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All Journal Communications in Science and Technology Jurnal Ilmu Alam dan Lingkungan Biosaintifika: Journal of Biology & Biology Education Jurnal Sylva Scienteae Jurnal Sylva Lestari
Prayogo, Yanico Hadi
Department Of Forest Products, IPB University, Bogor 16680, Indonesia; Tropical Biopharmaca Research Center, IPB University, Bogor 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Energy Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Veterinary

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Anti-Termite Activity of Melia azedarach Extracts Yanico Hadi Prayogo; Romi Irka Putra; Izza Firdausi Hadiyanto; Evie Nihayah; Wasrin Syafii; Rita Kartika Sari; Irmanida Batubara
Jurnal Sylva Lestari Vol. 10 No. 1 (2022): January
Publisher : Department of Forestry, Faculty of Agriculture, University of Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jsl.v10i1.549

Abstract

Natural preservatives have been widely considered as non-synthetic materials that can prevent the biodegradation of wood due to subterranean termite attacks, namely Coptotermes curvignathus. Melia azedarach is a fast-growing species that has been widely studied for its antifeedant compounds and shows good potential to be developed as a biopesticide, especially as an anti-termite. This study aimed to identify the termicide and antifeedant properties of the wood, leaves, and bark extracts of Melia azedarach against subterranean termites and identify their bioactive compounds. The acetone extract from the three parts of the tree was fractionated. The most active fractions were selected from each part based on the percentage of termite mortality and antifeedant activity and analyzed for its bioactive compounds by pyrolysis GCMS. The ethyl acetate fraction of Melia azedarach bark exhibited strong toxic properties compared to other fractions. In the leaf section, the diethyl ether fraction showed the best termite repellent (antifeedant) properties. The anti-termite properties influenced phenolic compounds and organic acid that dominated the bark ethyl acetate fraction and leaf diethyl ether fraction. These findings show the great potential of bioactive compounds from biomaterials to be developed as a promising biopesticide. Keywords: anti-termite, bioactive compound, Melia azedarach, natural preservative
Exploration of Mango Fruits (Mangifera indica) as α-Glucosidase Inhibitors Nadia Prilliane Putri; Khalida Shabiba Nursyamsi; Yanico Hadi Prayogo; Dina Ragillia Sari; Eka Budiarti; Irmanida Batubara
Biosaintifika: Journal of Biology & Biology Education Vol 9, No 3 (2017): December 2017
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v9i3.10516

Abstract

Mango fruit (Mangifera indica L.) is the tropical fruit that grows easily in Indonesia with plenty varieties. This study aimed to determine the varieties of mango fruit and the most potent part of mango as antidiabetic agent through α-glucosidase inhibitory activities. Four types of mango fruit (indramayu, manalagi, harum manis, and budiraja) were used in this study. Each part of the mango fruit:peel, flesh, endosperm, and endocarp were extracted by maceration process with three different solvents (n-hexane, ethyl acetate (EtOAc), and ethanol (EtOH)). An ability of all 46 extracts in inhibiting the α-glucosidase at a concentration of 500 ppm were determined. Then 11 extracts with the high inhibition value were determined their IC50 (concentration to inhibit 50% activity) values. EtOAc extract of manalagi, indramayu, and budi raja endosperm had the lowest IC50 value which was not statistically significantly different (at 95%) with EtOAc extract of budi raja peel. The bioautographic Thin Layer Chromatogram showed that the most active band is characterized by white luminescence under UV 366 nm, yellow color under UV 254 and visible light. The band with Rf 0.93 from EtOAc endosperm extract of indramayu and manalagi and Rf 0.73 from EtOAc budi raja peel extract are the most active band which predicted as a flavonoid. The result adds the value of the peel and seed of mango, as well as an alternative in blood sugar control, which is easy to obtain, relatively cheap, and liked by the community. 
Chemical Constituent of Acacia auriculiformis Wood Extractives and Their Antioxidant Activity Yanico Hadi Prayogo; Irmanida Batubara; Rita Kartika Sari; Saat Egra; Kosei Yamauchi; Tohru Mitsunaga; Wasrin Syafii
Jurnal Sylva Lestari Vol. 11 No. 3 (2023): September
Publisher : Department of Forestry, Faculty of Agriculture, University of Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jsl.v11i3.753

