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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Indonesian Journal of Pharmaceutical Science and Technology Communications in Science and Technology JSFK (Jurnal Sains Farmasi & Klinis) ARSHI Veterinary Letters Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Health Sains Jurnal Buana Farma Britain International of Exact Sciences Journal (BIoEx Journal) Indonesian Journal of Biological Pharmacy Jurnal Sylva Lestari Eduvest - Journal of Universal Studies Jurnal Veteriner dan Biomedis Current Biomedicine

Bayu Febram Prasetyo

Sub-Divisi Farmasi Veteriner, Sekolah Kedokteran Hewan Dan Biomedis, IPB University, Bogor, Indonesia

Author-ID : 265104

Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Anti Lithiasis Activity of Avocado (Persea americana Mill) Leaves Extract in White Male Rats IETJE WIENTARSIH; RINI MADYASTUTI; BAYU FEBRAM PRASETYO; ANGGARA ALDOBRATA
HAYATI Journal of Biosciences Vol. 19 No. 1 (2012): March 2012
Publisher : Bogor Agricultural University, Indonesia

In Indonesia, avocado leaves have been used as traditional medicines for diureticum to cure urolithiasis. This research was to determine anti lithiasis activity of avocado leaves (Persea americana Mill) extract on white male rats nefrolithiasis model induced by ethylene glycol. Ethanol extraction method was used to get extract of avogadro leaves. Twenty adult male white rats were divided into 4 different induction treatments i.e. aquadest, ethylene glycol 0.75% and ammonium chloride 2%, and extract of avocado leaves with different levels of 100 and 300 mg/kg bw respectively. Their body weight was measured daily to determine their growth ratio. And at the end of the trial, the kidney was analyzed its calcium level and inhibitory activity to formation of calcium oxalate crystals. The results showed that the amount of calcium level in the kidney of rats treated with extract of avogadro leaves was significantly decreased than that of rats treated with ethylene glycol 0.75% and ammonium chloride 2% (P < 0.05). The extract avocado leaves as a herbal remedy can be recommended as a phytotherapeutic agent especially for preventive action for urolithiasis diseases.

Aktivitas Sediaan Gel dari Ekstrak Lidah Buaya (Aloe barbadensis Mill.) pada Proses Persembuhan Luka Mencit (Mus musculus albinus) Vetnizah Juniantito; Bayu Febram Prasetyo
Jurnal Ilmu Pertanian Indonesia Vol. 11 No. 1 (2006): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (794.023 KB)

The purpose of this study was to examined the effectivity of Aloe vera gel formulation on the skin wound healing process based on the macroscopic and microscopic observation. Fourty five DDY strain, 6-8 weeks old mice were used for experimental animals. Mice were incised 1-1.5 cm in the dorsum using sterile scalpels. Mice were divided into three groups. Group I (control) were not treated by anything, Group II were treated by commercial drugs (Bioplacenton), and Group III were treated by Aloe vera gel. Bioplacenton and Aloe vera gel were given topically twice a day to the skin using sterile cotton buds. Each groups consisted of 15 mice and distributed into 5 observation days with 3 replication. Three mice from each groups were euthanized periodically at day 3rd, 5th, 7th, 14th, and 21st post incision for gross pathology examination and to sampling the skin. Gross examination revealed that Bioplacenton and Aloe vera gel showed better result on wound healing process, i.e. the scab formation, scab peeler and unite of the wounded skin edge compared to the control groups. Microscopically, the Bioplacenton and Aloe vera gel groups showed the fastest epidermal re-epithelization compared with the control group. Qualitatively Bioplacenton and Aloe vera gel groups showed more fibrosis and collagen fibres formation than the control groups especially at day 7th and 14th. Scoring Average of neocapillaries formation from all groups showed no difference. Scoring average of inflammatory cells number revealed that control groups showed more cells than the other groups that indicated an high inflammatory activity. Based on macroscopic and microscopic examination we suggest that the Aloe vera gel formulation has a benefit to promote wound healing, and could be used for the treatment of skin wound. Thus, the Aloe vera gel formulation is potential to developed as commercial drugs.

