Articles
<![CDATA[Regulasi Reseptor Cytotoxic T Lymphocyte Associated Protein 4 Limfosit T Terhadap Kanker dan Autoimun: Literature Review ]]>
<![CDATA[Rian Anggia Destiawan]]>;
<![CDATA[Anas Fadli Wijaya]]>;
<![CDATA[M Elyas Arif]]>;
<![CDATA[Septyana Eka Rahmawati]]>
<![CDATA[ Jurnal Biosains Pascasarjana Vol. 23 No. 2 (2021): JURNAL BIOSAINS PASCASARJANA ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
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DOI: 10.20473/jbp.v23i2.2021.49-54
<![CDATA[Cytotoxic T Lymphocyte Associated Protein 4 (CTLA-4) adalah reseptor limfosit T yang berikatan dengan B7-1 dan B7-2 dari sel dendritik. CTLA-4 berperan menghambat kerja limfosit T. CTLA-4 diekspresikan oleh limfosit T pada fase istirahat atau setelah teraktivasi. CTLA-4 ditemukan pada sel dendritik, monosit, limfosit B, limfosit T, granulosit, dan stem sel CD34+. CTLA-4 berperan penting dalam perkembangan tumor, kanker serta autoimun. Literatur review ini bertujuan untuk membahas regulasi CTLA-4 limfosit T terhadap penyakit kanker dan autoimun. Metode: pencarian sistematis pada tiga database yaitu NCBI, science direct, dan nature dengan kata kunci “CLTA-4 and T cell and cancer and autoimmune” tahun 2021. Hasil: didapatkan 6 pilihan intervensi untuk mengurangi ekspresi CTLA-4 dan 1 intervensi untuk meningkatkan ekspresi CTLA-4. Kesimpulan: berdasarkan analisis terhadap 7 artikel penelitian, penurunan ekspresi CTLA-4 dapat menghambat pertumbuhan kanker dan peningkatan ekspresi CTLA-4 dapat menghambat berkembangnya autoimun maka dapat. ]]>
<![CDATA[A CYTOKINE RESPONSE IN BRUCELLA ABORTUS BOVINE INFECTION: LITERATURE REVIEW ]]>
<![CDATA[septyana eka rahmawati]]>;
<![CDATA[RIAN ANGGIA destiawan]]>;
<![CDATA[novarina sulsia ista'in ningtyas]]>;
<![CDATA[Mutia Hariani Nurjanah]]>
<![CDATA[ Jurnal Biosains Pascasarjana Vol. 24 No. 1SP (2022): JURNAL BIOSAINS PASCASARJANA: SPECIAL ISSUE ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
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DOI: 10.20473/jbp.v24i1SP.2022.1-12
<![CDATA[Brucella Abortus infection in cattle is an infection that has a strategic effect on society, especially the economic sector. This disease is caused by gram-negative bacteria, namely Brucella abortion. Treatment of Brucella Abortus Infection in cattle is still not effective. Therapy based on the immune response caused by Brucella Abortus Infection, especially the cytokine response, is an effective choice considering that each type of cow has a different immune response in dealing with Brucella Abortus Infection. The purpose of writing this literature review is to identify cytokines that play a role in Brucella Abortus Infection in cattle. Method: automated PUBMED database search using keywords “Brucella Abortus Bovine”, “Cytokine”, and “Brucellosis”. Results: 11 articles that are relevant and meet the inclusion criteria to analyze the cytokines that play a role in Brucella Abortus Infection in cattle. Conclusion: Cytokines that play a role in Brucella Abortus infection in cattle are generally IL-1, IL-6, IL-12, IL-8, TNF-α, and IFN-γ.]]>
<![CDATA[EFFECT OF BLACK GRAPE EXTRACT ON CD4+ and CD8+ EXPRESSION IN MICE INFECTED WITH Salmonella typhimurium ]]>
<![CDATA[rian anggia destiawan]]>;
<![CDATA[septyana eka rahmawati]]>;
<![CDATA[anas fadli wijaya]]>;
<![CDATA[Ahdiah Imroatul Muflihah]]>;
<![CDATA[Mutia Hariani Nurjanah]]>;
<![CDATA[Sholihatil hidayati]]>;
<![CDATA[Ni Ketut Yuliana sari]]>
<![CDATA[ Jurnal Biosains Pascasarjana Vol. 24 No. 1SP (2022): JURNAL BIOSAINS PASCASARJANA: SPECIAL ISSUE ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
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DOI: 10.20473/jbp.v24i1SP.2022.54-63
<![CDATA[Salmonelosis is a disease caused by the Salmonella sp. that causes a decrease in CD4+ expression. Black grape can boost the immune system through CD4+/CD8+ proliferation. The purpose of this study was to evaluate the activity of black grape extract to CD4+ and CD8+ expression in mice infected with Salmonella typhimurium. Research method is extract of black grapes, Salmonella typhimurium 108 infection, bacterial evaluation, extract therapy, flowcytometery examination, and 95% Anova test. The results of Anova test showed that the expression of CD4+ and CD8+ is not different. Biologically, an increase in CD4+ and CD8+ expression at doses of 100 mg/KgBB. A decrease in CD4+ and CD8+ expression at doses of 200 mg/KgBB and 400 mg/KgBB. Conclusion, biologically, black grape extract can increase the expression of CD4+ and CD8+ at low doses, as well as may decrease the expression of CD4+ and CD8+ at moderate to high doses.]]>
