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All Journal journal of Basic Medical Veterinary Jurnal Kedokteran Hewan The International Journal of Tropical Veterinary and Biomedical Research Jurnal Medika Veterinaria
Hasan, Denny Irmawati
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Diagnosis of Fowl Cholera in Broiler Chicken Collected from Banda Aceh and Aceh Besar Aliza, Dwinna; Hasan, Denny Irmawati; Nazaruddin, Nazaruddin; Riady, Ginta
Jurnal Medika Veterinaria Vol 18, No 2 (2024): J. Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v18i2.43832

Abstract

Fowl cholera is a highly contagious bacterial disease affecting poultry worldwide including broiler chickens. This study aimed at diagnosing fowl cholera in broiler chicken collected from Banda Aceh and Aceh Besar based on anatomical pathology and histopathological lesions. Approximately 1,400 broilers chickens cadaver were collected from poultry market around Banda Aceh and Aceh Besar within 2022-2024, then necropsied at Pathology Laboratory, Veterinary Medicine Faculty, USK. All chicken were subjected to an anatomical pathology examination, followed by histopathological observation using hematoxylin-eosin staining method. The macroscopic results revealed multifocal necrosis in the liver, hemorrhages in several internal organs, oedema in lungs, ascites in thorax cavity, and arthritis. Histopathological examination highlighted characteristic lesions including vasculitis, submucosal edema in trachea, multifocal necrosis in liver, and desquamation of intestinal villi. The prevalence rate of fowl cholera disease during 2022, 2023, and 2024 were 8,2%, 11,2%, and 14.0%, respectively. In conclusion, broilers with fowl cholera shows inflammation lesions in several organs, focal necrosis in liver, ascites in thorax and abdominal cavity in acute form, and arthritis in chronic form.
Role of Vitamin D and E as Antioxidants Against Cerebral Endothelial Dysfunction: An In Vivo Study in White Rats (Rattus norvegicus) Sepsis Model Fajri, Fauzan; Fajar, Sukmawan; Hasan, Denny Irmawati; Dimiati, Herlina; Amna, Eka Yunita; Sovira, Nora; Anidar, Anidar; Safri, Mulya; Gunawan, Aris
Journal of Basic Medical Veterinary Vol. 13 No. 2 (2024): Journal of Basic Medical Veterinary, December 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v13i2.61610

Abstract

Sepsis is a life-threatening condition caused by the body's response to an infection, leading to organ dysfunction. A antioxidants can help neutralize harmful free radicals that cause cellular and tissue damage through oxidative stress. Vitamin D and E are two antioxidants that have been extensively studied for their potential effectiveness. This study aims to evaluate the effectiveness of vitamins D and E in reducing oxidative stress in the cerebral vascular endothelial cells of Wistar mice in a sepsis model. The study follows an experimental design and uses a posttest with a control group. The levels of NO and SOD in 24 sepsis model mice were measured using ELISA, and the cerebral endothelial tissues were examined histopathologically. An ANOVA test was performed, followed by the Post Hoc LSD test. NO and SOD levels decreased in sepsis rats from 66.88 ± 16.59 to 88.77 ± 12.83µmol/L. Sepsis mice given vitamin D and E showed significant results on changes in NO and SOD levels (p<0.05). Based on the histopathological results of necrosis, inflammation, and hemorrhagic cell damage in sepsis rats reached over 50% of the field of view, significantly different from sepsis mice that had been given vitamin D and E. Sepsis mice were given vitamin D and E influenced 96.2% and 98.7% on changes in NO, SOD, and cerebral endothelial dysfunction (p<0.05). These findings imply that vitamins D and E may be beneficial in managing sepsis-induced cerebral endothelial dysfunction, potentially impacting the treatment and outcomes of sepsis patients.
The Correlation Between pH Values and Acidity Degrees of Dadih from Gayo to Total Bacteria Colonies with Different Storage Time and Temperature Rastina, Rastina; Ferasyi, Teuku Reza; Azhari, Azhari; Rasmaidar, Rasmaidar; Hasan, Denny Irmawati; Helmi, T Zahrial; Sitepu, Dinda Meilinda Br
The International Journal of Tropical Veterinary and Biomedical Research Vol 9, No 2 (2024): Vol. 9 (2) November 2024
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v9i2.43677

Abstract

Dadih is a traditional food product that is produced by storing buffalo milk in bamboo tubes and left for 2-3 days. During the process of making Dadih, milk ferments into Dadih in a bamboo tube. The aim of this research is to determine the quality of buffalo Dadih from pH values, acidity degrees, and total bacterial colonies with different storage durations and temperatures. This research used 12 bamboo tubes with two treatments and three repetitions. This research used a laboratory experimental method with a 2x3 factorial pattern. This research showed that the highest room and refrigerator pH values were found in the first week, with an average of 7.13 0.15 and 7.9 0.1. The highest acidity degree values from room temperature and refrigerator were in the third week, with 359.47 16.95 and 254.03 6.34. Another finding was that the highest total bacterial colonies at room temperature and in the refrigerator were in the third week, with 3.33 0.89 and 2.8 0.76. It can be concluded that the buffalo Dadih from Gayo has a pH value and a total value of bacterial colonies that meet SNI standards. Meanwhile, the total titrated acid in Dadih does not yet have an SNI standard.
LASER ACUPUNCTURE AS A NON-INVASIVE STRATEGY TO OPTIMIZE RABBIT GROWTH: HISTOMORPHOMETRIC AND LEUCOCYTE ANALYSIS STUDY Ritonga, Mudhita Zikkrullah; Hasan, Denny Irmawati; Hidanah, Sri; Lokapirnasari, Widya Paramita
Jurnal Kedokteran Hewan Vol 18, No 4 (2024): December
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v18i4.42593

