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All Journal bionature As-syifaa Jurnal Farmasi Borneo Journal Of Pharmascientech Jurnal Kesehatan Tambusai Journal Microbiology Science Journal of Pharmaceutical and Sciences. Jurnal Novem Medika Farmasi Jurnal Pengabdian Farmasi dan Sains MPSJ
Rachmat Kosman, Rachmat
Universitas Muslim Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kayu Jawa (Lannea coromandelica (Houtt.) Merr.) Terhadap Bakteri Penyebab Infeksi Saluran Pencernaan Dengan Metode Difusi Agar Rabbana, Rahmawati; Kosman, Rachmat; Nuryanti, Siska
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 2 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i2.41

Abstract

The purpose of this research was to determine the antibacterial activity of the ethanol extract of Javanwood leaves Lannea coromandelica (Houtt.) Merr.) against bacteria that cause digestive tract infections. The research method begins with the extraction process using the maceration method with 96% ethanol solvent and evaporated using a rotary evaporator. Java wood leaf ethanol extract was subjected to screening tests with a concentration of 0.1%; 0.5%; and 1% against the test bacteria Eschericia coli, Salmonella typhi, Shigella dysenteriae and Vibrio cholerae. MIC and MBC tests were carried out and continued with antibacterial activity tests using the agar diffusion method with variations in concentrations of 0.5%; 1%; 2%; 4%; 8%; and 16%. The results of the screening test for Escherichia coli and Shigella dysenteriae bacteria at 0.5%. MIC values for Escherichia coli bacteria at 0.125% and Shigella dysenteriae bacteria at 2%. While the MBC value for Escherichia coli bacteria is at 0.5% and Shigella dysenteriae bacteria at 2%. The results of testing the antibacterial activity of the ethanol extract of Javanwood leaves against Escherichia coli and Shigella dysenteriae bacteria had the largest diameter of the inhibition zone at a concentration of 16%, respectively 17.10 mm; and 13.56 mm which is included in the criteria of having strong inhibition. Based on the results of the ethanol extract of Javanwood leaves, it has potential as an antibacterial.
AKTIVITAS ANTIBAKTERI FRAKSINASI EKSTRAK DAUN ASAM JAWA (Tamarindus indica L.) (Tamarindus indica L.) TERHADAP BAKTERI Salmonella thyphi DAN Escherichia coli DENGAN METODE KLT-BIOAUTOGRAFI Rusli, Rusli; Faradila, Aulia; Kosman, Rachmat
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.87

Abstract

Tropical infectious diseases are often caused by viruses, bacteria, fungi or even parasites. Indonesian people use medical plants to treats diseases. One of them is tamarind leaves which have the ability as an antibacterial. The purpose of this study was to determine the antibacterial activity of the fractionated extract of tamarind leaves (Tamarindus indica L.) against Salmonella thyphi and Escherichia coli. Tamarind leaf simplicial was extracted using the maceration method and evaporated with a rotary evaporator to obtain thick extract. Then fractionated using n-hexane and ethyl acetate and evaporated again with a rotary evaporator. After that, ethyl acetate fraction of tamarind leaves (Tamarindus indica L.) was used for antibacterial screening test with a concentration of 0,1% and 0,5%. Then, the TLC-Bioautography test was carried out and followed by the identification of chemical components. The results of the screening test of the ethyl acetate fraction of tamarind leaves (Tamarindus indica L.) showed antibacterial activity against Salmonella thyphi and Escherichia coli. TLC-Bioautography test result showed that it was active on Salmonella thyphi and Escherichia coli with an Rf value of 0,81. Then the results of the identification of the chemical component of the ethyl acetate fraction of tamarind leaves (Tamarindus indica L.) were positive for alkaloid and taninns. Based on this study, tamarind leaves have the potential as an antibacterial.
UJI AKTIVITAS ANTIBAKTERI FUNGI ENDOFIT PADA DAUN SENGGANI (Melastoma malabathricum L.) ASAL LAMPARA MONCONGLOE TERHADAP BAKTERI PENYEBAB INFEKSI SALURAN PENCERNAAN Hamdani, Nina; Kosman, Rachmat; Rusli, Rusli
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.91

