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Risk factors for acute kidney injury in children with critical illness Chalisah, Lilis; Sovira, Nora; Amna, Eka Yunita; Anidar, Anidar; Haris, Syafruddin; Bakhtiar, Bakhtiar
Paediatrica Indonesiana Vol 64 No 5 (2024): September 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.5.2024.398-404

Abstract

Background Acute kidney injury (AKI) is an acute functional kidney disorder that increases morbidity and mortality in children. The mortality rate for critically ill patients accompanied by AKI is quite high and is influenced by the degree of AKI, the severity of the disease, and organ function disorders. Understanding the risk factors of developing AKI in children with critical illness can help prevent AKI. Objective To determine the risk factors for AKI in children with critical illness. Methods This retrospective cohort study included 255 children aged 1 month to 18 years admitted at the pediatric intensive care unit (PICU) of dr. Zainoel Abidin Regional Public Hospital, Banda Aceh, Aceh, from January to December 2022 using medical record data. Bivariate and multivariate analyses were performed. Results Acute kidney injury occurred in 68 (26.7%) patients. Based on pRIFLE criteria, 34 (50%) patients had AKI in the failure stage. Risk factors for AKI in children with critical illness were in descending order of RR: sepsis (RR 14.3; 95%CI 11.68 to 18.66; P=0.000), mechanical ventilation (RR 12.13; 95%CI 8.75 to 15.98; P=0.000), respiratory disorders (RR 2.51; 95%CI 2.06 to 4.02; P=0.003), congenital heart disease (RR 2.08; 95%CI 2.00 to 3.05; P=0.004), CNS disorders (RR 1.24; 95%CI 1.02 to 2.49; P=0.048), nephrotoxic drug use (RR 1.41; 95%CI 1.24 to 3.08; P=0.000), and age 1 month to 5 years (RR 0.072; 95%CI 0.16 to 0.32; P=0.010). Conclusion Sepsis is a risk factor for AKI in children with critical illness, followed by mechanical ventilation use, respiratory disorders, nephrotoxic drug use. Age <5 years is a protective factor.
Role of Vitamin D and E as Antioxidants Against Cerebral Endothelial Dysfunction: An In Vivo Study in White Rats (Rattus norvegicus) Sepsis Model Fajri, Fauzan; Fajar, Sukmawan; Hasan, Denny Irmawati; Dimiati, Herlina; Amna, Eka Yunita; Sovira, Nora; Anidar, Anidar; Safri, Mulya; Gunawan, Aris
Journal of Basic Medical Veterinary Vol. 13 No. 2 (2024): Journal of Basic Medical Veterinary, December 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v13i2.61610

Abstract

Sepsis is a life-threatening condition caused by the body's response to an infection, leading to organ dysfunction. A antioxidants can help neutralize harmful free radicals that cause cellular and tissue damage through oxidative stress. Vitamin D and E are two antioxidants that have been extensively studied for their potential effectiveness. This study aims to evaluate the effectiveness of vitamins D and E in reducing oxidative stress in the cerebral vascular endothelial cells of Wistar mice in a sepsis model. The study follows an experimental design and uses a posttest with a control group. The levels of NO and SOD in 24 sepsis model mice were measured using ELISA, and the cerebral endothelial tissues were examined histopathologically. An ANOVA test was performed, followed by the Post Hoc LSD test. NO and SOD levels decreased in sepsis rats from 66.88 ± 16.59 to 88.77 ± 12.83µmol/L. Sepsis mice given vitamin D and E showed significant results on changes in NO and SOD levels (p<0.05). Based on the histopathological results of necrosis, inflammation, and hemorrhagic cell damage in sepsis rats reached over 50% of the field of view, significantly different from sepsis mice that had been given vitamin D and E. Sepsis mice were given vitamin D and E influenced 96.2% and 98.7% on changes in NO, SOD, and cerebral endothelial dysfunction (p<0.05). These findings imply that vitamins D and E may be beneficial in managing sepsis-induced cerebral endothelial dysfunction, potentially impacting the treatment and outcomes of sepsis patients.
Analisis Faktor Risiko Kejadian Stunting Pada Anak Umur 0 Sampai 12 Bulan Di Wilayah Kerja Puskesmas Kuta Baro Kabupaten Aceh Besar Nandita, Aisya Shaka; Fadhil, Iziddin; Amna, Eka Yunita
Future Academia : The Journal of Multidisciplinary Research on Scientific and Advanced Vol. 2 No. 4 (2024): Future Academia : The Journal of Multidisciplinary Research on Scientific and A
Publisher : Yayasan Sagita Akademia Maju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61579/future.v2i4.211

