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Rahmawati, Septyana Eka
Universitas Pendidikan Mandalika
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Regulasi Reseptor Cytotoxic T Lymphocyte Associated Protein 4 Limfosit T Terhadap Kanker dan Autoimun: Literature Review Rian Anggia Destiawan; Anas Fadli Wijaya; M Elyas Arif; Septyana Eka Rahmawati
Jurnal Biosains Pascasarjana Vol. 23 No. 2 (2021): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v23i2.2021.49-54

Abstract

Cytotoxic T Lymphocyte Associated Protein 4 (CTLA-4) adalah reseptor limfosit T yang berikatan dengan B7-1 dan B7-2 dari sel dendritik. CTLA-4 berperan menghambat kerja limfosit T. CTLA-4 diekspresikan oleh limfosit T pada fase istirahat atau setelah teraktivasi. CTLA-4 ditemukan pada sel dendritik, monosit, limfosit B, limfosit T, granulosit, dan stem sel CD34+. CTLA-4 berperan penting dalam perkembangan tumor, kanker serta autoimun. Literatur review ini bertujuan untuk membahas regulasi CTLA-4 limfosit T terhadap penyakit kanker dan autoimun. Metode: pencarian sistematis pada tiga database yaitu NCBI, science direct, dan nature dengan kata kunci “CLTA-4 and T cell and cancer and autoimmune” tahun 2021. Hasil: didapatkan 6 pilihan intervensi untuk mengurangi ekspresi CTLA-4 dan 1 intervensi untuk meningkatkan ekspresi CTLA-4. Kesimpulan: berdasarkan analisis terhadap 7 artikel penelitian, penurunan ekspresi CTLA-4 dapat menghambat pertumbuhan kanker dan peningkatan ekspresi CTLA-4 dapat menghambat berkembangnya autoimun maka dapat. 
A CYTOKINE RESPONSE IN BRUCELLA ABORTUS BOVINE INFECTION: LITERATURE REVIEW septyana eka rahmawati; RIAN ANGGIA destiawan; novarina sulsia ista'in ningtyas; Mutia Hariani Nurjanah
Jurnal Biosains Pascasarjana Vol. 24 No. 1SP (2022): JURNAL BIOSAINS PASCASARJANA: SPECIAL ISSUE
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i1SP.2022.1-12

Abstract

Brucella Abortus infection in cattle is an infection that has a strategic effect on society, especially the economic sector. This disease is caused by gram-negative bacteria, namely Brucella abortion. Treatment of Brucella Abortus Infection in cattle is still not effective. Therapy based on the immune response caused by Brucella Abortus Infection, especially the cytokine response, is an effective choice considering that each type of cow has a different immune response in dealing with Brucella Abortus Infection. The purpose of writing this literature review is to identify cytokines that play a role in Brucella Abortus Infection in cattle. Method: automated PUBMED database search using keywords “Brucella Abortus Bovine”, “Cytokine”, and “Brucellosis”. Results: 11 articles that are relevant and meet the inclusion criteria to analyze the cytokines that play a role in Brucella Abortus Infection in cattle. Conclusion: Cytokines that play a role in Brucella Abortus infection in cattle are generally IL-1, IL-6, IL-12, IL-8, TNF-α, and IFN-γ.
DETECTION Escherichia coli IN DRINKING WATER SOURCES IN CHICKEN FARMING IN NARMADA DISTRICT, LOMBOK BARAT REGENCY novarina sulsia ista'in ningtyas; alfiana laili dwi agustin; septyana eka rahmawati
Jurnal Biosains Pascasarjana Vol. 24 No. 1SP (2022): JURNAL BIOSAINS PASCASARJANA: SPECIAL ISSUE
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i1SP.2022.74-83

Abstract

Water plays an important role in human life. One of the sources of water used by the community is a source of water that comes from wells. The water source in the poultry area in Narmada is not only used for livestock needs but is utilized and consumed by the community especially farmers around the water source. The distance between the water source and the poultry area is less then 15 meters which is the cause of contamination. Research the aimed to detect contaminating bacterial in water source in Poultry of Narmada Regency. The study used a survey method with cross sectional study approach which was carried out in September 2022. Sample were taken using sterile bottles which were then cultured in EMBA, NA and biochemical test. The result of this study showed that there were four samples contaminated with E.coli which was marked with a metallic green on EMBA and the show basil and red colors under microscope.
EFFECT OF BLACK GRAPE EXTRACT ON CD4+ and CD8+ EXPRESSION IN MICE INFECTED WITH Salmonella typhimurium rian anggia destiawan; septyana eka rahmawati; anas fadli wijaya; Ahdiah Imroatul Muflihah; Mutia Hariani Nurjanah; Sholihatil hidayati; Ni Ketut Yuliana sari
Jurnal Biosains Pascasarjana Vol. 24 No. 1SP (2022): JURNAL BIOSAINS PASCASARJANA: SPECIAL ISSUE
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i1SP.2022.54-63