Abstract

Acacia auriculiformis showed good potential to be developed as a raw material for bioactive compounds. The heartwood of A. auriculiformis is still rarely explored. The purpose of this study was to identify the bioactive components of the heartwood. Six compounds were identified from the heartwood through nuclear magnetic resonance and mass spectroscopy, namely the C-3,4',7,8 hydroxyl substituted flavonoids and chalcone. Two methylated teracacidins and chalcone-like teracacidin were identified for the first time in the A. auriculiformis heartwood, along with three known compounds. These compounds showed good radical scavenging and reduction activity, compared to crude extract and ascorbic acid, using three different antioxidant assays. The molecular structure-dependent activity was observed to affect the trend of the different antioxidant activities. This finding shows good potential for further development of plant parts of A. auriculiformis from Indonesia as new raw materials for medicines. Keywords: Acacia auriculiformis, antioxidant, chalcone, flavonoid, heartwood
Phytochemical Profile of Rhizophora apiculata, Bruguiera gymnorhiza, and Bruguiera cylindrica for Wood Identification Andianto; Wahyudi, Imam; Sari, Rita Kartika; Pari, Gustan; Prayogo, Yanico Hadi
Jurnal Sylva Lestari Vol. 12 No. 2 (2024): May
Publisher : Department of Forestry, Faculty of Agriculture, University of Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jsl.v12i2.884

Abstract

Identification of wood species that are difficult to distinguish from their anatomical structure can be done through phytochemical (extractive substance) profiling. This research aimed to analyze the phytochemical profile as a sorter for three species of mangrove wood from Indramayu and Cilacap Regencies, Indonesia, using the liquid chromatography-mass spectrum. The phytochemical markers of taxonomic were the dominant compounds only found in one wood species. The results showed that the three types of wood are dominated by phytochemicals dissolved in ethanol. The results of LCMS analysis of the ethanol extract showed that the phytochemical markers were triterpenoid, flavonoid, and fatty acyls glycoside groups for Rhizophora apiculata, steroid and naphthalene groups for Bruguiera gymnorhiza, and alkaloid as well as fatty amide group for Bruguiera cylindrica. The dominant compounds that characterize these can be used in sorting between mangrove wood species. Keywords: characterizer, compound, mangrove, phytochemicals
Antidiabetic Activities of Agarwood (Aquilaria malaccensis) Leaf Extracts via Enhanced Insulin Secretion in BRIN-BD11 Pancreatic Beta-Cells Prayogo, Yanico Hadi; Sari, Rita Kartika; Hamidi, Zikri; Syafii, Wasrin; Harlina, Eva; Prasetyo, Bayu Febram
Jurnal Sylva Lestari Vol. 13 No. 3 (2025): September
Publisher : Department of Forestry, Faculty of Agriculture, University of Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jsl.v13i3.1197

Abstract

Agarwood leaves (Aquilaria malaccensis), a non-timber forest products, shows significant potential as a source of antidiabetic compounds. This study aims to evaluate the antidiabetic activity of agarwood leaves and their cytotoxicity on pancreatic beta-cells, as well as predict their compound bioactivity through an in silico approach. The leaves were extracted using ethanol, water, and a mixture of ethanol–water with the assistance of ultrasound irradiation. The extracts were then tested in vitro for their antidiabetic potential by assessing their ability to inhibit the alpha-glucosidase enzyme and their effect on insulin secretion, as well as their cytotoxicity on BRIN-BD11 pancreatic beta-cells. The phytocompounds in the extract were identified using liquid chromatography-mass spectrometry, and their binding behavior was studied by in silico molecular docking. Among the three, the ethanol–water extract showed the highest extraction yield. Cytotoxicity assays revealed that the ethanol–water extract was cytotoxic at high concentrations (1000 µg/mL), but safe at lower concentrations. The alpha-glucosidase inhibition was relatively weak. Nevertheless, the extracts significantly stimulated insulin secretion in BRIN-BD11 cells up to fivefold compared to untreated cells. In silico studies indicated that xanthone glycoside, flavonoid glycoside, and coumarin compounds exhibit strong binding affinities to multiple insulin-secretion-related proteins. These findings suggest that agarwood leaf extract, particularly ethanol–water extract, possesses promising antidiabetic activity through an insulinotropic mechanism. Keywords: agarwood, alpha-glucosidase, insulinotropic, molecular docking
Phytochemical Profiles and Cytotoxicity Activities of Eucalyptus Leaf Oils from Eucalyptus Clones Rita Kartika Sari; Yanico Hadi Prayogo; Agus Purwoko; Anne Carolina; Elisa Ganda Togu Manurung; Gunawan Pasaribu
Jurnal Sylva Lestari Vol. 14 No. 3 (2026): September
Publisher : Department of Forestry, Faculty of Agriculture, University of Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jsl.v14i3.1531