<![CDATA[Antimicrobial Test of Telang Flower Extract (Clitoria ternatea L.) against the Growth of Candida albicans ]]>
<![CDATA[Anas Fadli Wijaya]]>;
<![CDATA[Rian Anggia Destiawan]]>;
<![CDATA[Nosa Ika Cahyariza]]>
<![CDATA[ Prisma Sains : Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Vol 11, No 1: January 2023 ]]>
Publisher : <![CDATA[IKIP Mataram ]]>
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DOI: 10.33394/j-ps.v11i1.6857
<![CDATA[Candidiasis is an acute and subacute fungal infection caused by the Candida group, especially Candida albicans. Infectious diseases due to microbes can be treated using modern drugs, namely antifungals. In some cases, antimicrobials often develop resistance due to improper administration. The occurrence of such resistance encourages further research on new active ingredients that can be used as antimicrobial alternatives, especially from plant sources containing flavonoids. The purpose of this study is to determine the effect of antimicrobial content of ethanol extract 70% of Telang flowers on the growth of C. albicans. This research is a laboratory experimental research with post test control group design only method. Determination of antimicrobial activity is carried out by the pitting method. Telang flower extract that has been diluted with 10% DMSO, taken as much as 30µl then dripped into the well. Positive control using antimicrobial ketocenazole and negative control using DMSO 10% which was dripped on the well as much as 30µl. Based on the results of observations, the inhibition zone is only formed in positive control with an average of 15.5 + 0.4 mm. The results of ethanol extract of 70% Telang flowers that have been conducted did not show antimicrobial activity against fungal growth C. albicans. The absence of this inhibitory zone is due to the unknown concentration of active compounds of Telang flowers that are responsible as antimicrobials, so it is necessary to conduct research on the search for concentrations of active compounds that have the ability as antimicrobials.]]>
<![CDATA[UJI EFEKTIVITAS JENIS MASKER BERDASARKAN PERTUMBUHAN BAKTERI PADA MEDIA NUTRIENT AGAR ]]>
<![CDATA[Anas Fadli Wijaya]]>;
<![CDATA[Nosa Ika Cahyariza]]>;
<![CDATA[Rian Anggia Destiawan]]>
<![CDATA[ Jurnal Kesehatan Vol. 10 No. 1 (2022): April : Health Journal “Love That Renewed” ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan Santo Borromeus ]]>
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DOI: 10.55912/jks.v11i1.109
<![CDATA[Mikroorganisme patogen dapat tersuspensi dalam arus udara dan dapat menempuh jarak yang cukup jauh. Pencegahan terjadinya infeksi melalui udara dapat dilakukan dengan berbagai cara, salah satunya penggunaan masker. Tujuan dari penelitian ini adalah untuk mengetahui efektifitas berbagai variasi masker berdasarkan jumlah pertumbuhan bakteri pada media nutrient agar. Penelitian ini memiliki sifat eksperimental laboratorium dengan desain yang digunakan adalah post test control group design only. Dari ketiga masker uji yang digunakan (surgical masker, masker kain, dan KN95) tidak ditemukan adanya pertumbuhan bakteri pada media nutrient agar setelah diinkubasi 1x24 jam, bakteri hanya tumbuh pada kontrol yaitu hembusan tanpa masker dengan jumlah pertumbuhan 3 ± 0,7 koloni.]]>
<![CDATA[Media Alternatif Tepung Terigu Tinggi Protein Untuk Pertumbuhan Jamur Escherichia coli ]]>
<![CDATA[Anas Fadli Wijaya]]>;
<![CDATA[Rian Anggia Destiawan]]>
<![CDATA[ Jurnal Kesehatan Vol. 8 No. 2 (2020): Oktober : Health Journal “Love That Renewed” ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan Santo Borromeus ]]>
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DOI: 10.55912/jks.v8i2.143
