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All Journal Jurnal Penelitian Hasil Hutan Jurnal Kimia dan Kemasan PROSIDING SEMINAR KIMIA IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Indonesian Journal of Chemical Science Jurnal Sains Teknologi dan Lingkungan (JSTL) Indonesian Journal of Chemistry Jurnal Farmamedika (Pharmamedica Journal) Jurnal Penelitian Hasil Hutan Jurnal Kimia dan Kemasan Warta AKAB

Armi Wulanawati

Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, IPB University, Bogor

Author-ID : 572552

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Published : 18 Documents Claim Missing Document

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PERBANDINGAN INHIBISI BRUSEIN D TERHADAP PROTEIN NFKB PADA SEL KANKER PANKREAS SECARA FLEKSIBEL DAN RIGID DOCKING Harry Noviardi; Armi Wulanawati; Muhammad Sholehuddin malik Ibrohim
Jurnal Farmamedika (Pharmamedika Journal) Vol 2 No 2 (2017): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Pancreatic cancer is a malignant tumor types are particularly deadly. Patients with pancreatic cancer are generally treated with chemoradiotherapy and gemcitabine, but still provide a good clinical outcome. This study aims to determine the ratio of the potential of bruceine D as inhibitors of protein NFĸB transcription of pancreatic cancer cells by the Gibbs free energy (ΔG), inhibition constants, hydrogen interactions are flexible and rigid docking. Based on the analysis docking, docking flexibly deliver better results than rigid. Additionally, bruceine D provides the potential for better inhibition than gemcitabine.

PERBANDINGAN INHIBISI α-MANGOSTIN, β-MANGOSTIN, DAN γ-MANGOSTIN TERHADAP PROTEIN AKT-KINASE PADA SEL KANKER PANKREAS SECARA MOLECULAR DOCKING Harry Noviardi; Armi Wulanawati; Muhamad Sholehuddin Malik Ibrohim
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 1 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

The mangosteen pericarp contains a class of compounds called xanthones, including α-mangostin, β-mangostin, and, γ-mangostin. Mangosteen products have become popular natural medicine. cancer is a malignant tumor types are particularly deadly caused by proliferative effects to inhibit apoptosis cell. Akt protein is considered to be the key downstream effector of reducing apoptosis. This study aims to determine the ratio of the potential of α-mangostin, β-mangostin, γ-mangostin as inhibitors of Akt protein of pancreatic cancer cells by the Gibbs free energy (ΔG), inhibition constants, hydrogen interactions. The computationally study using molecular docking method.Based on the analysis docking, γ-mangostin provides the potential for better inhibition than gemcitabine.

ANALISIS STABILITAS LOTION MENGGUNAKAN EMULSIFIER HASIL PENYABUNAN MINYAK DAN ALKALI Armi Wulanawati; Chelsea Epriyani; Elline Sutanto
Jurnal Farmamedika (Pharmamedika Journal) Vol 4 No 1 (2019): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

The lotion is one of the solid dispersion emulsion products with suitable emulsifiers. Lotion is included in cosmetics (personal care) which is usually used to moisturize, soften, and soften the skin. Types of emulsions in personal care are oil in water (o/w) emulsions which tend to be polar in nature. Emulsifiers that are often used in lotion making are emulsifiers that are formed using the saponification method of paraffin oil and triethanolamine alkali. The stability of this emulsion can be influenced by pH and viscosity (polarity) values. Emulsions that have a similar degree of polarity to oil, will tend to be stable. It is known, paraffin has a low polarity, while some other types of oils such as 2-Ethylhexyl Palmitate, Dicaprilyl Ether, Cocoglycerides, Octyldodecanol have a higher polarity, whereas some types of alkalis such as KOH flakes, AMP 95, AMP Ultra PC 3000, Tris Amino Ultra and Neutrol TE have a higher pH than Triethanolamine. Based on these things, the emulsifier in the lotion was formed by reacting stearic acid in various types of oils and alkalis which had higher polarity and pH values than the previous use of oils and alkalis. Mixing between the oil and alkaline phases is carried out at 70−75ºC to facilitate the emulsification process. The results obtained from the lotion emulsion stability test showed that the lotions in all types of oils and alkalis were stable at storage temperatures (room temperature, 45ºC, and 50ºC), and the pH was in the range of 6.75–7.60, but the best lotion emulsions and standards SNI 16-4399-1996 is using an emulsifier composed of Neutrol TE alkali and Octyldodecanol oil which has pH value 6.76-7.03, and viscosity 35000-43000 cP.