Abstract

Although widely cultivated for wood production in Indonesia, studies on Eucalyptus leaf essential oils (ELEOs) from Eucalyptus clones remain limited. This study investigated the yield, phytochemical profiles, cytotoxic activities, and putative compounds associated with the cytotoxicity of ELEOs obtained from seven Eucalyptus clones cultivated in North Sumatra, Indonesia. The oils were extracted by water-and-steam distillation for 1.5 h, starting when the first oil droplet appeared. Phytochemical profiles were characterized by gas chromatography-mass spectrometry, and cytotoxicity against A549 lung cancer and B16-F10 murine melanoma cells was evaluated in vitro. Multivariate analyses, such as orthogonal partial least squares and principal component analysis, together with molecular docking, were used to identify compounds associated with cytotoxicity. Essential oil yield ranged from 0.15% to 0.39% (w/w), while eucalyptol, the principal quality marker of ELEO, ranged from 7.98% to 41.69% among the clones. The clone of Eucalyptus grandis x Eucalyptus open-pollinated clone (GOP) exhibited the lowest IC50 value for B16-F10 cells (165.3 microgram/mL), and the clone of E. urophylla x Eucalyptus open-pollinated clone (UOP1) exhibited the lowest IC50 value for A549 cells (111.9 microgram/mL). According to multivariate analyses and molecular docking, alpha-pinene, (-)-spathulenol, and (-)-globulol are compounds that likely exhibit cytotoxicity against B16-F10 cells, while gamma-terpinene, o-cymene, o-cymen-5-ol, and leptospermone are compounds that likely exhibit cytotoxicity against A549 cells. However, in normal cell lines, it was not possible to achieve cytotoxic selectivity, as the biological significance of the observed cytotoxic responses is not yet established. In general, the results indicated that the yield, phytochemical composition, and cytotoxic activity of ELEOs derived from Eucalyptus clones depend on the genetic background. Keywords: A549 lung cancer cell lines, B16-F10 murine melanoma cell lines, Gas Chromatography-Mass Spectrometry, molecular docking, multivariate analysis
Aktivitas Antioksidan, Tabir Surya, Dan Profil Fitokimia Lignin Hasil Ekstraksi dengan Deep Eutectic Solvent Maeda Wahyuningrum; Franklin Solano Sinaga; Nadiva Yasmin Narayana; Meisy Gloria Mandak; Tutur Simanjuntak; Manggar Arum Aristi; Yanico Hadi Prayogo; Raymon Alpindo Lumbangaol
Jurnal Sylva Scienteae Vol 9, No 2 (2026): Jurnal Sylva Scienteae Vol 9 No 2 Edisi APRIL 2026
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jss.v9i2.18339