<![CDATA[Escherichia coli infection is caused by contaminated food and drinking water, or direct contact with someone who is sick or with animals carrying the bacteria. Diagnosis of diseases caused by E. coli can be done in several ways, but in general it is done clinically, then strengthened by microscopic examination and culture. Commercial media that is often used for culturing bacteria is Nutrient Agar (NA). NA media is a synthetic medium with a high content of carbohydrates and proteins that support bacterial growth. One ingredient that has a high content of protein and carbohydrates is high-protein wheat flour. The purpose of this study was to determine the potential of high-protein wheat flour as an alternative medium for the growth of E. coli bacteria. This study was a laboratory experimental study using the post test control group design only method using 16 replications and 2 treatments, namely NA medium as a control and high protein wheat flour as an alternative medium. The results showed that the average number of E. coli growth on NA media was 336.5 colonies while on alternative high-protein wheat flour media it was 15.19 colonies. The value of p = 0.000 with a 2-way significance level (α = 0.05) then p <α. So there is a significant difference between the number of E. coli bacteria colonies in NA media and alternative high protein wheat flour media. Alternative medium for high-protein wheat flour takes a very long time to grow E. coli bacteria so it is not maximally used as an alternative medium for the growth of E. coli.]]>
<![CDATA[Pengaruh Penambahan Fruktosa Pada Media Potato Dextrose Agar (PDA) Terhadap Pertumbuhan Jamur Candida Albicans ]]>
<![CDATA[Anas Fadli Wijaya]]>;
<![CDATA[Rian Anggia Destiawan]]>
<![CDATA[ Jurnal Kesehatan Vol. 8 No. 1 (2020): April : Health Journal “Love That Renewed” ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan Santo Borromeus ]]>
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DOI: 10.55912/jks.v8i1.144
<![CDATA[Candida is a fungal infection caused by one of the Candida species, the most common being Candida albicans. Diagnosis of candidiasis due to C. albicans can be done in various ways, but the gold standard for examination is by culture. Specimen culture is carried out by planting on mushroom media. Potato Dextrose Agar (PDA) media is the most commonly used medium for culturing C. albicans. The amount of nutrient content in the media affects the level of fertility and incubation time of the microbes grown on the media. In PDA media, the type of sugar (dextrose) used for nutrition is monosaccharide. There are many types of monosaccharides, one of which is fructose. The purpose of this study was to determine the effect of adding fructose to PDA media on the growth of C. albicans. This study was a laboratory experimental study using the post test control group design only method using 16 replications and 2 treatments, namely PDA media without the addition of fructose and PDA media with the addition of fructose. The results showed that the average number of C. albicans growth on PDA media without the addition of fructose was 376.56 colonies while on PDA media with the addition of fructose it was 289.19 colonies. The value of p = 0.000 with a 2-way significance level (α = 0.05) then p <α. So there is a significant difference between the number of C. albicans fungal colonies on PDA media with and without the addition of fructose. The addition of fructose causes the growth of C. albicans to be slower than without the addition of fructose.]]>
<![CDATA[Media Alternatif Tepung Maizena Untuk Pertumbuhan Jamur Trichophyton rubrum ]]>
<![CDATA[Anas Fadli Wijaya]]>;
<![CDATA[Rian Anggia Destiawan]]>
<![CDATA[ Jurnal Kesehatan Vol. 9 No. 2 (2021): Oktober : Health Journal “Love That Renewed” ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan Santo Borromeus ]]>
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DOI: 10.55912/jks.v9i2.145
<![CDATA[Infectious diseases due to microbes in Indonesia are mostly caused by fungal infections. One of these microbes is Trichophyton rubrum. There are several ways to diagnose dermatophytosis, but in general it is done clinically, then confirmed by microscopic examination and culture. The commercial media that is often used for culturing mushrooms is Potato Dextrose Agar (PDA). PDA media is a semi-synthetic medium with a high carbohydrate content. One ingredient that contains high carbohydrates is cornstarch. The purpose of this study was to determine the potential of cornstarch as an alternative medium for the growth of the fungus T. rubrum. This research is a laboratory experimental study with the post test control group design only method using 16 replications and 2 treatments, namely PDA media as a control and cornstarch media as an alternative medium. The results showed that the average number of T. rubrum growth on PDA media was 163.94 colonies while on alternative media cornstarch was 35.51 colonies. The value of p = 0.000 with a 2-way significance level (α = 0.05) then p <α. So there is a significant difference between the number of T. rubrum fungus colonies on PDA media and cornstarch alternative media. Cornstarch alternative media can be used as an alternative medium for the growth of T. rubrum but not as optimal as PDA media.]]>
