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All Journal SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Insan Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Joko Priyanto Wibowo
Universitas Muhammadiyah Banjarmasin
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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EVALUASI AKTIVITAS ANTIOKSIDAN DAN PENGHAMBATAN ENZIM ?-GLUCOSIDASE DARI EKSTRAK KERING DAN FRAKSI DAUN JAMBU BOL (Syzygium malaccense): EVALUATION OF ANTIOXIDANT ACTIVITY AND INHIBITION OF ?-GLUCOSIDASE ENZYME FROM DRIED EXTRACT AND FRACTIONS OF JAMBU BOL (Syzygium malaccense) Islan Nor; Irfan Zamzani; Joko Priyanto Wibowo
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 1 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i1.630

Abstract

Jambu bol (Syzygium malaccense) diberbagai belahan dunia digunakan sebagai pengobatan tradisional untuk mengobati berbagai penyakit dan gejala, termasuk sakit kepala, batuk, peradangan, dan hipertensi. Penyakit degeneratif menimbulkan beberapa penyakit seperti diabetes melitus. Pada tahun 2014 terdapat 422 juta orang dewasa menderita Diabetes Melitus di dunia. Prevalensi meningkat dari 4,7% pada tahun 1980 menjadi 8,5% pada tahun 2014 pada orang dewasa. Angka tertinggi diabetes melitus di Indonesia ditempati oleh DKI Jakarta (3,4%), Kalimantan Timur (3,3%), Yogyakarta (3,2%), dan Sulawesi Utara (3,0%). Antioksidan berperan mencegah penyakit degeneratif yang dikarenakan oleh radikal bebas. Agen penghambat ?-glucosidase dapat menjadi solusi dalam menangani diabetes melitus tipe 2. Tanaman dengan aktivitas antioksidan dan penghambat enzim ?-glucosidase dapat menangani pasien dengan penyakit degeneratif terutama diabetes melitus dengan stres oksidatif, dan menjadi alternatif yang kurang berbahaya dibandingkan obat sintetis. Penelitian ini dilakukan dengan mengekstraksi daun jambu bol dan dikeringkan dengan metode freeze drying, ekstrak difraksinasi dan didapatkan lima fraksi. Ekstrak dan fraksi dilakukan evaluasi terhadap antioksidan dengan metode DPPH dan antihiperglikemik dengan metode penghambatan enzim ?-glucosidase. Hasil dari penelitian ini didapatkan hasil IC50 ekstrak daun jambu bol (Syzygium malaccense) sebesar 57,14 ± 0,42 µg/mL yang termasuk dalam kategori kuat, begitu pula dengan fraksinya yaitu Fr4 dan Fr6 dengan nilai IC50 sebesar 35,52 ± 0,81 µg/mL dan 39,56 ± 1,17 µg/mL, berturut-turut yang tergolong kategori kuat. Begitu pula aktivitas ekstrak dalam menghambat enzim ?-glucosidase dengan persen penghambatan sebesar 83,72 ± 2,06 %. Maka perlu dikembangkan lagi jambu bol (Syzygium malaccense) sebagai agen antioksidan dan agen antihiperglikemia.
DETERMINATION OF THE MINIMUM INHIBITORY CONCENTRATION OF THE ETHANOLIC EXTRACT OF KIPAHIT LEAVES ON THE GROWTH OF Propionibacterium acnes Joko Priyanto Wibowo; Noor Aida; Islan Nor; Irfan Zamzani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.844

