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Firmansyah
Jurusan Farmasi Universitas Pancasakti
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health

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Activity of Horseshoe Leaf Extract (Ipomoea pescaprae L.) As Analgesic and Antipyretic in Mice (Mus musculus) Sainal Edi Kamal; Firmansyah Firmansyah; Rusli Rusli; Gerfan Patandung
Jurnal Farmasi Sandi Karsa Vol 7 No 2 (2021): Jurnas Farmasi Sandi Karsa (JFS)
Publisher : Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36060/jfs.v7i2.84

Abstract

Analgesics or painkillers are substances that reduce or eliminate pain without losing consciousness (in contrast to general anesthetics while antipyretics are drugs or substances that can reduce body temperature in a feverish state. This study aims to determine the activity of leaf extracts Tapak Kuda (Ipomoea pescaprae L.) as an analgesic and antipyretic in mice (Mus musculus) and to determine the dose of ethanol extract of Tapak Kuda leaf which has analgesic and antipyretic effects. The method used was sample extraction by maceration using 96% ethanol solvent and extract The results obtained were divided into 3 concentrations, namely 100, 300, and 500 mg/kgBW mice, then paracetamol was used in the positive control group. In the analgesic study, acetic acid was used as a pain inducer and in the antipyretic study, 10% peptone was used as a fever inducer. Male mice 15 adults used g were divided into 5 groups and each group consisted of 3 tails. Group I was treated with 1% Na-CMC as a negative control. Group II positive control of paracetamol with treatment given orally at a dose of 1 ml/30 grams of body weight to mice. Groups III, IV, and V as the test group were given ethanol extract of the leaves of Tapak Kuda (Ipomoea pescaprae L.) with extract doses of 100, 300 and 500 mg/kg BW with a volume of 1 ml / 30 gram BW. The results showed that in the analgesic test the administration of the ethanol extract of the leaves of Tapak Kuda (Ipomoea pescaprae L.) with extract doses of 300 mg/kgBW and 500 mg/kgBW could provide an analgesic effect, while the results of the antipyretic test on the administration of the ethanolic extract of the leaves of Tapak Kuda (Ipomoea pescaprae L.) with extract doses of 100, 300, and 500 mg/kgBW also had antipyretic effects.
Efek Ekstrak Daun Sawo Manila (Manilkara zapota (L.) Van Royen) Sebagai Adjuvant Antibiotika Amoxicillin Terhadap Resistensi Escherichia coli Dan Staphylococcus aureus Muhammad Taufiq Duppa; Firmansyah Firmansyah; Syachriyani Syachrir; Anshari Masri
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 2 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i2.381

Abstract

Resistensi terhadap antibiotik yang tersedia pada bakteri patogen menjadi tantangan global karena jumlah strain resisten terhadap berbagai jenis antibiotik terus meningkat. Tujuan penelitian ini adalah mengetahui efek ekstrak daun Sawo Manila sebagai adjuvant antibiotika Amoksisilin terhadap resistensi bakteri Escherichia coli dan Staphylococcus aureus. Ekstrak daun Sawo Manila diperoleh dengan cara Maserasi menggunakan pelarut Etanol 96 %. Penetuan daya hambat dengan metode difusi cakram diinkubasi 1 x 24 jam. Penentuan uji interaksi Amoksilin adjuvant ekstrak daun Sawo Manila berdasarkan ZOI dengan metode AZDAST. Hasil penelitian menunjukkan daya hambat rata-rata Amoksisilin Adjuvant ekstrak daun Sawo Manila terhadap Escherichia coli 1 x 24 jam adalah 14,6 mm, daya hambat Amoksisilin adjuvant ekstrak daun Sawo Manila 10 % b/v terhadap Staphylococcus aureus  1 x 24 jam adalah 15,60 mm. Kesimpulan penelitian ini adalah Ekstrak daun Sawo 10% b/v Manila memiliki efek daya hambat terhadap Escherichia coli dan Staphylococcus aureus dan penentuan interaksi Amoksisilin adjuvant daun Sawo Manila 10% b/v memiliki aktivitas antibakteri sinergis terhadap Eschericihia coli dan Staphylococcus aureus.
Formulasi Pasta Gigi Antibakteri Ekstrak Daun Murbei (Morus alba L.) dengan Bahan Abrasif Cangkang Telur Bebek Muhammad Aris; Syachriyani Syachrir; Firmansyah Firmansyah; Ariyani Buang; Muhammad Taufiq Duppa
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 2 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i2.383

Abstract

Proses karies gigi dapat dicegah dengan menggunakan pasta gigi yang mengandung agen antibakteri untuk menghambat pertumbuhan bakteri. Bakteri yang menyebabkan karies gigi adalah Streptococcus mutans. Tujuan penelitian ini mengetahui ekstrak daun Murbei dengan bahan abrasif Cangkang Telur Bebek dapat di buat Pasta gigi dan mengetahui efek antibakteri Pasta gigi daun Murbei. Pasta gigi dibuat dalam tiga formula yaitu F 2 (ekstrak daun Murbei 4 % b/v), F 3 (ekstrak daun Murbei 6 % b/v), F 4 (ekstrak daun Murbei 8 % b/v) dan F 1 kontrol negatif (Basis Pasta Gigi tanpa ekstrak). Pada formula dilakukan uji mutu fisik sediaan dengan Cycling test yang meliputi uji organoleptik, uji homogenitas, uji pH, uji viskositas, uji tinggi busa dan uji daya sebar. Selanjutnya pasta gigi diuji efek antibakteri metode difusi sumuran. Hasil penelitian menunjukkan bahwa keempat formula memenuhi syarat uji mutu dan stabilitas fisik.  Hasil pengujian daya hambat Pasta gigi ekstrak daun Murbei terhadap Streptococcus mutans yaitu formula 2 (4%  b/v) rata-rata diameter daya hambat 24,64 mm, formula 3 (6% b/v) rata-rata diameter daya hambat 26,02 mm dan formula 4 (8% b/v) rata-rata diameter daya hambat 27,77 mm. Kesimpulan penelitian ini adalah Pasta gigi ekstrak daun Murbei konsentrasi 4 % b/v, 6 % b/v dan 8 % b/v dengan bahan abrasif Cangkang Telur Bebek memenuhi syarat mutu.   Daya hambat Pasta gigi ekstrak daun Murbei 4 % b/v berbeda bermakna dengan daya hambat 8 % b/v (dimana p < 0,05) terhadap Streptococcus mutans dengan daya hambat antibakteri kategori sangat kuat.
Co-Authors Andi Nurilmi Adriana Anshari Masri Ariyani Buang Ariyani Buang Gerfan Patandung Mocktar La Mamin Muhahammad Taufiq Duppa Muhammad Aris Muhammad Taufiq Duppa Narni Narni Rusli Rusli Sainal Edi Kamal Sopian Adrian Susilo Syachriyani Syachrir Syachriyani Syachriyani Syachriyani Syachriyani Yusriani Yusriani