<![CDATA[Pelatihan Pembuatan Permen Gummy Herbal Sebagai Nutrasetikal Imunbooster di TK Ar Rohim Jember ]]>
<![CDATA[Sholihatil Hidayati]]>;
<![CDATA[Dhina Ayu Susanti]]>;
<![CDATA[Rian Anggia Destiawan]]>;
<![CDATA[Warda Atika Silvana]]>
<![CDATA[ BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 4 (2023) ]]>
Publisher : <![CDATA[Universitas Majalengka ]]>
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DOI: 10.31949/jb.v4i4.6688
<![CDATA[TK Ar Rohim Jember, merupakan salah satu taman kanak-kanak yang berada di Kota Jember dengan posisi didaerah padat penduduk depan RS dr. Soebandi Jember. Posisi yang strategis ini membuat TK Ar Rohim menjadi salah satu pilihan masyarakat sekitar untuk menitipkan buah hatinya dalam mengenal pendidikan pra sekolah. Usia prasekolah disebut sebagai periode golden age dalam pertumbuhan dan perkembangan termasuk periode kritis yang membutuhkan makanan dengan kuantitas dan kualitas yang lebih baik dibandingkan orang dewasa. Berdasarkan hasil pengamatan di lapangan, dapat diidentifikasi beberapa permasalahan, antara lain anak usia prasekolah rawan mengalami gangguan gizi dan infeksi penyakit, kurangnya pemahaman orang tua/wali terkait kesehatan anak dan kebutuhan gizi anak, beberapa orang tua/wali memiliki tingkat ekonomi rendah sehingga enggan untuk membeli produk vitamin dipasaran yang dinilai mahal, kurangnya kreatifitas orang tua/wali dalam mengolah makan yang memiliki kandungan vitamin tinggi menjadi produk makanan yang diminati anak, kebanyakan anak kurang menyukai rasa dan bau tanaman herbal yang memiliki kandungan senyawa imunomodulator. Pengabdian kepada masyarakat ini dilakukan dengan tujuan memberikan edukasi kesehatan dan pelatihan dalam pembuatan permen gummy herbal untuk meningkatkan daya tahan tubuh kepada para orang tua/wali murid TK Ar Rohim Jember. Hasil penegabdian masyarakat ini menunjukkan bahawa anak-anak suka dengan permen gummy herbal yang dihasilkan. Dengan demikian, permen gummy herbal ini dapat menjadi pilihan sediaan yang mudah dibuat dan disukai anak-anak. Dengan kandungan bahan herbal pilihan yang mememiliki khasiat sebagai imunomodulator, maka permen gummy herbal ini diharapkan dapat meningkatkan daya tahan tubuh anak-anak TK Ar Rohim Jember.]]>
<![CDATA[Promosi Kesehatan Pecegahan Infeksi Salmonella Typhi Untuk Mendukung Program Kesehatan Masyarakat ]]>
<![CDATA[Rian Anggia Destiawan]]>;
<![CDATA[Sholihatil Hidayati]]>;
<![CDATA[Dhina Ayu Susanti]]>;
<![CDATA[Ahdiah Imroatul Muflihah]]>;
<![CDATA[Siti Huzaimah]]>;
<![CDATA[Tiara Wahyu Norbaity]]>
<![CDATA[ BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 1 (2024) ]]>
Publisher : <![CDATA[Universitas Majalengka ]]>
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DOI: 10.31949/jb.v5i1.6989
<![CDATA[Salmonella Merupakan bakteri gram negatif berbentuk batang, dan memiliki flagela. Nama Penyakit yang disebabkan oleh bakteri Salmonella adalah salmonellosis yang menyebabkan demam tifoid. Salmonellosis dapat ditularkan melalui makanan dan minuman. Tujuan dari pengabdian masyarakat adalah untuk menggalakkan kesehatan pencegahan infeksi salmonella typhi di masyarakat untuk mengurangi penyakit yang disebabkan oleh bakteri Salmonella typhi. Metode pengabdian masyarakat ini adalah dengan memberikan materi kepada masyarakat terkait penyakit tipus yang disebabkan oleh infeksi Salmonella typhi dan melihat masukan dari masyarakat. Hasil yang diperoleh dari pengabdian masyarakat dukungan masyarakat untuk demam tifoid yaitu dengan cara menjaga kebersihan lingkungan, Menjaga imunitas, menjaga kebersihan makanan, dan mencuci tangan sebelum makan. Kesimpulan dari pengabdian masyarakat ini adalah adanya pemahaman masyarakat baik dalam pencegahan penyakit tifoid yang disebabkan oleh bakteri Salmonella typhi.]]>