Abstract

Stunting is a growth and development disorder in children who experience poor nutritional intake, malnutrition, repeated infections and inadequate psychosocial stimulation, so for the diagnosis and management of stunting a comprehensive examination is needed. And stunting can also be defined as length or height less than - 2 standard deviations (SD) below the WHO median length and height curve (<-2 SD). Indonesia's 2022 Toddler Nutrition Status regarding stunting decreased from 24.4% in 2021 to 21.6 in 2022. The incidence of stunting in toddlers is high, namely Aceh Province (31.2%). This study aims to determine the dominant risk factors affecting the incidence of stunting in children aged 0-12 in the Kuta Baro Health Center working area, Aceh Besar Regency. To determine the risk factors for stunting in children aged 0-12 in the working area of the Kuta Baro Health Center, Aceh Besar Regency. This type of research uses obsevational analytic with the research design used is Cross Sectional. This research was conducted from March to July 2024. The results showed that the logistic regression analysis showed that the variables of exclusive breastfeeding and hand washing sanitation had a multivariate dominant relationship to stunting, with an exclusive breastfeeding p-value <0.05, namely 0.004 and hand washing sanitation p-value <0.05, namely 0.024. The dominant factors that have the most influence on the incidence of stunting are exclusive breastfeeding and hand washing sanitation. So that socialization / counseling to raise mothers' awareness of the importance of exclusive breastfeeding to infants / toddlers and promotion of PHBS in the working area of Puskesmas Kuta Baro Aceh Besar Regency.
Urinary neutrophil gelatinase-associated lipocalin to predict acute kidney injury in children with critical illness Fajri, Rizky; Sovira, Nora; Haris, Syafruddin; Dimiati, Herlina; Bakhtiar, Bakhtiar; Amna, Eka Yunita
Paediatrica Indonesiana Vol. 65 No. 1 (2025): January 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.1.2025.47-53

Abstract

Background Acute kidney injury (AKI) can increase mortality in children with critical illness. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is a biomarker for early prediction of AKI in children. Objective To determine the diagnostic value of uNGAL as a predictor of AKI in children with critical illness. Methods This observational cross-sectional study was conducted in the Emergency Room, Pediatric Intensive Care Unit, and Pediatric Ward of Zainoel Abidin Public Hospital, Banda Aceh, Indonesia, between August and December 2023. Subjects were 40 children aged 1 month to 18 years with critical illness. uNGAL levels were measured on the first day of admission. Blood urea and creatinine levels were measured on the first and third days of admission. We calculated the diagnostic sensitivity and specificity of uNGAL to predict AKI. The optimal uNGAL cut-off point for this purpose was determined using receiver operating characteristic (ROC) curve analysis. Result In the majority of patients (29/40; 72.5%) critical illness occurred at the ages of 5 to 18 years. The most common primary diseases were central nervous system disorders in 14/40 (35%) patients, gastrointestinal infection in 6/40 (15%) patients, and malignancy in 5/40 (12.5) patients. Median uNGAL levels were significantly elevated in subjects with renal impairment [17.37 (range 6.13-29.70) ng/mL] compared to those with normal renal function [4.87 (range 0.32-29.49) ng/mL] (P=0.0001). The optimal uNGAL cut-off point was >9.99 ng/mL, with an AUC of 0.842, 81% sensitivity, and 78.9% specificity to predict AKI. The OR of AKI in children with uNGAL levels >9.99 ng/mL was 10.66 (95%CI 2.30 to 49.30; P=0.003). Conclusion Urinary neutrophil gelatinase-associated lipocalin (uNGAL) can be used as a predictor of acute kidney injury in children with critical illness.
Pemantauan Perkembangan Anak Umur 0 - 12 Bulan Di Wilayah Kerja Puskesmas Ulee Kareng Kota Banda Aceh Zakia, Fitri; Amna, Eka Yunita; Lubis, Silvia Yasmin
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 3 (2025): Volume 12 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i3.17672

