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All Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Respirasi (JR) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia World Nutrition Journal Archives of The Medicine and Case Reports Tarumanagara Medical Journal Eduvest - Journal of Universal Studies
Krisadelfa Sutanto
Department Of Nutritional Sciences, Faculty Of Medicine, University Of Indonesia – Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Suplementasi Kalsium dan Risiko Penyakit Kardiovaskular pada Dewasa: Evidence-Based Case Report Yosephine Santoso; Krisadelfa Sutanto
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 5 (2026): Volume 13 Nomor 5
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i5.25529

Abstract

Suplementasi kalsium digunakan untuk pencegahan dan terapi osteoporosis, namun beberapa penelitian menunjukkan peningkatan risiko penyakit kardiovaskular akibat suplementasi ini, sementara studi lain tidak menemukan hubungan bermakna. Evidence-Based Case Report (EBCR) ini bertujuan mengevaluasi hubungan suplementasi kalsium dengan risiko penyakit kardiovaskular pada pasien dewasa. Penelusuran literatur dilakukan menggunakan PubMed, Scopus, dan Cochrane Library untuk artikel yang dipublikasikan tahun 2020–2025. Enam artikel yang memenuhi kriteria inklusi terdiri dari dua studi observasional kohort dan empat SR/MA. Critical appraisal dilakukan menggunakan Oxford Centre for Evidence-Based Medicine appraisal tools dan certainty of evidence dievaluasi dengan pendekatan GRADE. Evidence level tertinggi (Level 1a) berasal dari meta-analisis RCT, sedangkan studi kohort diklasifikasikan sebagai Level 2b. Sebagian besar studi memiliki kualitas sedang karena heterogenitas metodologi, luaran kardiovaskular yang umumnya merupakan hasil sekunder, serta kemungkinan residual confounding dan bias publikasi. Studi observasional menunjukkan adanya peningkatan risiko penyakit kardiovaskular pada pengguna suplementasi kalsium, terutama infark miokard dan stroke. Meta-analisis Yang dkk. dan Myung dkk. melaporkan peningkatan risiko penyakit jantung koroner sebesar 12–20%, terutama pada suplementasi ≥1.000 mg/hari dan monoterapi kalsium. Sebaliknya, meta-analisis Huo dkk. dan Sim dkk. tidak menemukan hubungan signifikan antara suplementasi kalsium dengan infark miokard, stroke, maupun mortalitas kardiovaskular. Heterogenitas evidence dipengaruhi oleh perbedaan desain studi, durasi follow-up, penggunaan vitamin D bersamaan, serta karakteristik populasi penelitian yang mayoritas terdiri dari wanita pascamenopause usia lanjut. Peningkatan risiko absolut tetap rendah meskipun risiko relatif meningkat. Bukti saat ini menunjukkan bahwa suplementasi kalsium dosis ≥1.000 mg/hari mungkin berhubungan dengan peningkatan kecil risiko penyakit kardiovaskular pada populasi tertentu, tetapi hubungan tersebut belum belum dapat disimpulkan secara definitif. Manfaat suplementasi untuk pencegahan osteoporosis tetap perlu dipertimbangkan, terutama pada individu berisiko tinggi fraktur. Penggunaan suplementasi kalsium sebaiknya dipersonalisasi berdasarkan risiko kardiovaskular, usia, komorbiditas, dan kecukupan asupan kalsium dari makanan.
Association Between Homocysteine Levels and Risk of Depression in Office Workers With Vegan Diet in Jakarta Karlina Lestari; Mudjihartini Ninik; Sutanto Krisadelfa
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.43683

Abstract

Depression is a significant global public health concern, and the rising prevalence of vegan diets is currently linked to an increased risk of depression in adults. One contributing factor may be vitamin B12 deficiency in vegans, which can elevate homocysteine levels. This study aims to examine the relationship between homocysteine levels and depression risk among vegan office workers in Jakarta. The research employs a quantitative, cross-sectional design. The population consists of all vegan office workers in Jakarta, with a sample of 58 respondents selected through purposive sampling. Data collection involved interviews, anthropometric measurements, and laboratory tests. The data were analyzed using univariate and bivariate analyses via SPSS version 20. The findings revealed that the average plasma homocysteine level in participants was 3.48 μg/L, considered low. The average PHQ-9 score was 4.75, indicating no depression or moderate depression. Bivariate analysis showed no significant association between homocysteine levels and depression risk, with a p-value of 0.412, suggesting no correlation between homocysteine levels and depression risk in vegan office workers in Jakarta
Effect of oral vitamin E supplementation on lipid profile in diabetes mellitus: evidence based case report Wulandari, Indah Sri; Sutanto, Krisadelfa
World Nutrition Journal Vol. 7 No. 2 (2024): WNJ. Volume 07 Issue 2, February 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V07.i2.0002

