inhibition of soursop leaves against T47D breast cancer cells is higher than that of soursop fruits and seeds. Annona muricata fruit, seed, and leaf aqueous extracts were less toxic than tamoxifen
Wound healing activity of topical Phaleria macrocarpa extract in type 2 diabetic rats Sulistyoningrum, Evy; Rosmelia, Rosmelia; Fidianingsih, Ika; Narantika, Shindy Galuh; Cleopatra, Neysa Nurprahutri; Azzahra, Fathimah
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.136-147

Abstract

BackgroundHyperglycemia interrupts wound healing, causing persistent and non-healing wounds. Phaleria macrocarpa extract (PME) has anti-diabetic, anti-inflammatory, antimicrobial, and antioxidant properties. This study aimed to assess P. macrocarpa activity on skin wound healing in diabetic rats. MethodsAn experimental study performed on 25 male Wistar rats. Ointments were prepared by adding vehicle (w/w) to PME at the desired concentration. Diabetes was induced by injecting rats with nicotinamide (NAD) 230 mg/kg and streptozotocin (STZ) 65 mg/kg. After hyperglycemia was confirmed, animals were randomly grouped into: i) normal rats, ii) diabetic rats; iii) diabetic rats + 2.5% ointment; iv) diabetic rats +5% ointment; and v) diabetic rats +10% ointment. Full-thickness skin wounds were induced on the dorsum and treatment was applied daily for 3 and 7 days, respectively. On days 4 and 8, wound closure was measured and animals were sacrificed for tissue samples. Wound healing was evaluated by measuring malondialdehyde (MDA) in tissue homogenates of the dermal wounds and analyzing histological changes by hematoxylin-eosin and Sirius-red staining. ResultsPME 10% ointment improved MDA levels and wound closure of inflammatory and proliferation phases. In inflammatory phase, 5% and 10% ointment reduced inflammation severity compared with diabetic rat group (p<0.05). In proliferation phase, PME 10% ointment group had a higher wound histological score (characterized by epidermal regeneration, fibroblast count, granulation tissue, and angiogenesis), and higher collagen bundle density compared with untreated groups (p<0.05).  ConclusionsTopical P. macrocarpa improves inflammatory and proliferation phases of excision wound healing in type 2 diabetes.
Co-Authors Absari, Nurmala Widya Adeniar Yusnina Adika Zhulhi Arjana Afiqoh, Ainun Nur Alissa Anna Safira Arif Reynaldi Alifiansyah Azzahra, Fathimah Camelia Herdini Cleopatra, Neysa Nurprahutri Dadik Subiyanto Dewajani Purnomosari Dodi Faras Ilmiawan Sutomo Dwi Nur Ahsani Dwi Nur Ahsani Eddy Supriyadi Ety Sari Handayani Evy Sulistyoningrum Fairuz, Ratna Amalia Fles, Renske Fuad Khadafianto Indrasari, SR Ismaiyah Ismaiyah Izzati Muhimmah Kharisma, Muhammad Khoiriyah, Umatul Kusumawardani, Endah Mohamad Rizki Adi Prasetyo Najmuddin, Abdulhalim Ahmad Narantika, Shindy Galuh Naufal Abdurrahman Nazarudin, Zohan Ninda Devita, Ninda Nurmasitoh, Titis Qoit Muhammad Abdul Ghalib Raisha Amini Rosmawati, Ima Dewi Rosmelia Rosmelia Tan, I. Bing Threeyana Ariyati Kadi Utami, Shindy Yudha Wijaya, Diani Puspa Yudha Prasetyo Utomo Zainuri Sabta Nugraha