Abstract

Acne is a skin disorder characterized by inflammation in the form of comedones, papules, pustules, and nodules. The disease is caused by the gram-positive bacterium,  Propionibacterium acnes. Treatment of the disease using antibiotic agents such as erythromycin and clindamycin has been reported to cause some side effects. Therefore, alternative antibacterial agents derived from natural products are required to reduce the occurrence of side effects. Kipahit (Tithonia diversifolia A. Gray) is one of the plants with pharmacological activities, such as antibacterial and antiprotozoal activities. The aim of this study was to determine the minimum inhibitory concentration (MIC) of a 96% ethanolic extract of kipahit leaves on the growth of P. acnes. Kipahit leaves were extracted through the ultrasound-assisted extraction (UAE) method. Minimum inhibitory concentration (MIC) was determined using the liquid dilution method. A serial dilution was performed to prepare a series of extract concentrations: 25%, 12.5%, 6.25%, 3.13%, 1.56%, 0.78%, and 0.39%. Whereas, clindamycin and DMSO 1% were used as positive and negative controls, respectively. Phytochemical  screening showed  that  the 96% ethanolic extract of kipahit leaves contains flavonoids, alkaloids, saponins, steroids/triterpenoids, tannins, and phenolic compounds. In addition, the extract showed   inhibitory activity against P. acnes at concentrations ranging from 25% to 1,56%. In contrast, the extract showed  no inhibitory activity at concentrations of 0.78% and 0.39%. Further experiments confirmed that kipahit leaf extract acted as a bacteriostatic agent (inhibiting bacterial growth) at a minimum concentration of 1.56%.  Keywords: Acne, Propionibacterium acnes, Kipahit, MIC
EVALUASI AKTIVITAS ANTIOKSIDAN DAN PENGHAMBATAN ENZIM ?-GLUCOSIDASE DARI EKSTRAK KERING DAN FRAKSI DAUN JAMBU BOL (Syzygium malaccense): EVALUATION OF ANTIOXIDANT ACTIVITY AND INHIBITION OF ?-GLUCOSIDASE ENZYME FROM DRIED EXTRACT AND FRACTIONS OF JAMBU BOL (Syzygium malaccense) Islan Nor; Irfan Zamzani; Joko Priyanto Wibowo
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 1 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i1.630

Abstract

Jambu bol (Syzygium malaccense) diberbagai belahan dunia digunakan sebagai pengobatan tradisional untuk mengobati berbagai penyakit dan gejala, termasuk sakit kepala, batuk, peradangan, dan hipertensi. Penyakit degeneratif menimbulkan beberapa penyakit seperti diabetes melitus. Pada tahun 2014 terdapat 422 juta orang dewasa menderita Diabetes Melitus di dunia. Prevalensi meningkat dari 4,7% pada tahun 1980 menjadi 8,5% pada tahun 2014 pada orang dewasa. Angka tertinggi diabetes melitus di Indonesia ditempati oleh DKI Jakarta (3,4%), Kalimantan Timur (3,3%), Yogyakarta (3,2%), dan Sulawesi Utara (3,0%). Antioksidan berperan mencegah penyakit degeneratif yang dikarenakan oleh radikal bebas. Agen penghambat ?-glucosidase dapat menjadi solusi dalam menangani diabetes melitus tipe 2. Tanaman dengan aktivitas antioksidan dan penghambat enzim ?-glucosidase dapat menangani pasien dengan penyakit degeneratif terutama diabetes melitus dengan stres oksidatif, dan menjadi alternatif yang kurang berbahaya dibandingkan obat sintetis. Penelitian ini dilakukan dengan mengekstraksi daun jambu bol dan dikeringkan dengan metode freeze drying, ekstrak difraksinasi dan didapatkan lima fraksi. Ekstrak dan fraksi dilakukan evaluasi terhadap antioksidan dengan metode DPPH dan antihiperglikemik dengan metode penghambatan enzim ?-glucosidase. Hasil dari penelitian ini didapatkan hasil IC50 ekstrak daun jambu bol (Syzygium malaccense) sebesar 57,14 ± 0,42 µg/mL yang termasuk dalam kategori kuat, begitu pula dengan fraksinya yaitu Fr4 dan Fr6 dengan nilai IC50 sebesar 35,52 ± 0,81 µg/mL dan 39,56 ± 1,17 µg/mL, berturut-turut yang tergolong kategori kuat. Begitu pula aktivitas ekstrak dalam menghambat enzim ?-glucosidase dengan persen penghambatan sebesar 83,72 ± 2,06 %. Maka perlu dikembangkan lagi jambu bol (Syzygium malaccense) sebagai agen antioksidan dan agen antihiperglikemia.
DETERMINATION OF THE MINIMUM INHIBITORY CONCENTRATION OF THE ETHANOLIC EXTRACT OF KIPAHIT LEAVES ON THE GROWTH OF Propionibacterium acnes Joko Priyanto Wibowo; Noor Aida; Islan Nor; Irfan Zamzani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.844