PF-18 Photomicrograph of Nanogel Andrographolide-Beta Cyclodextrine Inclusion Complex As Anti-Burns Bayu Febram Prasetyo; Ietje Wientarsih; Dondin Sajuthi; Vetnizah Juniantito
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (464.194 KB)

Inclusion complex is a complex formed between drug molecules which act as guest or located inside the cavity of host molecule. Host molecules are commonly originated from the derivative group of cyclodextrin. Among cyclodextrin groups, beta cyclodextrin (BCD) is mostly used in formula development and drug delivery system [1].Andrographolide (AG) is a pure isolate chemically syntesized from sambiloto herbs (Andrographis paniculata Nees), in the form of needle cystal-like which is colorless and extremely bitter. AG has variety of medical properties, particularly as anti-inflamation to treat skin burns [2]. However AG has poor solubility in water. This will result in low abillity to solute, penetrate membrane, and distribute the drug when applied transdermally in burn skin. In burn skin, there is tendency to skin damage, especially in stratum corneum which acts as semipermeable barrier. The ability of drugs that applied transdermally tends to be high.Formation of inclusion complex using AG and BCD to increase the ability of AG in penetrating membrane should be done. Transmission Electron Microscope (TEM) is a fast technique to confirm the formation of drug or inclusion complex by comparing the shape and particle size [3]. Study on percutaneous penetration of AG-BCD inclusion complex is produced through solvent evaporation method at mole ration 1:2 in viscolam gel preparation.

Formation of Andrographlolide-BetaCyclodextrin Inclusion to Increase Solubility and Dissolution Rate Bayu Febram Prasetyo; Ietje Wientarsih; Dondhin Sajuthi; Vetnizah Juniantito
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 2 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Andrographolide (AG) is a pure isolate of the chemical synthesis of sambiloto (Andrographis paniculata Nees.) which has various pharmacological properties such as anti-inflammatory and antimicrobial. In order to improve the ability of AG to penetrate the membrane in transdermal use, an inclusion complex was formed using beta-cyclodextrin (BCD) by modifying the physical chemistry properties of AG, particularly the solubility in its base, partition, and distribution on the skin, as well as by changing the permeability of the stratum corneum. The inclusion complexes of AG with BCD were prepared by the solvent evaporation method in the mole ratios of 1:1, 1:2, and 2:1. The solid of the yield of AG inclusion complex in BCD has been tested with a solubility test until it reached equilibrium at 37 ± 5 °C for 24 hours and In vitro dissolution rate test using the II USP method (paddle type), then compared to a single AG compound, and a physical mixture of AG-BCD. Based on the solubility and dissolution rate tests, it showed that the formation of AG-BCD inclusion complex was obtained at the mole ratio of 1:2. Moreover, the AG solubility increased 38 timesand the dissolution rate in the 60th minute increased twice in the inclusion complex with BCD.Key words: andrographolide, inclusion complex, beta cyclodextrin, solubility, dissolution rate

Uji Aktivitas Antioksidan dan Daya Hambat Enzim Tirosinase Ekstrak Etanol Azolla filiculoides Lam. Bayu Febram Prasetyo
Jurnal Sains Farmasi & Klinis Vol 8, No 1 (2021): J Sains Farm Klin 8(1), April 2021
Publisher : Fakultas Farmasi Universitas Andalas

Azolla (Azolla filiculoides Lam.) merupakan tanaman paku air dari famili Azollaceae. Azolla filiculoides digunakan sebagai pakan alami dengan ketersediaannya melimpah di alam yang belum termanfaatkan secara optimal. Tanaman ini dapat bersimbiosis dengan Cyanobacteria. Azolla memiliki senyawa bioaktif yang berfungsi sebagai antioksidan dan inhibitor tirosinase. Tujuan dari penelitian ini adalah untuk menguji aktivitas antioksidan menggunakan metode DPPH (2.2-difenil 1-pikrihidrasil ) dan daya hambat tirosinase pada ekstrak etanol Azolla filiculoides. Ekstraksi menggunakan metode maserasi dan pelarut etanol 96%. Hasil uji fitokimia menunjukkan bahwa ekstrak etanol Azolla mengandung senyawa flavonoid, tanin, saponin, steroid dan triterpenoid. Kandungan fitokimia tersebut berpotensi sebagai antioksidan dan inhibitor tirosinase, terutama senyawa flavonoid dan tanin. Uji aktivitas antioksidan menunjukkan bahwa ekstrak etanol Azolla filiculoides memiliki aktivitas antioksidan yang kuat dengan nilai IC50 sebesar 23.00 ppm. Uji aktivitas inhibisi tirosinase ekstrak azolla menunjukkan daya hambat yang lebih efektif pada aktivitas diphenolase (IC50 996.60 ppm) dibandingkan aktivitas monophenolase (IC50 1893.09 ppm).