Abstract

Pemantauan perkembangan anak sangat penting dilakukan untuk memastikan anak berkembang sesuai dengan tahap yang diharapkan dan mengidentifikasi gangguan perkembangan anak lebih awal, dikarenakan perkembangan pada masa balita sangat menentukan perkembangan masa selanjutnya. Tujuan penelitian ini adalah mengetahui pemantauan perkembangan anak umur 0 – 12 Bulan di wilayah kerja Puskesmas Ulee Kareng Kota Banda Aceh. Penelitian ini menggunakan desain deskriptif dengan pendekatan cross sectional. Hasil penelitian ini menunjukkan pemantauan perkembangan anak pada semua Posyandu telah rutin dilakukan setiap bulan, mayoritas menggunakan KKA yaitu sebanyak 8 desa (88.9 %), dan tidak di dapatkan penyimpangan. Karakteristik demografi terbanyak yang datang adalah usia anak 7-12 bulan sebanyak 57 orang (63.3 %), jenis kelamin anak laki – laki sebanyak 55 orang (61.1 %), usia ibu 26 – 35 tahun sebanyak 61 orang (67.8 %), tingkat pendidikan ibu yaitu pendidikan tinggi sebanyak 49 orang (54.4%), pekerjaan ibu kategori IRT sebanyak 75 orang (83.3 %), dan pengetahuan ibu terhadap buku KIA dan KKA baik sebanyak 57 orang (63.3 %).
Hubungan Riwayat Pemberian Asi Eksklusif Dengan Angka Kejadian Infeksi Saluran Pernapasan Atas Pada Balita Di Rumah Sakit Pertamedika Ummi Rosnati Mahara, Cut; Julinar, Julinar; Amna, Eka Yunita
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 3 (2025): Volume 12 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i3.17555

Abstract

Infeksi Saluran Pernapasan Atas ialah suatu penyakit menular yang disebabkan oleh invasi virus dan bakteri yang menimbulkan reaksi inflamasi pada jalur pernapasan, seperti nasofaringitis, faringitis, sinusitis, laringitis, rinitis dan tonsilitis. Salah satu faktor yang mempengaruhi timbulnya ISPA ialah balita yang tidak diberikan ASI eksklusif berisiko lebih besar mengidap ISPA karena efek proteksi ASI mampu mencegah timbulnya gangguan kesehatan di awal kehidupan. Tujuan penelitian ini untuk menganalisis hasil pemberian ASI eksklusif dengan frekuensi ISPA pada anak di bawah lima tahun. Desain cross-sectional dipakai dalam studi observasional analitik. Sampel penelitian terdiri dari 74 anak berumur 6-59 bulan dengan menggunkan metode total sampling. Analisis data univariat dan bivariat didapatkan umur balita < 35 bulan sebanyak 58,1%, jenis kelamin  balita laki- laki yaitu sebanyak 51,4%, balita yang tidak diberikan ASI eksklusif yaitu sebanyak 52,7%, balita yang mengalami ISPA sebanyak 59,5%. Klasifikasi penyakit ISPA paling banyak yaitu kategori faringitis sebanyak 25,7%. Menurut hasil uji Chi-square (p-value 0,785 > α = 0,05), tidak ada hubungan antara usia balita dengan kejadian ISPA dan Berdasarkan hasil uji Chi-square (p-value = 0,006 < α = 0,05), terdapat korelasi antara riwayat pemberian ASI dengan insiden ISPA.
Central obesity and its association with metabolic syndrome in adolescent students of Aceh Sport High School: A cross-sectional study Nadia, Nurul; Dimiati, Herlina; Amna, Eka Yunita; Andid, Rusdi; Sovira, Nora; Thaib, T.M.
AcTion: Aceh Nutrition Journal Vol 10, No 2 (2025): June
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i2.2485

