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All Journal Jurnal Biosains Pascasarjana Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat
Mutia Hariani Nurjanah
STIKES Karya Putra Bangsa Tulungagung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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A CYTOKINE RESPONSE IN BRUCELLA ABORTUS BOVINE INFECTION: LITERATURE REVIEW septyana eka rahmawati; RIAN ANGGIA destiawan; novarina sulsia ista'in ningtyas; Mutia Hariani Nurjanah
Jurnal Biosains Pascasarjana Vol. 24 No. 1SP (2022): JURNAL BIOSAINS PASCASARJANA: SPECIAL ISSUE
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i1SP.2022.1-12

Abstract

Brucella Abortus infection in cattle is an infection that has a strategic effect on society, especially the economic sector. This disease is caused by gram-negative bacteria, namely Brucella abortion. Treatment of Brucella Abortus Infection in cattle is still not effective. Therapy based on the immune response caused by Brucella Abortus Infection, especially the cytokine response, is an effective choice considering that each type of cow has a different immune response in dealing with Brucella Abortus Infection. The purpose of writing this literature review is to identify cytokines that play a role in Brucella Abortus Infection in cattle. Method: automated PUBMED database search using keywords “Brucella Abortus Bovine”, “Cytokine”, and “Brucellosis”. Results: 11 articles that are relevant and meet the inclusion criteria to analyze the cytokines that play a role in Brucella Abortus Infection in cattle. Conclusion: Cytokines that play a role in Brucella Abortus infection in cattle are generally IL-1, IL-6, IL-12, IL-8, TNF-α, and IFN-γ.
EFFECT OF BLACK GRAPE EXTRACT ON CD4+ and CD8+ EXPRESSION IN MICE INFECTED WITH Salmonella typhimurium rian anggia destiawan; septyana eka rahmawati; anas fadli wijaya; Ahdiah Imroatul Muflihah; Mutia Hariani Nurjanah; Sholihatil hidayati; Ni Ketut Yuliana sari
Jurnal Biosains Pascasarjana Vol. 24 No. 1SP (2022): JURNAL BIOSAINS PASCASARJANA: SPECIAL ISSUE
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i1SP.2022.54-63

Abstract

Salmonelosis is a disease caused by the Salmonella sp. that causes a decrease in CD4+ expression. Black grape can boost the immune system through CD4+/CD8+ proliferation. The purpose of this study was to evaluate the activity of black grape extract to CD4+ and CD8+ expression in mice infected with Salmonella typhimurium. Research method is extract of black grapes, Salmonella typhimurium 108 infection, bacterial evaluation, extract therapy, flowcytometery examination, and 95% Anova test. The results of Anova test showed that the expression of CD4+ and CD8+ is not different. Biologically, an increase in CD4+ and CD8+ expression at doses of 100 mg/KgBB. A decrease in CD4+ and CD8+ expression at doses of 200 mg/KgBB and 400 mg/KgBB. Conclusion, biologically, black grape extract can increase the expression of CD4+ and CD8+ at low doses, as well as may decrease the expression of CD4+ and CD8+ at moderate to high doses.
DETECTION OF CD4+ T-LYMFOCYTE ADAPTIVE IMMUNITY CELL EXPRESSION IN MICE INFECTED WITH Salmonella typhimurium Mutia Hariani Nurjanah
Jurnal Biosains Pascasarjana Vol. 24 No. 1SP (2022): JURNAL BIOSAINS PASCASARJANA: SPECIAL ISSUE
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i1SP.2022.39-43

Abstract

Salmonella typhi is a gram-negative, intracellular facultative bacterium that can live and even reproduce in macrophages, resistant to lysosomal enzymes, which has the ability to prevent phagosome-lysosome fusion, making it difficult to kill. stimulates the immune response in the host (Abbas et alll, 2016; Tores et alll, 2000). White turmeric (Curcuma zedoaria) is one of the herbal plants used as an immunomodulator. Immodulators in white turmeric substances function to increase the function of phagocytosis in macrophages to destroy Salmonella typhimurium bacteria. The purpose of this study was to determine the difference between white turmeric extract as an immunomodulator on the number of CD4+ T lymphocytes in BALB/c mice infected with Salmonella typhimurium. This research is a true experimental research with a posttest only control group design. Mice were divided into 5 groups consisting of negative control group, positive control and test group. Analysis of CD4+ lymphocyte data showed a significant difference p=0.013, this indicated that administration of white turmeric extract (Curcuma zedoaria) had an effect on the number of CD4+ T lymphocytes in BALB/c mice infected with Salmonella typhimurium
GAMBARAN ERITROSIT SEDIMENTATION RATE PADA IBU HAMIL DI DESA BEDILJATI WETAN KECAMATAN SUMBERDADI KABUPATEN TULUNGAGUNG Mutia Hariani Nurjanah; Arif Santoso; Yunita Safitri
Jurnal Farmasindo Vol 7 No 2 (2023): Desember
Publisher : Program Studi D3 Farmasi Politeknik Indonusa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Suatu respon terhadap perubahan hormonal multifaktoral yang terjadi pada ibu hamil merupakan perubahan hematologi pada kehamilan adalah perubahan laju eritrosit dan anemia hal ini disebabkan meningkatnya kebutuhan zat besi. Upaya yang dilakukan untuk menilai perubahan hematologi pada ibu hamil adalah pemeriksaan laboratorium. Eritrosit sedimentation rate (ESR) merupakan proses pemeriksaan pengedapan atau sedimentasi darah yang digunakan dalam penilaian respons fase akut terhadap peradangan. Peningkatan nilai ESR menunjukkan adanya penyakit deman rematik, inflamasi/autoimun dan infeksi. Tujuan penelitian untuk mengetahui gambaran ESR pada ibu hamil di Desa Bediljati Wetan Kecamatan Sumberdadi Kabupaten Tulungagung. Teknik sampling yang digunakan sampling purposif. Sampel penelitian ialah ibu hamil yang berjumlah 20 responden. Hasil penelitian ESR ibu hamil didapatkan hasil pemeriksaan ESR normal sebanyak 3 responden (15%) dan ESR lebih dari normal sebanyak 17 responden (85%). Dari hasil tersebut disimpulkan bahwa gambaran laju endap darah meningkat sebanyak 85% pada 20 responden ibu hamil.
Co-Authors AHDIAH IMROATUL MUFLIHAH Anas Fadli Wijaya Arif Santoso Ni Ketut Yuliana Sari Novarina Sulsia Ista'In Ningtyas Rahmawati, Septyana Eka RIAN ANGGIA DESTIAWAN Sholihatil Hidayati Yunita Safitri