Abstract

Salmonelosis is a disease caused by the Salmonella sp. that causes a decrease in CD4+ expression. Black grape can boost the immune system through CD4+/CD8+ proliferation. The purpose of this study was to evaluate the activity of black grape extract to CD4+ and CD8+ expression in mice infected with Salmonella typhimurium. Research method is extract of black grapes, Salmonella typhimurium 108 infection, bacterial evaluation, extract therapy, flowcytometery examination, and 95% Anova test. The results of Anova test showed that the expression of CD4+ and CD8+ is not different. Biologically, an increase in CD4+ and CD8+ expression at doses of 100 mg/KgBB. A decrease in CD4+ and CD8+ expression at doses of 200 mg/KgBB and 400 mg/KgBB. Conclusion, biologically, black grape extract can increase the expression of CD4+ and CD8+ at low doses, as well as may decrease the expression of CD4+ and CD8+ at moderate to high doses.
PHENOTYPIC DETECTION OF Escherichia coli PRODUCING Extended Spectrum Beta Lactamases (ESBLs) IN THE REPRODUCTIVE TRACT BALI COW Lalu Purnama Tasyakusuma; kholik kholik; maratun janah; alfiana laili dwi agustin; septyana eka rahmawati
Jurnal Biosains Pascasarjana Vol. 24 No. 1SP (2022): JURNAL BIOSAINS PASCASARJANA: SPECIAL ISSUE
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i1SP.2022.64-73

Abstract

Escherichia coli bacteria that are resistant to β-lactam antibiotics and may be able to produce Extended-spectrum β-lactamase (ESBLs) have been found in the reproductive tract of Bali cattle. Escherichia coli that produce ESBL will cause antimicrobial resistance (AMR) which has become a global health problem. The purpose of this study was to detect phenotypically the presence of Escherichia coli that produces ESBL from the reproductive tract of Bali cattle. This research was conducted in February 2022 in Lando Village, Terara District, East Lombok Regency using 8 female Bali cattle on smallholder farms. Reproductive fluid samples were collected using a plastic sheet gun which was inserted into the Brain Infusion Heart (BHI) media and incubated at the Public Health and Calibration Laboratory of West Nusa Tenggara Province. The samples were then cultured in EMBA media for the isolation of Escherichia coli. The isolated Escherichia coli were then identified by gram staining and biochemical tests based on Bergey's manual of determinative bacteriology. The identified Escherichia coli were screened using the disc diffusion method using the antibiotics Penicillin G10U, Ceftazidime 30 μg, and Cefotaxime 30 μg followed by a confirmation test using the double disk synergy test (DDST) method. The results of the screening test showed that only 12.5% of Escherichia coli (1 out of 8 samples) were resistant to Penicillin G, but they had not been detected to produce ESBL phenotypically.
Training for Disaster Response Youth Cadres About Post Earthquake Injury Using Student Centered Learning (Scl) Approach septyana eka rahmawati; Eka Rudy Purwana; Hardiansyah hardiansyah; Dewi Purnamawati
Jurnal Biosains Pascasarjana Vol. 25 No. 1 (2023): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v25i1.2023.74-78