Abstract

Obesity remains a significant nutritional issue in the pediatric population and is closely linked to metabolic disorders. According to the World Health Organization (2022), 160 million individuals aged 5–19 years are classified as obese.  This study aimed to evaluate the association between central obesity and metabolic syndrome (MetS) in sports students. This cross-sectional study was conducted at Aceh Sports High School from May to August 2024, involving 43 students selected through simple random sampling. Although the sample size was relatively small, these findings offer valuable preliminary insights. The data collected included demographics, anthropometric measurements, blood pressure, and blood tests (glucose, HDL cholesterol, and triglycerides). Central obesity was assessed using waist circumference and MS was evaluated based on the NCEP ATP III criteria. Data were analyzed descriptively, followed by the chi-square test. The majority of the participants were not at risk of MS (51,2%). However, chi-square analysis revealed a statistically significant association between waist circumference and MetS (p<0,001, OR = 3,75 95% CI = 2,072– 6,788). In conclusion, while most participants were not at risk of MetS, central obesity emerged as a strong predictor. These findings underscore the need for early screening and intervention, even in physically active adolescents.
Hubungan Pengetahuan dan Perilaku Ibu Dengan Kejadian Dermatitis Atopik Pada Balita di Rumah Sakit Ibu dan Anak Aceh Tahun 2024 Mudarris, Muhammad Raisul; Julinar; Amna, Eka Yunita
Future Academia : The Journal of Multidisciplinary Research on Scientific and Advanced Vol. 3 No. 3 (2025): Future Academia : The Journal of Multidisciplinary Research on Scientific and A
Publisher : Yayasan Sagita Akademia Maju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61579/future.v3i3.602

Abstract

Dermatitis atopik merupakan penyakit kulit yang sering dialami balita, ditandai dengan kulit kering, gatal, dan lesi berulang, serta dapat mengganggu kenyamanan dan kualitas hidup anak. Penelitian ini bertujuan memahami hubungan pengetahuan dan perilaku ibu dengan kejadian dermatitis atopik pada balita di Rumah Sakit Ibu dan Anak Aceh tahun 2024. Metode penelitian menggunakan analitik observasional dengan desain cross-sectional. Sampel dalam penelitian ini sebanyak 50 ibu yang memiliki anak usia 3–59 bulan dan mengunjungi poli kulit dan kelamin, dipilih secara simple random sampling. Data primer diperoleh melalui kuesioner, sedangkan data sekunder dari rekam medis. Analisis data dilakukan secara univariat dan bivariat menggunakan uji Fisher’s Exact Test. Hasil penelitian menunjukkan mayoritas ibu berusia 20–35 tahun, berpendidikan tinggi, dan bekerja sebagai ibu rumah tangga. Sebanyak 48% balita mengalami dermatitis atopik di poli kulit dan kelamin rumah sakit ibu dan anak Aceh pada tahun 2024. Uji statistik menunjukkan tidak terdapat hubungan antara pengetahuan ibu dengan kejadian dermatitis atopik (p=0,164), namun terdapat hubungan signifikan antara perilaku ibu dengan kejadian dermatitis atopik (p=0,000). Kesimpulan bahwa perilaku ibu berhubungan dengan kejadian dermatitis atopik pada balita, sedangkan pengetahuan ibu tidak berhubungan. Saran, edukasi perilaku pencegahan perlu ditingkatkan untuk menurunkan angka kejadian dermatitis atopik pada balita.
Gambaran Kegiatan Pemantauan Perkembangan Anak Pada Puskesmas Wilayah Kota Banda Aceh Halsa, Ulliya Permata; Amna, Eka Yunita; Lubis, Silvia Yasmin
Future Academia : The Journal of Multidisciplinary Research on Scientific and Advanced Vol. 3 No. 3 (2025): Future Academia : The Journal of Multidisciplinary Research on Scientific and A
Publisher : Yayasan Sagita Akademia Maju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61579/future.v3i3.611