Abstract

Penelitian ini bertujuan untuk mengevaluasi aktivitas antioksidan, potensi tabir surya, dan profil fitokimia lignin yang diekstraksi dari limbah cangkang kemiri (Aleurites moluccana) menggunakan metode Deep Eutectic Solvent (DES) sebagai pendekatan green chemistry. Ekstraksi lignin dilakukan menggunakan sistem DES berbasis kolin klorida-asam laktat dengan perbandingan molar 1:2 pada suhu 135 °C selama 3 jam. Lignin hasil ekstraksi dianalisis kandungan fenolik dan flavonoid total, aktivitas antioksidan menggunakan metode DPPH, nilai Sun Protection Factor (SPF) secara in vitro menggunakan spektrofotometri UV-Vis, serta karakterisasi gugus fungsi menggunakan FTIR. Hasil penelitian menunjukkan bahwa lignin hasil ekstraksi DES memiliki kandungan fenolik total yang tinggi (389 mg GAE/g) dan kandungan flavonoid sebesar 15 mg QE/g. aktivitas antioksidan lignin tergolong sangat kuat dengan nilai IC50 sebesar 28,67 ppm. Uji aktivitas tabir surya menunjukkan bahwa pada konsentrasi 100 ppm, lignin mampu memberikan nilai SPF 9,9 yang termasuk kategori proteksi maksimal. Analisis FTIR mengonfirmasi keberadaan gugus hidroksil fenolik, karbonil, dan struktur aromatik yang berperan penting dalam aktivitas antioksidan dan penyerapan UV. Hasil ini menunjukkan bahwa lignin cangkang kemiri hasil ekstraksi DES berpotensi besar sebagai bahan aktif alami untuk aplikasi tabir surya ramah lingkungan
Resistance to Termites and Colour Change in Gombong Bamboo (Gigantochloa pseudoarundinacea) Modified with Boron Compounds, Vegetable Oil, and Heating Lilih Cipta Pangestu; Trisna Priadi; Yanico Hadi Prayogo
Jurnal Sylva Lestari Vol. 14 No. 1 (2026): January
Publisher : Department of Forestry, Faculty of Agriculture, University of Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jsl.v14i1.1270

Abstract

Bamboo is a potential material in the furniture, construction, and craft industries due to its rapid growth and good physical and mechanical properties. However, its vulnerability to attacks by wood–destroying organisms, particularly termites, necessitates preservation to extend its service life. This study evaluated the resistance of gombong bamboo to subterranean and drywood termites, as well as its color changes. The modification treatments involve boric acid equivalent (BAE) impregnation, heat treatment (60 °C, 150 °C, and 180 °C), and vegetable oils (linseed and neem oil). Statistical analysis using one-way ANOVA was performed to determine the significance of each treatment factor on weight loss and colour parameters, followed by Duncan’s Multiple Range Test for mean comparison. In addition, color change and the chemical composition of the most effective oil treatment in terms of termite resistance were analysed using Gas Chromatography-Mass Spectrometry (GC-MS). The results showed that BAE, neem oil, and the combined treatments (BAE-vegetable oils) effectively improved bamboo resistance to both termite tests. The synergy between BAE impregnation, heat treatment (180 °C), and neem oil produced the highest level of termite resistance. Heat treatment at elevated temperatures also caused significant colour changes, particularly a reduction in brightness (L*) and an increase in dark brown tones attributed to thermal degradation of hemicellulose and extractives. GC-MS analysis revealed that neem oil was dominated by fatty acids and other compounds known for their antimicrobial, antifeedant, and termite-repellent activities, which likely contributed to the enhanced biological performance of the treated bamboo. Keywords: bamboo modification, bio-based treatment, impregnation, sustainable bamboo utilization
In-vitro, In-vivo, and In-silico Studies of Insulinotropic Activity and Cytotoxicity of Mahagony Seed Extracts and Its Nanophytosome Zikri Hamidi; Rita Kartika Sari; Yanico Hadi Prayogo; Wasrin Syafii; Adinda Zahra Marissa Kasmi; Bayu Febram Prasetyo; Eva Harlina; Setyanto Tri Wahyudi
Communications in Science and Technology Vol 10 No 2 (2025)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.10.2.2025.1676

Abstract

This present study set out with the objective of evaluating the effect of ethanol–water solvent composition on extraction yield, insulinotropic activity (IA), cytotoxicity, and phytochemical profile (PP) of mahogany (Swietenia mahagoni) seed (MS) extracts. It also sought to study in silico and encapsulate the best extract, and to assay the antidiabetic of the extract and its nanophytosome. The extraction of MSs was achieved through the utilization of ethanol, ethanol–water (1:1), and water through ultrasound–assisted extraction. The extracts of IA and cytotoxicity were assayed in vitro using BRIN–BD11 cell lines and analyzed using LC-MS. The most effective extract was identified for its active compounds using molecular docking, encapsulation, characterization, and testing for its antidiabetic properties in vivo. The highest yield was observed in the water extract (MW), followed by the ethanol–water extract (MEW) and the ethanol extract (ME). MEW and MW demonstrated low level of cytotoxicity, with MEW exhibiting the highest level of IA. An in silico study identified four key antidiabetic compounds through the IA mechanism. The study demonstrated that MEW and its nanophytosome (250 mg/kg mouse weight) effectively reduced blood glucose level, and enhanced both erythrocyte function, and insulin secretion. This finding provides a new perspective in the development of natural-based antidiabetic agents through the nanophytosome formulation of mahogany seed extract.
Dimensi Serat dan Nilai Turunan Serat Kayu Gmelina (Gmelina arborea Roxb.) dan Waru (Hibiscus tiliaceus L.) Kutana, Agung Nugrawan; Prayogo, Yanico Hadi; Wahyudi, Imam; Hanifah, Nisrina Putri; Pangestu, Kidung Tirtayasa Putra; Prayitno, Joko
Jurnal Ilmu Alam dan Lingkungan Vol. 17 No. 2 (2026): Jurnal Ilmu Alam dan Lingkungan
Publisher : Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/fw12ft30