Abstract

Efforts to deal with crises due to disasters or so-called disaster management are a series of activities that began before the occurrence of outbreaks and disasters which were carried out through prevention, mitigation (mitigating/mitigating the impact) and preparedness in dealing with outbreaks and disasters. In general, disaster management is aimed at preventing and limiting the number of victims, so there must be early intervention efforts made by people exposed to training so that the severity of the disaster does not occur. due to the earthquake at SMA Negeri 8 Mataram with a student centered learning (SCL) approach. This study uses a quasi-experimental design with one pre and post test design. A total of 40 Disaster Response Cadre (KATANA) cadres were given disaster response cadre training and disaster preparedness was measured before and after the training. Data analysis used paired t test. The results show that there is an effect of post-disaster intervention disaster response training on disaster preparedness with a p-value of 0.000 <0.05. Conclusion, the results of this study are expected to be a program innovation for youth cadres to improve disaster preparedness.    
Pemeriksaan Hewan Kurban di Musholla Al Atqiyah Karang Sukun Baru Kota Mataram Kholik, Kholik; Riwu, Katty Hendriana Priscillia; Rahmawati, Septyana Eka; Rusdiana, Nur; Asmara, Zinie Hikmah
Bakti Sekawan : Jurnal Pengabdian Masyarakat Vol 3 No 2 (2023): Desember
Publisher : Puslitbang Sekawan Institute Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35746/bakwan.v3i2.433

Abstract

Musholla Al-Atqiyah yang terletak di Kota Mataram setiap tahunnnya menyelenggarakan pemotongan hewan kurban sapi dan kambing. Pemotungan hewan kurban tersebut meminta bantuan dokter hewan di Fakultas Kedokteran Hewan Universitas Pendidikan Mandalika dalam pemeriksaan ante-mortem dan post-mortem. Tujuan kegiatan pemeriksaan kurban adalah untuk menghasilkan daging yang aman, sehat, utuh, dan halal sehingga memberikan jaminan rasa aman kepada masyarakat. Pemeriksaan ante-mortem terhadap hewan kurban sapi dan kambing dilakukan dengan pemeriksan fisik dan cara berjalan untuk melihat adanya gejala klinis penyakit dan abnormalitas organ tubuh. Pemeriksaan post-mortem pada hewan kurban sapi dan kambing dilakukan dengan inspeksi, palpasi dan pengirisan terhadap terhadap organ dan jaringan hewan kurban. Hasil pemeriksaan kesehatan ante-mortem terhadap 11 hewan kurban yang terdiri dari 3 ekor sapi dan 8 ekor kambing di musholla Al-Atqiyah Kota Mataram tidak ditemukan gejala hewan yang sakit. Hasil pemeriksaan post-mortem terkait organ hati, jantung, limfa, paru-paru, dan ginjal sebagai indikasi adanya penyakit dari 11 hewan kurban yang dipotong tidak ditemukan adanya perubahan organ dan tanda-tanda penyaki zoonosis, hanya ditemukan adanya cacing Fasciola sp, sehingga daging dan organ dalam hewan kurban diijinkan untuk didistribusikan untuk dikonsumsi.
SKELETON ANALYSIS OF THE CRANII REGION IN THE CASE OF DOLPHINS (Tursiops trucantus) STRANDED ON SENGGIGI BEACH WEST LOMBOK REGENCY Rahmawati, Septyana Eka; Munawaroh, Muhammad; Barmawi, Muhammad; Kholik; Riwu, Katty Hedriana Priscilia; wijaya, I Gusti Made Arjana
Jurnal Biosains Pascasarjana Vol. 26 No. 2 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i2.2024.174-184

Abstract

Cetaceans are a group of marine mammals fully adapted to aquatic life including whales and dolphins. Dolphins belong to a group of marine animals known as Cetaceans that have evolved completely to live in water. In Indonesian waters, almost all cetacean species have been classified as protected biota. Many cetacean deaths have been linked to water pollution and underwater seismic activity. The bottlenose dolphin (genus Tursiop) is one of the most studied cetacean species due to its wide distribution in tropical and temperate waters and its friendly behavior towards humans. This research shows that the results of the size of the Tursiops truncatus bones in the Cranii section found on Senggigi Beach are different from the results of the size of the Cranii bones of Tursiops truncatus found on Korea's Jeju Island. In a review of literature written about the bones of the Tursiops truncatus species from Korea, Jeju Island. Each part of the Os Cranii on Tursiop truncatus found on Jeju Island, Korea has a very different size from the Tursiop truncatus found on Senggigi Beach which can be concluded that the size of the Os Cranii on Tursiops truncatus found on Jeju Island, Korea has the same size. larger than the size of Tursiops truncatus found on Senggigi Beach, West Lombok Regency. The cause of differences in bone size could be due to diet and habitat. A study on stable isotope analysis of marine mammals off the coast of Northwest Africa and unique trophic niches says mammalian bones reflect not only differences in trophic level but also shifts in foraging areas.
EFEKTIVITAS EKSTRAK ETANOL DAUN BIDARA (Ziziphus mauritina) TERHADAP DAYA VERMISIDAL Fasciola sp Muhammad Agus Munandar Putra; Mashur; Katty Hendriana Priscilia Riwu; Septyana Eka Rahmawati
JURNAL SANGKAREANG MATARAM Vol. 11 No. 2 (2024): DESEMBER 2024
Publisher : SANGKAREANG