Abstract

Perkembangan adalah bertambahnya kemampuan serta struktur dan fungsi tubuh yang lebih kompleks dalam pola yang teratur, dapat diperkirakan dan diramalkan sebagai hasil dari proses diferensiasi sel, jaringan tubuh, organ-organ dan sistem organ yang terorganisasi dan berkembang sedemikian rupa sehingga masing-masing dapat memenuhi fungsinya. Tujuan pada penelitian ini untuk mengetahui gambaran kegiatan pemantauan perkembangan anak pada masyarakat di Kota Banda Aceh. Jenis penelitian ini adalah deskriptif kuantitatif dengan desain cross sectional. Teknik pengambilan sampel dalam penelitian ini adalah stratified random sampling. Sampel pada penelitian ini sebanyak 100 kader di Puskesmas Wilayah Kota Banda Aceh. Hasil penelitian didapatkan semua kader berjenis kelamin perempuan dan pekerjaan utama sebagai IRT, usia didominasi pada kategori dewasa muda (20 tahun – 40 tahun) sebanyak 46 orang (52%), pendidikan terakhir didominasi pada kategori pendidikan menengah (SMP/SMA) sebanyak 55 orang (63%), Pengetahuan kader tentang perkembangan anak sebagian besar memiliki pengetahuan baik sebanyak 65 orang (74%) dengan motivasi dan alasan kader dalam mengikuti kegiatan pemantauan perkembangan anak adalah menambah wawasan pengetahuan kader, meningkatkan keterampilan, meningkatkan pelayanan kesehatan masyarakat, dan membantu program pemerintah dalam mencegah stunting, pemantauan perkembangan pada puskesmas wilayah Kota Banda Aceh dilakukan setiap bulan dengan menggunakan KIA/KKA.
Risk factors for poor initial response to valproic acid therapy in children with epilepsy Sari, Eva Devita; Anidar, Anidar; Amna, Eka Yunita; Andid, Rusdi; Yusuf, Sulaiman; Sovira, Nora
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.286-90

Abstract

Background The initial response in the first three months of valproic acid therapy is a prognostic factor for predicting treatment success, and it is considered to be poor if seizures persist during the three months of valproic acid treatment. Several factors might influence the initial response to valproic acid therapy, including gender, age, family history of epilepsy, electroencephalogram (EEG), head circumference, type of seizure, cerebral palsy, and pre-therapy seizure frequency. Objective To determine the risk factors for poor early response to valproic acid therapy in children with epilepsy. Methods This retrospective cohort study was conducted in children newly diagnosed with epilepsy. Data were collected from medical records of patients who had been treated at the Pediatric Polyclinic of dr. Zainoel Abidin Hospital for one year. Results Of 90 subjects, most were male (58; 64.4%) and aged three years or older (79; 87.8%). Forty-five (50%) patients had a family history of epilepsy. More than a quarter of the subjects (35; 38.9%) showed initial poor responses to valproic acid therapy. Bivariate analysis revealed risk factors for poor initial response to valproic acid therapy were age ≥ 3 years, family history of epilepsy, normal EEG, normal head circumference, generalized seizure type, cerebral palsy, and pre-therapy seizure frequency. However, multivariate analysis revealed that risk factors for poor initial response to valproic acid therapy in children with epilepsy that retained significance were family history of epilepsy (RR 6.58; 95%CI 1.67 to 25.95; P=0,001), abnormal EEG (RR 5.27; 95%CI 1.16 to 23.87; P=0,000), focal seizures (RR 7.10; 95%CI 1.15 to 43.80; P=0,000), and cerebral palsy (RR 62.62; 95%CI 3.93 to 996.45; P=0,001). Conclusion The risk factors for poor initial response to valproic acid therapy in children with epilepsy are family history of epilepsy, abnormal EEG, focal seizures, and cerebral palsy.