Finding a Potential Bruceine D Inhibitor for Apoptotic Resistance Protein Pancreatic Cancer Based on Molecular Docking Armi Wulanawati; Harry Noviardi; Muhamad Sholehuddin Malik Ibrohim
Indonesian Journal of Chemistry Vol 18, No 3 (2018)
Publisher : Universitas Gadjah Mada

Pancreatic cancer arises when cells in the pancreas begin to multiply out of control. In pancreatic cancer, over expression of heat proteins (Hsp70, Hsp 90), constitutive activation of NFĸB, and Bcl-2 family are closely linked with resistance to apoptosis. Apoptotic resistance has been attributed to defects in apoptotic signaling pathways. Bruceine D, which found in abundance Brucea javanica, possesses potent anti-pancreatic cancer activity. In vitro result, bruceine D could induce apoptosis of pancreatic cancer cell. The aim of this study was to find the potential effect of bruceine D inhibitor on apoptotic resistance proteins in pancreatic cancer based on molecular docking. Docking showed a binding affinity between bruceine D with proteins involved in apoptosis using AutoDock. The results showed that free binding energy of Hsp70 is -5.19; Hsp90 -7.26; NFĸB1 -5.49; NFĸB2 -6.14; Bcl-W -6.02; Bcl-xL -5.45 kcal/mol. Based on the result, we conclude that bruceine D with Hsp90 protein has potential the best binding affinity than other proteins.

Effect of the Addition Variations Cocamide Diethanolamine on Physical Characteristics Preparation of Citronella Oil Shampoo Nyi Raden Alyaa S Eryaputri; Siti Triannisa; Alifiana F Damayanti; Alifah J Za’ani; Muhammad Eggy Fahlevy; M Farhan; Najla Amelia; Raditha N Putri; Shilvia Fetria S; Armi Wulanawati
Indonesian Journal of Chemical Science Vol 12 No 2 (2023)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v12i2.69143

Dandruff is still one of the causes of reduced self-confidence which can hinder the comfort of doing activities. Dandruff is a disorder in the form of excessive flaking of dead skin on the scalp, sometimes accompanied by pruritus (itching) and inflammation. Fragrant citronella oil (Cymbopogon nardus (L.)) is a natural product and contains several chemical compounds, including citronellal, citronellol, geraniol which have antifungal and antibacterial activity, so it is used as the main ingredient in the anti-dandruff shampoo. Applying citronella oil directly to the skin is considered less practical and effective. Surfactants such as ammonium lauryl sulfate also function as cleaning agents and foaming agents as well as emulsifying agents. Cocamide DEA is used to increase the viscosity, stabilize and improve foam quality. HPMC is added to increase the thickness of the shampoo, and menthol provides a refreshing and cooling effect. The shampoo formulation was made into 3 formulations consisting of citronella oil shampoo base and various concentrations of Cocamide DEA 6%, 8%, and 10%, as well as lemon scent to offset the scent of citronella oil. The shampoo obtained is thick, has a distinctive aroma, bone white in color, pH 9 and foam height of 1-5 cm. The higher the concentration of Cocamide DEA used, the higher the foam produced in the citronella leaf extract shampoo preparation.

POTENTIAL OF COW’S BLOOD AS A MOTORIZED VEHICLE EXHAUST EMISSION REDUCTION Wulanawati, Armi; Sari, Silvia Mekar; Fachrurrazie, Fachrurrazie
PROSIDING SEMINAR KIMIA Vol 2 No 1 (2023): Prosiding SNK 2023
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar

Motorized vehicle is a means of transportation needed to support various human activities. But on the other hand, this tool is the biggest contributor (85%) to the problem of air pollution that occurs in Indonesia. This is due to motorized vehicle exhaust emissions producing various kinds of pollutants, including hydrocarbon compounds (HC), carbon monoxide (CO), and nitrogen oxides (NOx) which are dangerous and toxic gases, and carbon dioxide (CO2) as a factor in global warming. Hazardous exhaust emissions are formed due to incomplete combustion in the working process of the motor due to a lack of oxygen gas supply. Therefore, it is necessary to find a way to overcome this impact, among others by adding additives that have a high oxygen content to the fuel. The oxygen source can be found abundantly in the blood because it contains hemoglobin, rich in oxygen. Be discovered, cow's blood from animal slaughter waste if it is directly disposed of without processing can also cause environmental pollution. Thus, this research was carried out by synthesizing additives from cow’s red blood cells mixed with methanol at a concentration of 0.1% (w/v) using a maceration time of 3 h. The use of these additives in motorized vehicle fuels resulted in reduced emissions of HC, CO, NOx, and CO2 respectively by 65.96%; 71.43%; 66.67%; and 36.15%. Keywords: cow's blood, exhaust emissions, motorized vehicles, air pollution