Abstract

Acne is a skin disorder characterized by inflammation in the form of comedones, papules, pustules, and nodules. The disease is caused by the gram-positive bacterium,  Propionibacterium acnes. Treatment of the disease using antibiotic agents such as erythromycin and clindamycin has been reported to cause some side effects. Therefore, alternative antibacterial agents derived from natural products are required to reduce the occurrence of side effects. Kipahit (Tithonia diversifolia A. Gray) is one of the plants with pharmacological activities, such as antibacterial and antiprotozoal activities. The aim of this study was to determine the minimum inhibitory concentration (MIC) of a 96% ethanolic extract of kipahit leaves on the growth of P. acnes. Kipahit leaves were extracted through the ultrasound-assisted extraction (UAE) method. Minimum inhibitory concentration (MIC) was determined using the liquid dilution method. A serial dilution was performed to prepare a series of extract concentrations: 25%, 12.5%, 6.25%, 3.13%, 1.56%, 0.78%, and 0.39%. Whereas, clindamycin and DMSO 1% were used as positive and negative controls, respectively. Phytochemical  screening showed  that  the 96% ethanolic extract of kipahit leaves contains flavonoids, alkaloids, saponins, steroids/triterpenoids, tannins, and phenolic compounds. In addition, the extract showed   inhibitory activity against P. acnes at concentrations ranging from 25% to 1,56%. In contrast, the extract showed  no inhibitory activity at concentrations of 0.78% and 0.39%. Further experiments confirmed that kipahit leaf extract acted as a bacteriostatic agent (inhibiting bacterial growth) at a minimum concentration of 1.56%.  Keywords: Acne, Propionibacterium acnes, Kipahit, MIC
UJI CEMARAN MIKROBA SUSU KEDELAI DI WILAYAH BANJARMASIN UTARA DENGAN METODE ANGKA LEMPENG TOTAL Wibowo, Joko Priyanto; Hakim, Khoirul Usmanul; Mirajunnisa
Jurnal Insan Farmasi Indonesia Vol 7 No 2 (2024): JIFI : Special edition
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i2.2099

Abstract

The microbial contamination of soymilk is possibly due to the improper production process. Soymilk product must pass the safety and quality assessment prior to distribution as a commercial product. The research was conducted to determine the level of microbial contamination in soymilk product that are distributed by street vendors in North Banjarmasin. The Total Plate Count (TPC) method was performed to five samples of soymilk to determine the level of microbial contamination. The Total Plate Count (TPC) number of the samples as follow: SG (22,000 ± 2,500 CFU/mL), CU (27,667 ± 2,363 CFU/mL), SA (12,667 ± 1,268 CFU/mL), SM (18,667 ± 1,528 CFU/mL), and KU (18,500 ± 1,323 CFU/mL). In conclusion, all samples of soymilk product North Banjarmasin meet the standard criteria of the Badan Standarisasi Nasional (BSN), which is the TPC less than 1×106 CFU/mL.
Edukasi pencegahan diare dan pembuatan hand sanitizer di panti asuhan Ar-Risalah Banjarmasin Sazali, Ahmad; Supar, Evania Elianti; Fauzi, Yuniarti Erisha; Yolanda, Yolanda; Ahdyani, Risa; Wibowo, Joko Priyanto; Zamzani, Irfan
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 1 (2025): January
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v%vi%i.27134