Abstract

Penelitian ini bertujuan untuk menganalisis dimensi serat dan nilai turunan serat kayu gmelina (Gmelina arborea Roxb.) dan waru (Hibiscus tiliaceus L.) serta membandingkan karakteristik anatomi serat kedua jenis kayu tersebut. Sampel kayu dimaserasi menggunakan metode Schultze dan diamati secara mikroskopis pada pembesaran 40× dan 100×. Parameter yang diukur meliputi panjang serat, diameter serat, diameter lumen, dan tebal dinding sel. Data dimensi serat digunakan untuk menghitung nilai turunan serat berupa Runkel ratio, flexibility ratio, felting power, Muhlsteph ratio, dan coefficient of rigidity. Hasil penelitian menunjukkan bahwa kayu gmelina memiliki panjang serat 1251,65 µm, diameter serat 31,10 µm, diameter lumen 18,26 µm, dan tebal dinding sel 6,42 µm, sedangkan kayu waru memiliki panjang serat 1083,96 µm, diameter serat 22,69 µm, diameter lumen 15,72 µm, dan tebal dinding sel 3,48 µm. Nilai turunan serat kayu gmelina berturut-turut adalah Runkel ratio 0,70, flexibility ratio 0,59, felting power 40,24, Muhlsteph ratio 31,10, dan coefficient of rigidity 0,21, sedangkan kayu waru memiliki nilai Runkel ratio 0,44, flexibility ratio 0,69, felting power 47,77, Muhlsteph ratio 51,97, dan coefficient of rigidity 0,15. Berdasarkan total nilai turunan dimensi serat, kayu waru memperoleh skor 250 dan termasuk kelas kualitas II, sedangkan kayu gmelina memperoleh skor 200 dan termasuk kelas kualitas III. Hasil penelitian menunjukkan bahwa kayu waru memiliki serat yang lebih fleksibel dengan lumen relatif lebih besar dan dinding sel lebih tipis, sedangkan kayu gmelina memiliki serat yang lebih besar namun lebih kaku akibat dinding sel yang lebih tebal.
Co-Authors Adinda Zahra Marissa Kasmi Agus Purwoko Andianto Anne Carolina Bayu Febram Prasetyo Bayu Febram Prasetyo Dina Ragillia Sari Eka Budiarti Elisa Ganda Togu Manurung Eva Harlina Eva Harlina Evie Nihayah Franklin Solano Sinaga Gunawan Pasaribu Gustan Pari Hamidi, Zikri Hanifah, Nisrina Putri Imam Wahyudi Indrawan, Imam Wahyudi Irmanida Batubara Izza Firdausi Hadiyanto JOKO PRAYITNO Khalida Shabiba Nursyamsi Kosei Yamauchi Kutana, Agung Nugrawan Lilih Cipta Pangestu Maeda Wahyuningrum Manggar Arum Aristi Meisy Gloria Mandak Nadia Prilliane Putri Nadiva Yasmin Narayana Pangestu, Kidung Tirtayasa Putra Raymon Alpindo Lumbangaol Rita Kartika Sari Rita Kartika Sari Rita Kartika Sari Romi Irka Putra Saat Egra Setyanto Tri Wahyudi Tohru Mitsunaga Trisna Priadi Tutur Simanjuntak Wasrin Syafii Wasrin Syafii Zikri Hamidi