Abstract

This study evaluates the effects of laser acupuncture on jejunum morphometry and the differential leucocyte responses in rabbits. Twenty-four Hycole rabbits, aged four to twelve weeks with an average weight of 1046 g, were administered laser acupuncture once a week for six weeks. The rabbits were housed in individual cages and randomly divided into three groups. Group 1 (control) received inactive laser acupuncture for predetermined acupuncture points (Bladder 13, Bladder 15, and Bladder 21). Group 2 received active laser acupuncture at the exact points BL 13, BL 15, and BL 21, using a laser dose of 0.2 Joules. Group 3 received laser acupuncture near, but not precisely at, these exact points. Blood samples were collected at the end of the 12th week, and the jejunum was excised for histomorphometric analysis. The results indicated that rabbits in group 2 had significant increases (P0.05) in villus height (VH), and villus width (VW) compared to groups 1 and 3. The results of differential leucocytes measurements in groups 1, 2, and 3 were lymphocytes 64.2037%, 61.80.374%, 61.80.489% (normal: 30-85%); monocytes 130.447%, 12.20.374%, and 13.40.244% (normal: 4-13.4%), granulocytes 23.40.748%, 260.447%, and 24.80.374 (normal: 21-73%), respectively. These findings indicate that laser acupuncture targeted at BL13, BL15, and BL21 points promotes villi development and maintains differential leukocyte parameters within the normal range.
COMPARATIVE STUDY OF BLOOD GLUCOSE LEVELS AND THE DEGREE OF LIVER AND KIDNEY DAMAGE IN DIABETIC ANIMAL MODELS INDUCED BY ALLOXAN, STREPTOZOTOCIN, AND STREPTOZOTOCIN-NICOTINAMIDE Miswari, Irna; Husna, Fauzul; Zulkarnain, Zulkarnain; Syahrizal, Dedy; Syahputra, Andika Ari; Hasan, Denny Irmawati
Jurnal Kedokteran Hewan Vol 19, No 2 (2025): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v19i2.40839

Abstract

The objective of this study was to assess differences in body weight, blood glucose levels, and liver and kidney tissue damage among rats induced with alloxan, streptozotocin, or streptozotocin-nicotinamide. This was an experimental study using a completely randomized design. The rats were allocated into four experimental groups. Group 1 (KN) was considered as the normal control group, while groups K1, K2, and K3 were induced with streptozotocin (60 mg/kg bw), alloxan (150 mg/kg bw), and nicotinamide (120 mg/kg bw) followed by streptozotocin (60 mg/kg bw), respectively. The compounds were administered intraperitoneally using suitable solvents. Body weight and blood glucose levels were monitored weekly. Upon completion of the study, liver and kidney tissues were harvested and processed for histopathological analysis using hematoxylin-eosin staining. The findings revealed that all diabetic induction models had significantly elevated blood glucose levels compared to the control group. Additionally, there were significantly differences (P0.05) in liver and kidney tissue damage among the groups treated with streptozotocin (STZ), alloxan, and STZnicotinamide. In conclusion, STZ induction produced more consistent hyperglycemia with less tissue damage compared to alloxan, while, nicotinamide co-administration effectively reduced cellular degeneration, suggesting its protective role against diabetes-induced tissue injury.
Histopathologic Features of Trachea and Lungs in Chickens with Chronic Respiratory Disease Annisa, Aiza; Darmawi, Darmawi; Etriwati, Etriwati; Balqis, Ummu; Salim, M. Nur; Nazaruddin, Nazaruddin; Aliza, Dwinna; Aisyah, Siti; Awaluddin, Awaluddin; Hasan, Denny Irmawati; Akmal, Muslim; Helmi, T. Zahrial; Asmilia, Nuzul
Jurnal Medika Veterinaria Vol 18, No 1 (2024): J.Med.Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v18i1.37429