Abstract

AbstrakBakteri menjadi satu penyebab terjadinya infeksi. Organ saluran pencernaan merupakan bagian yang sering terinfeksi. Escherichia coli beberapa diantaranya berada pada saluran pencernaan, namun yang bersifat patogen dapat menyebabkan diare. Tujuan kegiatan pengabdian masyarakat untuk meningkatkan pengetahuan terhadap pencegahan diare dan peningkatan ketrampilan pembuatan hand sanitizer bagi mitra di panti asuhan yayasan Ar-Risalah Banjarmasin. Metode yang diberikan berupa pendidikan kesehatan dengan rangkaian pemaparan materi mengenai bahaya dan pencegahan diare serta pelatihan pembuatan sedian gel hand sanitizer. Kegiatan ini diikuti orang warga panti asuhan Ar-Risalah sebanyak 15 orang pada 23 Maret 2024. Hasil kegiatan berupa tingkatan pengetahuan tentang bahaya dan pencegahan diare terdiri atas berpengetahuan yang baik sebanyak 6 orang (41%) dan berpengetahuan cukup sebanyak 6 orang (39%) serta berpengetahuan kurang sebanyak 3 orang (20%) pada peserta pengabdian masyarakat dan ketrampilan pembuatan sediaan hand sanitizer peserta mulai trampil. Produk sediaan gel hand sanitizer dapat dimanfaatkan dalam mencegah kasus diare dan mampu meningkatkan hidup sehat. Kata kunci: diare; hand sanitizer; panti asuhan Abstract Bacteria are one cause of infection. The organs of the digestive tract are the parts that are often infected. Some of Escherichia coli are located in the digestive tract, but those that are pathogenic can cause diarrhea. The purpose of community service activities is to increase knowledge about diarrhea prevention and improve hand sanitizer making skills for partners at the Ar-Risalah Banjarmasin foundation orphanage. The method provided was in the form of health education with a series of material presentations on the dangers and prevention of diarrhea as well as training in making hand sanitizer gel preparations. This activity was attended by 15 residents of the Ar-Risalah orphanage on March 23, 2024. The results of the activity in the form of a level of knowledge about the dangers and prevention of diarrhea consisted of 6 people (41%) who had good knowledge and 6 people (39%) who had sufficient knowledge and 3 people (20%) who had less knowledge in community service participants and the skills in making hand sanitizer preparations for participants began to be skilled. Hand sanitizer gel preparations can be used to prevent diarrhea cases and be able to improve healthy living. Keywords: diarrhea; hand sanitizer; orphanage
PERAN KOMUNIKASI, INFORMASI, DAN EDUKASI (KIE) DALAM MENINGKATKAN PENGETAHUAN MASYARAKAT TENTANG GOUT ARTHITIS DI KAMPUNG HIJAU KOTA BANJARMASIN Priyanto Wibowo, Joko; Hadi, Ismanurrahman; Ria Utami, Primanitha; Rachmawati, Hidajah; Setiawan, Didik; Lutfiyati, Heni; Lestari, Dwi; Suhendi, Andi
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 8, No 8 (2025): MARTABE : JURNAL PENGABDIAN KEPADA MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v8i8.%p

Abstract

asam urat atau artritis gout merupakan penyakit degeneratif yang ditandai dengan nyeri pada persendian, umumnya sering terjadi pada usia 30-40 tahun dan 2 kali lipat lebih berisiko pada pria dibandingkan wanita. Tujuan kegiatan pengabdian ini untuk meningkatkan pengetahuan serta pencegahan asam urat terhadap masyarakat Kampung Hijau, Banjarmasin dan memberikan penyuluhan serta penyampaian informasi obat (PIO). Metode yang dilakukan pada pengabdian ini adalah observasi secara langsung kepada masyarakat dengan menggunakan evaluasi berupa pre-test dan post-test. Pengabdian ini menunjukkan hasil yang signifikan antara pre-test dan post-test yang artinya terjadi peningkatan pemahaman setelah dilakukannya edukasi penyakit asam urat kepada masyarakat mengenai  tanda dan gejala asam urat, pencegahan, terapi yang dapat digunakan serta rentang batas normal asam urat. Upaya pengabdian ini secara efektif meningkatkan pengetahuan masyarakat tentang asam urat dan mendorong penerapan gaya hidup sehat. untuk mewujudkan masyarakat yang lebih sejahtera dan berkualitas.
ANTIBIOFILM ACTIVITY OF FIVE NATIVE PLANTS OF KALIMANTAN ISLAND AGAINST Staphylococcus aureus Wibowo, Joko Priyanto; Wahid, Abdul Rahman; Paramitha, Dewi Setya; Wewengkang, Restu Dara; Nurrahmah, Medina
Jurnal Farmasi Sains dan Praktis Vol 11 No 3 (September-December 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i3.12917