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Fasciolosis is a parasitic disease that often attacks ruminant livestock and causes losses for farmers in the form of reduced livestock productivity and can even cause death. This disease is caused by infection with the worm Fasciola sp. This study aims to determine the effectiveness of ethanol extract of bidara leaves (Ziziphus mauritina) on the vermicidal power of Fasciola sp. The samples used in this study were adult fasciola worms taken from the Majeluk Slaughterhouse (RPH) and bidara leaf extract. This research used a Completely Randomized Design (CRD) with seven treatments and three replications each. The treatment consists of bidara leaf extract with a concentration of 2.5%; 3.5%; 4.5%; Albendazole with a concentration of 2.5%; 3.5%; 4.5% as a positive control and use of distilled water as a negative control. The data obtained were analyzed using variance and continued with the Duncan test. The results of this study showed that the use of bidara leaf extract had a significant effect (P<0.05) on vermicidal fasciola sp. The higher the concentration of bidara extract and Albendazole, the faster the death of Fasciola sp. The use of bidara leaf extract and Albendazole 4.5% is the most effective concentration when compared with concentrations of 2.5% and 3.5%. However, of the bidara leaf extract and Albendazole, the most effective is Albendazole 4.5% with the fastest worm death time, namely 4.37 minutes.
Deteksi Ektoparasit pada Ikan Nila (Oreochromis niloticus) di Balai Benih Ikan (BBI) Desa Aik Bukak Kecamatan Batukliang Utara Kabupaten Lombok Tengah Arsyad, Nurlaela Sagita; Atma, Candra Dwi; Dharmawibawa, Iwan Doddy; Rahmawati, Septyana Eka
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.408

Abstract

Tilapia (Oreochromis niloticus) is one of the most widely cultivated freshwater fish in Indonesia, due to its high consumption rate and ease of maintenance. However, ectoparasite infection is a serious threat to fish health and productivity. This study aims to identify the presence and types of ectoparasites in Tilapia at the Fish Seed Center (BBI) of Aik Bukak Village, North Batukliang District, Central Lombok Regency. A total of 20 Tilapia samples from five parent ponds were examined using native scraping and biopsy techniques. The results of the analysis at the Histology and Pathology Laboratory, Faculty of Veterinary Medicine, Mandalika Education University, showed that 18 of the 20 samples were infected with ectoparasites. Morphological identification showed two types of parasites, namely Gyrodactylus sp. (Monogenea) and Trichodina sp. (Protozoa), which were found on the gills, mucus, and scales of the fish. These results indicate that ectoparasites are still a major problem in Tilapia cultivation at the research location.
Co-Authors . Kholik AHDIAH IMROATUL MUFLIHAH Alfiana Laili Dwi Agustin Alfiana Laili Dwi Agustin Anas Fadli Wijaya Arsyad, Nurlaela Sagita Asmara, Zinie Hikmah Atma, Candra Dwi Barmawi, Muhammad Dewi Purnamawati Dharmawibawa, Iwan Doddy Eka Rudy Purwana Fachry Abda El Rahman Hardiansyah Hardiansyah I Ketut Sudana Ira Arundina Katty Hendriana Priscilia Riwu Khairullah, Aswin Rafif Kholik Kurniawan, Shendy Canadya Lalu Purnama Tasyakusuma M. Elyas Arif Budiman Maratun Janah Mashur Muhammad Agus Munandar Putra Munawaroh, Muhammad Mutia Hariani Nurjanah Ni Ketut Yuliana Sari Novarina Sulsia Ista'In Ningtyas Nur Rusdiana Qodri, Hasby faizul RIAN ANGGIA DESTIAWAN Riwu, Katty Hedriana Priscilia Riwu, Katty Hendriana Priscilia Riwu, Katty Hendriana Priscillia Roni Handayani Roni Handayani Sholihatil Hidayati Theresia Indah Budhy Sulisetyawati wijaya, I Gusti Made Arjana