Abstract

Introduction: Diabetes mellitus, a prominent non-communicable disease, presents as a chronic condition associated with various complications, including heart disease, nerve damage, chronic kidney disease, and dyslipidemia. A pivotal abnormality in diabetic dyslipidemia is insulin resistance, which stimulates the production of Hepatic VLDL1 (very-low-density lipoprotein 1). The resulting overproduction of VLDL1 is metabolically linked to an abundance of small, dense LDL (low-density lipoprotein) particles and a reduction in large, cholesterol-rich HDL2 (high-density lipoprotein). Conversely, vitamin E, known for its antioxidant and anti-inflammatory properties, acts as a remover of peroxyl radicals, preventing lipid oxidation and safeguarding polyunsaturated fatty acids (PUFA) within cells and plasma lipoproteins. Method: This study investigates the impact of oral vitamin E supplementation on the lipid profile in diabetic patients. Employing advanced search techniques on databases like PubMed, Cochrane Library, and Google Scholar, we conducted a comprehensive literature search using MeSH terms, advanced search methods, and specific eligibility criteria. The results yielded one systematic review with a meta-analysis and two randomized controlled trials (RCTs) that met the predefined PICO and eligibility criteria. Results: The systematic review and meta-analysis, along with one RCT, reported no significant reduction in lipid profiles with oral vitamin E supplementation in diabetic patients. In contrast, the other RCT observed an improvement in lipid profiles among diabetic patients receiving oral vitamin E supplementation. Conclusion: Supplementing with oral vitamin E does not enhance the lipid profile of individuals with diabetes mellitus.
Correlation of energy and protein intake with nitrogen balance changes in late acute phase critically ill patients Githa Putri Puspita Sari; Fiastuti Witjaksono; Krisadelfa Sutanto; Anna Maurina Singal
World Nutrition Journal Vol. 8 No. 2 (2025): WNJ. Volume 08 Issue 2, February 2025
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i2.0007

Abstract

Background: The hypercatabolic process due to metabolic stress in critically ill patients, especially in the acute phase, is very high, causing protein degradation. Inadequate intake and high protein losses will result in a negative nitrogen balance. Objective: To analyze the correlation of energy and protein intake in the late acute phase with nitrogen balance changes. Methods: This study’s method was cross−sectional with consecutive sampling, conducted in the ICU of the university of Indonesia hospital. Energy and protein intake were assessed for 7 days. On days 3 and 7 of treatment, 24−hour urine urea nitrogen levels and nitrogen balance (NB) were assessed. Twenty three subjects participants in this study. Results: There was a positive correlation between energy and protein intake with NB on day 3 (r=0.5, p=0.01 ;r=0.6, p=0.003). The mean nitrogen balance changes was positive, namely 3.8 g. There was a significant correlation between energy and protein intake with NB changes (p>0.01) Conclusion: Energy and protein intake were positively correlated with nitrogen balance in the early acute phase. The results show that the administration of energy and protein starting at low intake in the early acute phase and gradually reaching the target intake during the late acute phase leads to an improvement in nitrogen balance.
Protein and branched-chain amino acid intake are associated with functional capacity in malnourished head and neck cancer patients undergoing chemoradiotherapy Tarafainy Basalamah; Nurul Ratna Mutu Manikam; Tirza Z. Tamin; Wiji Lestari; Krisadelfa Sutanto; Ibrahim Agung
World Nutrition Journal Vol. 10 No. 1 (2026): WNJ. Volume 10 Issue 1, Agustus 2026
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V010.i1.0003

Abstract

Introduction: Head and neck cancer (HNC) patients are at high risk of malnutrition and functional decline. Protein and branched-chain amino acids (BCAA) are key nutrients for muscle protein synthesis and may influence functional capacity. This study examined the association between protein and BCAA intake and functional capacity in malnourished HNC patients receiving chemoradiotherapy. Methods: A cross-sectional study was conducted at a radiotherapy outpatient clinic among malnourished HNC patients undergoing chemoradiotherapy (week 4–5). Energy and protein intake were assessed using three non-consecutive 24-hour food recalls, while BCAA intake was estimated using a semi-quantitative FFQ. Functional capacity was evaluated using the six-minute walk test (6MWT). Associations were analyzed using Spearman’s correlation test. Results: A total of 94 participants were included (mean age 46.9 ± 11.9 years; 61.7% male), with most diagnosed at stage IV disease. Median protein intake was 40.65 g/day (0.79 g/kg BW/day), with 74.5% classified as having inadequate protein intake. Median total BCAA intake was 9.08 g/day. The mean 6MWT distance was 332.9 ± 123.9 m. Significant moderate positive correlations were found between protein intake and 6MWT distance (r = 0.444; p < 0.001) and between BCAA intake and 6MWT distance (r = 0.419; p < 0.001). Conclusion: Protein and BCAA intake showed a moderate association with functional capacity among malnourished HNC patients undergoing chemoradiotherapy. These findings support the importance of optimizing protein and BCAA intake to preserve functional status during active cancer treatment.
Co-Authors Anna Maurina Singal arieska felicia Chandra, Dian Novita Dewi Friska Dewi Wulandari Dian Purwantini Diana Sunardi Diana Sunardi Diyah Eka Andayani Fariz, Nurwidya Fiastuti Witjaksono Fiastuti Witjaksono Fiastuti Witjaksono Githa Putri Puspita Sari Githa Putri Puspita Sari Handayani Eka Puspita Sari Ibrahim Agung K.N, Beta Novianti Karlina Lestari Linda Mahardhika Melissa Mauli Sibarani Ninik Mudjihartini Nurul Ratna Mutu Manikam Paramita, Dewita Nina Paramita Putri Novia Choiri Insani Rania Imaniar Singal, Anna Maurina Syam, Shaogi Tarafainy Basalamah Tirza Z Tamin Wahyu Ika Wardhani Wiji Lestari Wiji Lestari Wina Sinaga Wulandari, Indah Sri Yohannessa Wulandari Yosephine Santoso