Potensi Cuka Apel terhadap Waktu Kematian Caplak (Rcichepalus Sanguenus) pada Anjing Affan Zufar; Bayu Febram Prasetyo; Upik Kesumawati Hadi
Jurnal Health Sains Vol. 2 No. 6 (2021): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v2i6.181

Apple cider vinegar is widely discussed today in addition to having many benefits for body health and facial treatments, this preparation also has antiparasitic properties, especially to repel ticks on dogs. This study aims to analyze the effect of apple vinegjzsar administration on the time of tick death (Rhipicephalus sanguineus). The sample in this study used 50 ticks divided into 5 ticks for 5 treatment groups (K-, 10% Apple Vinegar, 15% Apple Vinegar, 20% Apple Vinegar, K +) with two repetitions. In negative controls using aquades, no tick deaths were found. At the Apple Vinegar concentration of 10% there were 8 tick deaths with an average death at 2 hours 50 minutes after administering the preparations At the Apple Vinegar concentration 15% there were 10 tick deaths with an average death at 2 hours 47 minutes after administration of the preparations. At the Apple Vinegar concentration of 20% there were 10 tick deaths with an average death at 1 hour 15 minutes after administration of the preparation. In the positive control using fipronil 3% with the trademark Deticks there was an average of 5 ticks mortality. The results of this study concluded that Apple Vinegar is very effective as an anti-tick with a minimum concentration of 20% can kill ticks quickly. In addition, it was also found that Apple Vinegar with a concentration of 20% was more effective at killing ticks than fipronil 3%.

Terapi giardiasis penyebab diare non-spesifik pada kucing Rizal Arifin Akbari; Ietje Wientarsih; Bayu Febram Prasetyo; Rini Madyastuti
ARSHI Veterinary Letters Vol. 2 No. 1 (2018): ARSHI Veterinary Letters - Februari 2018
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Kucing jantan berumur 4 tahun bernama Rambo datang ke Klinik Star Vet Ciomas Bogor dengan keluhan menderita diare selama 6 bulan. Kucing memiliki kebiasaan diberikan minum air mentah, sering minum air toilet dan air got. Kucing di diagnosa menderita Giardiasis dengan menggunakan teknik fecal flotation yang ditunjukan dengan adanya kista Giardia sp. sebanyak >30 kista per lapang pandang. Kucing di terapi menggunakan antibiotika metronidazol dosis 20 mg/kg BB, imunomodulator (Echinacea extract) dosis 0.1 ml/kg BB dan Vitamin B12 dosis 0.025 mg/kg BB secara peroral selama 10 hari. Dilakukan pemantauan melalui pengamatan bentuk feses dan menghitung jumlah kista Giardia pada hari ke-0, 5, dan 10 pascaterapi. Pada hari ke-10 pascaterapi, feses sudah mulai berbentuk dan tidak ditemukan kista Giardia sp. sehingga kucing dinyatakan sembuh dari Giardiasis.

Effect of Boswellic Acid Administration on Blood Biochemical Profile of Sprague Dawley Rats in Cyclophosphamide-Induced Cardiotoxicity Conditions Miranti Fardesiana Putri; Ietje Wientarsih; Bayu Febram Prasetyo; Vetnizah Juniantito
Britain International of Exact Sciences (BIoEx) Journal Vol 4 No 2 (2022): Britain International of Exact Sciences Journal, May
Publisher : Britain International for Academic Research (BIAR) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/bioex.v4i2.660

Cyclophosphamide (CP) is a chemotherapeutic agent that belongs to the alkylating agent group that is widely used in the treatment of cancer. Cardiotoxicity is often a side effect of using CP in medical therapy. In this study, 24 Sprague Dawley rats were randomly divided into 4 groups. Group 1 (K1) was given injection with aqua pro injection intraperitoneally (IP) once a week for 21 days. Group 2 (K2) was given IP CP with a dose of 50 mg/kg BW, once a week for 21 days. Group 3 (K3) was given boswellic acid extract at a dose of 250 mg/kg BW orally, every day for 21 days. Group 4 (K4) was given boswellic acid nanoparticles at a dose of 250 mg/kg BW orally, every day for 21 days. During the treatment the body weight of the rats was weighed every day. At the end of the treatment, the rats were euthanized and blood samples were taken for blood biochemical evaluation, namely CPK, LDH, AST, and ALT. The results showed that the levels of CPK, LDH, AST, and ALT in K2 were significantly higher (p<0.05) than K1, K3 and K4. Statistically, the results of CPK, LDH, AST and ALT in K3 and K4 were not significantly different (p<0.05) compared to K1. The two groups (K3 and K4) were not significantly different (p<0.05) but on average the CPK, LDH, AST, and ALT results in K4 had lower scores than K3. This can indicate the protective effect of boswellic acid and boswellic acid nanoparticles on the heart against cyclophosphamide-induced cardiotoxicity.