Abstract

Senggani leaf (Melastoma malabathricum L.) is a plant that has antibacterial activity. The purpose of this study was to determine the isolate of the endophytic fungus senggani leaves (Melastoma malabathricum L.) which has antibacterial activity against digestive tract bacteria using the TLC-Bioautography method. The results of this study showed two isolates of senggani leaf endophytic fungi (Melastoma malabathricum L.). IFDS 6 obtained spots with Rf value = 0.58 for Eschericia coli bacteria, Rf value 0.67 for Vibrio cholerae, Salmonella typhi and Shigella dysentriae bacteria. Meanwhile, IFDS 8 obtained spots with an Rf value 0.78 on the bacteria Eschericia coli, Vibrio cholerae, Salmonella typhi, and Shigella dysentriae
POTENSI AKTIVITAS ANTIBAKTERI FUNGI ENDOFIT DAUN PARANG ROMANG (Boehmeria virgata) (G.Forst.) Guill TERHADAP BAKTERI UJI MICROCOCCUS LUTEUS DAN BACILLUS SUBTILIS SECARA KLT-BIOAUTOGRAFI FITRIANI, SITTI ANNISA; Kosman, Rachmat; Rusli, Rusli
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 4 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i4.299

Abstract

Parang romang (Boehmeria virgata (G.Forst) Guill) is a plant used to treat various infectious diseases, one of which is the digestive tract. Antibacterials are compounds that can inhibit or kill bacteria that cause infection. Endophytic fungi produce bioactive compounds in the form of antioxidants, anticancer, antiviral, antifungal and so on. This research uses the TLC-Bioatography method. The research started with the isolation of endophytic fungi and antagonist tests, which obtained active isolates against the test bacteria Micrococcus luteus and Bacillus subtilis, namely IFBV-6. Then this isolate was fermented and continued with testing using the TLC-Bioautography method. The resulting fermentate was dissolved in chloroform:methanol (5:1) solvent. Test results from TLC-Bioautography of IFBV-6 fermentate showed Rf values ​​of 0.9, 0.81 and 0.58. In the case of Micrococcus luteus and bacillus subtilis bacteria, good Rf values ​​from TLC show that there is quite good separation, ranging from 0.2-0.8, indicating clear antibacterial activity. In this test, each fermentation code has the same Rf value and number of spots. The results of identifying the chemical components of endophytic fungal isolates from parang romang leaves of Boehmeria virgata (G.Forst) Guill) gave positive results using alkaloid and saponin spotting.
Co-Authors Achmad Rosyadi Yusuf Hibai, Achmad Rosyadi Yusuf Adrias, Cici Rahmayanti Amalia.B, Putri Andi Maulana Kamri Aulia Wati, Aulia Azhary, Nursyahidah Basri, Putri Septiani Bayu Putra, Bayu Faradila, Aulia Febrilia Mahmud, Melly Fitriana FITRIANI, SITTI ANNISA Hamdani, Nina Hamsinah Hamsinah, Hamsinah Hativa, Hativa Herwin Herwin, Herwin Ika Indra Wijaya, Ika Indra Ira Damayanti, Ira Irma Santi, Irma Iskandar , A. Nasyrah Jamaluddin Jamaluddin Junaedi, Fhadillah Kurniati Tappang, Kurniati Melinda, Pina Muhammad Amin Muzakkir Baits, Muzakkir Nur Ismayani, Nur Nurfadila Nurfadila, Nurfadila Nurmaya Effendi Nurul Inayah Nurung, Ayyub Harly Pirman AP, Pirman Putra , Bayu R. Rusli Rabbana, Rahmawati Rahmadani, Andi Syafirah Rahman, Safriana Rahmawati, Rahmawati Ramadhani, Fitrah Anggun Riany Novianti Y., Riany Rizqi Nur Azizah Rusli Safriani Rahman, Safriani Sahide, Rusli Sari, Dewi Mustika Sari, Erwika Dwika Siska Nuryanti, Siska Sitti Amirah Sri Wahyuni Sudrianto Sudrianto, Sudrianto Sukmawati Sukmawati Sukmawati Syarif, Sukmawati Wirawan, Alif Yusra Zainal Abidin