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All Journal Sari Pediatri Paediatrica Indonesiana journal of Basic Medical Veterinary Journal of Health and Nutrition Research Narra X
Mulya Safri, Mulya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Journal : Narra X

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Role of vitamin C in reducing cardiovascular oxidative stress: An in vivo study using sepsis rat models Raihani, Rifa; Sovira, Nora; Andid, Rusdi; Yusuf, Sulaiman; Safri, Mulya; Dimiati, Herlina; Fajri, Fauzan; Sentosa, Sukmawan F.; Hasan, Denny I.
Narra X Vol. 3 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i1.179

Abstract

The aim of this study was to evaluate the effect of vitamin C on reducing cardiovascular oxidative stress in sepsis rat models. An experimental animal study with a post-test control group design was conducted at the Laboratory of Animal Research, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia, from September to December 2023, using 18 male Wistar strain rats (Rattus norvegicus). Rats were divided into three groups: control (Group K), lipopolysaccharide 5 mg/kg body weight (BW) (Group L), and lipopolysaccharide 5 mg/kg BW with oral vitamin C (18 mg/day) (Group LC). Rats were euthanized after two weeks with ketamine (15–20 mg/kg intraperitoneally) and cervical dislocation. Blood samples (3 mL) and heart organs were collected. Nitric oxide (NO) levels were measured through enzyme-linked immunosorbent assay (ELISA), and cardiac muscle cells were observed using an Olympus CX21 microscope.  The LC group exhibited a significantly lower mean endothelial dysfunction score than the L group (p<0.001), although no significant difference in NO levels was observed between L and LC groups (p=0.262), indicating that vitamin C did not significantly affect NO levels. This suggests that the improvement in endothelial function observed in the LC group may be mediated through mechanisms other than NO modulation. The MANOVA test revealed that vitamin C administration accounted for 84.8% of changes in endothelial function in the sepsis rat model (p<0.001). In conclusion, vitamin C confers a protective effect against severe cardiac and endothelial damage, as evidenced by the amelioration of necrosis, inflammatory cell infiltration, congestion, and vacuolization caused by lipopolysaccharide.
Household clean and healthy living behaviors and stunting severity among children under five in Indonesia: A cross-sectional study Maghfirah, Dhiyal; Safri, Mulya; Maharani, Cut R.; Yusuf, Sulaiman; Sofia, Sofia
Narra X Vol. 3 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i3.232

Abstract

The prevalence of stunting among children under five in Indonesia reached 21.5% in 2023, underscoring a persistent public health challenge. Behavioral factors, including Clean and Healthy Living Behavior (CHLB), are known to influence health outcomes and may contribute to child growth. The aim of this study was to examine the association between household CHLB and stunting severity among children under five years of age. A cross-sectional study was conducted from September to October 2024 in the Sukajaya Primary Health Center area. Using a total sampling technique, 62 mothers of stunted children aged 0–59 months were recruited. Data were collected through direct interviews using structured questionnaires and anthropometric measurements of children’s height and weight. Statistical analysis included chi-square tests and multivariable logistic regression using SPSS version 23.0. The results showed that children with severe stunting were significantly younger than those with moderate stunting (26.9±14.9 months, p<0.001). Overall, household CHLB implementation was suboptimal; however, no statistically significant association was identified between the overall CHLB and stunting severity (p=0.091). Multivariable analysis identified child age (OR=0.916, p=0.001) based on weight-for-age z-scores (OR=0.298; p=0.019) as an independent predictor of stunting severity, whereas household CHLB was not significantly associated (p=0.132). In conclusion, stunting severity among children under five was primarily associated with child age and nutritional status rather than household CHLB implementation. These findings highlight the importance of early-life nutritional interventions to prevent progression to severe stunting.
Co-Authors Amna, Eka Yunita Anidar Anidar, Anidar Bakhtiar Bakhtiar Darnifayanti, Darnifayanti Dora Darussalam, Dora Edward, Eka Destianti Fajar, Sukmawan Fajri, Fauzan Gunawan, Aris Hasan, Denny I. Hasan, Denny Irmawati Herlina Dimiati, Herlina Heru Noviat Herdata, Heru Noviat Ismy, Jufitriani Kowita, Nurul Huda Maghfirah, Dhiyal Maharani, Cut R. Nora Sovira, Nora Pratiwi, Sari Novita Raihani, Rifa Rusdi Andid, Rusdi Sentosa, Sukmawan F. Sofia Sofia, Sofia Sulaiman Yusuf Syafruddin Haris, Syafruddin Utami, Maharani Risiska