Evaluation of Drug Uses for Calicivirus and Panleukopenia Treatment in Bogor Animal Clinic on 2017 and 2018 Muhammad Agung Nulhakim; Bayu Febram Prasetyo; Rini Madyastuti Purwono
Eduvest - Journal of Universal Studies Vol. 1 No. 9 (2021): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Drug therapy in cases of infections by viruses is only to prevent secondary infections. The use of drugs for each action must be evaluated through a drug use evaluation program (EPO) in order to guarantee a rational and effective drug. This study aims to examine the drugs in case for handling and the effectiveness of drug use in cases of infections caused by viruses, in this study the therapeutic use of drugs in cases of feline calicivirus and feline panleukopenia. This research is a descriptive study using data from 543 patients who came to get treatment of clinic in Bogor City during 2017 and 2018, 29 of which were infected with feline calicivirus and 32 infected with feline panleukopenia. Evaluation of drug use in these two viral diseases is done descriptively by comparing research data with literature. The results showed the use of drugs in the case of feline calicivirus there were 12 types of drug treatment, while in the case of feline panleukopenia there were 9 types of drug treatment. The use of drugs most often used is based on the records of veterinary clinical records, namely the preparation of metronidazole combined with cefadroxil to handle cases of feline calicivirus and metronidazole alone to handle cases of feline panleukopenia.

Pengaruh Penambahan Tepung Protein Maggot Black Soldier Fly (Hermetia illucens) terhadap Palatabilitas Pakan Kucing Komersial Bayu Febram Prasetyo; Dedi Rahmat Setiadi; Handri Dwi Agung
Jurnal Sain Veteriner Vol 41, No 2 (2023): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.81730

Larva Black Soldier Fly (BSF) spesies Hermetia illucens mengandung nutrisi protein yang berpotensi menjadi sumber pakan alternatif hewan peliharaan yang ramah lingkungan, berkelanjutan, dan memiliki komposisi nutrisi yang ideal. Namun, laporan penggunaannya masih belum diketahui sebagai bahan pakan kucing. Uji palatabilitas pakan komersial dengan penambahan tepung protein maggot bertujuan untuk mengetahui daya terima pakan yang dikonsumsi. Uji palatabilitas dilakukan dengan metode monadik atau single bowl pada kucing domestik jantan dalam dua tahap, adaptasi pakan dan pemberian pakan uji pada empat kelompok perlakuan (0,25%, 50%, dan 75%) dengan penambahan tepung maggot, yang masing-masing terdiri dari 3 ekor kucing. Hasil pengujian diperoleh dari jumlah konsumsi pakan harian dengan cara jumlah pakan yang diberikan dikurangi dengan jumlah sisa pakan. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan yang nyata (P>0,05) pada perlakuan P1 119±15,36 (g/hari) dan 204±26,31 (kkal/hari) pada jumlah konsumsi pakan dan jumlah kebutuhan kucing harian. Dapat disimpulkan bahwa tepung protein maggot BSF dapat menjadi sumber bahan pakan kucing.

Co-Authors Adinda, Nada Affan Zufar Agustin Indrawati Ahmad Kurniawan Alauddin, Daffa Rizal Dzulfaqaar Amanda, Marsha Amrozi Andriyanto Andriyanto ANGGARA ALDOBRATA Anisa Rahma, Anisa Anisa, Rahma Ath-Thaariq, Affan Aufar Aziziah, Nurul Madinah Bachmid, Salma Safitri Baharun, Rasyid Bambang Pontjo Priosoeryanto Bhila, Aisya Salsa Budiono, Novericko Ginger Dedi Rahmat Setiadi Diaz, Fariz Arrachman Dondhin Sajuthi Dondin Sajuthi Eva Harlina Fadia, Sindy Siti Farra Sasmita Fikram, Muhammad Fikri Hanifah Firdausi, Zalfaa Nurr Fitri, Arni Diana Ghazali, Farhan Rizqy Hamidi, Zikri Handri Dwi Agung Hikmarizky, Firda IETJE WIENTARSIH Kasmi, Adinda Zahra Marissa Khamidah, Nabila Nurrisma Lina Noviyanti Sutardi Madyastuti, Rini May, Ng U Mifthadillah, Sekar Ayu Miranti Fardesiana Putri Mufida, Anis Arifatu Muhammad Agung Nulhakim Natawiria, Maria Stella Linda Nur Anisa BS Nurdiansyah, Rio Dwi Haryadi Prayogo, Yanico Hadi Rahmadani, Satria Tegar Rahmalia Dini Hanifa Ramadhaniah, Vetty Rasyid, Baharun Rita Kartika Sari Rizal Arifin Akbari Saragih, Adrian Setyanto Tri Wahyudi SUPRIYONO Upik Kesumawati Hadi Vetnizah Juniantito Wasrin Syafii Winarto, Tytha Nadhifa Wulandari, Nenis Rahma Zheng, Lee Xiang

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