Abstract

The purpose of this case study is to determine the changes that exist in chickens infected with Chronic Respiratory disease (CRD). A broiler male chicken aged 40 days was found dead in a chicken basket at Ulee Kareng chicken slaughterhouse in a state of feather loss and feces attached to cloaca, on January 6th, 2023. The chicken was brought to pathology laboratory of Faculty of Veterinary Medicine, Universitas Syiah Kuala for necropsy and organ collection. Organs associated with CRD cases were trachea and lungs and histopathological preparations were carried out, stained with Haematoxylin Eosin, and observed under a microscope. The results of histopathological examination showed hemorrhage and hyperplasia of the tracheal epithelium. Hemorrhage was caused by edema which causes increased vascular permeability and epithelial cell hyperplasia occured due to the body's response to infection or inflammation. In the lungs there was bleeding due to damage to the blood vessel wall which caused increased vascular permeability, so that fluid and blood plasma come out of the blood vessels. Fibrinogen then underwent polymerization which resulted in fibrinous thrombi. Congestion happened as the result of fluid accumulation in a location that occured in a passive process so the fluid failed to escape. Because of the accumulation of fluid (congestion), the blood supply to the lung tissue is interrupted, resulting in several points of necrosis in the lungs.
Newcastle Disease Case in Broiler Chicken Angreini, Meliyantika; Balqis, Ummu; Etriwati, Etriwati; Hasan, Denny Irmawati; Aisyah, Siti; Salim, M. Nur; Nazaruddin, Nazaruddin; Darmawi, Darmawi
Jurnal Medika Veterinaria Vol 17, No 2 (2023): J.Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v17i2.35151

Abstract

Newcastle Disease (ND) is a highly contagious disease with a high mortality rate, infecting poultry, and chickens are very susceptible to ND infection. The purpose of this case report is to find out how to diagnose ND disease in chickens. A 30-day-old white male broiler cadaver obtained from Pasar Lambaro, Aceh Besar was found dead in a holding cage with conjunctival hemorrhage and hair loss. Based on the physical examination of the external condition of the cadaver, it can be seen that the eye membranes are experiencing hemorrhage. There was nasal mucosa hemorrhage and mucous exudate in the nasal cavity. The oral mucosa was also found to have mucous exudate, while the cloaca was bleeding and there was residual green feces. The results of anatomic pathology examination found ptechie in the proventriculus and ventricles, swollen lungs with blackish red color and hemorrhage,with the presence of cheese. There was hemorrhage in other organs including trachea, intestines and tonsils, whilst the brain experienced hyperemia. The spleen was swollen and there were foci of necrosis. Based on the anamnesis, external examination, pathological anatomical examination, and histopathology, the diagnosis of the cause of death of broiler chickens was Newcastle Disease (ND).
EFFECT OF BLACK CUMIN OIL ADMINISTRATION ON CORTISOL LEVEL AND LIVER HISTOPATHOLOGY OF HEAT STRESSED BROILER CHICKENS Hasan, Denny Irmawati; Sugito, Sugito; Sabri, Mustafa; Hambal, Muhammad; Balqis, Ummu
Jurnal Kedokteran Hewan Vol 13, No 1 (2019): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v13i1.12858

Abstract

The aim of this study was to observe cortisol levels and liver histopathology of broiler chicken that were treated with black cumin oil (BCO) under heat stress. A total of 15 broiler chickens were used in this study and divided into 5 groups, K- (without treatment), K+ (given heat stress), P1 (given heat stress and 0.56mL BCO/400kg body weight, P2 (given heat stress and 1.11 mL BCO/400 g body weight), and P3 (given heat stress and 2.22 mL BCO/400 g body weight). Heat stress was given for 5 hours with temperature range of 34-35 C for 7 days. Cortisol was measured using the cortisol enzyme-linked immunosorbent assay (ELISA) kit. Liver histopathology was stained with hematoxylin eosin and observed with electron microscope. The data were analyzed using one way analysis of variance (ANOVA). This study found that application of heat stress to broiler chickens increased cortisol levels and induced histopathological changes in the liver. The BCO administration reduced cortisol level significantly (P0.05) in heat-stressed broilers. BCO administration also significantly reduced (P0.05) the degenerative changes in liver histopathology such as fat degeneration, hemorrhage and necrosis in broiler chickens under heat stress, but did not significantly influence the inflammatory cells infiltration. As conclusion, BCO administration to broiler chickens under heat stress can reduce cortisol levels and minimize histopathological changes in the liver.
Co-Authors Amna, Eka Yunita Angreini, Meliyantika Anidar Anidar, Anidar Annisa, Aiza Awaluddin Awaluddin Azhari Azhari Darmawi . Dedy Syahrizal Dwinna Aliza Etriwati E Faisal Mustafa Fajar, Sukmawan Fajri, Fauzan Ginta Riady Gunawan, Aris Helmi, T Zahrial Helmi, T. Zahrial Herlina Dimiati, Herlina Hidanah, Sri Husna, Fauzul M. Nur Salim Miswari, Irna Muhammad Hambal Mulya Safri, Mulya Muslim Akmal N. Nazaruddin Nora Sovira, Nora Nuzul Asmilia Rasmaidar Rasmaidar Rastina, Rastina Ritonga, Mudhita Zikkrullah Sitepu, Dinda Meilinda Br Siti Aisyah Sugito - Syahputra, Andika Ari Teuku Reza Ferasyi Ummu Balqis Widya Paramita Lokapirnasari Zulkarnain Zulkarnain