Abstract

Infections caused by Staphylococcus aureus are an increasing concern in the healthcare sector, particularly due to the rise of antibiotic-resistant strains. Natural products provide a promising alternative source for discovering new antibacterial and antibiofilm agents. This study aimed to evaluate the antibiofilm activity of five plant species natives to Kalimantan Island against S. aureus. Plant materials were extracted using the ultrasound-assisted extraction (UAE) method with 70% ethanol at 40 kHz and temperature of 30 °C for 30 minutes. Phytochemical screening was performed using standard qualitative tests to detect major secondary metabolite groups, including alkaloids, flavonoids, tannins, saponins, and terpenoids. The antibiofilm assay was carried out using a spectrophotometric microplate method, where biofilm formation was quantified in the presence of plant extracts (500 ppm) compared to negative control (solvent). Data were analyzed statistically using ANOVA (p < 0.05) followed by post-hoc tests to determine significant differences among samples. Among the tested extracts, the gelinggang extract exhibited the strongest antibiofilm effect, inhibiting biofilm formation by 84.39 ± 7.21 %, followed by sangkareho (70.63 ± 7.29 %), kratom (66.54 ± 6.11 %) and matoa (58.36 ± 5.91 %). While, limpasu showed the weakest antibiofilm activity (18.22 ± 1.21 %) in this study. The observed activity may be attributed to the presence of phenolic and flavonoid compounds known to disrupt quorum sensing and biofilm matrix synthesis. These findings highlight the potential of Kalimantan’s native plants, particularly gelinggang, as promising sources of natural antibiofilm agents for combating antibiotic-resistant S. aureus infections.
Antibacterial and Antibiofilm Activity of the Extract and Fractions of Kelakai (Stenochlaena palustris (Burm.F) Bedd) against Methicillin-resistant Staphylococcus aureus Wibowo, Joko Priyanto; Wewengkang, Restu Dara; Nurrahmah, Medina; Fajeriyati, Nurul; Zamzani, Irfan; Jati, Afif Pranaya
Borneo Journal of Pharmacy Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i4.8991

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major concern in healthcare due to its resistance to antibiotics and ability to form biofilms. This study investigated the antibacterial and antibiofilm activity of the extract and fractions of kelakai (Stenochlaena palustris) leaves against MRSA. Phytochemical screening revealed the presence of alkaloids, flavonoids, steroids, tannins, and triterpenoids in S. palustris leaves. The ethanolic extract of S. palustris leaves exhibited dose-dependent antibacterial activity against MRSA at concentrations up to 500 ppm. Among the fractions, the n-hexane fraction exhibited antibacterial activity at 500 and 1000 ppm, while the methanolic fraction showed inhibition only at 1000 ppm. The ethyl acetate fraction did not show any inhibition. All fractions and extract demonstrated antibiofilm activity, with the n-hexane fraction exhibiting the strongest activity (91.33 ± 1.52%) at 125 ppm. The crude extract of S. palustris leaves showed the weakest antibiofilm activity (32.66 ± 8.14%). These findings suggest that S. palustris leaves contain compounds with antibacterial and antibiofilm properties against MRSA, with the n-hexane fraction being the most promising. Further studies are needed to isolate and characterize the active compounds responsible for these activities.
Co-Authors Ahdyani, Risa Ahmad Sazali Andi Suhendi Didik Setiawan Dwi Lestari Fajeriyati, Nurul Fauzi, Yuniarti Erisha Hadi, Ismanurrahman Hakim, Khoirul Usmanul Heni Lutfiyati, Heni Hidajah Rachmawati Irfan Zamzani Islan Nor Jati, Afif Pranaya Mirajunnisa Noor Aida Nurrahmah, Medina Paramitha, Dewi Setya Ria Utami, Primanitha Supar, Evania Elianti Wahid, Abdul Rahman Wewengkang, Restu Dara Yolanda Yolanda, Yolanda Zamzani, Irfan Zamzani, Irfan