Penapisan Senyawa Kandidat Obat Covid-19 dari Ekstrak Asparagus dengan Mekanisme Inhibisi Spike Protein Varian B.1.1.7 terhadap Ligan Panglipur, Hanum Sekar; Fachrurrazie, Fachrurrazie; Wulanawati, Armi; Untung, Joko; Cahyotomo, Anom; Tirta, Ardina Purnama; Solihat, Imas; Amalia, Annissa
Journal Warta AKAB Vol 47, No 2 (2023): Warta AKAB
Publisher : Politeknik AKA Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55075/wa.v47i2.164

Penyebaran yang cepat dan terus meluas semenjak ditemukannya virus Severe Acute Respiratory Syndrome Coronavirus 2 atau SARS-CoV-2 pada 2019, telah memberikan dampak yang luas pada aspek kesehatan dan kesejahteraan global, khususnya Indonesia. Pencarian terapi standar melalui jalur paru seperti nebulizer, menggunakan ekstrak Asparagus diharapkan mampu menjadi alternatif dan terobosan bagi pengobatan SARS-CoV-2. Pengobatan ini merujuk pada proses penapisan antara Spike Glikoprotein (SGP) virus SARS-CoV-2 varian B.1.1.7 dengan reseptor sel manusia ACE2. Penapisan dilakukan dengan mereaksikan senyawa-senyawa yang terdapat pada ekstrak Asparagus dengan SGP virus SARS-CoV-2, sehingga infeksi dapat dicegah. Asparagus dipilih karena mengandung banyak senyawa fitokimia yang diharapkan dapat memberikan karakteristik antivirus, dan dapat menjadi acuan pengobatan COVID-19 melalui studi in silico. Didapat bahwa Dioscin merupakan senyawa yang paling kuat berinteraksi dengan SGP virus SARS-CoV-2 varian B.1.1.7 dari 67 senyawa pada ekstrak Asparagus yang dipelajari. Selain Dioscin terdapat 3 senyawa lainnya yang dapat menjadi acuan untuk pengobatan COVID-19, yakni Shatavarin IV, Aspafilioside A, dan Solasonin dengan nilai afinitas masing-masing -8.3, -8.1, -7.9, dan -7.9 kkal/mol.

Pemanfaatan Eceng Gondok dan Crude Palm Oil sebagai Bioaditif Bahan Bakar Kendaraan Bermotor Wulanawati, Armi; Hairunnisa, Hairunnisa; Sinaga, Friska Wati; Islami, Yosianda Andusia
JURNAL SAINS TEKNOLOGI & LINGKUNGAN Vol. 10 No. 2 (2024): JURNAL SAINS TEKNOLOGI & LINGKUNGAN
Publisher : LPPM Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jstl.v10i2.598

Eceng gondok contains chlorophyll which is an oxygenate type additive which can increase the combustion reaction in fuel and reduce exhaust emissions. Therefore, eceng gondok has the potential to be used as a bioadditive in fuel by adding carotene from crude palm oil which functions as an antioxidant through electron transfer, thereby protecting chlorophyll from autooxidation. The two chlorophyll and carotene extracts at a ratio of 0:1, 2:3, 3:1, 4:1, 3:2, and 1:0 respectively were mixed with toluene and Fatty Acid Methyl Ester as a bioadditive formula. in gasoline fuel. The research results show that there is an increase in octane value of 0.1-0.5% according to ASTM D 2699 and GC-FID and results in a reduction in CO and CO2 exhaust emissions of 52.38% and 37% respectively. .00% on the use of chlorophyll : carotene (2:3) bioadditives in gasoline. This shows that eceng gondok and crude palm oil can be used as bioadditives in gasoline motor vehicles.

Co-Authors Alifah J Za’ani Alifiana F Damayanti Amalia, Annissa Ayu Romawati Ayu Romawati, Ayu Cahyotomo, Anom Charlena Chelsea Epriyani Deswita Deswita Deswita Deswita Deswita Deswita Djeni Hendra Djeni Hendra Elline Sutanto Fachrurrazie, Fachrurrazie Hairunnisa Hairunnisa Harry Noviardi Harry Noviardi Heru Satrio Wibisono Heru Satrio Wibisono, Heru Satrio Islami, Yosianda Andusia Kamela Gustina Kamela Gustina, Kamela M Farhan Muhamad Sholehuddin Malik Ibrohim Muhamad Sholehuddin Malik Ibrohim Muhammad Eggy Fahlevy Muhammad Sholehuddin malik Ibrohim Najla Amelia Nyi Raden Alyaa S Eryaputri Panglipur, Hanum Sekar Raditha N Putri Sari, Silvia Mekar Sembiring, Rinawati Shilvia Fetria S Sinaga, Friska Wati Siti Triannisa Solihat, Imas Sudirman Sudirman Sulistioso Giat S. Sulistioso Giat S. Sulistioso GS Sulistioso GS Tetty Kemala Tirta, Ardina Purnama Untung, Joko

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